1. Treatment of relapsing chronic infections of the respiratory tract: a comparative study of the effectiveness of non specific immunotherapy with the immunoadjuvant p40 and of vaccinotherapy
- Author
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R. Veronesi, J.C. Bazin, Bernard Bizzini, and E. Henocq
- Subjects
Immunity, Cellular ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,business.industry ,medicine.medical_treatment ,General Medicine ,Adjuvant P40 ,Immunotherapy ,Corynebacterium ,Immunoadjuvant ,Infectious Diseases ,medicine.anatomical_structure ,Non specific ,Adjuvants, Immunologic ,Immunity ,Recurrence ,Immunology ,medicine ,Humans ,business ,Respiratory Tract Infections ,Respiratory tract - Abstract
O tratamento de infecções crônicas recidivantes (I.C.R.) encontra muitas dificuldades. No presente estudo, o uso do imunoadjuvante P40, quer isolado, quer associado a vacinoterapia no tratamento de I.C.R., demonstrou ser muito eficaz, ao passo que a vacinoterapia isoladamente não o foi. Foi aventada a hipótese de que a imunidade mediada por células pode desempenhar papel importante no contrôle das I.C.R., uma vez que a melhora clínica dos pacientes foi acompanhada de positivação de testes cutâneos anteriormente negativos, testes estes realizados quer com o agente infeccioso específico, quer com antígeno inespecífico de refôrço. The treatment of relapsing chronic infections (RCI) encounters many difficulties. In the present study, the use of the immuno adjuvant P40 either alone or in association with vaccinotherapy for the treatment of RCI turned out to be very effective, whereas vaccinotherapy alone was not. It is hypothesized that cell-mediated immunity may play a major role in controlling RCI, since the clinical improvement of the patients kept up with the positivation of previously negative skin tests carried out with either the specific infecting agent or with recall-anti gens.
- Published
- 1984