1. Prevention of chemotherapy-induced nausea and vomiting after high-dose melphalan and stem cell transplantation: review of the evidence and suggestions.
- Author
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Tendas A, Marchesi F, Mengarelli A, Annibali O, Tomarchio V, Saltarelli D, Chierichini A, Di Venanzio M, Sollazzo F, Piedimonte M, Cupelli L, Bruno A, De Angelis G, Delbono L, Niscola P, Perrotti AP, de Fabritiis P, and Arcese W
- Subjects
- Adult, Antiemetics therapeutic use, Antineoplastic Agents, Alkylating administration & dosage, Aprepitant administration & dosage, Dexamethasone administration & dosage, Female, Humans, Induction Chemotherapy, Male, Melphalan administration & dosage, Multiple Myeloma drug therapy, Nausea etiology, Quality of Life, Serotonin Antagonists administration & dosage, Serotonin Antagonists therapeutic use, Transplantation Conditioning adverse effects, Transplantation Conditioning methods, Transplantation, Autologous, Vomiting etiology, Antineoplastic Agents, Alkylating adverse effects, Hematopoietic Stem Cell Transplantation adverse effects, Melphalan adverse effects, Nausea prevention & control, Vomiting prevention & control
- Abstract
Introduction: High-dose melphalan (HDMel) is the most common conditioning chemotherapy regimen for autologous stem cell transplantation (SCT) in patients affected by multiple myeloma (MM). No consensus exists for the emetogenicity or prophylaxis of chemotherapy-induced nausea and vomiting (CINV) in this regimen., Methods: Data on the incidence and efficacy/safety of CINV prophylaxis among patients affected by MM undergoing autologous SCT with the HDMel regimen was extracted from electronic databases and analyzed., Results: Eleven studies involving multiple CINV prophylaxis regimens were identified and included. No consensus on HDMel emetogenicity was reached, but most studies summarized the emetogenicity as moderate-high risk. An aprepitant-based three-drug regimen (aprepitant + serotonin receptor antagonist (5HT3RA) + dexamethasone) showed better efficacy than a two-drug regimen (5HT3RA + dexamethasone) for CINV prevention without increasing the frequency in adverse events., Conclusions: The aprepitant-based three-drug regimen should be the regimen of choice for CINV prophylaxis for MM patients undergoing autologous SCT with HDMel conditioning.
- Published
- 2019
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