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3 results on '"Browning, Sean D."'

1. Characteristics and Risk Factors of Hospitalized and Nonhospitalized COVID-19 Patients, Atlanta, Georgia, USA, March-April 2020.

Author

Pettrone K, Burnett E, Link-Gelles R, Haight SC, Schrodt C, England L, Gomes DJ, Shamout M, O'Laughlin K, Kimball A, Blau EF, Ladva CN, Szablewski CM, Tobin-D'Angelo M, Oosmanally N, Drenzek C, Browning SD, Bruce BB, da Silva J, Gold JAW, Jackson BR, Morris SB, Natarajan P, Fanfair RN, Patel PR, Rogers-Brown J, Rossow J, Wong KK, Murphy DJ, Blum JM, Hollberg J, Lefkove B, Brown FW, Shimabukuro T, Midgley CM, Tate JE, and Killerby ME

Subjects
Age Factors, Disease Progression, Female, Georgia epidemiology, Humans, Male, Middle Aged, Multimorbidity, Patient Acceptance of Health Care, Risk Assessment methods, Risk Assessment statistics & numerical data, Risk Factors, SARS-CoV-2, COVID-19 epidemiology, COVID-19 psychology, COVID-19 therapy, Diabetes Mellitus blood, Diabetes Mellitus epidemiology, Glycated Hemoglobin analysis, Hospitalization statistics & numerical data, Hypertension drug therapy, Hypertension epidemiology, Obesity diagnosis, Obesity epidemiology, Patient Care Management methods, Patient Care Management standards, Patient Care Management statistics & numerical data
Abstract

We compared the characteristics of hospitalized and nonhospitalized patients who had coronavirus disease in Atlanta, Georgia, USA. We found that risk for hospitalization increased with a patient's age and number of concurrent conditions. We also found a potential association between hospitalization and high hemoglobin A1c levels in persons with diabetes.

Published
2021
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2. Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020

Author

Killerby, Marie E., Link-Gelles, Ruth, Haight, Sarah C., Schrodt, Caroline A., England, Lucinda, Gomes, Danica J., Shamout, Mays, Pettrone, Kristen, O'Laughlin, Kevin, Kimball, Anne, Blau, Erin F., Burnett, Eleanor, Ladva, Chandresh N., Szablewski, Christine M., Tobin-D’Angelo, Melissa, Oosmanally, Nadine, Drenzek, Cherie, Murphy, David J., Blum, James M., Hollberg, Julie, Lefkove, Benjamin, Brown, Frank W., Shimabukuro, Tom, Midgley, Claire M., Tate, Jacqueline E., Browning, Sean D., Bruce, Beau B., da Silva, Juliana, Gold, Jeremy A.W., Jackson, Brendan R., Bamrah Morris, Sapna, Natarajan, Pavithra, Neblett Fanfair, Robyn, Patel, Priti R., Rogers-Brown, Jessica, Rossow, John, and Wong, Karen K.

Subjects
Adult, Male, medicine.medical_specialty, Health (social science), Georgia, Adolescent, Epidemiology, Health, Toxicology and Mutagenesis, Pneumonia, Viral, Disease, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Health Information Management, Risk Factors, 030225 pediatrics, Acute care, Diabetes mellitus, medicine, Outpatient clinic, Humans, 030212 general & internal medicine, Full Report, Young adult, Cities, Pandemics, Aged, business.industry, Medical record, COVID-19, General Medicine, Odds ratio, Middle Aged, medicine.disease, Hospitalization, Emergency medicine, Female, business, Coronavirus Infections, Kidney disease
Abstract

The first reported U.S. case of coronavirus disease 2019 (COVID-19) was detected in January 2020 (1). As of June 15, 2020, approximately 2 million cases and 115,000 COVID-19-associated deaths have been reported in the United States.* Reports of U.S. patients hospitalized with SARS-CoV-2 infection (the virus that causes COVID-19) describe high proportions of older, male, and black persons (2-4). Similarly, when comparing hospitalized patients with catchment area populations or nonhospitalized COVID-19 patients, high proportions have underlying conditions, including diabetes mellitus, hypertension, obesity, cardiovascular disease, chronic kidney disease, or chronic respiratory disease (3,4). For this report, data were abstracted from the medical records of 220 hospitalized and 311 nonhospitalized patients aged ≥18 years with laboratory-confirmed COVID-19 from six acute care hospitals and associated outpatient clinics in metropolitan Atlanta, Georgia. Multivariable analyses were performed to identify patient characteristics associated with hospitalization. The following characteristics were independently associated with hospitalization: age ≥65 years (adjusted odds ratio [aOR] = 3.4), black race (aOR = 3.2), having diabetes mellitus (aOR = 3.1), lack of insurance (aOR = 2.8), male sex (aOR = 2.4), smoking (aOR = 2.3), and obesity (aOR = 1.9). Infection with SARS-CoV-2 can lead to severe outcomes, including death, and measures to protect persons from infection, such as staying at home, social distancing (5), and awareness and management of underlying conditions should be emphasized for those at highest risk for hospitalization with COVID-19. Measures that prevent the spread of infection to others, such as wearing cloth face coverings (6), should be used whenever possible to protect groups at high risk. Potential barriers to the ability to adhere to these measures need to be addressed.

Published
2020

3. Predictors at Admission of Mechanical Ventilation and Death in an Observational Cohort of Adults Hospitalized With Coronavirus Disease 2019.

Author

Jackson, Brendan R, Gold, Jeremy A W, Natarajan, Pavithra, Rossow, John, Fanfair, Robyn Neblett, Silva, Juliana da, Wong, Karen K, Browning, Sean D, Morris, Sapna Bamrah, Rogers-Brown, Jessica, Hernandez-Romieu, Alfonso C, Szablewski, Christine M, Oosmanally, Nadine, Tobin-D'Angelo, Melissa, Drenzek, Cherie, Murphy, David J, Hollberg, Julie, Blum, James M, Jansen, Robert, and Wright, David W

Subjects
HOSPITALS, ANTIHYPERTENSIVE agents, COVID-19, SCIENTIFIC observation, CONFIDENCE intervals, VITAL signs, PATIENTS, PUBLIC health, RETROSPECTIVE studies, RANDOM forest algorithms, ARTIFICIAL respiration, HOSPITAL admission & discharge, HOSPITAL care, MEDICAL records, ODDS ratio, LONGITUDINAL method, ADULTS
Abstract

Background Coronavirus disease (COVID-19) can cause severe illness and death. Predictors of poor outcome collected on hospital admission may inform clinical and public health decisions. Methods We conducted a retrospective observational cohort investigation of 297 adults admitted to 8 academic and community hospitals in Georgia, United States, during March 2020. Using standardized medical record abstraction, we collected data on predictors including admission demographics, underlying medical conditions, outpatient antihypertensive medications, recorded symptoms, vital signs, radiographic findings, and laboratory values. We used random forest models to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for predictors of invasive mechanical ventilation (IMV) and death. Results Compared with age <45 years, ages 65–74 years and ≥75 years were predictors of IMV (aORs, 3.12 [95% CI, 1.47–6.60] and 2.79 [95% CI, 1.23–6.33], respectively) and the strongest predictors for death (aORs, 12.92 [95% CI, 3.26–51.25] and 18.06 [95% CI, 4.43–73.63], respectively). Comorbidities associated with death (aORs, 2.4–3.8; P  < .05) included end-stage renal disease, coronary artery disease, and neurologic disorders, but not pulmonary disease, immunocompromise, or hypertension. Prehospital use vs nonuse of angiotensin receptor blockers (aOR, 2.02 [95% CI, 1.03–3.96]) and dihydropyridine calcium channel blockers (aOR, 1.91 [95% CI, 1.03–3.55]) were associated with death. Conclusions After adjustment for patient and clinical characteristics, older age was the strongest predictor of death, exceeding comorbidities, abnormal vital signs, and laboratory test abnormalities. That coronary artery disease, but not chronic lung disease, was associated with death among hospitalized patients warrants further investigation, as do associations between certain antihypertensive medications and death. [ABSTRACT FROM AUTHOR]

Published
2021
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