1. HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia.
- Author
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Tan LK, Mohd-Farid B, Salsabil S, Heselynn H, Wahinuddin S, Lau IS, Gun SC, Nor-Suhaila S, Eashwary M, Mohd-Shahrir MS, Ainon MM, Azmillah R, Muhaini O, Shahnaz M, and Too CL
- Subjects
- Alleles, Asia, Southeastern, Databases, Nucleic Acid, Gene Frequency, Genetics, Population, Haplotypes, Humans, Malaysia epidemiology, Ethnicity, HLA-A Antigens genetics, HLA-B27 Antigen genetics, HLA-C Antigens genetics, HLA-DQ beta-Chains genetics, HLA-DRB1 Chains genetics
- Abstract
A total of 951 Southeast Asia Malays from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, there were significant deviation from Hardy-Weinberg proportions for the HLA-A (p<0.0001), -B (p<0.0001), -DRB1 (p<0.0001) and -DQB1 (p<0.01) loci. Minor deviations from HWEP were detected for HLA-C (p=0.01). This genotype data was available in Allele Frequencies Network Database (AFND) Gonzalez-Galarza et al. (2015)., (Copyright © 2016. Published by Elsevier Inc.)
- Published
- 2016
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