1. Efficacy of Fluvoxamine in the Treatment of Major Depression With Comorbid Anxiety Disorders
- Author
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Andrea R. Kolsky, Jerrold F. Rosenbaum, Shamsah B. Sonawalla, Maya K. Spillmann, Jonathan E. Alpert, Andrew A. Nierenberg, and Maurizio Fava
- Subjects
Adult ,Male ,medicine.medical_specialty ,Patient Dropouts ,Adolescent ,Fluvoxamine ,Comorbidity ,Severity of Illness Index ,Drug Administration Schedule ,Internal medicine ,mental disorders ,Ambulatory Care ,medicine ,Humans ,Psychiatry ,Depression (differential diagnoses) ,Aged ,Psychiatric Status Rating Scales ,Depressive Disorder ,Hamilton Rating Scale for Depression ,Middle Aged ,medicine.disease ,Anxiety Disorders ,Psychiatry and Mental health ,Treatment Outcome ,Major depressive disorder ,Anxiety ,Antidepressant ,Female ,medicine.symptom ,Psychology ,Selective Serotonin Reuptake Inhibitors ,Anxiety disorder ,medicine.drug - Abstract
Background: Major depression with comorbid anxiety disorder is associated with poor antidepressant outcome compared with major depression without comorbid anxiety disorder. The purpose of our study was to assess changes in depressive symptoms and anxiety levels in outpatients with major depression with comorbid anxiety disorder following 12 weeks of open treatment with fluvoxamine. Method: We enrolled 30 outpatients (mean ± SD age = 39.4 ± 11.3 years; 16 women and 14 men) with DSM-IV major depressive disorder accompanied by one or more current comorbid DSM-IV anxiety disorders in our study. Patients were treated openly with fluvoxamine initiated at 50 mg/day, with an upward titration to a maximum of 200 mg/day (mean ± SD dose = 143 ± 45 mg/day). Efficacy assessments included the 17-item Hamilton Rating Scale for Depression (HAM-D-17) and Clinical Global Impressions-Severity of Illness (CGI-S) and Improvement (CGI-I) scales for both depression and anxiety. Intent-to-treat analysis was used to assess outcome. Results: The mean ± SD number of comorbid anxiety disorders per patient was 2. 1 ± 1.1. Following fluvoxamine treatment, the mean ± SD HAM-D-17 score dropped from 20.2 ± 3.3 to 11.0 ± 7.0 (p more...
- Published
- 1999
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