6 results on '"Wyler, C. A."'
Search Results
2. Influenza immunization of HIV-1-infected patients does not increase HIV-1 viral load.
- Author
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Yerly S, Wunderli W, Wyler CA, Kaiser L, Hirschel B, Suter S, Perrin LH, and Siegrist CA
- Subjects
- Adult, Child, DNA, Viral blood, Female, HIV Core Protein p24 blood, HIV-1 genetics, HIV-1 isolation & purification, Humans, Male, Polymerase Chain Reaction, RNA, Viral blood, Virus Replication, Acquired Immunodeficiency Syndrome immunology, Acquired Immunodeficiency Syndrome virology, HIV Seropositivity immunology, HIV Seropositivity virology, HIV-1 physiology, Influenza Vaccines
- Published
- 1994
- Full Text
- View/download PDF
3. HIV-1 in newborns.
- Author
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Speiser DE, Wyler CA, and Siegrist CA
- Subjects
- Acquired Immunodeficiency Syndrome immunology, Female, HIV Infections immunology, Humans, Immunity, Cellular, Infant, Newborn, Pregnancy, Pregnancy Complications, Infectious immunology, HIV Infections congenital, HIV-1
- Published
- 1994
- Full Text
- View/download PDF
4. Specific tolerance to HIV-1 antigens in an infant with rapid progression to AIDS.
- Author
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Siegrist CA, Wyler CA, Gerritsen EJ, Perrin L, Speiser D, and Suter S
- Subjects
- Female, HIV Infections transmission, Humans, Infant, Lymphocytes immunology, Male, Pregnancy, Pregnancy Complications, Infectious immunology, HIV Antigens analysis, HIV Infections immunology, HIV-1 immunology
- Published
- 1993
- Full Text
- View/download PDF
5. Epidemiology of vertically transmitted HIV-1 infection in Switzerland: results of a nationwide prospective study. Swiss Neonatal HIV Study Group.
- Author
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Kind C, Brändle B, Wyler CA, Calame A, Rudin C, Schaad UB, Schüpbach J, Senn HP, Perrin L, and Matter L
- Subjects
- Child, Child, Preschool, Female, Follow-Up Studies, HIV Infections mortality, HIV Infections transmission, Humans, Infant, Infant, Newborn, Male, Prevalence, Prospective Studies, Survival Analysis, Switzerland epidemiology, HIV Infections epidemiology, HIV-1
- Abstract
A nationwide study involving 286 children of human immunodeficiency virus (HIV)-infected mothers living in Switzerland has been performed with the participation of all paediatricians interested in HIV infection in the country. Of these children 201 could be followed up prospectively from birth up to a median age of 22 months. Prevalence of HIV infection in Swiss parturients was estimated at 0.1% and apparently remained stable from 1986 to 1989. Vertical transmission rate was estimated at 14%-20%. Variables of maternal or perinatal history were not associated with transmission rate. Transmission to pairs of siblings of the same mothers was discordant in 33% (6 of 18), with always the elder sibling being infected. Postneonatal mortality in infants of HIV-infected mothers followed up from birth was increased 15-fold over the general population with a very high incidence (2 in 100) of sudden infant death apparently unrelated to HIV infection.
- Published
- 1992
- Full Text
- View/download PDF
6. Combination antiretroviral therapy and duration of pregnancy
- Author
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Aebi, C, Battegay, M, Bernasconi, E, Biedermann, K, Cheseaux, JJ, Drack, G, Erb, P, Flepp, M, Francioli, P, Furrer, HJ, Gianinazzi, MP, Gyr, T, Hirschel, B, Hosli, I, Hug, I, Irion, O, Keller, K, Kind, C, Laubereau, B, Lauper, U, Lorenzi, P, Matter, L, Nadal, D, Perrin, L, Rickenbach, M, Rudin, C, Schreyer, A, Schupbach, J, Telenti, A, Vernazza, P, Wolf, K, Wunder, D, Wyler, CA, Giaquinto, C, Ruga, E, De Rossi, A, Grosch-Worner, I, Seel, K, Schafer, A, Mok, J, Johnstone, F, Jimenez, J, Garcia-Rodriguez, MC, Bates, I, de Jose, I, Hawkins, F, de Gevara, CL, Pena, JM, Garcia, JG, Lopez, JRA, Asensi-Botet, F, Otero, MC, Perez-Tamarit, D, Ridaura, S, Gregori, P, de la Torre, R, Scherpbier, H, Kreyenbroek, M, Boer, K, Bohlin, AB, Lindgren, S, Ehrnst, A, Belfrage, E, Lidman, K, Christensson, B, Levy, J, Hainaut, M, Peltier, A, Barlow, P, Wibaut, S, Lecroart, MC, Ferrazin, A, Bassetti, D, De Maria, A, Gotta, C, Mur, A, Paya, A, Vinolas, M, Lopez-Vilchez, MA, Martinez-Gomez, P, Carreras, R, Coll, O, Fortuny-Guasch C, Boguna, J, Caro, MC, Canet, Y, Pardi, G, Ravizza, M, Guerra, B, Lanari, M, Bianchi, S, Bovicelli, L, Prati, E, Duse, M, Scaravelli, G, Stegagno, M, De Santis, M, Semprini, AE, Savasi, V, Vigano, A, Probizer, FR, Maccabruni, A, Bucceri, A, Rancilio, L, Taylor, GP, Lyall, H, Penn, Z, Valerius, NH, Martinelli, P, Buffolano, W, Sansone, M, Tibaldi, C, Ziarati, N, Benedetto, C, Niemiec, T, Horban, A, Newell M.-L., Aebi C., Battegay M., Bernasconi E., Biedermann K., Cheseaux J.-J., Drack G., Erb P., Flepp M., Francioli P., Furrer H.J., Gianinazzi M.-P., Gyr T., Hirschel B., Hosli I., Hug I., Irion O., Keller K., Kind C., Laubereau B., Lauper U., Lorenzi P., Matter L., Naddal D., Perrin L., Rickenbach M., Rudin C., Schreyer A., Schupbach J., Telenti A., Vernazza P., Wolf K., Wunder D., Wyler C.-A., Giaquinto C., Ruga E., De Rossi A., Grosh-Worner I., Seel K., Schafer A., Mok J., Johnstone F., Jimenez J., Garcia-Rodriguez M.C., Bates I., De Jose I., Hawkins F., Ladron de Gevara C., Ma Pena J., Gonzalez Garcia J., Arribas Lopez J.R., Asensi-Botet F., Otero M.C., Perez-Tamarit D., Ridaura S., Gregori P., De la Torre R., Scherpbier H., Kreyenbroek M., Boer K., Bohlin A.B., Lindgren S., Ehrnst A., Belfrage E., Lidman K., Christensson B., Levy J., Hainaut M., Peltier A., Barlow P., Wibaut S., Lecroart M.C., Ferrazin A., Bassetti D., De Maria A., Gotta C., Mur A., Paya A., Vinolas M., Lopez-Vilchez M.A., Martinez-Gomez P., Carreras R., Coll O., Fortuny C., Boguna J., Casellas Caro M., Canet Y., Pardi G., Ravizza M., Guerra B., Lanari M., Bianchi S., Bovicelli L., Prati E., Duse M., Scaravelli G., Stegagno M., De Santis M., and Semprini A.E.
- Subjects
Epidemiology ,HIV Infections ,Substance Abuse, Intravenou ,Cohort Studies ,Pregnancy ,Immunology and Allergy ,Medicine ,HIV Infection ,Prospective Studies ,Pregnancy Complications, Infectious ,Substance Abuse, Intravenous ,Prospective cohort study ,Obstetrics ,Infectious ,Substance Abuse ,Pregnancy Outcome ,Gestational age ,Viral Load ,Antiretroviral therapy ,Reverse Transcriptase Inhibitor ,Infectious Diseases ,Combination ,Reverse Transcriptase Inhibitors ,Drug Therapy, Combination ,Female ,Intravenous ,Prematurity ,Delivery ,Zidovudine ,Viral load ,Infant, Premature ,Human ,Cohort study ,medicine.drug ,Adult ,medicine.medical_specialty ,Combination therapy ,Anti-HIV Agents ,Immunology ,CD4 Lymphocyte Count ,Delivery, Obstetric ,Gestational Age ,HIV-1 ,Humans ,Infant, Newborn ,Drug Therapy ,antiretroviral therapy ,combination therapy ,epidemiology ,pregnancy ,prematurity ,Premature ,business.industry ,Infant ,Anti-HIV Agent ,Obstetric ,Odds ratio ,Newborn ,medicine.disease ,Surgery ,Pregnancy Complications ,Prospective Studie ,Pregnancy Complications, Infectiou ,Cohort Studie ,business - Abstract
Objective: To assess the association between type and timing of initiation of antiretroviral therapy in pregnancy and duration of pregnancy. Design: Prospective study. Methods: Data on 3920 mother child pairs were examined (3015 mother-child pairs from the European Collaborative Study and 905 from the Swiss Mother + Child HIV Cohort Study). Factors examined included gestational age, antiretroviral therapy during pregnancy, maternal CD4 count, viral load, illicit drug use (IDU) and mode of delivery. Deliveries at less than 37 weeks were defined as premature. Results: The prematurity rate was 17% and median gestational age 39 weeks. Twenty-three per cent (896 of 3920) of women received antiretroviral therapy during pregnancy: 64% (573 of 896) zidovudine monotherapy, 24% (215) combination therapy without protease inhibitors (PI) and 12% (108) combination therapy with PI. In multivariate analysis, adjusted for maternal CD4 count and IDU, odds ratio (OR) of prematurity was 2.60 195% confidence interval (CI), 1.43-4.751 and 1.82 (95% CI, 1.13-2.92) for infants exposed to combination therapy with and without a Pl, respectively, compared to no treatment. Exposure to monotherapy was not associated with prematurity, but severe immunosuppression and IDU in pregnancy were. Women on combination therapy from before pregnancy were twice as likely to deliver prematurely as those starting therapy in the third trimester (OR, 2.17 95% CI, 1.03-4.58). Conclusions: Pregnancy issues should be discussed when making decisions about initiation of combination antiretroviral therapy for HIV-infected women. Elective caesarean section to reduce vertical transmission at 36 weeks rather than 38 weeks may be advisable in women on combination therapy with PI. © 2000 Lippincott Williams & Wilkins.
- Published
- 2000
- Full Text
- View/download PDF
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