1. ABO blood type association with SARS-CoV-2 infection mortality: A single-center population in New York City.
- Author
-
Szymanski J, Mohrmann L, Carter J, Nelson R, Chekuri S, Assa A, Spund B, Reyes-Gil M, Uehlinger J, Baron S, and Paroder M
- Subjects
- ABO Blood-Group System, Aged, Aged, 80 and over, COVID-19 therapy, Disease-Free Survival, Female, Humans, Incidence, Male, Middle Aged, New York City epidemiology, Retrospective Studies, Survival Rate, COVID-19 blood, COVID-19 mortality, Hospital Mortality, Hospitals, SARS-CoV-2 metabolism
- Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a variable clinical course with significant mortality. Early reports suggested higher rates of SARS-CoV-2 infection in patients with type A blood and enrichment of type A individuals among COVID-19 mortalities., Study Design and Methods: The study includes all patients hospitalized or with an emergency department (ED) visit who were tested for SARS-CoV-2 between March 10, 2020 and June 8, 2020 and had a positive test result by nucleic acid test (NAT) performed on a nasopharyngeal swab specimen. A total of 4968 patients met the study inclusion criteria, with a subsequent 23.1% (n = 1146/4968) all-cause mortality rate in the study cohort. To estimate overall risk by ABO type and account for the competing risks of in-hospital mortality and discharge, we calculated the cumulative incidence function (CIF) for each event. Cause-specific hazard ratios (csHRs) for in-hospital mortality and discharge were analyzed using multivariable Cox proportional hazards models., Results: Type A blood was associated with the increased cause-specific hazard of death among COVID-19 patients compared to type O (HR = 1.17, 1.02-1.33, p = .02) and type B (HR = 1.32,1.10-1.58, p = .003)., Conclusions: Our study shows that ABO histo-blood group type is associated with the risk of in-hospital death in COVID-19 patients, warranting additional inquiry. Elucidating the mechanism behind this association may reveal insights into the susceptibility and/or immunity to SARS-CoV-2., (© 2021 AABB.)
- Published
- 2021
- Full Text
- View/download PDF