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Planar glass-etalon Fabry–Pérot (FP) optical ultrasound sensors offer an alternative to piezoelectric sensors for the measurements of high-intensity focused ultrasound (HIFU) fields and other metrological applications. In this work, a model of the frequency-dependent directional response of the FP sensor was developed using the global matrix method, treating the sensor as a multilayered elastic structure. The model was validated against the experimentally measured directional response of an air-backed cover-slip FP sensor with well-known material properties. In addition, the model was compared with the measurements of an all-hard-dielectric sensor suitable for HIFU measurements. The model was then used to calculate modal dispersion curves for both glass-etalon sensors, allowing the features of the directional response to be linked to specific wave phenomena. The features in the directivity of the air-backed cover-slip sensor are due to guided Lamb waves. Symmetric Lamb modes give rise to regions of high sensitivity, whereas anti-symmetric modes cause regions of low sensitivity. For the all-hard-dielectric sensor, two features correspond to the water-substrate and water-spacer compressional and shear critical angles. A region of high sensitivity close to the shear critical angle is associated with a leaky-Rayleigh wave, which has a frequency-dependent phase speed. At higher frequencies, this feature is counteracted by a region of low sensitivity, which occurs when there is no difference in the vertical displacement of the mirrors forming the FP cavity. The model may be used to improve and optimize the design of FP sensors or could be used to assist with the accurate deconvolution of the directional response from array measurements in metrological and imaging applications. [ABSTRACT FROM AUTHOR]

Background: Prostate cancer is frequently treated using external beam radiation therapy (EBRT). Prior to therapy, the prostate is commonly implanted with a small number of permanent fiducial markers used to monitor the position of the prostate during therapy. In the case of local cancer recurrence, high-intensity focused ultrasound (HIFU) provides a non-invasive salvage treatment option. However, the impact of the fiducial markers on HIFU treatment has not been thoroughly studied to date. The objective of this study was to experimentally investigate the effect of a single EBRT fiducial marker on the efficacy of HIFU treatment delivery using a tissue-mimicking material (TMM). Methods: A TMM with the acoustic properties of the prostate was developed based on a polyacrylamide hydrogel containing bovine serum albumin. Each phantom was implanted with a cylindrical fiducial marker and then sonicated using a 3.3 MHz focused bowl HIFU transducer. Two sets of experiments were performed. In the first, a single lesion was created at different positions along either the anteroposterior or left-right axes relative to the marker. In the second, a larger ablation volume was created by raster scanning. The size and position of the ablated volume were assessed using a millimetre grid overlaid on the phantom. Results: The impact of the marker on the position and size of the HIFU lesion was significant when the transducer focus was positioned within 7 mm anteriorly, 18 mm posteriorly or within 3 mm laterally of the marker. Beyond this, the generated lesion was not affected. When the focus was anterior to the marker, the lesion increased in size due to reflections. When the focus was posterior, the lesion decreased in size or was not present due to shadowing. Conclusions: The presence of an EBRT fiducial marker may result in an undertreated region beyond the marker due to reduced energy arriving at the focus, and an overtreated region in front of the marker due to reflections. Depending on the position of the targeted regions and the distribution of the markers, both effects may be undesirable and reduce treatment efficacy. Further work is necessary to investigate whether these results indicate the necessity to reconsider patient selection and treatment planning for prostate salvage HIFU after failed EBRT. [ABSTRACT FROM AUTHOR]

Measurement of high acoustic pressures is necessary in order to fully characterize clinical high-intensity focused ultrasound (HIFU) fields, and for accurate validation of computational models of ultrasound propagation. However, many existing measurement devices are unable to withstand the extreme pressures generated in these fields, and those that can often exhibit low sensitivity. Here, a planar Fabry–Pérot interferometer with hard dielectric mirrors and spacer was designed, fabricated, and characterized, and its suitability for measurement of nonlinear focused ultrasound fields was investigated. The noise equivalent pressure (NEP) of the scanning system scaled with the adjustable pressure detection range between 49 kPa for pressures up to 8 MPa and 152 kPa for measurements up to 25 MPa, over a 125 MHz measurement bandwidth. Measurements of the frequency response of the sensor showed that it varied by less than 3 dB in the range 1–62 MHz. The effective element size of the sensor was 65 \mu \textm and waveforms were acquired at a rate of 200 Hz. The device was used to measure the acoustic pressure in the field of a 1.1 MHz single-element spherically focused bowl transducer. Measurements of the acoustic field at low pressures compared well with measurements made using a Polyvinylidene difluoride needle hydrophone. At high pressures, the measured peak focal pressures agreed well with the focal pressure modeled using the Khokhlov–Zabolotskaya–Kuznetsov equation. Maximum peak positive pressures of 25 MPa and peak negative pressures of 12 MPa were measured, and planar field scans were acquired in scan times on the order of 1 min. The properties of the sensor and scanning system are well suited to measurement of nonlinear focused ultrasound fields, in both the focal region and the low-pressure peripheral regions. The fast acquisition speed of the system and its low NEP are advantageous, and with further development of the sensor, it has potential in application to HIFU metrology. [ABSTRACT FROM AUTHOR]