1. Boosting the VZV-Specific Memory B and T Cell Response to Prevent Herpes Zoster After Kidney Transplantation
- Author
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Marcia M. L. Kho, Willem Weimar, S. Reshwan K. Malahe, Joke M. Zuijderwijk, Ronella de Kuiper, Marieken J. Boer-Verschragen, Annemiek A. van der Eijk, Dennis A. Hesselink, Marlies E. J. Reinders, and Nicole M. van Besouw
- Subjects
booster vaccination ,herpes zoster ,kidney transplantation ,varicella zoster virus ,humoral response ,T-cell reactivity ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundSolid organ transplant recipients are at high risk to develop (complicated) herpes zoster (HZ). Booster vaccination could prevent HZ. However, end-stage renal disease (ESRD) patients show poor immunological responses to vaccinations. We studied the effect of a live attenuated VZV booster vaccine on VZV-specific B and T cell memory responses in ESRD patients and healthy controls. NL28557.000.09, www.toetsingonline.nlMethodsVZV-seropositive patients, aged ≥50 years, awaiting kidney transplantation, were vaccinated with Zostavax®. Gender and age-matched VZV-seropositive potential living kidney donors were included as controls. VZV-specific IgG titers were measured before, at 1, 3 and 12 months post-vaccination. VZV-specific B and T cell responses before, at 3 months and 1 year after vaccination were analysed by flow-cytometry and Elispot, respectively. Occurrence of HZ was assessed at 5 years post-vaccination.Results26 patients and 27 donors were included. Median VZV-specific IgG titers were significantly higher at all time-points post-vaccination in patients (mo 1: 3104 IU/ml [1967-3825], p
- Published
- 2022
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