1. Diffuse alveolar hemorrhage in a healthy stem cell donor following administration of granulocyte colony - stimulating factor.
- Author
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Kolben Y, Darawshy F, Barhoum B, Abutbul A, and Kuint R
- Subjects
- Adult, Female, Filgrastim administration & dosage, Hematopoietic Stem Cell Mobilization methods, Hematopoietic Stem Cell Transplantation, Hemorrhage chemically induced, Humans, Lung Diseases chemically induced, Tissue Donors, Filgrastim adverse effects, Hematopoietic Stem Cell Mobilization adverse effects, Hemorrhage diagnosis, Lung Diseases diagnosis
- Abstract
Background: Granulocyte colony - stimulating factor (G-CSF) is frequently used in healthy adults prior to stem cell donation in order to mobilize stem cells to peripheral blood. Adverse events of G-CSF occur in about 30% and mainly include bone pain, fatigue, and headache. Pulmonary adverse events are rare., Case Presentation: Here, we describe a case of a healthy donor who developed diffuse alveolar hemorrhage after G-CSF administration. We suggest the underlying mechanism of this injury., Conclusion: Diffuse alveolar hemorrhage can occur following G-CSF administration. Treating physicians should be aware of this infrequent but often life-threatening pulmonary side effect of G-CSF., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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