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Complexation between a viologen radical cation (V.+) and cyclobis(paraquat‐p‐phenylene) diradical dication (CBPQT2(.+)) has been investigated and utilized extensively in the construction of mechanically interlocked molecules (MIMs) and artificial molecular machines (AMMs). The selective recognition of a pair of V.+ using radical‐pairing interactions, however, remains a formidable challenge. Herein, we report the efficient encapsulation of two methyl viologen radical cations (MV.+) in a size‐matched bisradical dicationic host — namely, cyclobis(paraquat‐2,6‐naphthalene)2(.+), i.e. CBPQN2(.+). Central to this dual recognition process was the choice of 2,6‐bismethylenenaphthalene linkers for incorporation into the bisradical dicationic host. They provide the space between the two bipyridinium radical cations in CBPQN2(.+) suitable for binding two MV.+ with relatively short (3.05–3.25 Å) radical‐pairing distances. The size‐matched bisradical dicationic host was found to exhibit highly selective and cooperative association with the two MV.+ in MeCN at room temperature. The formation of the tetrakisradical tetracationic inclusion complex — namely, [(MV)2⊂CBPQN]4(.+) – in MeCN was confirmed by VT 1H NMR, as well as by EPR spectroscopy. The solid‐state superstructure of [(MV)2⊂CBPQN]4(.+) reveals an uneven distribution of the binding distances (3.05, 3.24, 3.05 Å) between the three different V.+, suggesting that localization of the radical‐pairing interactions has a strong influence on the packing of the two MV.+ inside the bisradical dicationic host. Our findings constitute a rare example of binding two radical guests with high affinity and cooperativity using host‐guest radical‐pairing interactions. Moreover, they open up possibilities of harnessing the tetrakisradical tetracationic inclusion complex as a new, orthogonal and redox‐switchable recognition motif for the construction of MIMs and AMMs. [ABSTRACT FROM AUTHOR]

Keywords: binding stoichiometry; host-guest systems; molecular recognition; radical-pairing interactions EN binding stoichiometry host-guest systems molecular recognition radical-pairing interactions 25787 25787 1 11/17/21 20211122 NES 211122 B Die selektive Erkennung b von zwei gestapelten Viologen-Radikalkationen in Lösung unter Verwendung eines größenangepassten radikalischen Wirts wird von J. Fraser Stoddart et al. in der Zuschrift auf S. 25658 beschrieben. Binding stoichiometry, host-guest systems, molecular recognition, radical-pairing interactions Durch die Verwendung von 2,6-Bismethylennaphthalin als Linker ist der bisradikalische dikationische Wirt in der Lage, zwei Methylviologen-Radikalkationen als Gäste mit starker und kooperativer Bindung aufzunehmen. [Extracted from the article]

Binding stoichiometry, host-guest systems, molecular recognition, radical-pairing interactions Keywords: binding stoichiometry; host-guest systems; molecular recognition; radical-pairing interactions EN binding stoichiometry host-guest systems molecular recognition radical-pairing interactions 25583 25583 1 11/17/21 20211122 NES 211122 B Selective recognition b of two stacked viologen radical cations in solution using a size-matched radical host is reported by J. Fraser Stoddart and co-workers in their Research Article on page 25454. By employing 2,6-bismethylenenaphthalene as the linker, the bisradical dicationic host is able to accommodate two methyl viologen radical cation guests with strong and cooperative binding. [Extracted from the article]