1. CD8+CD28- T cells in vertically HIV-infected children.
- Author
-
Brugnoni D, Airo P, Timpano S, Malacarne F, Ugazio AG, Cattaneo R, and Duse M
- Subjects
- Age Factors, Apoptosis, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes immunology, Child, Child, Preschool, HIV Seropositivity, Humans, Infant, Infectious Disease Transmission, Vertical, Lymphocyte Count, CD28 Antigens immunology, CD8-Positive T-Lymphocytes immunology, HIV Infections immunology, HIV Infections transmission
- Abstract
To evaluate whether vertical HIV infection interferes with the expression of CD28 on T lymphocytes, 25 HIV-infected children and 29 seroreverted children born to HIV+ mothers were studied. The percentage of CD28- cells among CD8+ T lymphocytes was higher in HIV-infected children than in controls (P < 0.001). In fact, in HIV-infected children, this percentage was elevated from the first year of life, while in healthy seroreverted children, the proportion of CD28- cells among CD8+ cells rose progressively with age (r = 0.49; P = 0.008). In HIV+ children, the CD8+ CD28-, but not CD8+ CD28+ cell proportion was significantly correlated with immunological markers of disease progression, such as CD4+ cell loss (r = -0.65; P < 0.001) and the level of in vitro spontaneous lymphocyte apoptosis (r = 0.53; P = 0.03).
- Published
- 1997
- Full Text
- View/download PDF