1. Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study
- Author
-
Huang, Daniel Q, Fowler, Kathryn J, Liau, Joy, Cunha, Guilherme M, Louie, Ashley L, An, Julie Y, Bettencourt, Ricki, Jung, Jinho, Gitto, Zachary, Hernandez, Christie, Lopez, Scarlett J, Gupta, Hersh, Sirlin, Claude B, Marks, Robert M, and Loomba, Rohit
- Subjects
Biomedical Imaging ,Chronic Liver Disease and Cirrhosis ,Rare Diseases ,Digestive Diseases ,Clinical Research ,Hepatitis ,Liver Disease ,Liver Cancer ,Cancer ,Prevention ,Oral and gastrointestinal ,Carcinoma ,Hepatocellular ,Contrast Media ,Female ,Humans ,Liver Cirrhosis ,Liver Neoplasms ,Magnetic Resonance Imaging ,Male ,Middle Aged ,Non-alcoholic Fatty Liver Disease ,Prospective Studies ,Retrospective Studies ,abbreviated MRI ,cirrhosis ,hepatocellular carcinoma ,NAFLD ,surveillance ,Clinical Sciences ,Pharmacology and Pharmaceutical Sciences ,Gastroenterology & Hepatology - Abstract
BackgroundRetrospective studies report that visualisation of the liver may be severely limited using ultrasound (US), potentially contributing to diminished sensitivity for detection of hepatocellular carcinoma (HCC) among patients with nonalcoholic fatty liver disease (NAFLD) and cirrhosis, but there are limited prospective data.AimsTo compare liver visualisation scores prospectively for US and abbreviated hepatobiliary phase (HBP) magnetic resonance imaging (AMRI) in a cohort of participants with NAFLD cirrhosis and a clinical indication for HCC surveillance.MethodsThis prospective multicenter study included 54 consecutive participants (67% women) with NAFLD cirrhosis who underwent contemporaneous US as well as HBP-AMRI with gadoxetic acid. Primary outcome was the proportion of imaging examinations with severe limitations in liver visualisation (visualisation score C) compared head-to-head between US and AMRI.ResultsThe mean (± standard deviation) age was 63.3 years (±8.4) and body mass index was 32.0 kg/m2 (±6.0). Nineteen participants (35%) had severe visualisation limitations on US, compared with 10 (19%) with AMRI, p
- Published
- 2022