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Your search keyword '"Kauffmann, Frederic"' showing total 2 results
Start Over Author "Kauffmann, Frederic" Topic histomorphometry
2 results on '"Kauffmann, Frederic"'

1. Alveolar ridge alterations after lateral guided bone regeneration with and without hyaluronic acid: a prospective randomized trial with morphometric and histomorphometric evaluation.

Author

Kauffmann, Frederic, Fickl, Stefan, Sculean, Anton, Fischer, Kai R., and Friedmann, Anton

Subjects
ALVEOLAR process surgery, OPERATIVE dentistry, COLLAGEN, HYALURONIC acid, TREATMENT effectiveness, RANDOMIZED controlled trials, COMPARATIVE studies, BONE regeneration, BONE density, STATISTICAL sampling, LONGITUDINAL method, EVALUATION
Abstract

Objective: To clinically and histologically evaluate the potential effect of a cross-linked, high molecular weight hyaluronic acid (xHyA) on the outcomes of guided bone regeneration performed with a demineralized bovine bone mineral (DBBM) covered with a natural collagen membrane. Method and materials: Eleven patients (eight females and three males, mean age53years) with a total of 27 surgical sites were treated. Treatments were performed with either DBBM and natural collagen membrane fixed with tacks (group A) or DBBM mixed with xHyAand subsequently covered with natural collagen membrane (group B). Clinical evaluations were made at baseline (Tl), immediately after guided bone regeneration (T2), and at the time of implant placement (T3). Additionally, at the time of implant placement, core biopsies were retrieved and submitted for histologic analysis. Results: Healing was uneventful in all cases. At 6months, group B revealed a statistically significantly higher crestal ridge dimension compared to group A (P =.007). The histologic analysis revealed a tendency for greater mineralized tissue formation in group B compared to group A (67.5% versus 41.6%) and contained a higher amount of new bone (37.2%) and less DBBM residues (20.9%) than group A (12.8% new bone and 28.8% DBBM residues, respectively). Conclusions: Within their limits, the present data indicate that, during guided bone regeneration with natural collagen membrane, the combination of DBBM and xHyA may improve the qualityand quantityof boneformed with DBBM alone. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Horizontal Augmentation of Chronic Mandibular Defects by the Guided Bone Regeneration Approach: A Randomized Study in Dogs

Author

Friedmann, Anton, Fickl, Stefan, Fischer, Kai R, Dalloul, Milad, Goetz, Werner, Kauffmann, Frederic, University of Zurich, and Friedmann, Anton

Subjects
Technology, Microscopy, QC120-168.85, 3104 Condensed Matter Physics, bone substitutes, collagen membranes, QH201-278.5, 610 Medicine & health, animal study, Engineering (General). Civil engineering (General), histomorphometry, 2500 General Materials Science, Article, TK1-9971, guided bone regeneration (GBR), degradation profile, Descriptive and experimental mechanics, lateral augmentation, 10066 Clinic of Conservative and Preventive Dentistry, General Materials Science, ddc:610, Electrical engineering. Electronics. Nuclear engineering, TA1-2040
Abstract

Various biomaterial combinations have been studied focusing on their ability to stabilize blood clots and maintain space under soft tissue to support new bone formation. A popular combination is Deproteinized Bovine Bone Mineral (DBBM) placed with a native collagen membrane (NCM) tacked to native bone. In this study, we compared the outcome of this treatment option to those achieved with three different graft/membrane combinations with respect to total newly occupied area and the mineralized compound inside. After bi-lateral extraction of two mandibular premolars in five adult beagles L-shaped alveolar defects were created. A total of 20 defects healed for 6 weeks resulting in chronic type bone defects. At baseline, four options were randomly allocated to five defects each: a. DBBM + NCM with a four-pin fixation across the ridge; b. DBBM + RCLC (ribose cross-linked collagen membrane); c. DBBM + NPPM (native porcine pericardium membrane); and d. Ca-sulfate (CS) + RCLC membrane. Membranes in b/c/d were not fixed; complete tensionless wound closure was achieved by CAF. Termination after 3 months and sampling followed, and non-decalcified processing and toluidine blue staining were applied. Microscopic images obtained at standardized magnification were histomorphometrically assessed by ImageJ software (NIH). An ANOVA post hoc test was applied; histomorphometric data are presented in this paper as medians and interquartile ranges (IRs). All sites healed uneventfully, all sites were sampled and block separation followed before Technovit embedding. Two central sections per block for each group were included. Two of five specimen were lost due to processing error and were excluded from group b. New bone area was significantly greater for option b. compared to a. (p = 0.001), c. (p = 0.002), and d. (p = 0.046). Residual non-bone graft area was significantly less for option d. compared to a. (p = 0.026) or c. (p = 0.021). We conclude that collagen membranes with a prolonged resorption/barrier profile combined with bone substitutes featuring different degradation profiles sufficiently support new bone formation. Tacking strategy/membrane fixation appears redundant when using these biomaterials.

Published
2022

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