1. Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?
- Author
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Kobayashi-Ishihara M and Tsunetsugu-Yokota Y
- Subjects
- Humans, Gene Expression Regulation, Viral, RNA Processing, Post-Transcriptional, Host-Pathogen Interactions genetics, Virus Latency genetics, HIV-1 genetics, HIV-1 physiology, HIV-1 drug effects, HIV Infections virology, HIV Infections drug therapy
- Abstract
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly attributed to the intricate nature of HIV-1 latency, wherein various host and viral factors participate in multiple physiological processes. While substantial progress has been made in discovering therapeutic targets for HIV-1 transcription, targets for the post-transcriptional regulation of HIV-1 infections have received less attention. However, cumulative evidence now suggests the pivotal contribution of post-transcriptional regulation to the viral latency in both in vitro models and infected individuals. In this review, we explore recent insights on post-transcriptional latency in HIV-1 and discuss the potential of its therapeutic targets, illustrating some host factors that restrict HIV-1 at the post-transcriptional level.
- Published
- 2024
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