1. Pathogenic Role of Epstein-Barr Virus in Lung Cancers.
- Author
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Becnel D, Abdelghani R, Nanbo A, Avilala J, Kahn J, Li L, and Lin Z
- Subjects
- Animals, Disease Models, Animal, Epstein-Barr Virus Infections diagnosis, Gene Expression Regulation, Viral, Humans, Lung Neoplasms metabolism, Lung Neoplasms pathology, Virus Latency genetics, Cell Transformation, Viral, Disease Susceptibility, Epstein-Barr Virus Infections complications, Epstein-Barr Virus Infections virology, Herpesvirus 4, Human physiology, Lung Neoplasms etiology
- Abstract
Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein-Barr virus (EBV) is the first identified human oncogenic virus and it alone causes ~200,000 cancer cases and ~1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic.
- Published
- 2021
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