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Eating disorders are debilitating, life-threatening, and costly mental disorders that significantly impair physical health and adversely affect psychosocial functioning. Nowadays, six main feeding and eating disorders are identified in diagnostic systems, and Bulimia nervosa is one of them. The aim of this paper is twofold: First, it seeks to shed light on the concept of bulimia as understood by the Persian school of medicine. This study has attempted to consider the roots of this disease within this tradition. It will compare the concept of bulimia nervosa in conventional medicine with that of Canine appetite disease in Persian medicine in the Islamic Golden Era (9th-12th centuries). Secondly, it will analyze and show the evolution of the term bulimia throughout history. For this purpose, Avicenna’s Canon of Medicine, primary PM resources, and important databases were reviewed using the related keywords. Although these diseases are in the category of emerging mental illness, evidence suggests that its roots can be found in Persian medicine. The comparison made between the definition of Canine appetite in this school and modern definitions of Bulimia nervosa shows striking similarities between the two diseases, suggesting that both are the same disease. [ABSTRACT FROM AUTHOR]

Summary: The present study aimed to introduce Avicenna's views on pest control and the medicinal plants he proposed as natural pesticides. Also, we addressed the strategies that he leveraged to formulate and prescribe them, and, finally, we put his views into perspective with modern science. The data were collected using Al-Qanun Fi Al-Tibb (The Canon of Medicine) as well as scientific databases. According to Al-Qanun Fi Al-Tibb, 42 medicinal plants are described as natural pest control agents. After introducing the pest control properties of each plant, Avicenna explained the appropriate strategies for use of these plants. These strategies or formulations included incensing, spraying, spreading, rubbing, smudging, and scent-dispersing, which are equivalent to the modern pesticide formulations of fumigants, aerosols, pastes and poisoned baits, lotions, creams, and slow-release formulations, respectively. This study revealed that Avicenna introduced the pest control approach with natural plants in his book Al-Qanun Fi Al-Tibb and, thus, harnessed the power of nature to control nature. Future research is recommended to find the pest control merits of the presented medicinal plants, in order to incorporate them into pest control programs and reduce environmental pollution resulting from the complications of current synthetic pesticides. [ABSTRACT FROM AUTHOR]

Eating disorders are debilitating, life-threatening, and costly mental disorders that significantly impair physical health and adversely affect psychosocial functioning. Nowadays, six main feeding and eating disorders are identified in diagnostic systems, and Bulimia nervosa is one of them. The aim of this paper is twofold: First, it seeks to shed light on the concept of bulimia as understood by the Persian school of medicine. This study has attempted to consider the roots of this disease within this tradition. It will compare the concept of bulimia nervosa in conventional medicine with that of Canine appetite disease in Persian medicine in the Islamic Golden Era (9th-12th centuries). Secondly, it will analyze and show the evolution of the term bulimia throughout history. For this purpose, Avicenna’s Canon of Medicine, primary PM resources, and important databases were reviewed using the related keywords. Although these diseases are in the category of emerging mental illness, evidence suggests that its roots can be found in Persian medicine. The comparison made between the definition of Canine appetite in this school and modern definitions of Bulimia nervosa shows striking similarities between the two diseases, suggesting that both are the same disease.

Introduction: This study reevaluates the historical origins of occlusion therapy for amblyopia, focusing on the contributions of the 9th-century Islamic scholar, Ali ibn Sahl ibn Rabban al-Tabari (838–870 CE). Methods: The investigation delved into al-Tabari's writings, particularly "Firdous al-Hikma," to extract insights into his approach to addressing reduced vision in one eye.Additionally, the study examined subsequent advancements in occlusion therapy by scholars such as Thabit ibn Qurrah and Rhazes, building upon al-Tabari'sfoundational work. Results: Al-Tabari's reports contain significant insights into occlusion therapy for amblyopia, predating commonly attributed origins of the treatment. Within "Firdous al-Hikma," he outlines methods for addressing reduced vision, advocating for the covering of the healthier eye to promote the function of the weaker eye. These findings highlight the pioneering efforts of al-Tabari and his contemporaries in the Islamic civilization and challenge the conventional narrative surrounding the history of occlusion therapy. Subsequent advancements by scholars such as Thabit ibn Qurrah and Rhazes expanded upon al-Tabari's work, advocating for similar therapeutic approaches within the Islamic civilization. Their contributions further solidified the practice of occlusion therapy, laying the groundwork for its continued evolution and refinement in subsequent centuries. Discussion: Al-Tabari's contributions to occlusion therapy underscore the rich heritage of scientific inquiry in theIslamic civilization during the medieval period. This historical perspective sheds light on the diverse contributions to medical knowledge and practice outside of Western contexts and emphasizes the importance of recognizing and honoring these contributions in the broader history of medicine. [ABSTRACT FROM AUTHOR]

Veterinary toxicology is one of the subspecialties of veterinary medicine. On the other hand, traditional medical sources also contain veterinary knowledge, entailing human medical information. In this study, we aimed to extract and present relevant information on the part of the history of veterinary medicine, especially veterinary toxicology, through research on Al-Razi’s book Al-Hawi fi Al-Tib. We queried keywords of poison, poisoning, animal, and related terms in Al-Hawi fi Al-Tib. Also, we searched international and domestic databases, including Web of Science, Scopus, PubMed, Google Scholar, SID, and IranDoc, to obtain relevant data. Our results showed that Al-Razi directly mentioned the toxicity of ten toxic plants in the animals. It is suggested that Al-Razi has contributed to the knowledge of veterinary medicine and the subspecialty of veterinary toxicology in particular. Future studies recommended to vet other historical medical sources, including traditional medicine textbooks, to find relevant information about veterinary medicine and veterinary toxicology. [ABSTRACT FROM AUTHOR]

Infertility and erectile dysfunction (ED) are common health issues and exacerbate as men age. In recent years, it has been realized that cardiovascular disease (CVD) forecasts the incidence of ED; however, there is less evidence of the relationship between fertility with CVD. According to Avicenna, an eminent physician of Persian medicine, there is a connection between CVD, male sexual problems, and fertility. The aim of this study is to discuss the mentioned connection and the role of medicinal plants in mitigating CVD and as a result, male infertility. This library-based study focused on Avicenna's outstanding manuscript “The Canon of Medicine”. Scientific databases, such as PubMed, Scopus, and Google Scholar were searched to investigate current pharmacological findings and mechanisms of action of medicinal plants mentioned in “The Canon of Medicine”. Avicenna pinpointed that CVD is responsible for insufficient production of the endogenous gaseous substance required for the erection, causing infertility. He mentioned the association between the ability to produce semen of good quality and fertility potential to improve heart function. Medicinal plants mentioned in his manuscript mainly possess antioxidant and anti-inflammatory effects, improve plasma lipid profile, reduce triacylglycerol, and show cardioprotective effects, which consequently boost fertility by improvement of sperm parameters. Expression of the association between cardiac function and male fertility demonstrates Avicenna's significant contribution to improving the sciences of male fertility and cardiology in the medieval era. In addition, the recommended medicinal plants seem to be a valuable source for identifying new remedies for the treatment of male sexual disorders and infertility.

Research on Persian medical literature has revealed a long history of moral excellence and devotion to the medical field. Ali Ibn Rabban Tabari also emphasized the importance of these qualities, as Islamic culture highly values the traits of physicians. In our discussion, we will explore the qualities of physicians and medical students from the perspective presented by Ali ibn Sahl Rabban al-Tabari in his widely read book, Firdous al-Hikma. One section of this work focuses on the professional, ethical, and physical qualities that define a doctor and a medical student. The book stands out as one of Iran’s medical encyclopedias.Among them is Ali ibn Rabban Tabari, a prominent figure in the history of Persian Medicine, who made significant contributions to the establishment of ethical principles in the field of medicine. His perspectives and insights hold considerable value as one of the earliest endeavors in this area, exerting a substantial influence on the advancement of medical ethics.

Topical wounds are common complications, and it is necessary to find new remedies and approaches for their treatment. In this study, Avicenna’s definitions of topical wounds and his treatment strategies are investigated and compared with contemporary findings. Data were extracted from the fourth chapter of the fourth volume of the Canon of Medicine and databases of PubMed, Scopus and Google Scholar using keywords of wound healing, Avicenna, Persian medicine, etc. Avicenna tries to clarify categorizations, semiology, pathophysiology, dressing, remedies and treatment strategies for wound. Many of his descriptions—like callus and the importance of angiogenesis in wound healing—are close to current definitions. He also mentioned to strategies like using gauze in dressing, control of bleeding and swelling (inflammation), washing and clearing wounds, using suture and surgery in some cases and also prescribing tonic foods. Furthermore, the efficacy of many natural remedies mentioned by Avicenna like Boswellia sacra Flück., Hordeum vulgare L., Prangos ferulacea Lindl., Quercus persica Jaub. & Spach, Brassica oleracea L., and Plantago major L. have been evaluated and approved by contemporary investigations. These results demonstrate the impact of Avicenna’s knowledge on wounds and wound healing process. Therefore, besides historical impact, it is important as a novel natural source to find new medicaments based on this ancient knowledge.

Research on Persian medical literature has revealed a long history of moral excellence and devotion to the medical field. Ali Ibn Rabban Tabari also emphasized the importance of these qualities, as Islamic culture highly values the traits of physicians. In our discussion, we will explore the qualities of physicians and medical students from the perspective presented by Ali ibn Sahl Rabban al-Tabari in his widely read book, Firdous al-Hikma. One section of this work focuses on the professional, ethical, and physical qualities that define a doctor and a medical student. The book stands out as one of Iran’s medical encyclopedias. Among them is Ali ibn Rabban Tabari, a prominent figure in the history of Persian Medicine, who made significant contributions to the establishment of ethical principles in the field of medicine. His perspectives and insights hold considerable value as one of the earliest endeavors in this area, exerting a substantial influence on the advancement of medical ethics. [ABSTRACT FROM AUTHOR]

Background and Aim: Tinnitus is a common disorder of the auditory system with a rich history dating back to ancient times. This review aims to provide a historical perspective on tinnitus in Traditional Persian Medicine (TPM) by summarizing the views of TPM scholars on its etiology and treatment. Methods: A qualitative research (summative content analysis) was conducted, utilizing TPM texts to identify the historical perspectives of TPM scholars on tinnitus. The analysis focused on their understanding of tinnitus, its causes, and recommended treatments. Results: In TPM, tinnitus was referred to as Tanin and Davi. The accumulation of phlegm and internal gases in the head or ears was considered as the main cause of tinnitus, with sudden movement or ripple of these vapors leading to auditory nerve stimulation and resulting in tinnitus. TPM scholars recommended addressing the sources of these vapors, such as gastrointestinal issues, and promoting humeral balance through temperament modification and the use of medicinal herbs for treatment. Conclusion: The TPM view on tinnitus was similar to the Greco-Roman understanding of the disease, with Persian scholars expanding on its details. TPM scholars believed in addressing the underlying causes of tinnitus and promoting humeral balance to alleviate symptoms. These historical perspectives provide insight into traditional medical systems and their approaches to the management of health conditions. [ABSTRACT FROM AUTHOR]

This paper offers a historical exploration of how death was diagnosed in Persian medicine, highlighting the evolution of diagnostic criteria and the contributions of key scholars. In the post-medieval era, defining death and establishing diagnostic criteria underwent significant development, albeit with ongoing debates. Notably, medieval Persian scholars, such as Qutb al-Din al-Shirazi, played a crucial role in this discourse. Qutb al-Din al-Shirazi, a prominent Persian polymath, synthesized earlier knowledge to provide a comprehensive set of diagnostic criteria for death in traditional Persian medicine. These criteria encompassed physical examinations like assessing nail shininess, feeling pulsatile vessels in specific areas, observing pupillary reactions to light, and even monitoring the movement of a thread near the mouth and nose. His mention of the pupillary light reflex is one of the earliest known references to this phenomenon in medical history. Medieval Persian practices also involved placing a water container on the chest of the individual to detect the absence of chest wall motion associated with respiration as a sign of death. Furthermore, scholars like Ibn-e Sina (Avicenna) stressed the importance of monitoring pulse and respiration as vital signs, especially when administering potentially lethal drugs. In cases of uncertain diagnosis, such as stroke, medieval Persians postponed burials for up to three days. These historical insights provide a fascinating glimpse into the evolving understanding of death in Persian medicine and the intricate methods used for its diagnosis.

Background: Historical evidence revealed that alcoholic beverages have been produced, used and abused thousands of years before the discovery of alcohol by Rhazes for medical purposes. Alcohol-induced liver disease (e.g., steatosis, steatohepatitis, fibrosis and cirrhosis) is one of the most prevalent causes of chronic liver disease all over the world. This study aims to find the early report of this complication in an ancient Persian historical text. Methods: In this study, the book of Minooye Kherad, a Zoroastrian manuscript on wisdom which was written in the late Sassanid Empire (224–637 CE) is reviewed. Results: However, the concept of alcohol hepatotoxicity as one of the most important complications of alcoholism is a new terminology, by researching historical documents it can be found that one of the oldest reports of benefits and disadvantages of drinking wine focusing on liver complications is mentioned in the book of Minooye. Conclusion: Description of the liver disease and damage caused by excessive alcohol consumption in this valuable book can be considered as the early report of hepatotoxicity of alcoholic beverages in the medical history.

The Academy of Jundishapur was the world's first university established during the Sassanid Empire in old Persia. Some of the important features of this scientific center of the ancient world include a policy of tolerance, conducting annual international congresses, compiling the first comprehensive medical textbook, doing the hospital rounds, physician licensure exam, special attention to the ethics, and using an educational curriculum. Moreover, its unique style of education made Jundishapur a brilliant school in the history of science. This outstanding academy maintained its impact on the scientific movement of that era for four centuries. It finally declined after transmission to Baghdad medical school. In this study, we have discussed the features of the Jundishapur school which made it a successful model for medical education.

The journal of research on history of medicine (RHM) starts to be published from Feb. 2012. It passed its first decade of life by publishing current issue. By analyzing these 10 volumes, it shows that there are 284 articles that are written by 342 authors from 18 countries. These authors are affiliated to 90 institutions, that Shiraz University of medical sciences has the most contribution among them. In addition, the share of Iranian authors is more than other countries significantly. The journal is indexed in 14 indexing and abstracting databases. It needs to set a program for improving the quality of international cooperation, indexing of the journal and published papers for next decade.

The Academy of Jundishapur was the world's first university established during the Sassanid Empire in old Persia. Some of the important features of this scientific center of the ancient world include a policy of tolerance, conducting annual international congresses, compiling the first comprehensive medical textbook, doing the hospital rounds, physician licensure exam, special attention to the ethics, and using an educational curriculum. Moreover, its unique style of education made Jundishapur a brilliant school in the history of science. This outstanding academy maintained its impact on the scientific movement of that era for four centuries. It finally declined after transmission to Baghdad medical school. In this study, we have discussed the features of the Jundishapur school which made it a successful model for medical education. [ABSTRACT FROM AUTHOR]

Abu Reyhan Biruni (973-1048 CE) was a Persian polymath in medieval era. He had more than 100 books and treatises on different subjects like astronomy, culture, history, mathematics and pharmacy. In medical sciences, he was one of the first persons who introduced pharmacy as a separated field from medicine. He was pioneer to define pharmacy and pharmacist similar to current definitions. It was one of the earliest definitions of pharmacy. Biruni can be introduced as a pharmacist, nor physician. He also had a book on pharmacy, Al-Saydana fi al-Tibb (Pharmacy in Medicine). This book is one of the most important works on pharmacy in medieval era. He clarifies the role of pharmacists to serve pharmaceutical services to the patients. It shows the importance of pharmacy as an independent field of medical sciences in Persia and Islamic civilization about a thousand years ago.

History of anatomy is as long as the history of medicine itself. Development of this basic science was not possible without the dedicative effort of those physicians and scholars who were committed to discover the mysteries of human anatomy. In this regard, Iranian scholars played an important role in the development of the anatomical sciences despite the religious limitations in their societies. Mansur ibn Ilyas Shirazi is an Iranian physician of fourteenth century who wrote the first color illustrated anatomical book, Mansur's Anatomy. A considerable portion of the book has been dedicated to the central and peripheral nervous system so that he could be considered as one of the pioneers of neuroanatomy. [ABSTRACT FROM AUTHOR]

Background: Historical evidence revealed that alcoholic beverages have been produced, used and abused thousands of years before the discovery of alcohol by Rhazes for medical purposes. Alcohol-induced liver disease (e.g., steatosis, steatohepatitis, fibrosis and cirrhosis) is one of the most prevalent causes of chronic liver disease all over the world. This study aims to find the early report of this complication in an ancient Persian historical text. Methods: In this study, the book of Minooye Kherad, a Zoroastrian manuscript on wisdom which was written in the late Sassanid Empire (224--637 CE) is reviewed. Results: However, the concept of alcohol hepatotoxicity as one of the most important complications of alcoholism is a new terminology, by researching historical documents it can be found that one of the oldest reports of benefits and disadvantages of drinking wine focusing on liver complications is mentioned in the book of Minooye. Conclusion: Description of the liver disease and damage caused by excessive alcohol consumption in this valuable book can be considered as the early report of hepatotoxicity of alcoholic beverages in the medical history. [ABSTRACT FROM AUTHOR]

Persian Medicine, which flourished in the Islamic Golden Age (9th to 12th century AD), considers the human body a unified whole whose organs are in constant interaction and equilibrium with each other. The skin is one of these interdependent organs that play an important role in protecting internal organs, and as an excretion route, it can expel substances that are not consumed by the body. Alternatively, the uterus, a vital organ in pregnancy, excretes excess body material during menstruation to maintain a woman’s health. This narrative study discussed the importance of aligning the structure and function of these two organs based on the main textbooks of Persian Medicine, especially those written during this historical period. Likewise, electronic databases were used for investigating related articles The skin and uterus are two excretory organs. When the secretion of excess material through menstruation is physiologically or pathologically impaired, the body transfers these substances to the skin as the organ associated with the uterus. Thus, the clinical manifestations of some skin diseases can be a sign of imbalance in the function of the uterus and its related organs. Consequently, the structural and functional similarities of both organs can provide a new guide in the approach to their participatory diseases in the integration of Persian and conventional medicine. [ABSTRACT FROM AUTHOR]

Cataract is mentioned as one of the most important blindness factors in the world. Management and treatment methods of cataract dates back to antiquity. Avicenna is one of prominent Persian scientists that played an important role in the development of ophthalmology in ancient Persia. In this review, Avicenna’s points of view about cataract is discussed in the Canon of medicine and compared with the current medicine. Cataract or “Nozol-al-maâ” is an obstructive disease due to the accumulation of a dense liquid layer between the lens and cornea. Avicenna categorized cataracts based on their density, size and color. To treat and manage cataract, he took three approaches: changing life style and nutrition in the first step; using simple and complex medicines in the next step; and performing surgery in the last stage. Nowadays, in vivo and in vitro studies have proven the effects of some food, nutraceuticals and medicinal plants in preventing cataractogenesis progression. As surgery is the only remedy of cataract today and postoperative problems may occur, finding new non-surgical procedures can be noteworthy.

The journal of research on history of medicine (RHM) starts to be published from Feb. 2012. It passed its first decade of life by publishing current issue. By analyzing these 10 volumes, it shows that there are 284 articles that are written by 342 authors from 18 countries. These authors are affiliated to 90 institutions, that Shiraz University of medical sciences has the most contribution among them. In addition, the share of Iranian authors is more than other countries significantly. The journal is indexed in 14 indexing and abstracting databases. It needs to set a program for improving the quality of international cooperation, indexing of the journal and published papers for next decade. [ABSTRACT FROM AUTHOR]

Reviewing ancient manuscripts of Persian medicine (PM) reveals that there have been some basic principles for decision-making in epidemic infectious diseases that existed in the past. These PM rules for clinical reasoning were applied through a personalized approach along with public health advice in such situations. Currently, the coronavirus pandemic has been the biggest problem in the world. Its mainstay of treatment is based on preventative measures and symptomatic treatments. Meanwhile, traditional medical systems for providing preventive, supportive, and rehabilitative care to patients have received more attention than before. Thus, the specific individual approach considered by PM scholars for clinical courses of epidemic infectious diseases may help shed more light on the spread of knowledge on epidemic diseases in ancient Persia. [ABSTRACT FROM AUTHOR]

The term “crisis” in medical context is an important turning point or stage which occurs in some diseases and if not managed correctly, can become life threatening. Despite the use of the term in modern medicine, it was a much wider and sophisticated traditional medical concept. The first usage has been seen in the Greek writings of Hippocrates. In the Islamic Golden Age, this concept entered Persian Medicine by translation of Greek medical treatises. Great Persian Medicine scholars have paid particular attention to the concept and have written exclusive chapters about it. One of such scholars, Hakim Mohammad Azam Khan Chishti (1814-1902), an Indo-Persian physician and medical writer, wrote several comprehensive encyclopedic books - in Persian language - about various aspects of Persian Medicine including crises. In this historical review we discuss his biography and his books, especially his important book Rokn-e-Azam, which is a comprehensive work on the concept of crisis in which he collected and discussed opinions of great medical scholars from ancient times to the 19th century. Despite his fidelity, unfortunately he rarely criticized the previous literature and thus did not add an additional value to the subject else than his comprehensive review. In the recent worldwide accepted roadmap towards Integrative Medicine, studying such inclusive traditional manuscripts may give better insight and understanding of the behavior of acute and chronic diseases and their appearance, exacerbations and remissions.

Aim: Artificial rupture of the amniotic membranes during the labor, which is called amniotomy, is a common procedure in modern obstetric and midwifery protocols. There is no definite agreement regarding the timing of amniotomy in a delayed labor. In this study, we have discussed the history of amniotomy in medieval Persia mentioning the Persian medicine recommendations in this regard. Methods: We studied main Persian medicine textbooks such as Canon of Medicine by Avicenna to investigate the history of labor management and amniotomy indications. In addition, amniotomy in current literature was studied using PubMed and Google Scholar databases. Results: Persian medicine has recommended artificial rupture of membranes for labor augmentation based on its own theories. Methods for facilitation of the labor have been divided into two groups: one group before and the other during the labor. Avicenna has carefully explained the indication of amniotomy. He has recommended artificial rupture of membranes in cases of intact membranes with cervical dilatation and fetal descent. A needle or a kind of surgical knife called Mabzaa had been introduced for this procedure. Conclusions: It seems that Iranian physicians are the first scholars who have introduced the amniotomy for labor management in the 11th century. Persian medicine recommendations for labor facilitation should be considered in future studies. [ABSTRACT FROM AUTHOR]

Quṭb al-Din Shīrāzī (1236-1311 AD), the Persian polymath had great contributions to the fields of philosophy, mathematics, medicine, astronomy, music, literature, and Islamic studies. He lived during the Ilkhanid kingdom in Iran. He wrote an autobiography in the preface of his medical manuscript, al-Tuḥfa al-Sa‘dīya. He discussed his views on science and then, he explained his life story, in particular his education and contribution to science. He mentioned the reasons that led him to write al-Tuḥfa al-Sa‘dīya, his main medical work. As a great polymath, he traveled to many countries, and his words cleared the scientific atmosphere of 14th century AD. Also, he directly introduced his teachers and their abilities and works. Furthermore, scientists who worked on the Canon of Medicine had commentaries on this book, which were comprehensively introduced in this autobiography. [ABSTRACT FROM AUTHOR]

The Food and drug were developed by pharmacists and physicians, in particular Persian scientists throughout medical history. There was an especial view on the subject of nutrition and medications in Persian medicine (PM). Avicenna was one of the main Persian physicians who contributed to this field in the Canon of medicine “Al-qanun-fi-al-tibb”, his main medical and pharmaceutical text book in the 10th century AD. In this paper, different categorizations of foods and drugs and their definitions in the Avicenna’s Canon of medicine were considered and compared with the similar categories in current medicine. These groups of foods and drugs included absolute aliment (Ghidhāol-motlaq), functional foods “Ghidhā od-dawā”, pharconutrient “Dawāol-ghadhā”, absolute medicament or drug “Dawāol-motlaq”, and poisons “Sammol-motlaq”. Also, there were several other classifications for foods and drugs in the Canon of medicine that act without their temperaments (qualities) such as “Dho-l-khāsiyyahis”.These definitions and classifications 1000 years ago and matching with current accepted terminologies are important both historically and also in the field of traditional pharmacy.

BACKGROUND: Traditional medicine is a complete system, including diagnostic methods, etiology and treatment based on interpersonal differences. Owing to a lack of investigations in the field of Iranian traditional medicine as well as its many present challenges, certain studies in this area can prove quite practical in identifying and solving ongoing challenges. This study investigates the challenges of the health system in Iranian traditional medicine in the context of control levers. METHODS: The study was qualitative content analysis. A framework analysis, "Control Knob Approach", was considered appropriate to promote apprehension of challenges of health systems in Iranian traditional medicine. Data were collected by purposeful sampling through in-depth and semi-structured individual interviews with 35 experts of Iranian traditional medicine. Directed content analysis was used to analyze the data, which extracted the initial codes after performing the recorded interviews on paper and immersing them in the data analysis. RESULTS: Upon analysis of data by Iranian medicine experts, five main categories including financing, payment system, regulations, behavior and organization were defined alongside 13 subcategories. CONCLUSION: According to current challenges and the tendency of society to receive traditional medicine services, as well as the long history of traditional medicine in Iran, fair access to traditional medicine services should be provided. This access must be through the production of indigenous knowledge and the formulation of regulatory and educational policies and guidelines and the empowerment of relevant, healthy, effective, evidencebased and cost-effective forces. [ABSTRACT FROM AUTHOR]

According to the World Health Organization (WHO), dementia is a disorder that occurs as result of a neurodegenerative process in brain, and usually is chronic or progressive by nature. Most descriptions of senile dementia date back to Alois Alzheimer. In 1906, Alzheimer described the first patient, Auguste Deter, who suffered from the disorder that later became known as Alzheimer's disease. Although, the history of the disease before 1906 is quite rich, little has been said about the contributions of ancient and medieval physicians to the understanding of dementia. Over the centuries, the concept of senile dementia changed from an inevitable mental decline with aging, to different sets of clinical features with narrow limits of diagnosis of a disease in its own right. Documentation of the historical origins of prevention, diagnosis, and therapies of dementia would make an important contribution to a more complete understanding of this pathological degeneration of dementia. The present review focuses on the contributions of Avicenna (AD 980-1037) to the development of diagnosis and the discovery of etiology of different forms of dementia, with the goal of revealing the extent to which dementia was understood in the golden age of Islam in Persia. [ABSTRACT FROM AUTHOR]

Anesthesia is one of the main issues in surgery and has progressed a lot since two centuries ago. The formal history of surgery indicates that beginning of anesthesia backs to the 18th century, but reviewing the history of medicine shows that pain management and anesthesia has a long history in ancient times. The word "anesthesia", comes from Greek language: an-(means: "without") and aisthēsis (means: "sensation"), the combination of which means the inhibition of sensation. The oldest reports show that the Sumerians maybe were the first people that they cultivated and harvested narcotic sedative like the opium Poppy as early as 3400 BC and used them as pain killers. There are some texts which show us that Greek and Mesopotamia's doctors prescribed alcoholic beverages before their surgeries. In the Byzantine time, physicians used an elixir known as "laudanum" that was a good sedative prior the patient's operation. Ancient Persia and China were as the biggest civilizations, of which medicine anesthesia had a great role in. Also, Persian and other Muslim physicians developed the field of anesthesiology in early medieval era which is called Islamic Golden Age. [ABSTRACT FROM AUTHOR]

Some believe that ancient mythological and literary texts solely aimed to amuse and entertain, and were sprouted from their feelings and thoughts, and do not regard the study of the ancient and mythological stories as having the definiteness and clarity which science is known for it. Hence, this is why mythological stories in reality convey the beliefs, nature, attitudes and the extent of human knowledge at some point in history. They account for one of the most important signs of civilization and an important factor in creating cultural ties and dominance in the past. It is on this basis that literature is considered as a symbol of cultural competence and civilization of various nations. Although Ferdosi’s Shanameh from Iran and Fēng Shén Yǎn Yì from China are independent works, numerous similarities in various fields including mythological and medical elements are to be found. It can be concluded that the effects of each of these works have acknowledged the signs of old historical relations between Iran and China.

For several centuries, opium addiction has been a social problem all over the world. It has been prevalent in Iran from the Safavid era (1501-1736 A.D). During this period, Hakim Imad al-Din Mahmud ibn-Mas'ud Shirazi (1515-1592 A.D), also known as Imad was one of the Persian physicians who wrote one of the earliest books in the field of opium and addiction (called Afiounieh) in history. In this book, he introduced two sustained release rectal (suppository) and oral (pill) dosage forms for Muslim addicts who fast in the month of Ramadan. He aimed to formulate them for these people so that they could keep fasting by using the slow release drugs. In these formulations, his innovation has important impacts in the history of both addiction and pharmaceutical sciences. [ABSTRACT FROM AUTHOR]

Medical history explains that Persian physicians used scientific methods based on clinical experiences and observations for treatment from pre-Islamic time (before 637 AD) and centuries later (in the Islamic era). Rhazes was one of the Persian physicians acknowledged as a pharmacist, chemist and prominent scientific writer on various subjects of medicine and philosophy. In this study, we aimed to investigate clinical experiences, as well as the ethical and critical views of Rhazes in medical practice. Rhazes promoted ethics in the medical profession. He expressed critical key points about ancient written texts. He broke ancient physicians' taboos in medical theories and evaluated them based on his own experiences. He designed animal and preclinical evaluations for his theories and also performed the first clinical trials with control groups in the history. His critical views about medical sciences as well as his beliefs in experiments resulted in many medical, chemical and pharmaceutical findings. Therefore, in history, he can be considered as the pioneer in using trials and experiments for approving medical methods. [ABSTRACT FROM AUTHOR]

An editorial is presented on the history of medicine in Persia. It expresses views on various forms of diseases which include melancholia, conversion disorders, and false pregnancy. An overview of various neurological and psychiatric disorders is presented in the book Hidayat al-Mutaallemin fi al-Tibb (Learner's Guide to Medicine) written by Akhawayani Bokhari.

Some believe that ancient mythological and literary texts solely aimed to amuse and entertain, and were sprouted from their feelings and thoughts, and do not regard the study of the ancient and mythological stories as having the definiteness and clarity which science is known for it. Hence, this is why mythological stories in reality convey the beliefs, nature, attitudes and the extent of human knowledge at some point in history. They account for one of the most important signs of civilization and an important factor in creating cultural ties and dominance in the past. It is on this basis that literature is considered as a symbol of cultural competence and civilization of various nations. Although Ferdosi's Shanameh from Iran and Fēng Shén Yǎn Yì from China are independent works, numerous similarities in various fields including mythological and medical elements are to be found. It can be concluded that the effects of each of these works have acknowledged the signs of old historical relations between Iran and China. [ABSTRACT FROM AUTHOR]

Migraine is a common type of headache which has a deep history dating back thousands of years. Avicenna (980-1032), a Persian scholar, made a great contribution to neurology including headache and migraine. The aim of this study is to consider Avicenna's description about migraine (Shaghighe in Persian language) including definition, etiology and intervention. Also, his definition and treatment approaches were considered based on current concepts and findings. Although Avicenna believed in humoral theory and divided migraine into two categories, hot and cold, and suggested special treatments for them as well as general considerations, most of his definitions and explained pathologies are supported by current concepts of medicine. He believed that the migraine can result from bone of skull and also intra-parenchymal; or from skull underneath membrane (dura-mater); or reaching substances from the painful side or from outer vein and arteries (extra cranial); or from brain and meninges (pia-mater). Furthermore, current findings show most medicinal plants mentioned by Avicenna for the treatment of migraine can have potentially significant effects such as remedies which stop central and peripheral sensitization [anti-neuroinflammatory agents, decreasing nitric oxide level, cyclooxygenase (COX)-2 inhibitors], as well as serotonergics, neuroprotective agents and analgesics. [ABSTRACT FROM AUTHOR]

During the final hours of pregnancy, uterine contractions cause the foetus to move through the birth canal and leave the mother's body. Haly Abbas (died 982-994 CE), is believed to be the first writer to explain the role of these contractions. However, this concept had in fact been described in the text titled Bab-e-Borzouyeh, written four centuries earlier by the physician Borzouyeh (Perzoes in Latin) as a prologue to his translation of the Indian collection of fables known as the Panchatantra. Because Haly Abbas probably had access to ancient Persian medical texts, the earliest report of uterine contractions may need to be re-attributed to this earlier author. [ABSTRACT FROM AUTHOR]

The cardiology and field of cardiovascular approaches are often mentioned as of the earliest concerns throughout the history of mankind civilization. During the golden ages of Islamic era, 9th to 12th centuries A.D., medical knowledge from various fields including cardiology was flourished by prominent Persian physicians and scholars. Among those outstanding physicians and scientists of the Islamic golden era, Avicenna is known as a famous and pioneer character. To outline the cardiovascular knowledge and contribution of Avicenna, current review compiled all his evidence-based concepts of cardiovascular findings from current medical literatures as well as those mentioned in his important medical encyclopedia, the Canon of Medicine. In this review, Avicenna's findings on cardiovascular anatomy such as his description of Willis circle, capillary circulation and arterial and ventricular contractions in the cardiovascular system have been mentioned. Also, his books and manuscripts on cardiology as well as findings and theories on cardiovascular and allied diseases were discussed. These findings are included in his descriptions on cardiac tamponade, stroke, palpitation, atherosclerosis, hypertension, association of the cardiovascular complications with erection and ejaculation, interaction between the heart and emotions as well as some of his mentioned drugs for cardiological disorders and the early concepts of drug targeting. These results can show Avicenna's great contribution to improve the sciences of cardiology in early medieval era. [ABSTRACT FROM AUTHOR]

Although hysteria is associated largely with the nineteenth century, we find the subject treated in a tenth-century Persian medical text, the Hidayat al-Muta`allemin Fi al-Tibb [A Guide to Medical Learners] by al-Akhawayni Bukhari (d. 983 AD), a prominent physician in the Persian history of medicine. In this article, we discuss al-Akhawayni’s views on seizure and hysteria and his differentiation between the two conditions, and we place it in a historical context. [ABSTRACT FROM PUBLISHER]

Abstract: The Sassanid Empire in Persia (224–637 AD) ruled one of the most influential eras in world history. They with the Romans and later the Byzantines were two global powers in ancient times. Medicine was well organized in the official Sassanid system. Hospitals, medical centers, and universities were developed throughout Persia during their reign. This study brings to light for the first time the era's medical views on the heart and blood, based on extant Sassanid Pahlavi manuscripts and documents. Although these documents are non-medical texts (because Sassanid medical texts were destroyed in attacks on Iran by neighboring powers, such as Alexander the Macedonian and leaders of the Arab Empire throughout history), some novel theories on the history of cardiology can be found among them. Physicians of that time made a preliminary description of pulmonary circulation. They knew about the role of blood circulation in feeding bodily organs. They believed that blood is a factor for spreading infection because of its invisible monsters (divan). Their beliefs can be considered as the first theories on infection due to an external living factor, today known as the microbe. Other Sassanid beliefs and findings about the heart and blood in medicine are described in this review. [Copyright &y& Elsevier]

Functional dyspepsia (FD) is a common annoying disorder without any approved medication for its treatment; although, some "off-label" treatments including antidepressants are commonly used. Adv Pharm Bull, 2021, 11(1), 8-9 doi: 10.34172/apb.2021.001 https://apb.tbzmed.ac.ir Jollab: A Safe Remedy for Functional Dyspepsia in Persian Medicine Mehdi Pasalar 1,2 ID, Babak Daneshfard 3* ID, Kamran Bagheri Lankarani 4 ID 1 Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. 5,6 We have recently shown that Jollab, a mixture of rose water, saffron and candy sugar in syrup dosage form, could improve the FD symptoms as well as the quality of life and depressive symptoms, simultaneously. [Extracted from the article]

Context: In Iran, conventional production methods of herbal oils are widely used by local practitioners. Administration of oils is rooted in traditional knowledge with a history of more than 3000 years. Scientific evaluation of these historical documents can be valuable for finding new potential use in current medicine. Objective: The current study (i) compiled an inventory of herbal oils used in ancient and medieval Persia and (ii) compared the preparation methods and therapeutic applications of ancient times to current findings of medicinal properties in the same plant species. Materials and methods: Information on oils, preparation methods and related clinical administration was obtained from ancient Persian documents and selected manuscripts describing traditional Persian medicine. Moreover, we investigated the efficacy of medicinal plant species used for herbal oils through a search of the PubMed, Scopus and Google Scholar databases. Results: In Iran, the application of medicinal oils date back to ancient times. In medieval Persian documents, 51 medicinal oils produced from 31 plant species, along with specific preparation methods, were identified. Flowers, fruits and leaves were most often used. Herbal oils have been traditionally administered via oral, topical and nasal routes for gastrointestinal, musculoskeletal, and neural diseases, respectively. According to current investigations, most of the cited medicinal plant species were used for their anti-inflammatory and analgesic properties. Conclusions: Medicinal oils are currently available in Iranian medicinal plant markets and are prepared using traditional procedures for desirable clinical outcomes. Other than historical clarification, the present study provides data on clinical applications of the oils that should lead to future opportunities to investigate their potential medicinal use. [ABSTRACT FROM AUTHOR]

Although the exact time of performing plastic surgery is not addressed in the medical and historical literature, it can be supposed that these surgical procedures have a long and fascinating history. Recent excavations provided many documents regarding the application of medical instruments, surgical and even reconstructive procedures during the pre-historic and ancient periods. Actually, there is no historical definite time-zone separating general and cosmetic operations in the pre-modem time; however, historically there have been many surgeons who tried to perform reconstructive procedures during their usual medical practice. This article presents a brief look at the history of plastic surgery form the ancient to the contemporary era, with a special focus on Iran. [ABSTRACT FROM AUTHOR]

Abstract: Throughout history, illustrations had played a key role in the promotion and evolution of medicine by providing a medium for transmission of scientific observations. Due to religious prohibitions, color drawings of the human body did not appear in medieval Persia and during the Islamic Golden Age. This tradition, however, has been overlooked with the publication of the first color atlas and text of human anatomy, Tashrihi Mansuri (Mansur''s Anatomy), by Mansur ibn Ilyas in the fourteenth century AD. Written in Persian and containing several vivid illustrations of the human body, this book gained widespread attention by both scholars and lay persons. In this article, a brief history of Mansur''s Anatomy and an English translation of selected sections from this book regarding the heart and blood vessels are presented. [Copyright &y& Elsevier]