1. Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity.
- Author
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Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Yao X, Liang ZL, Wu T, Li JX, Yan Q, Yang CL, Jiang HM, Huang HJ, Xian YL, Shih JW, Ng MH, Li YM, Wang JZ, Zhu FC, and Xia NS
- Subjects
- Adolescent, Adult, Cohort Studies, Female, Follow-Up Studies, Hepatitis E epidemiology, Humans, Male, Middle Aged, Placebos administration & dosage, Risk Assessment, Vaccines, Synthetic administration & dosage, Viral Hepatitis Vaccines administration & dosage, Young Adult, Hepatitis E immunology, Hepatitis E prevention & control, Hepatitis E virus immunology, Vaccines, Synthetic immunology, Viral Hepatitis Vaccines immunology
- Abstract
Immunity acquired from infection or vaccination protects humans from symptomatic hepatitis E. However, whether the risk of hepatitis E virus (HEV) infection is reduced by the immunity remains unknown. To understand this issue, a cohort with 12 409 participants randomized to receive the hepatitis E vaccine Hecolin(®) or placebo were serologically followed up for 2 years after vaccination. About half (47%) of participants were initially seropositive. A total of 139 infection episodes, evidenced by four-fold or greater rise of anti-HEV level or positive seroconversion, occurred in participants who received three doses of treatment. Risk of infection was highest among the baseline seronegative placebo group participants (2.04%). Pre-existing immunity and vaccine-induced immunity lower the risk significantly, to 0.52% and 0.30%, respectively. In conclusion, both vaccine-induced and naturally acquired immunity can effectively protect against HEV infection., (© 2013 The Authors Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases.)
- Published
- 2014
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