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Your search keyword '"De Paoli, Lorella"' showing total 2 results
Start Over Author "De Paoli, Lorella" Topic hematopoietic stem cell transplantation
2 results on '"De Paoli, Lorella"'

1. High Throughput Molecular Characterization of Normal Karyotype Acute Myeloid Leukemia in the Context of the Prospective Trial 02/06 of the Northern Italy Leukemia Group (NILG).

Author

Salmoiraghi, Silvia, Cavagna, Roberta, Zanghì, Pamela, Pavoni, Chiara, Michelato, Anna, Buklijas, Ksenija, Elidi, Lara, Intermesoli, Tamara, Lussana, Federico, Oldani, Elena, Caprioli, Chiara, Stefanoni, Paola, Gianfaldoni, Giacomo, Audisio, Ernesta, Terruzzi, Elisabetta, De Paoli, Lorella, Borlenghi, Erika, Cavattoni, Irene, Mattei, Daniele, and Scattolin, Annamaria

Subjects
CANCER chemotherapy, HEMATOPOIETIC stem cell transplantation, KARYOTYPES, LONGITUDINAL method, MULTIVARIATE analysis, GENETIC mutation, STATISTICAL sampling, RANDOMIZED controlled trials, ACUTE myeloid leukemia, DISEASE remission
Abstract

By way of a Next-Generation Sequencing NGS high throughput approach, we defined the mutational profile in a cohort of 221 normal karyotype acute myeloid leukemia (NK-AML) enrolled into a prospective randomized clinical trial, designed to evaluate an intensified chemotherapy program for remission induction. NPM1, DNMT3A, and FLT3-ITD were the most frequently mutated genes while DNMT3A, FLT3, IDH1, PTPN11, and RAD21 mutations were more common in the NPM1 mutated patients (p < 0.05). IDH1 R132H mutation was strictly associated with NPM1 mutation and mutually exclusive with RUNX1 and ASXL1. In the whole cohort of NK-AML, no matter the induction chemotherapy used, by multivariate analysis, the achievement of complete remission was negatively affected by the SRSF2 mutation. Alterations of FLT3 (FLT3-ITD) and U2AF1 were associated with a worse overall and disease-free survival (p < 0.05). FLT3-ITD positive patients who proceeded to alloHSCT had a survival probability similar to FLT3-ITD negative patients and the transplant outcome was no different when comparing high and low-AR-FLT3-ITD subgroups in terms of both OS and DFS. In conclusion, a comprehensive molecular profile for NK-AML allows for the identification of genetic lesions associated to different clinical outcomes and the selection of the most appropriate and effective treatment strategies, including stem cell transplantation and targeted therapies. [ABSTRACT FROM AUTHOR]

Published
2020
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2. Randomized trial comparing standard vs sequential high-dose chemotherapy for inducing early CR in adult AML

Author

Arianna Masciulli, Irene Cavattoni, Anna Maria Scattolin, Pamela Zanghì, Dario Ferrero, Lorella De Paoli, Chiara Cattaneo, Paolo Corradini, Elisabetta Terruzzi, Erika Borlenghi, Orietta Spinelli, Elisabetta Todisco, Brunangelo Falini, Agostino Cortelezzi, Chiara Pavoni, Sergio Cortelazzo, Giacomo Gianfaldoni, Alessandro Rambaldi, Filippo Marmont, Tamara Intermesoli, Daniele Mattei, Cristina Boschini, Elena Oldani, Renato Bassan, Fabio Ciceri, Massimo Bernardi, Ernesta Audisio, Enrico Pogliani, Leonardo Campiotti, Alberto Bosi, Bassan, Renato, Intermesoli, Tamara, Masciulli, Arianna, Pavoni, Chiara, Boschini, Cristina, Gianfaldoni, Giacomo, Marmont, Filippo, Cavattoni, Irene, Mattei, Daniele, Terruzzi, Elisabetta, De Paoli, Lorella, Cattaneo, Chiara, Borlenghi, Erika, Ciceri, Fabio, Bernardi, Massimo, Scattolin, Anna M, Todisco, Elisabetta, Campiotti, Leonardo, Corradini, Paolo, Cortelezzi, Agostino, Ferrero, Dario, Zanghì, Pamela, Oldani, Elena, Spinelli, Orietta, Audisio, Ernesta, Cortelazzo, Sergio, Bosi, Alberto, Falini, Brunangelo, Pogliani, Enrico M, and Rambaldi, Alessandro

Subjects
Adult, Male, medicine.medical_specialty, Randomization, Adolescent, Clinical Trials and Observations, medicine.medical_treatment, Gastroenterology, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Idarubicin, Humans, Aged, Etoposide, Chemotherapy, business.industry, Hazard ratio, Remission Induction, Cytarabine, Hematopoietic Stem Cell Transplantation, Hematology, Odds ratio, Induction Chemotherapy, Middle Aged, Chemotherapy regimen, Survival Analysis, Confidence interval, Leukemia, Myeloid, Acute, Female, business, medicine.drug
Abstract

Here we evaluated whether sequential high-dose chemotherapy (sHD) increased the early complete remission (CR) rate in acute myelogenous leukemia (AML) compared with standard-intensity idarubicin-cytarabine-etoposide (ICE) chemotherapy. This study enrolled 574 patients (age, 16-73 years; median, 52 years) who were randomly assigned to ICE (n = 286 evaluable) or sHD (2 weekly 3-day blocks with cytarabine 2 g/m2 twice a day for 2 days plus idarubicin; n = 286 evaluable). Responsive patients were risk-stratified for a second randomization. Standard-risk patients received autograft or repetitive blood stem cell-supported high-dose courses. High-risk patients (and standard-risk patients not mobilizing stem cells) underwent allotransplantation. CR rates after 2 induction courses were comparable between ICE (80.8%) and sHD (83.6%; P = .38). sHD yielded a higher single-induction CR rate (69.2% vs 81.5%; P = .0007) with lower resistance risk (P < .0001), comparable mortality (P = .39), and improved 5-year overall survival (39% vs 49%; P = .045) and relapse-free survival (36% vs 48%; P = .028), despite greater hematotoxicity delaying or reducing consolidation blocks. sHD improved the early CR rate in high-risk AML (odds ratio, 0.48; 95% confidence interval [CI], 0.31-0.74; P = .0008) and in patients aged 60 years and less with de novo AML (odds ratio, 0.46; 95% CI, 0.27-0.78; P = .003), and also improved overall/relapse-free survival in the latter group (hazard ratio, 0.70; 95% CI, 0.52-0.94; P = .01), in standard-risk AML, and postallograft (hazard ratio, 0.61; 95% CI, 0.39-0.96; P = .03). sHD was feasible, effectively achieved rapid CR, and improved outcomes in AML subsets. This study is registered at www.clinicaltrials.gov as #NCT00495287.

Published
2019

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