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9,102 results on '"Allosteric Regulation"'

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1. Positive feedback in Ras activation by full-length SOS arises from autoinhibition release mechanism.

2. Dynamic allostery drives autocrine and paracrine TGF-β signaling

3. Chemical screening by time-resolved X-ray scattering to discover allosteric probes

4. Structural insights into GABAA receptor potentiation by Quaalude.

5. Targeting SHP2 Cryptic Allosteric Sites for Effective Cancer Therapy.

6. FGF1 Suppresses Allosteric Activation of β3 Integrins by FGF2: A Potential Mechanism of Anti-Inflammatory and Anti-Thrombotic Action of FGF1

7. Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding.

8. The violin model: Looking at community networks for dynamic allostery.

9. Differential Activation and Desensitization States Promoted by Noncanonical α7 Nicotinic Acetylcholine Receptor Agonists.

10. Allosteric regulation by membranes and hydrophobic subsites in phospholipase A2 enzymes determine their substrate specificity

11. Lipoprotein-associated phospholipase A2: A paradigm for allosteric regulation by membranes

12. Members of the KCTD family are major regulators of cAMP signaling

13. LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

14. Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface

15. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

16. Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects

17. Allosteric Inhibition of a Vesicular Glutamate Transporter by an Isoform-Specific Antibody

18. Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor

19. In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase‑2

20. Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations

21. Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation.

22. Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen

23. Discovery of allosteric binding sites by crystallographic fragment screening

24. An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties.

25. An Allosteric Shift in CD11c Affinity Activates a Proatherogenic State in Arrested Intermediate Monocytes

26. Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions

27. The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.

28. Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation

29. A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.

30. An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor.

31. Allosteric regulation of mammalian Na+/I− symporter activity by perchlorate

32. Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators

33. Modulation of the cardiac Na+-Ca2+ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications

34. Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain

35. Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch.

36. Minimally disruptive optical control of protein tyrosine phosphatase 1B.

37. Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

38. Individualized management of genetic diversity in Niemann-Pick C1 through modulation of the Hsp70 chaperone system

39. GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.

40. Structure and dynamics of the ASB9 CUL-RING E3 Ligase

41. Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch

42. Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor

43. The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

44. KRAS4A directly regulates hexokinase 1

45. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

46. The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53

47. Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I

48. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

49. PTPσ inhibitors promote hematopoietic stem cell regeneration.

50. Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP

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