Search

Your search keyword '"hpv 16 integration"' showing total 3 results
Start Over Descriptor "hpv 16 integration" Topic hpv prevalence
3 results on '"hpv 16 integration"'

2. State of HPV16 integration in Lithuanian women with cervical neoplasia.

Author

Sepetiene, Agne, Gudlevicienė, Zivile, Bumbuliene, Zana, Drasutiene, Grazina, and Didziapetriene, Janina

Abstract

Cervical cancer morbidity and mortality in Lithuania is one of the biggest in the European Union. The main risk factor of cervical cancer is human papillomavirus (HPV). The deletion of the HPV E2 gene influences HPV DNA integration into the cell genome, as well as a rapid progression of cervical lesions. The purpose of this study is to determine HPV, its types, and HPV 16 integration in different grades of cervical intraepithelial neoplasias (CIN). 253 women with cytological lesions were involved in the study. After a histology, 31 women were diagnosed with CIN I, 35 with CIN II, and 51 with CIN III. The biggest prevalence of HPV infection was detected in women younger than 25 years old (69.7%) and in women with CIN II (90.9%). HPV 16 was detected in 67.8% of all cases, with the highest prevalence in CIN III (84.4%). A partial integration form was detected in 65.0% of HPV 16 infected women, a complete virus integration in 26.5%, and an episomal form in 8.4% of cases. Our study concludes that in all the cases confirmed using a histology, the partial virus integration form of CIN was identified the most. It was less frequently detected in CIN I cases (60.0%), but more frequently in CIN II and CIN III cases (72.8 and 69.3%, respectively). [ABSTRACT FROM AUTHOR]

Published
2011
Full Text
View/download PDF

3. State of HPV16 integration in Lithuanian women with cervical neoplasia

Author

Grazina Drasutiene, Zana Bumbuliene, Zivile Gudlevicienė, Janina Didziapetriene, and Agne Sepetiene

Subjects
Gynecology, Cervical cancer, medicine.medical_specialty, business.industry, viruses, hpv 16 integration, HPV infection, Reproductive medicine, virus diseases, Histology, General Medicine, hpv prevalence, cervical intraepithelial neoplasia, medicine.disease, Cervical intraepithelial neoplasia, female genital diseases and pregnancy complications, E2 protein, Medicine, media_common.cataloged_instance, Risk factor, European union, business, media_common
Abstract

Cervical cancer morbidity and mortality in Lithuania is one of the biggest in the European Union. The main risk factor of cervical cancer is human papillomavirus (HPV). The deletion of the HPV E2 gene influences HPV DNA integration into the cell genome, as well as a rapid progression of cervical lesions. The purpose of this study is to determine HPV, its types, and HPV 16 integration in different grades of cervical intraepithelial neoplasias (CIN). 253 women with cytological lesions were involved in the study. After a histology, 31 women were diagnosed with CIN I, 35 with CIN II, and 51 with CIN III. The biggest prevalence of HPV infection was detected in women younger than 25 years old (69.7%) and in women with CIN II (90.9%). HPV 16 was detected in 67.8% of all cases, with the highest prevalence in CIN III (84.4%). A partial integration form was detected in 65.0% of HPV 16 infected women, a complete virus integration in 26.5%, and an episomal form in 8.4% of cases. Our study concludes that in all the cases confirmed using a histology, the partial virus integration form of CIN was identified the most. It was less frequently detected in CIN I cases (60.0%), but more frequently in CIN II and CIN III cases (72.8 and 69.3%, respectively).

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results