1. Prevalence, determinants and genetic diversity of hepatitis C virus in the multi-ethnic population living in Suriname.
- Author
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Mac Donald-Ottevanger MS, Vreden S, van der Helm JJ, van de Laar T, Molenkamp R, Dams E, Roosblad J, Codrington J, Hindori-Mohangoo AD, and Prins M
- Subjects
- Adult, Aged, Female, Genotype, Hepacivirus classification, Humans, Male, Middle Aged, Odds Ratio, Phylogeny, Prevalence, Risk Factors, Seroepidemiologic Studies, Suriname epidemiology, Suriname ethnology, Young Adult, Ethnicity, Genetic Variation, Hepacivirus genetics, Hepatitis C epidemiology, Hepatitis C virology
- Abstract
Little is known about the epidemiology of HCV in Suriname, a former Dutch colony in South America. To study the prevalence, determinants and genetic diversity of HCV, a one-month survey was conducted at the only Emergency Department in the capital Paramaribo. Participants (≥18 years) completed an interviewer-led standardized HCV risk-factor questionnaire, were tested for HCV-antibodies, and if positive also for HCV RNA. The overall HCV prevalence was 1.0% (22/2128 participants; 95%CI 0.7-1.5). Male sex (OR=4.11; 95%CI 1.30-13.01), older age (OR=1.06 per year increase; 95%CI 1.04-1.09), Javanese ethnicity (OR=7.84; 95%CI 3.25-18.89) and cosmetic tattooing (OR=31.7; 95%CI 3.25-323.87) were independently associated with HCV-infection. Phylogenetic analysis revealed six distinct HCV subtypes, all HCV-genotype 2 (HCV-2): subtype 2f (also circulating in Indonesia) plus five yet unassigned HCV-2 subtypes exclusively linked to Suriname., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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