1. Low B-cell content is associated with a CD73-low tumour microenvironment and unfavourable prognosis in classic Hodgkin lymphoma.
- Author
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Grund J, Iben K, Reinke S, Bühnen I, Plütschow A, Müller-Meinhard B, Garcia Marquez MA, Schlößer HA, von Tresckow B, Kellermeier F, Borchmann P, Engert A, Bröckelmann PJ, and Klapper W
- Subjects
- Humans, Tumor Microenvironment, Antineoplastic Combined Chemotherapy Protocols adverse effects, Prospective Studies, Bleomycin therapeutic use, Dacarbazine therapeutic use, Doxorubicin therapeutic use, Vinblastine therapeutic use, Prognosis, Hodgkin Disease drug therapy
- Abstract
B-cell content in the tumour microenvironment (TME) of classic Hodgkin lymphoma (HL) is known to be associated with prognosis. Here we demonstrate that whole slide image analysis using routinely available slides predicts outcomes in patients treated with ABVD in a prospective trial with a high B-cell content being associated with a favourable prognosis. B cells in the TME did not correlate with B cells in peripheral blood. In the TME maturation, stages of B cells (naive and memory) were consistent. However, we detected down-regulation of CD73 in HL with low B cells suggestive of an antibody-independent function of B cells in the TME of HL., (© 2023 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
- Published
- 2023
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