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1. XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women.

Author

Barbisan, G., Pérez, L. O., Difranza, L., Fernández, C. J., Ciancio, N. E., and Golijow, C. D.

Abstract

The article presents a study which analyzes of the role of X-ray repair cross-complementing group 1 (XRCC1) in the DNA base excision repair mechanism and in the development of cervical cancer in Argentine women. Based on the 217 samples gentotyped for two XRCC1 single nucleotide polymorphisms (SNPs), samples carrying heterozygous SNP had a reduced risk of cervical cancer development. It concludes that XRCC1 genotypes and haplotypes contribute to mitigating the risk of cervical cancer.

Published
2011

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