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This focused review aims to summarize recent developments in the processes involving additions of secondary propargylamines to various heteroallenes and subsequent transition metal-catalyzed or electrophile-mediated cyclizations. The utility of this convenient and tunable strategy spans from the carbon dioxide fixation and target-oriented synthesis of complex natural and biologically active products to the generation of extended synthetic libraries of diverse oxygen-, nitrogen- and sulfur-containing heterocycles. For comparative purposes, the analogous transformations of propargylic alcohols are also highlighted in this account. [ABSTRACT FROM AUTHOR]

A new protocol for the one-pot synthesis of pyrrolones and butenolides involving an isocyanide-based multicomponent reaction (Ugi or Passerini) followed by a triethylamine-promoted cycloisomerization is described. [ABSTRACT FROM AUTHOR]

A novel three-component reaction of 2-oxoaldehydes, cyclic 1,3-dicarbonyl compounds, and 4-aminopyridines leading to the formation of zwitterionic Michael adducts is described. [ABSTRACT FROM AUTHOR]

A comprehensive study on gold- and silver-catalyzed cycloisomerizations of hydroxypropargylamides into oxazepines is described. Three different types of hydroxypropargylamide substrates derived from either amide coupling or Ugi reactions have been validated resulting in establishment of selective and general access to a medium-ring oxazepine core. [ABSTRACT FROM AUTHOR]

A novel microwave-assisted protocol allowing the successful application of 2-aminoimidazoles in the Groebke-Blackburn-Bienaymé reaction for the facile construction of the 1H-imidazo[1,2-a]imidazol-5-amine core was developed. [ABSTRACT FROM AUTHOR]

A novel copper(II) triflate-catalyzed reaction of 2-aminonicotinaldehydes with terminal alkynes providing access to 1,8-naphthyridine core is described. [ABSTRACT FROM AUTHOR]