9 results on '"Bonthuis, Marjolein"'
Search Results
2. The ERA-EDTA Registry Annual Report 2017: a summary.
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Kramer, Anneke, Boenink, Rianne, Noordzij, Marlies, Bosdriesz, Jizzo R, Stel, Vianda S, Beltrán, Palma, Ruiz, Juan C, Seyahi, Nurhan, Farnés, Jordi Comas, Stendahl, Maria, Garneata, Liliana, Winzeler, Rebecca, Golan, Eliezer, Lopot, František, Korejwo, Grzegorz, Bonthuis, Marjolein, Lassalle, Mathilde, Roblero, Maria F Slon, Kuzema, Viktorija, and Hommel, Kristine
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CHRONIC kidney failure ,HEMODIALYSIS patients ,KIDNEY transplantation ,HEMODIALYSIS ,KIDNEY diseases - Abstract
Background This article presents a summary of the 2017 Annual Report of the European Renal Association–European Dialysis and Transplant Association (ERA-EDTA) Registry and describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 37 countries. Methods The ERA-EDTA Registry received individual patient data on patients undergoing RRT for ESRD in 2017 from 32 national or regional renal registries and aggregated data from 21 registries. The incidence and prevalence of RRT, kidney transplantation activity and survival probabilities of these patients were calculated. Results In 2017, the ERA-EDTA Registry covered a general population of 694 million people. The incidence of RRT for ESRD was 127 per million population (pmp), ranging from 37 pmp in Ukraine to 252 pmp in Greece. A total of 62% of patients were men, 52% were ≥65 years of age and 23% had diabetes mellitus as the primary renal disease. The treatment modality at the onset of RRT was haemodialysis for 85% of patients. On 31 December 2017, the prevalence of RRT was 854 pmp, ranging from 210 pmp in Ukraine to 1965 pmp in Portugal. The transplant rate in 2017 was 33 pmp, ranging from 3 pmp in Ukraine to 103 pmp in the Spanish region of Catalonia. For patients commencing RRT during 2008–12, the unadjusted 5-year patient survival probability for all RRT modalities combined was 50.8%. [ABSTRACT FROM AUTHOR]
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- 2020
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3. Association between timing of dialysis initiation and clinical outcomes in the paediatric population: an ESPN/ERA-EDTA registry study.
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Preka, Evgenia, Bonthuis, Marjolein, Harambat, Jerome, Jager, Kitty J, Groothoff, Jaap W, Baiko, Sergey, Bayazit, Aysun K, Boehm, Michael, Cvetkovic, Mirjana, Edvardsson, Vidar O, Fomina, Svitlana, Heaf, James G, Holtta, Tuula, Kis, Eva, Kolvek, Gabriel, Koster-Kamphuis, Linda, Molchanova, Elena A, Muňoz, Marina, Neto, Gisela, and Novljan, Gregor
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CHRONIC kidney failure , *HYPERTENSION , *GLOMERULAR filtration rate , *PEDIATRIC nephrology , *HEMODIALYSIS - Abstract
Background There is no consensus regarding the timing of dialysis therapy initiation for end-stage kidney disease (ESKD) in children. As studies investigating the association between timing of dialysis initiation and clinical outcomes are lacking, we aimed to study this relationship in a cohort of European children who started maintenance dialysis treatment. Methods We used data on 2963 children from 21 different countries included in the European Society of Pediatric Nephrology/European Renal Association–European Dialysis and Transplant Association Registry who started renal replacement therapy before 18 years of age between 2000 and 2014. We compared two groups according to the estimated glomerular filtration rate (eGFR) at start: eGFR ≥8 mL/min/1.73 m2 (early starters) and eGFR <8 mL/min/1.73 m2 (late starters). The primary outcomes were patient survival and access to transplantation. Secondary outcomes were growth and cardiovascular risk factors. Sensitivity analyses were performed to account for selection- and lead time-bias. Results The median eGFR at the start of dialysis was 6.1 for late versus 10.5 mL/min/1.73 m2 for early starters. Early starters were older [median: 11.0, interquartile range (IQR): 5.7–14.5 versus 9.4, IQR: 2.6–14.1 years]. There were no differences observed between the two groups in mortality and access to transplantation at 1, 2 and 5 years of follow-up. One-year evolution of height standard deviation scores was similar among the groups, whereas hypertension was more prevalent among late initiators. Sensitivity analyses resulted in similar findings. Conclusions We found no evidence for a clinically relevant benefit of early start of dialysis in children with ESKD. Presence of cardiovascular risk factors, such as high blood pressure, should be taken into account when deciding to initiate or postpone dialysis in children with ESKD, as this affects the survival. [ABSTRACT FROM AUTHOR]
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- 2019
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4. Hemodialysis vascular access and subsequent transplantation: a report from the ESPN/ERA-EDTA Registry.
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Boehm, Michael, Bonthuis, Marjolein, Noordzij, Marlies, Harambat, Jérôme, Groothoff, Jaap W., Melgar, Ángel Alonso, Buturovic, Jadranka, Dusunsel, Ruhan, Fila, Marc, Jander, Anna, Koster-Kamphuis, Linda, Novljan, Gregor, Ortega, Pedro J., Paglialonga, Fabio, Saravo, Maria T., Stefanidis, Constantinos J., Aufricht, Christoph, Jager, Kitty J., and Schaefer, Franz
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AGE factors in disease , *CHRONIC kidney failure , *CONFIDENCE intervals , *REPORTING of diseases , *ARTERIOVENOUS fistula , *GLOMERULONEPHRITIS , *HEALTH services accessibility , *HEMODIALYSIS , *HEMOGLOBINS , *KIDNEY transplantation , *MEDICAL referrals , *MEDICAL practice , *ORGAN donors , *PEDIATRICS , *REGRESSION analysis , *RISK assessment , *VASCULITIS , *LOGISTIC regression analysis , *PROPORTIONAL hazards models , *CENTRAL venous catheters , *PATIENTS' attitudes , *DESCRIPTIVE statistics , *ODDS ratio - Abstract
Background: Current guidelines advocate use of arteriovenous fistula (AVF) over central venous catheter (CVC) for children starting hemodialysis (HD). European data on current practice, determinants of access choice and switches, patient survival, and access to transplantation are limited.Methods: We included incident patients from 18 European countries who started HD from 2000 to 2013 for whom vascular access type was reported to the ESPN/ERA-EDTA Registry. Data were evaluated using descriptive statistics, logistic and Cox regression models, and cumulative incidence competing risk analysis.Results: Three hundred ninety-three (55.1%) of 713 children started HD with a CVC and were more often females, younger, had more often an unknown diagnosis, glomerulonephritis, or vasculitis, and lower hemoglobin and height-SDS at HD initiation. AVF patients were 91% less likely to switch to a second access, and two-year patient survival was 99.6% (CVC, 97.2%). Children who started with an AVF were less likely to receive a living donor transplant (adjusted HR, 0.30; 95% CI, 0.16-0.54) and more likely to receive a deceased donor transplant (adjusted HR, 1.50; 95% CI, 1.17-1.93), even after excluding patients who died or were transplanted in the first 6 months.Conclusions: CVC remains the most frequent type of vascular access in European children commencing HD. Our results suggest that the choice for CVC is influenced by the time of referral, rapid onset of end-stage renal disease, young age, and an expected short time to transplantation. The role of vascular access type on the pattern between living and deceased donation in subsequent transplantation requires further study. [ABSTRACT FROM AUTHOR]
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- 2019
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5. The European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2015: a summary.
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Kramer, Anneke, Pippias, Maria, Noordzij, Marlies, Stel, Vianda S, Afentakis, Nikolaos, Ambühl, Patrice M, Andrusev, Anton M, Fuster, Emma Arcos, Monzón, Federico E Arribas, Åsberg, Anders, Barbullushi, Myftar, Bonthuis, Marjolein, Caskey, Fergus J, Nuez, Pablo Castro de la, Cernevskis, Harijs, Grottes, Jean-Marin des, Garneata, Liliana, Golan, Eliezer, Hemmelder, Marc H, and Ioannou, Kyriakos
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KIDNEY transplantation ,HEMODIALYSIS ,MEDICAL registries - Abstract
Background: This article summarizes the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Registry's 2015 Annual Report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2015 within 36 countries. Methods: In 2016 and 2017, the ERA-EDTA Registry received data on patients who were undergoing RRT for ESRD in 2015, from 52 national or regional renal registries. Thirty-two registries provided individual patient-level data and 20 provided aggregated-level data. The incidence, prevalence and survival probabilities of these patients were determined. Results: In 2015, 81 373 individuals commenced RRT for ESRD, equating to an overall unadjusted incidence rate of 119 per million population (pmp). The incidence ranged by 10-fold, from 24 pmp in Ukraine to 232 pmp in the Czech Republic. Of the patients commencing RRT, almost two-thirds were men, over half were aged≥65 years and a quarter had diabetes mellitus as their primary renal diagnosis. Treatment modality at the start of RRT was haemodialysis for 85% of the patients, peritoneal dialysis for 11% and a kidney transplant for 4%. By Day 91 of commencing RRT, 82% of patients were receiving haemodialysis, 13% peritoneal dialysis and 5% had a kidney transplant. On 31 December 2015, 546 783 individuals were receiving RRT for ESRD, corresponding to an unadjusted prevalence of 801 pmp. This ranged throughout Europe by more than 10-fold, from 178 pmp in Ukraine to 1824 pmp in Portugal. In 2015, 21 056 kidney transplantations were performed, equating to an overall unadjusted transplant rate of 31 pmp. This varied from 2 pmp in Ukraine to 94 pmp in the Spanish region of Cantabria. For patients commencing RRT during 2006-10, the 5-year unadjusted patient survival probabilities on all RRT modalities combined was 50.0% (95% confidence interval 49.9-50.1). [ABSTRACT FROM AUTHOR]
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- 2018
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6. Outcomes of renal replacement therapy in boys with prune belly syndrome: findings from the ESPN/ERA-EDTA Registry.
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Yalcinkaya, Fatos, Bonthuis, Marjolein, Erdogan, Beyza Doganay, van Stralen, Karlijn J., Baiko, Sergey, Chehade, Hassib, Maxwell, Heather, Montini, Giovanni, Rönnholm, Kai, Sørensen, Søren Schwartz, Ulinski, Tim, Verrina, Enrico, Weber, Stefanie, Harambat, Jérôme, Schaefer, Franz, Jager, Kitty J., and Groothoff, Jaap W.
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TREATMENT effectiveness , *PRUNE belly syndrome , *REPORTING of diseases , *HEMODIALYSIS , *KIDNEY diseases , *PEDIATRICS , *TIME , *TRANSPLANTATION of organs, tissues, etc. , *THERAPEUTICS - Abstract
Background: As outcome data for prune belly syndrome (PBS) complicated by end-stage renal disease are scarce, we analyzed characteristics and outcomes of children with PBS using the European Society for Pediatric Nephrology/European Renal Association-European Dialysis and Transplant Association (ESPN/ERA-EDTA) Registry data. Methods: Data were available for 88 male PBS patients aged <20 years who started renal replacement therapy (RRT) between 1990 and 2013 in 35 European countries. Patient characteristics, survival, and transplantation outcomes were compared with those of male patients requiring RRT due to congenital obstructive uropathy (COU) and renal hypoplasia or dysplasia (RHD). Results: Median age at onset of RRT in PBS was lower [7.0; interquartile range (IQR) 0.9-12.2 years] than in COU (9.6; IQR: 3.0-14.1 years) and RHD (9.4; IQR: 2.7-14.2 years). Unadjusted 10-year patient survival was 85% for PBS, 94% for COU, and 91% for RHD. After adjustment for country, period, and age, PBS mortality was similar to that of RHD but higher compared with COU [hazard ratio (HR) 1.96, 95% confidence interval (CI) 1.03-3.74]. Seventy-four PBS patients (84%) received a first kidney transplant after a median time on dialysis of 8.4 (IQR 0.0-21.1) months. Outcomes with respect to time on dialysis before transplantation, chance of receiving a first transplant within 2 years after commencing RRT, and death-censored, adjusted risk of graft loss were similar for all groups. Conclusions: This study in the largest cohort of male patients with PBS receiving RRT to date demonstrates that outcomes are comparable with other congenital anomalies of the kidney and urinary tract, except for a slightly higher mortality risk compared with patients with COU. [ABSTRACT FROM AUTHOR]
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- 2018
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7. The association of donor and recipient age with graft survival in paediatric renal transplant recipients in a European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplantation Association Registry study.
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Chesnaye, Nicholas C., van Stralen, Karlijn J., Bonthuis, Marjolein, Groothoff, Jaap W., Harambat, Jérôme, Schaefer, Franz, Canpolat, Nur, Garnier, Arnaud, Heaf, James, de Jong, Huib, Sørensen, Søren Schwartz, Tönshoff, Burkhard, and Jager, Kitty J.
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KIDNEY transplantation ,KIDNEY exchange ,ORGAN donors ,DISEASE relapse ,CHRONIC kidney failure ,HEMODIALYSIS - Abstract
Background. The impact of donor age in paediatric kidney transplantation is unclear. We therefore examined the association of donor-recipient age combinations with graft survival in children. Methods. Data for 4686 first kidney transplantations performed in 13 countries in 1990-2013 were extracted from the ESPN/ERA-EDTA Registry. The effect of donor and recipient age combinations on 5-year graft-failure risk, stratified by donor source, was estimated using Kaplan-Meier survival curves and Cox regression, while adjusting for sex, primary renal diseases with a high risk of recurrence, pre-emptive transplantation, year of transplantation and country. Results. The risk of graft failure in older living donors (50-75 years old) was similar to that of younger living donors {adjusted hazard ratio [aHR] 0.74 [95% confidence interval (CI) 0.38-1.47]}. Deceased donor (DD) age was non-linearly associated with graft survival, with the highest risk of graft failure found in the youngest donor age group [0-5 years; compared with donor ages 12-19 years; aHR 1.69 (95% CI 1.26-2.26)], especially among the youngest recipients (0-11 years). DD age had little effect on graft failure in recipients' ages 12-19 years. Conclusions. Our results suggest that donations from older living donors provide excellent graft outcomes in all paediatric recipients. For young recipients, the allocation of DDs over the age of 5 years should be prioritized. [ABSTRACT FROM AUTHOR]
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- 2017
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8. The European Renal Association - European Dialysis and Transplant Association Registry Annual Report 2014: a summary.
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Pippias, Maria, Kramer, Anneke, Noordzij, Marlies, Afentakis, Nikolaos, de la Torre, Ramón Alonso, Ambühl, Patrice M., Aparicio Madre, Manuel I., Monzón, Felipe Arribas, Åsberg, Anders, Bonthuis, Marjolein, Caamaño, Encarnación Bouzas, Bubic, Ivan, Caskey, Fergus J., de la Nuez, Pablo Castro, Cernevskis, Harijs, Garcia Bazaga, Maria de los Ángeles, des Grottes, Jean-Marin, Fernández González, Raquel, Ferrer-Alamar, Manuel, and Finne, Patrik
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HEMODIALYSIS ,KIDNEY disease treatments ,EPIDEMIOLOGY ,KIDNEY transplantation ,KIDNEY disease diagnosis - Abstract
Background: This article summarizes the European Renal Association - European Dialysis and Transplant Association Registry's 2014 annual report. It describes the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in 2014 within 35 countries. Methods: In 2016, the ERA-EDTA Registry received data on patients who in 2014 where undergoing RRT for ESRD, from 51 national or regional renal registries. Thirty-two registries provided individual patient level data and 19 provided aggregated patient level data. The incidence, prevalence and survival probabilities of these patients were determined. Results: In 2014, 70 953 individuals commenced RRT for ESRD, equating to an overall unadjusted incidence rate of 133 per million population (pmp). The incidence ranged by 10-fold; from 23 pmp in the Ukraine to 237 pmp in Portugal. Of the patients commencing RRT, almost two-thirds were men, over half were aged ≥65 years and a quarter had diabetes mellitus as their primary renal diagnosis. By day 91 of commencing RRT, 81% of patients were receiving haemodialysis. On 31 December 2014, 490 743 individuals were receiving RRT for ESRD, equating to an unadjusted prevalence of 924 pmp. This ranged throughout Europe by more than 10-fold, from 157 pmp in the Ukraine to 1794 pmp in Portugal. In 2014,19 406 kidney transplantations were performed, equating to an overall unadjusted transplant rate of 36 pmp. Again this varied considerably throughout Europe. For patients commencing RRT during 2005-09, the 5-year-adjusted patient survival probabilities on all RRT modalities was 63.3% (95% confidence interval 63.0-63.6). The expected remaining lifetime of a 20- to 24- year-old patient with ESRD receiving dialysis or living with a kidney transplant was 21.9 and 44.0 years, respectively. This was substantially lower than the 61.8 years of expected remaining lifetime of a 20-year-old patient without ESRD. [ABSTRACT FROM AUTHOR]
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- 2017
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9. Infants Requiring Maintenance Dialysis: Outcomes of Hemodialysis and Peritoneal Dialysis
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K. van Hoeck, Khadizha Emirova, Karlijn J. van Stralen, J.M. des Grottes, G. von Gersdorff, Kitty J. Jager, C. Afonso, O. Berbeca, Vidar O. Edvardsson, Diamant Shtiza, D. Roussinov, L. Backmän, Jadranka Buturović-Ponikvar, Polina Miteva, Stefano Picca, Tamás Szabó, Anastasios Kapogiannis, Paloma Maria Parvex, Staffan Schön, B. Rippe, Ludmila Podracka, Conceição Mota, Aleksandra Zurowska, Ilona Zagozdzon, Sibylle Tschumi, S. Gatcan, Mirjana Kostic, Gordana Milosevski-Lomic, Enrico Vidal, Natalia Tomilina, N. Abazi, Valerie Said-Conti, Guido F. Laube, Ana Sánchez-Moreno, Runolfur Palsson, Marjolein Bonthuis, A. Cassula, Dusan Paripovic, Brigitte Adams, A. Sukalo, Anna Bjerre, A. Alonso Melgar, S. Puric, Jérôme Harambat, D. Pokrajac, Antal Szabó, N. Zaikova, Aysun Karabay Bayazit, Frederic Collart, Cécile Couchoud, Aline C. Hemke, Boris Bikbov, B. Höcker, Nina Battelino, Karel Vondrak, S. Rudaitis, D. Batinić, Carmine Pecoraro, F. Braddon, Gabriel Mircescu, M. Lemac, Marie Evans, Brankica Spasojević-Dimitrijeva, N. Ristoka Bojkovska, Sergey Baiko, Torbjørn Leivestad, Silvio Maringhini, C.E. Kuenhi, R. Pruthi, Christoph J. Mache, S. Mannings, Franz Schaefer, Andries J. Hoitsma, Elisabeth Maurer, Tomáš Seeman, Gregor Novljan, Augustina Jankauskiene, Enrico Verrina, Rezan Topaloglu, José Eduardo Esteves Da Silva, Antonella Trivelli, R. Oberbauer, Lars Pape, Nikolaos Afentakis, Bruno Gianoglio, M. Lasalle, K. Krupka, Nicholas C. Chesnaye, Gabriel Kolvek, Jaap W. Groothoff, Christer Holmberg, Nikoleta Printza, James G. Heaf, Eva Kis, S. Pavićević, Patrik Finne, C. Scholz, Maria Stendahl, Divna Kruscic, C.S. Berecki, Manish D. Sinha, Carola Grönhagen-Riska, J. Slavicek, Z.S. Györke, Amira Peco-Antic, Emilija Sahpazova, M. Almeida, Burkhard Tönshoff, Karl G. Prütz, G Reusz, Elena A. Molchanova, D. Ivanov, Maria Herthelius, Reinhard Kramar, Sara Testa, U. Toots, Liliana Garneata, University of Zurich, Bonthuis, Marjolein, Clinicum, Children's Hospital, Lastentautien yksikkö, University of Helsinki, HUS Children and Adolescents, and Çukurova Üniversitesi
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CHRONIC KIDNEY-DISEASE ,Ischemia/complications ,Male ,Time Factors ,genetic structures ,Hemolytic-Uremic Syndrome/complications ,Peritoneal Dialysis/methods ,medicine.medical_treatment ,030232 urology & nephrology ,CHILDREN ,Chronic/etiology/therapy ,Health Services Accessibility ,Kidney Failure ,0302 clinical medicine ,Glomerulonephritis ,3123 Gynaecology and paediatrics ,Ischemia ,Vasculitis/complications ,Cause of Death ,Medicine ,ESPN/ERA-EDTA Registry ,Registries ,European Registery for Children on Renal Replacement Therapy ,Kidney transplantation ,ddc:618 ,2727 Nephrology ,STAGE RENAL-DISEASE ,Age Factors ,Kidney Diseases, Cystic ,3. Good health ,Europe ,Survival Rate ,Treatment Outcome ,Renal Dialysis/methods ,Nephrology ,Pediatric nephrology ,SURVIVAL ,outcome ,Kidney Diseases ,Median body ,Female ,Hemodialysis ,Peritoneal Dialysis ,psychological phenomena and processes ,Vasculitis ,Glomerulonephritis/complications ,medicine.medical_specialty ,610 Medicine & health ,hemodialysis (HD) ,survival ,Urogenital Abnormalities/complications ,maintenance dialysis ,Peritoneal dialysis ,REPLACEMENT THERAPY ,03 medical and health sciences ,AGE ,Metabolic Diseases ,Renal Dialysis ,030225 pediatrics ,Internal medicine ,MANAGEMENT ,otorhinolaryngologic diseases ,Humans ,RRT modality ,end-stage renal disease (ESRD) ,infant ,peritoneal dialysis (PD) ,renal replacement therapy (RRT) ,Mortality ,Survival rate ,Dialysis ,Proportional Hazards Models ,Retrospective Studies ,TRANSPLANTATION ,business.industry ,1ST YEAR ,Infant, Newborn ,Infant ,Metabolic Diseases/complications ,Newborn ,medicine.disease ,Kidney Transplantation ,Surgery ,Transplantation ,10036 Medical Clinic ,3121 General medicine, internal medicine and other clinical medicine ,Urogenital Abnormalities ,Kidney Transplantation/statistics & numerical data ,Hemolytic-Uremic Syndrome ,Cystic/complications ,EXPERIENCE ,Kidney Failure, Chronic ,business ,Kidney disease - Abstract
Background: The impact of different dialysis modalities on clinical outcomes has not been explored in young infants with chronic kidney failure. Study Design: Cohort study. Setting & Participants: Data were extracted from the ESPN/ERA-EDTA Registry. This analysis included 1,063 infants 12 months or younger who initiated dialysis therapy in 1991 to 2013. Factor: Type of dialysis modality. Outcomes & Measurements: Differences between infants treated with peritoneal dialysis (PD) or hemodialysis (HD) in patient survival, technique survival, and access to kidney transplantation were examined using Cox regression analysis while adjusting for age at dialysis therapy initiation, sex, underlying kidney disease, and country of residence. Results: 917 infants initiated dialysis therapy on PD, and 146, on HD. Median age at dialysis therapy initiation was 4.5 (IQR, 0.7-7.9) months, and median body weight was 5.7 (IQR, 3.7-7.5) kg. Although the groups were homogeneous regarding age and sex, infants treated with PD more often had congenital anomalies of the kidney and urinary tract (CAKUT; 48% vs 27%), whereas those on HD therapy more frequently had metabolic disorders (12% vs 4%). Risk factors for death were younger age at dialysis therapy initiation (HR per each 1-month later initiation, 0.95; 95% CI, 0.90-0.97) and non-CAKUT cause of chronic kidney failure (HR, 1.49; 95% CI, 1.08-2.04). Mortality risk and likelihood of transplantation were equal in PD and HD patients, whereas HD patients had a higher risk for changing dialysis treatment (adjusted HR, 1.64; 95% CI, 1.17-2.31). Limitations: Inability to control for unmeasured confounders not included in the Registry database and missing data (ie, comorbid conditions). Low statistical power because of relatively small number of participants. Conclusions: Despite a widespread preconception that HD should be reserved for cases in which PD is not feasible, in Europe, we found 1 in 8 infants in need of maintenance dialysis to be initiated on HD therapy. Patient characteristics at dialysis therapy initiation, prospective survival, and time to transplantation were very similar for infants initiated on PD or HD therapy. (C) 2016 by the National Kidney Foundation, Inc.
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- 2016
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