Search

Cucumis bisexualis has been widely served as a beneficial wild fruit in China. Four new homoisoflavonoids (1–4), together with eight known homoisoflavonoid derivatives (5–12) were isolated from the 90% EtOH extract of C. bisexualis, using repeated open column chromatography and preparative thin‐layer chromatography. They were elucidated based on the analysis of spectral data and references from the fruits of C. bisexualis for the first time. These compounds (1–12) were evaluated for their in vitro inhibitory effects against the increase of aspartate aminotransferase and alanine aminotransferase levels in H2O2‐induced HepG2 cells in the range of their maximum nontoxic concentration. Among them, compounds 3, 4, 8, and 9 exhibited certain hepatoprotective activities. Practical applications: Cucumis bisexualis A.M. Lu ＆ G.C. Wang is an edible and medical fruit with many functional properties. A detailed study was made to identify the bioactive constituents of C. bisexualis and four new homoisoflavonoids (1–4) and eight known homoisoflavonoid derivatives (5–12) were isolated from the fruits of C. bisexualis for the first time. Compounds 3, 4, 8, and 9 exhibited certain hepatoprotective activities. This study suggests that natural compounds isolated from C. bisexualis could be used as promising hepatoprotective agents. [ABSTRACT FROM AUTHOR]

• Murraya koenigii is not only an ingredient, but also a medical plant for people. • Three new alkaloids and a new natural alkaloid were isolated from M. koenigii. • Thirteen known alkaloids were obtained from M. koenigii for the first time. • Compounds 1 , 15 , 16 , and 17 (10 μM) showed moderate hepatoprotective activities. • Compounds 2 , 3 , 9 , and 13 showed moderate activation of PPAR α and PPAR γ receptors. Three new alkaloids (1 - 3) and a new natural alkaloid (4), named (1′ R, 3′ R, 4′ R, 6′ S)-endocycliomurrayamine-A (1), 3-formyle-7-hydroxy-9 H -carbazole-1- O - β - d -glucopyranoside (2), 4′-hydroxyphenyl-6-ethyl-1 H -pyrrole-2-carboxaldehyde (3), and 4-hydroxyphenoxy -N- methyl-propanamide (4), together with thirteen known alkaloid derivatives (5 – 17) were isolated from Murraya koenigii. Among them, compounds (8 – 17) were isolated from this plant for the first time. The structures of compounds (1 – 17) were elucidated on the basis of their spectroscopic analysis and references. Compounds 1 , 15 , 16 , and 17 (10 μM) showed moderate hepatoprotective activities against d -galactosamine-induced HL-7702 cells damage. Compounds 2 , 3 , 9 , and 13 showed moderate activation of PPAR α and PPAR γ receptors. [ABSTRACT FROM AUTHOR]

The flower of Hosta plantaginea (Lam.) Aschers (Liliaceae) is a traditional medicinal material in Mongolian medicine for treating sore throat, hoarseness, pulmonary fever, and toxic fever in folk. The present work investigated anti-prostate cancer and hepatoprotective activities of flavonoid derivatives from H. plantaginea (Lam.) Aschers. Aim of the study : To isolate and identify the chemicals of H. plantaginea (Lam.) Aschers for anti-prostate cancer and hepatoprotective activities. Active chemicals were isolated and purified from H. plantaginea (Lam.) Aschers by chromatographic methods, and their structures were established on spectroscopic analysis and references. These compounds were evaluated for their anti-prostate cancer activities using the LNCaP prostate cancer cells, and assayed for their hepatoprotective activities on CCl 4 -induced injury of human L-O2 cells, respectively. Four new flavonol-lignan heterodimers (1 – 4), together with nine known flavonoid derivatives (5 – 13) were isolated from this plant for the first time. Among them, some compounds exhibited moderate anti-prostate cancer and hepatoprotective activities. Compounds 1 , 2 , 5 , and 6 showed anti-prostate cancer activities using the LNCaP prostate cancer cells with IC 50 values of 17.84, 33.26, 54.13, and 81.55 μg/mL, and compounds 3 , 4 , 8 , and 9 exhibited moderate hepatoprotective activities, respectively. A preliminary structure-activity relation was summarized in this paper. Image 1 [ABSTRACT FROM AUTHOR]

• Nine new flavonoids derivatives (1 – 9) were isolated from Heleocharis dulcis. • Neuroprotective and hepatoprotective activities of compounds (1 – 25) were assayed. • Structure-effectiveness relationship was found and discussed scientifically. Chinese water chestnut, the bulb of Heleocharis dulcis , has been widely consumed as fruit or vegetable in China since ancient times. It exhibits health-promoting properties that leads to an extensive study of their active components. Successive chromatography of active fragments of H. dulcis resulted in isolation of five new chalcone-flavonone heterodimers (1 – 3 , 6 , 9), four new diverse flavonoids (4 , 5 , 7 , 8), and sixteen known flavonoids derivatives (10 – 25) were elucidated on the basis of their IR, UV, NMR, MS spectrometry data analysis and references from H. dulcis for the first time. Among these isolates, compounds 4 , 7 , 9 , 12 , 13 , and 17 showed moderate neuroprotective activity, which increased the cell survival rate from 49.23 ± 3.68% for the model to 67.75 ± 2.75%, 57.83 ± 2.46%, 67.98 ± 2.74%, 58.65 ± 3.43%, 56.14 ± 1.99%, and 56.70 ± 1.38% at 10 μM, respectively. Moreover, compounds 1 – 3 , 15 , 16 , 18 , and 20 were found to moderately improve the HepG2 cell survival rates from 39.53% (APAP, 10 mM) to 45.53–53.44%. The outcome of the study provided crucial information regarding the structural diversity and health benefits of the edible bulbs of H. dulcis. [ABSTRACT FROM AUTHOR]