37 results on '"Atsushi Noguchi"'
Search Results
2. Refraction and pupil diameter in 3-year- and 1-month-old children as measured by Spot Vision Screener
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Fumiatsu Maeda, Haruki Abe, Nobuko Mizuno, Kiyoshi Yaoeda, Atsushi Noguchi, and Shunya Tatara
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Male ,Cylindrical power ,Spherical power ,genetic structures ,Pupil diameter ,lcsh:Medicine ,Refraction, Ocular ,Pupil ,Article ,03 medical and health sciences ,0302 clinical medicine ,Vision Screening ,Physical examination ,Japan ,Medicine ,Humans ,lcsh:Science ,Multidisciplinary ,business.industry ,lcsh:R ,Infant, Newborn ,Eye refraction ,Infant ,Refraction ,eye diseases ,Risk factors ,Child, Preschool ,030221 ophthalmology & optometry ,Optometry ,Female ,lcsh:Q ,sense organs ,business ,030217 neurology & neurosurgery - Abstract
Spot Vision Screener (SVS) can conduct refraction tests for both eyes within a short period. This study aims to evaluate the refraction and pupil diameters of 3-year- and 1-month-old Japanese children using SVS in regular medical checkup. We examined 2438 eyes of 1219 children (age: 3-year- and 1-month) in Fujieda (Shizuoka, Japan) to assess their refraction and pupil diameters and eye-position screening conducted by SVS. SVS successfully measured 1217 children (99.8%). Regarding the right eye refraction, the spherical power was +0.70 ± 0.55 D (median, +0.75 D), and the cylindrical power was −0.67 ± 0.49 D (median, −0.50 D). The pupil diameter of the right eyes was 5.57 ± 0.79 (median, 5.60) mm. we could obtain a large number of basic data for 3-year- and 1-month-old Japanese children. However, refraction and pupil diameter of children were not normally distributed, so careful handling of children’s basic data on the eye is necessary.
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- 2019
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3. Anti-cyclic citrullinated peptide antibody titers decrease in rheumatoid arthritis patients treated with tocilizumab: A pilot study
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Atsushi Noguchi, Kenji Oku, Tatsuya Atsumi, Miho Suzuki, Toshiyuki Bohgaki, Yoshihiro Matsumoto, Ryo Hisada, Shinsuke Yasuda, and Masaru Kato
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rheumatoid arthritis ,Adult ,Male ,musculoskeletal diseases ,B-cell subpopulation ,Naive B cell ,Anti-cyclic citrullinated peptide antibody ,Antibodies, Monoclonal, Humanized ,Anti-Citrullinated Protein Antibodies ,CD19 ,Arthritis, Rheumatoid ,tocilizumab ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Tocilizumab ,Rheumatology ,medicine ,Humans ,030212 general & internal medicine ,skin and connective tissue diseases ,030203 arthritis & rheumatology ,biology ,business.industry ,Antibody titer ,Middle Aged ,medicine.disease ,Titer ,chemistry ,Rheumatoid arthritis ,Immunology ,biology.protein ,Female ,Lymph ,Antibody ,business ,Biomarkers ,Immunosuppressive Agents - Abstract
Objectives: To analyze the effects of tocilizumab on peripheral B-cell subpopulation and its ability to produce anti-cyclic citrullinated peptide (CCP) antibody in patients with rheumatoid arthritis (RA). Methods: Thirteen consecutive RA patients initiated with tocilizumab were enrolled in our prospective study. Anti-CCP antibody titers and clinical parameters were evaluated during treatment. Peripheral blood B-cell subsets were analyzed using flow cytometry according to the Human Immunology Project. Results: Disease activity was significantly improved and anti-CCP antibody titers significantly decreased at week 24 compared to baseline. The percentages of post-switch memory B cells in CD19+ cells transiently increased at week 12, but there was no significant difference in any of the investigated B-cell subpopulations at week 24 compared to baseline. The ratios of post-switch memory to naïve B cells (post-switch/naïve) correlated negatively with anti-CCP antibody titers regardless of the time-points. Conclusion: Our study indicated that tocilizumab has a potential to reduce anti-CCP antibody production presumably by affecting post-switch/naïve ratio, and that anti-CCP antibody titers reflect B-cell distribution/subpopulation. As anti-CCP antibodies are produced in lymph nodes or ectopic lymphoid structures in synovial tissues, not in circulation, transient increment of post-switch memory B cells after tocilizumab treatment may reflect the altered balance of B-cell distribution between circulation and arthritic joints, resulting in suppressed production of anti-CCP antibody in situ.
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- 2019
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4. Prediction of the intolerance or non-responder to Janus kinase inhibitors in patients with rheumatoid arthritis: a preliminary retrospective study with integrative cluster analysis
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Masanari, Sugawara, Yuichiro, Fujieda, Atsushi, Noguchi, Shun, Tanimura, Yuka, Shimizu, Ikuma, Nakagawa, Masaru, Yoshimura, Nobuya, Abe, Michihito, Kono, Masaru, Kato, Kenji, Oku, Olga, Amengual, Isao, Yokota, Hiroki, Takahashi, and Tatsuya, Atsumi
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Arthritis, Rheumatoid ,Rheumatology ,Immunology ,Cluster Analysis ,Humans ,Janus Kinase Inhibitors ,Immunology and Allergy ,Lung Diseases, Interstitial ,Retrospective Studies - Abstract
To identify the subpopulation of rheumatoid arthritis (RA) non-responders to Janus kinase inhibitors (JAKis) using cluster analysis.This retrospective study enrolled RA patients who had been treated with JAKis (tofacitinib or baricitinib) between July 2013 and September 2019 in six centres. The endpoint was set as inadequate response to JAKis (JAKis-IR), defined as either non-response to JAKis or their intolerance. Non-response to JAKis was defined as achieving neither American College of Rheumatology 20% response nor Disease Activity Score (ΔDAS28-CRP)1.2 at 12 weeks. Withdrawal time point included earlier than after 12 weeks from baseline. A hierarchical cluster analysis was performed with variables related with clinical and serological parameters at baseline.The 132 RA patients enrolled were classified into four groups (Group A-D). Groups consisted of three components defined at baseline, as seropositivity, advanced joint destruction, interstitial lung disease presumably associated with RA (RA-ILD). Group A (n=32): seronegative, presence of advanced joint destruction, absence of RA-ILD. Group B (n=35): seropositive, absence of advanced joint destruction and RA-ILD. Group C (n=20): seropositive, absence of advanced joint destruction, presence of RA-ILD. Group D (n=45): seropositive, presence of advanced joint destruction and RA-ILD. The rate of JAKis-IR in four groups was as follows: A, 34.3%; B, 17.1%; C, 20.0%; and D, 8.9%. The difference in JAKis-IR rate between group A and D was statistically significant.A subpopulation of RA patients with a combination of the following three components, seronegativity, advanced joint destruction and absence of RA-ILD, was identified as being prone to JAKis-IR.
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- 2021
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5. Continuous warfarin administration versus heparin bridging therapy in post colorectal polypectomy haemorrhage: a study protocol for a multicentre randomised controlled trial (WHICH study)
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Mikitaka Iguchi, Yasuaki Nagami, Masami Nakatani, Takako Miyazaki, Shigetsugu Tsuji, Kenichiro Imai, Ko Miura, Toshiaki Narasaka, Takeshi Yamashina, Satoshi Ono, Shu Kiyotoki, Mitsuhiro Kono, Hayato Miyamoto, Atsushi Noguchi, Yuusaku Sugihara, Masatsugu Okuyama, Motohiko Kato, Masafumi Yamamura, Toshiki Horii, Tomoyuki Yada, Tomohiko Mannami, Hideto Kawaratani, Takuji Akamatsu, Hironori Uno, Tomoyuki Hayashi, Hisako Yoshida, Kazuki Yamamori, Kazuki Kakimoto, Noboru Watanabe, Shinjiro Yamaguchi, Yasuhiro Fujiwara, Haruka Fujinami, Koichiro Kawaguchi, Yosuke Kinoshita, Kyosuke Tanaka, Takaaki Kishino, Takuji Kawamura, Masaki Murata, Keiichiro Abe, Yoshihide Naito, Osamu Takaishi, Mitsutaka Kumamoto, Hisatomo Ikehara, Yoshinobu Yamamoto, Ryoji Fujii, Shinji Kitamura, Takehisa Suekane, Takao Yaoita, Junichi Okamoto, Zhaoliang Li, Satoru Hashimoto, Taishi Sakai, Takayuki Katsuno, Yoriaki Komeda, Masahiro Ochi, and Hiroaki Minamino
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medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Medicine (miscellaneous) ,Colorectal adenoma ,Postoperative Hemorrhage ,Heparin bridge ,law.invention ,03 medical and health sciences ,Study Protocol ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Humans ,Multicenter Studies as Topic ,Pharmacology (medical) ,Prospective Studies ,Randomized Controlled Trials as Topic ,lcsh:R5-920 ,business.industry ,Heparin ,Colorectal polypectomy ,Standard treatment ,Anticoagulant ,Warfarin ,Anticoagulants ,Vitamin K antagonist ,medicine.disease ,Polypectomy ,Surgery ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,business ,lcsh:Medicine (General) ,Colorectal Neoplasms ,medicine.drug ,Abdominal surgery - Abstract
Background Endoscopic removal of colorectal adenoma is considered an effective treatment for reducing the mortality rates associated with colorectal cancer. Warfarin, a type of anticoagulant, is widely used for the treatment and prevention of thromboembolism; however, bleeding may increase with its administration after polypectomy. In recent times, a high incidence of bleeding after endoscopic polypectomy has been reported in patients receiving heparin bridge therapy. However, previous studies have not compared the bleeding rate after endoscopic colorectal polypectomy between patients who continued with anticoagulant therapy and those who received heparin bridge therapy. We hypothesised that endoscopic colorectal polypectomy under the novel treatment with continuous warfarin is not inferior to endoscopic colorectal polypectomy under standard treatment with heparin bridge therapy with respect to the rate of postoperative bleeding. This study aims to compare the efficacy of endoscopic colorectal polypectomy with continuous warfarin administration and endoscopic colorectal polypectomy with heparin bridge therapy with respect to the rate of postoperative bleeding. Methods We will conduct a prospective multicentre randomised controlled non-inferiority trial of two parallel groups. We will compare patients scheduled to undergo colorectal polypectomy under anticoagulant therapy with warfarin. There will be 2 groups, namely, a standard treatment group (heparin bridge therapy) and the experimental treatment group (continued anticoagulant therapy). The primary outcome measure is the rate of postoperative bleeding. On the contrary, the secondary outcomes include the rate of cumulative bleeding, rate of overt haemorrhage (that does not qualify for the definition of haemorrhage after endoscopic polypectomy), incidence of haemorrhage requiring haemostasis during endoscopic polypectomy, intraoperative bleeding during endoscopic colorectal polypectomy requiring angiography, abdominal surgery and/or blood transfusion, total rate of bleeding, risk factors for postoperative bleeding, length of hospital stay, incidence of thromboembolism, prothrombin time-international ratio (PT-INR) 28 days after the surgery, and incidence of serious adverse events. Discussion The results of this randomised controlled trial will provide valuable information for the standardisation of management of anticoagulants in patients scheduled to undergo colorectal polypectomy. Trial registration UMIN-CTR UMIN000023720. Registered on 22 August 2016
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- 2020
6. Rheumatoid vasculitis mimicking cryptococcal infection
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Akemi Ishida-Yamamoto, Atsushi Noguchi, Shin Iinuma, and Chiaki Takahashi
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Aged, 80 and over ,Male ,medicine.medical_specialty ,Neutrophils ,business.industry ,MEDLINE ,Cryptococcosis ,Dermis ,Rheumatoid Vasculitis ,Dermatology ,medicine.disease ,Basophils ,Diagnosis, Differential ,Correspondence ,Rheumatoid vasculitis ,Humans ,Medicine ,Lymphocytes ,business - Published
- 2021
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7. Differences in therapeutic effects of topically applied corticosteroid and tacrolimus on atopic dermatitis-like symptoms in NC/Nga mice
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Kyi Chan Ko, Yasushi Suga, Mitsutoshi Tominaga, Hironori Matsuda, Nobuaki Takahashi, Kenji Takamori, Yayoi Kamata, Yoshie Umehara, Atsushi Noguchi, and Hideoki Ogawa
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Male ,0301 basic medicine ,medicine.medical_specialty ,Thymic stromal lymphopoietin ,Petrolatum ,medicine.drug_class ,Administration, Topical ,Dermatology ,Biochemistry ,Tacrolimus ,Dermatitis, Atopic ,Ointments ,Mice ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Thymic Stromal Lymphopoietin ,Adrenal Cortex Hormones ,Internal medicine ,Animals ,Humans ,Medicine ,Mast Cells ,Molecular Biology ,Betamethasone Valerate ,Clobetasol ,Transepidermal water loss ,Dermatophagoides farinae ,Emollients ,business.industry ,Pruritus ,Therapeutic effect ,Atopic dermatitis ,medicine.disease ,Calcineurin ,Disease Models, Animal ,Treatment Outcome ,030104 developmental biology ,Endocrinology ,Cytokines ,Corticosteroid ,Epidermis ,Clobetasol propionate ,business ,Ubiquitin Thiolesterase ,Immunosuppressive Agents ,medicine.drug - Abstract
Background Topical corticosteroid and calcineurin inhibitor have similar therapeutic benefits in atopic dermatitis (AD), but the differences in therapeutic mechanisms of action of these agents against AD symptoms are not fully understood. Objective This study was performed to examine the different effects of topical betamethasone valerate (BMV), clobetasol propionate (CBP), and tacrolimus (TAC) on itch-related behavior and dermatitis in NC/Nga mice with AD-like symptoms. Methods AD-like dermatitis was induced in the dorsal skin of NC/Nga mice by repeated topical application of Dermatophagoides farinae body (Dfb) ointment twice weekly for three weeks. Mice with dermatitis scores over 5 were divided into five groups with equal dermatitis scores and treated with BMV, CBP, TAC, or Vaseline (Vas) once daily for two consecutive days, or were not treated (NT). Scratching behavior was analyzed using a SCLABA ® -Real system. Transepidermal water loss (TEWL) before and after treatment was measured using a Tewameter ® TM210. Skin collected from each group was analyzed histologically. Results After the second treatment, dermatitis showed significantly greater improvement in the CBP and TAC-treated groups than in the Vas-treated and NT groups. The numbers of scratching bouts were significantly lower in CBP and TAC-treated mice than in Vas-treated mice. TEWL was significantly lower in TAC-, but not in CBP-, treated mice than in Vas-treated mice. Immunohistochemical examination showed that BMV, CBP and TAC did not reduce the increased densities of epidermal protein gene product 9.5- and substance P-immunoreactive fibers. The numbers of dermal CD4-immunoreactive T cells were significantly lower in BMV and CBP-treated mice than in Vas-treated and NT mice. The numbers of dermal eosinophils were significantly lower in BMV, CBP and TAC-treated mice than in Vas-treated and NT mice, with CBP showing the strongest effect. CBP significantly reduced epidermal thickness compared with Vas and NT. There were no significant differences in the numbers of interleukin-31-immunoreactive cells and mast cells, or in expression of epidermal thymic stromal lymphopoietin among all five groups. Conclusion The therapeutic potency of TAC against AD-like symptoms, including pruritus, is equal to that of the corticosteroid CBP. Epidermal innervation of sensory nerves itself might not be related to the therapeutic effects of topical tacrolimus and corticosteroids in its early phase.
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- 2017
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8. Power Doppler signal calibration in the finger joint between two models of ultrasound machine: a pilot study using a phantom and joints in patients with rheumatoid arthritis
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Atsushi Noguchi, Kenneth Sutherland, Michihito Kono, Katsumi Saito, Ryosuke Sakano, Tatsuya Atsumi, Tamotsu Kamishima, Tatsunori Horie, and Mutsumi Nishida
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rheumatoid arthritis ,Adult ,Male ,medicine.medical_specialty ,Pannus ,Pilot Projects ,Signal ,Imaging phantom ,030218 nuclear medicine & medical imaging ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Finger Joint ,Calibration ,signal calibration ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Aged ,030203 arthritis & rheumatology ,Radiological and Ultrasound Technology ,Phantoms, Imaging ,business.industry ,Power Doppler ,Ultrasound ,Reproducibility of Results ,Ultrasonography, Doppler ,phantom ,General Medicine ,Blood flow ,Middle Aged ,medicine.disease ,Flow velocity ,Female ,Finger joint ,Radiology ,business ,Biomedical engineering - Abstract
Background Despite the advantages of ultrasound (US) in the management of rheumatoid arthritis (RA) patients, power Doppler (PD) US may be highly dependent on the type of US machine used. Purpose To present a method to calibrate the PD signal of two models of US machines by use of a flow phantom and finger joints of patients with RA. Material and Methods For the phantom study, the PD signal count was measured in the flow phantom perfusing blood mimicking fluid at various injection rates and pulse repetition frequencies (PRFs). The quantitative PD index was calculated with ImageJ. For the clinical study, the second and third metacarpophalangeal joints of five consecutive patients with RA were examined. The quantitative PD index was measured at various PRFs by use of two models of machine (the same models as the phantom study). Results For the phantom and clinical studies, negative correlations were found between the PRF and the quantitative PD index when the flow velocity was constant and positive correlations between flow velocity and the quantitative PD index at constant PRF. There was a significant difference in the depiction performance of synovial blood flow between the two models, which can be calibrated by adjusting the PRF values derived from the phantom study in each model. Conclusion Signal calibration of pannus vascularity between US machines may be possible by adjusting the PRF value according to flow phantom data. Different US machines can thus provide equivalent examination results concerning the pannus vascularity.
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- 2017
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9. Calcineurin inhibitors for adult-onset Still's disease: a multicentre retrospective cohort study
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Hiroyuki, Nakamura, Yuichiro, Fujieda, Masato, Tarumi, Hirohiko, Kitakawa, Ryo, Hisada, Ikuma, Nakagawa, Atsushi, Noguchi, Takashi, Kurita, Hiroshi, Kataoka, Hideki, Kasahara, Yoshiharu, Amasaki, Isao, Yokota, and Tatsuya, Atsumi
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Adult ,Cohort Studies ,Macrophage Activation Syndrome ,Calcineurin Inhibitors ,Humans ,Still's Disease, Adult-Onset ,Retrospective Studies - Abstract
To clarify the efficacy and safety of calcineurin inhibitors (CNI) for treating adult-onset Still's disease (AOSD).This multicentre historical cohort study enrolled the consecutive patients with AOSD according to Yamaguchi classification criteria. The endpoints were set as the time from the initiation of treatment to events, the persistency rate of CNI and safety. Based on the recurrent event data analysis, these endpoints were evaluated for each event. We divided the events into two groups according to the treatment that included CNI or conventional therapy without CNI.One hundred seventy-eight patients with 247 events were analysed. CNI were predominantly used in 72 events with a recurrent history, typical skin rash, high ferritin levels, and/or severe complications such as macrophage activation syndrome, disseminated intravascular coagulation, serositis, meningitis. CNI led to a significantly longer event-free survival (hazard ratio: 0.57, 95% confidential interval: 0.32-0.99) after adjustment of concomitant medications. Subgroup analysis showed that CNI were effective for AOSD patients with high ALT level (hazard ratio: 0.11, 95% confidential interval: 0.02-0.59) and severe complications (hazard ratio: 0.11, 95% confidential interval: 0.01-0.94). The persistency rate of CNI was 71% at 5th year. Adverse events occurred more frequently in the CNI group (18% versus 8%, p=0.02); however, CNI did not involve in increased risk of adverse events, including nephrotoxicity, after adjustment (p=0.23).Our retrospective analysis suggested that CNI could be an effective and safe option for treating AOSD.
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- 2019
10. Antifibrotic efficacy of nintedanib in a cellular model of systemic sclerosis-associated interstitial lung disease
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Ilia, Atanelishvili, Tanjina, Akter, Atsushi, Noguchi, Olha, Vuyiv, Lutz, Wollin, Richard M, Silver, and Galina S, Bogatkevich
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Indoles ,Scleroderma, Systemic ,Humans ,Fibroblasts ,Lung Diseases, Interstitial ,Lung ,Protein Kinase Inhibitors ,Cells, Cultured ,Idiopathic Pulmonary Fibrosis - Abstract
Nintedanib is approved for the treatment of idiopathic pulmonary fibrosis (IPF) and was demonstrated to slow disease progression in patients with IPF by reducing decline in forced vital capacity by 50%. Recently, nintedanib has been reported to exert anti-fibrotic activity on systemic sclerosis (scleroderma, SSc) skin fibroblasts and to diminish skin and lung fibrosis in mouse models. The goal of the present study was to determine the effects of nintedanib on a cellular model of SSc-associated interstitial lung disease (ILD).Study was performed using lung fibroblasts (LF) isolated from five patients with SSc-ILD and from three control subjects.Nintedanib inhibited LF proliferation and migration in a concentration- and time-dependent manner. The proliferation rate of LF stimulated with PDGF in the presence of nintedanib was reduced 1.9-fold within 24 h as compared to cells stimulated with PDGF alone. Migration of SSc-ILD LF incubated with 100 nM nintedanib was reduced from 62.8±12.5% to 39.1±9.0% in the presence of PDGF and from 38.2±7.9% to 26.6±7.2% in serum-free medium. Nintedanib attenuated PDGF-induced Ca2+ efflux, reduced α-SMA promoter activity and α-SMA protein expression. Furthermore, nintedanib blocked PDGF-induced differentiation of normal LF to myofibroblasts, reduced production of collagen and fibronectin, and decreased contractility of SSc-ILD LF in both floating and fixed collagen gels.Our data demonstrate significant antifibrotic efficacy of nintedanib in SSc-ILD LF suggesting that nintedanib has the potential not only to prevent but also to reverse the increased activity of LF consequently attenuating excessive lung fibrosis observed in SSc-ILD.
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- 2019
11. Bi-ventricular interplay in patients with systemic sclerosis-associated pulmonary arterial hypertension: Detection by cardiac magnetic resonance
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Toshiyuki Bohgaki, Tatsuya Atsumi, Hiroshi Ohira, Atsushi Noguchi, Kazumasa Ohmura, Kenji Oku, Masaharu Nishimura, Masaru Kato, Michihito Kono, Ichizo Tsujino, Tetsuya Horita, Shinsuke Yasuda, and Noriko Oyama-Manabe
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Adult ,Male ,medicine.medical_specialty ,Cardiac magnetic resonance ,Heart Ventricles ,Hypertension, Pulmonary ,Hemodynamics ,030204 cardiovascular system & hematology ,Pulmonary arterial hypertension ,Single Center ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Humans ,In patient ,skin and connective tissue diseases ,Associated Pulmonary Arterial Hypertension ,Aged ,Retrospective Studies ,030203 arthritis & rheumatology ,Connective tissue diseases ,Scleroderma, Systemic ,integumentary system ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,Pulmonary hypertension ,Bi ventricular ,Cardiology ,Systemic sclerosis ,Female ,CTD ,Radiology ,business ,Follow-Up Studies - Abstract
Objectives: Pulmonary arterial hypertension (PAH) associated with systemic sclerosis (SSc) has a poor prognosis compared to PAH associated with other connective tissue diseases (CTD). The objective of this study was to examine the difference in hemodynamic state between SSc-PAH and other CTD-PAH by performing cardiac magnetic resonance (CMR) imaging.Methods: A single center retrospective analysis was conducted comprising 40 consecutive CTD patients who underwent right heart catheterization and CMR at the same period from January 2010 to October 2015. Results: Thirty-two patients had pre-capillary pulmonary hypertension. Of these, 15 had SSc and 17 had other CTD. CMR measurements, particularly the ratio of right to left end-diastolic volume (RVEDV/LVEDV), correlated well with mean pulmonary arterial pressure (mPAP). Conversely, RVEDV/LVEDV and mPAP correlated differently in SSc and non-SSc patients. In SSc patients, the ratio of RVEDV/LVEDV to mPAP was significantly higher compared to non-SSc patients. In the follow-up study, 2 SSc patients exhibited increased RVEDV/LVEDV in spite of decreased mPAP following treatment. Kaplan-Meier analysis revealed poor prognosis of patients with increased RVEDV/LVEDV following treatment. Conclusions: Our data indicated that altered bi-ventricular interplay detected at CMR may represent SSc-related cardiac involvement and reflect poor prognosis of SSc-PAH.
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- 2016
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12. Effect of Posterior Corneal Vesicles on Corneal Endothelial Cell Density and Anisometropic Amblyopia
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Naoki Okumura, Chie Sotozono, Atsushi Noguchi, and Shigeru Kinoshita
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Refractive error ,Visual acuity ,genetic structures ,Adolescent ,Visual Acuity ,Cell Count ,030105 genetics & heredity ,Astigmatism ,Amblyopia ,complex mixtures ,Cornea ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Ophthalmology ,medicine ,Humans ,In patient ,Child ,Dioptre ,Retrospective Studies ,Corneal Dystrophies, Hereditary ,business.industry ,Vesicle ,Endothelial Cells ,Middle Aged ,medicine.disease ,eye diseases ,Posterior polymorphous corneal dystrophy ,030221 ophthalmology & optometry ,Female ,sense organs ,medicine.symptom ,Corneal endothelial cell density ,business - Abstract
PURPOSE To evaluate the effect of corneal vesicles in patients with posterior corneal vesicles (PCV) on corneal endothelial cell (CEC) density and the acquisition of amblyopia. METHODS In this retrospective study of patients with PCV (18 eyes of 14 patients), CEC density was examined by noncontact specular microscopy during each follow-up examination. Best-corrected visual acuity and the objective refractive error were also examined. RESULTS Of the 14 total patients, 10 were diagnosed with PCV and 4 were diagnosed with bilateral suspected PCV or posterior polymorphous corneal dystrophy (PPCD), and in all patients, no ocular abnormality other than corneal vesicles was observed. In patients with PCV and patients with bilateral suspected PCV or PPCD, mean CEC density was 1131 ± 338 and 1095 ± 492 cells/mm, respectively. In both PCV group and the bilateral suspected PCV or PPCD-group patients who were followed for 164.2 ± 25.4 months (range: 123-186 months), CEC density tended not to decrease. In patients with PCV, the mean best-corrected visual acuity of the unaffected eyes was significantly higher than that of the affected eyes with corneal vesicles (-0.10 ± 0.06 and 0.05 ± 0.13, respectively, P = 0.012). Four of 9 affected eyes (1 eye was excluded because of retinal atrophy) exhibited amblyopia, and all 4 eyes had astigmatism higher than 2 diopters. CONCLUSIONS Although CEC density of patients with PCV in this study was found to be stable over a long-term follow-up period, strict attention should be given to the possibility of amblyopia in eyes with PCV.
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- 2018
13. Successful Colistin Treatment of Multidrug-Resistant Pseudomonas aeruginosa Infection Using a Rapid Method for Determination of Colistin in Plasma: Usefulness of Therapeutic Drug Monitoring
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Sumio Iwasaki, Tatsuya Fukumoto, Takehiro Yamada, Ken Iseki, Shinsuke Yasuda, Kouji Akizawa, Issei Higuchi, Hiroaki Yamaguchi, Kenji Oku, Nobuhisa Ishiguro, Ikuma Nakagawa, Atsushi Noguchi, and Ayako Furugen
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medicine.drug_class ,Antibiotics ,Pharmaceutical Science ,Bacteremia ,Drug resistance ,Aztreonam ,Pharmacology ,chemistry.chemical_compound ,Drug Resistance, Multiple, Bacterial ,polycyclic compounds ,medicine ,Tobramycin ,Humans ,Pseudomonas Infections ,colistin ,drug monitoring ,medicine.diagnostic_test ,business.industry ,Septic shock ,General Medicine ,biochemical phenomena, metabolism, and nutrition ,Middle Aged ,bacterial infections and mycoses ,medicine.disease ,multidrug-resistant Pseudomonas aeruginosa ,Anti-Bacterial Agents ,Treatment Outcome ,chemistry ,Therapeutic drug monitoring ,Pseudomonas aeruginosa ,Colistin ,bacteria ,lipids (amino acids, peptides, and proteins) ,Female ,business ,medicine.drug - Abstract
A 56-year-old woman with systemic lupus erythematosus had bacteremia due to multidrug-resistant Pseudomonas aeruginosa (MDRP). She was initially treated with imipenem-cilastatin, tobramycin, and aztreonam; however, MDRP was still detected intermittently in her plasma. Multidrug-susceptibility tests demonstrated that MDRP was susceptible only to colistin. Therefore, in addition to these antibiotics, the administration of intravenous colistin methanesulfonate, a prodrug formula of colistin, was started at a daily dose of 2.5 mg/kg (as colistin base activity). The initial dose setting was based on the patient's renal function (baseline creatinine clearance=32.7 mL/min). After initiating colistin, the patient's C-reactive protein levels gradually decreased. Blood cultures showed no evidence of MDRP on days 8, 14, and 22 after colistin initiation. However, the patient's renal function went from bad to worse owing to septic shock induced by methicillin-resistant Staphylococcus aureus (MRSA) infection. A few days later, the trough plasma levels of colistin were 7.88 mg/L, which appeared to be higher than expected. After decreasing the colistin dose, the patient's renal function gradually improved. On the final day of colistin treatment, the plasma levels decreased to 0.60 mg/L. MDRP could not be detected in blood culture after colistin treatment. Therefore, we successfully treated a case of bloodstream infection due to MDRP by therapeutic drug monitoring (TDM) of colistin. It is suggested that the monitoring of blood colistin levels by liquid chromatography-tandem mass spectrometry can contribute to safer, more effective antimicrobial therapy of MDRP because TDM facilitates quick decisions on dose adjustments.
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- 2015
14. Autologous haematopoietic stem cell transplantation for Japanese patients with systemic sclerosis: Long-term follow-up on a phase II trial and treatment-related fatal cardiomyopathy
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Toshio Odani, Kenji Oku, Masaru Kato, Atsushi Noguchi, Junichi Sugita, Tomoyuki Endo, Toshiyuki Bohgaki, Yuichiro Fujieda, Shinsuke Yasuda, Takanori Teshima, Hiroyuki Nakamura, and Tatsuya Atsumi
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Oncology ,Adult ,Male ,medicine.medical_specialty ,genetic structures ,Cyclophosphamide ,Long term follow up ,Cardiomyopathy ,Transplantation, Autologous ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,skin and connective tissue diseases ,030203 arthritis & rheumatology ,Scleroderma, Systemic ,integumentary system ,business.industry ,Interstitial lung disease ,Hematopoietic Stem Cell Transplantation ,Middle Aged ,medicine.disease ,Transplantation ,Haematopoiesis ,surgical procedures, operative ,Female ,Stem cell ,business ,Cardiomyopathies ,medicine.drug - Abstract
The objective of this study is to elucidate the efficacy and safety of autologous haematopoietic stem cell transplantation (HSCT) for Japanese patients with systemic sclerosis (SSc).A phase II clinical trial included SSc patients diagnosed within the last three years having at least one of the following clinical features: diffuse skin sclerosis with modified Rodman total thickness skin score (mRSS) ≥ 15, refractory digital ulcer or interstitial lung disease (ILD). HSCT were performed after conditioning using cyclophosphamide.Fourteen patients were enrolled and underwent HSCT. Median follow-up period was 137 months. Overall survival or event-free survival rate was 93% or 40% at 10 years, respectively. Eight patients (57%) achieved more than a 50% decrease in mRSS from baseline within six months after HSCT. Six patients (43%) required additional immunosuppressive treatments due to progression of diffuse skin sclerosis and/or ILD during follow-up period. Adverse events related to HSCT occurred in six patients (43%). Severe cardiomyopathy occurred in two patients, and one of them had a fatal course.HSCT is a feasible treatment bringing favourable results to more than half of our patients with SSc. Careful selection of the patients is essential for whom benefited from HSCT, considering the risk-benefit balance of the treatment.
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- 2017
15. Effectiveness of whole-body magnetic resonance imaging for the efficacy of biologic anti-rheumatic drugs in patients with rheumatoid arthritis: A retrospective pilot study
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Yuka Shimizu, Shinsuke Yasuda, Olga Amengual, Kenji Oku, Toshiyuki Bohgaki, Sawako Abe, Toshiyuki Watanabe, Keita Sakamoto, Tatsuya Atsumi, Michihito Kono, Tamotsu Kamishima, Atsushi Noguchi, and Tetsuya Horita
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Adult ,Male ,medicine.medical_specialty ,Arthritis ,Pilot Projects ,Logistic regression ,030218 nuclear medicine & medical imaging ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Synovitis ,Internal medicine ,medicine ,Humans ,Aged ,Retrospective Studies ,030203 arthritis & rheumatology ,medicine.diagnostic_test ,business.industry ,Retrospective cohort study ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Antirheumatic Agents ,Rheumatoid arthritis ,Female ,Whole body ,business - Abstract
To evaluate the scoring of whole-body magnetic resonance imaging (WBMRI) for efficacy assessment in rheumatoid arthritis (RA) patients receiving biological disease-modifying anti-rheumatic drugs (bDMARDs).Thirty consecutive RA patients receiving bDMARDs were included in this retrospective study. Contrast WBMRI was performed before and 1 year after bDMARDs initiation.At baseline, mean age was 57.1 years and mean disease duration was 3.0 years. Median disease activity score in 28 joints improved from 5.1 to 2.1. Treatment with bDMARDs improved mean whole-body synovitis score from 31.2 to 23.2 and median whole-body bone-edema score from 11 to 3. Whole-body bone-erosion score improved in seven patients and deteriorated in 17 patients. Logistic regression analysis identified whole-body synovitis score as a poor prognostic factor for whole-body bone-erosion progression. Bone-edema score in individual bones was identified as a poor prognostic factor for the progression of bone-erosion. Changes in hand synovitis score correlated with those of other joints, but neither changes in bone-edema nor erosion score of hands correlated with those of other joints in WBMRI.WBMRI scoring may be a novel useful tool to evaluate the efficacy of anti-rheumatic drugs, as well as a potential predictor of joint prognosis, in patients with RA.
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- 2017
16. Precise Endoscopic and Pathologic Features in a Crohn's Disease Case with Two Fistula-associated Small Bowel Adenocarcinomas Complicated by an Anal Canal Adenocarcinoma
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Nobuhide Oshitani, Tetsuo Arakawa, Noriko Kamata, Yutaro Egashira, Atsushi Noguchi, Toshio Watanabe, Kenji Watanabe, Hirokazu Yamagami, Kenichi Morimoto, Kazunari Tominaga, Mitsue Sogawa, Kiyoshi Maeda, and Yasuhiro Fujiwara
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Adult ,Male ,medicine.medical_specialty ,Fistula ,Small bowel adenocarcinoma ,Ileum ,Adenocarcinoma ,Gastroenterology ,Endoscopy, Gastrointestinal ,Neoplasms, Multiple Primary ,Crohn Disease ,Perianal fistula ,Internal medicine ,Intestinal Fistula ,Internal Medicine ,medicine ,Humans ,Crohn's disease ,medicine.diagnostic_test ,business.industry ,Cancer ,General Medicine ,Anus Neoplasms ,medicine.disease ,Anal canal adenocarcinoma ,Endoscopy ,Ileal Neoplasms ,medicine.anatomical_structure ,business - Abstract
The patient was a 40-year-old man who had suffered from Crohn's disease (CD) for 19 years and developed an intractable perianal fistula and two strictures in the small bowel. Dilatation of the two strictures using double-balloon endoscopy did not improve the subileus symptoms. An anal canal adenocarcinoma was also detected using double-balloon endoscopy. The ileum and rectoperianal area were partially resected, and a precise immunohistochemical pathologic assessment revealed that all three lesions were fistula-associated adenocarcinomas. Accumulating endoscopic findings of CD-associated cancer and precise pathologic diagnostic findings will help to establish a suitable surveillance method.
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- 2013
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17. Pixel-by-Pixel Arterial Spin Labeling Blood Flow Pattern Variation Analysis for Discrimination of Rheumatoid Synovitis: A Pilot Study
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Hiroyuki Sugimori, Taro Sakashita, Tamotsu Kamishima, Atsushi Noguchi, Tatsuya Atsumi, Kenneth Sutherland, Michihito Kono, and Minghui Tang
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musculoskeletal diseases ,Adult ,Male ,Wrist Joint ,rheumatoid arthritis ,post labeling delay ,Pannus ,Pilot Projects ,030218 nuclear medicine & medical imaging ,Arthritis, Rheumatoid ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Synovitis ,Finger Joint ,ASL ,medicine ,Technical Note ,Humans ,Radiology, Nuclear Medicine and imaging ,skin and connective tissue diseases ,Aged ,medicine.diagnostic_test ,Pixel ,business.industry ,Magnetic resonance imaging ,Blood flow ,Middle Aged ,medicine.disease ,musculoskeletal system ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Rheumatoid arthritis ,Arterial spin labeling ,Female ,Spin Labels ,hand ,Nuclear medicine ,business ,030217 neurology & neurosurgery ,Artery - Abstract
We examined the capability of a gray-scale arterial spin labeling blood flow pattern variation (BFPV) map with two different post labeling delay (PLD) times to discriminate pannus in patients with rheumatoid arthritis (RA) at 3T. There was a statistically significant difference in the BFPV values between artery, pannus, and surrounding tissue. Furthermore, the color-coded BFPV map was able to accurately distinguish pannus from other tissues. These results suggest this approach may be capable of identifying pannus noninvasively.
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- 2016
18. Predicting sentinel lymph node metastasis in breast cancer with lymphoscintigraphy
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Atsushi Noguchi, Masahisa Onoguchi, Takeshi Ohnishi, Terumi Hashizume, Kazuyoshi Motomura, Akiyoshi Kajita, Toshizo Katsuda, and Masahiro Funauchi
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Adult ,medicine.medical_specialty ,Sentinel lymph node ,Breast Neoplasms ,Metastasis ,Breast cancer ,Biopsy ,Metastatic prediction ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Lymph node ,Aged ,Aged, 80 and over ,Tumor size ,medicine.diagnostic_test ,Sentinel Lymph Node Biopsy ,business.industry ,General surgery ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Lymphatic Metastasis ,Reference values ,Lymph Nodes ,Radiology ,Lymph ,business ,Lymphoscintigraphy - Abstract
金沢大学医薬保健研究域保健学系, Objective: Lymphoscintigraphy is an effective method for detecting sentinel lymph nodes (SLNs). However, the rate and degree of SLN detection is not uniform. We quantified SLNs detected with lymphoscintigraphy, and investigated correlations with factors that may influence detection. We then attempted to predict SLN metastasis from lymph node counts, comparing the predictions to subsequent biopsy results. Methods: We assessed lymph node counts in 100 breast cancer patients in whom a single SLN was detected with a fixed lymphoscintigraphy procedure. We examined correlations between the counts and factors known to influence lymphoscintigraphic SLN detection (age, body mass index, tumor size, and presence or absence of metastasis), and determined reference values (lymph node counts of 10.0, 19.4 and 53.0) which were used to predict SLN metastasis in 100 subsequent patients. The predictions were then compared with the SLN biopsy findings. Results: SLN counts correlated strongly with the presence or absence of metastasis, with metastasis-positive lymph nodes showing significantly lower counts than negative nodes (p < 0.001). Prediction of SLN metastasis achieved a 100% positive predictive value at a reference value of 10.0, and a 100% negative predictive value at a reference value of 53.0. At a reference value of 19.4, the sensitivity, specificity, and diagnostic accuracy were 77.8, 73.2, and 74.0%, respectively. Conclusions: The SLN counts detected with lymphoscintigraphy were significantly lower in metastasis-positive lymph nodes than in metastasis-negative lymph nodes. This suggests that prediction of SLN metastasis in breast cancer is possible using lymphoscintigraphy. © 2010 The Japanese Society of Nuclear Medicine.
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- 2010
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19. The production of interferon-γ-inducible protein 10 by granulocytes and monocytes is associated with ulcerative colitis disease activity
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Atsushi Noguchi, Kazuhide Higuchi, Shosaku Narumi, Yasuhiro Fujiwara, Hirokazu Yamagami, Tetsuo Arakawa, Kenji Watanabe, and Nobuhide Oshitani
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Adult ,Male ,medicine.medical_specialty ,Biopsy ,Granulocyte ,Monocytes ,Disease activity ,Interferon γ ,Surgical oncology ,Internal medicine ,medicine ,Humans ,Intestinal Mucosa ,Aged ,business.industry ,Monocyte ,Gastroenterology ,Colonoscopy ,Middle Aged ,Hepatology ,medicine.disease ,Ulcerative colitis ,Chemokine CXCL10 ,medicine.anatomical_structure ,Immunology ,Blood Component Removal ,Colitis, Ulcerative ,Female ,business ,Granulocytes - Abstract
To clarify which types of cells produce interferon-gamma-inducible protein 10 (IP-10) and whether IP-10 is associated with the development of ulcerative colitis (UC), we investigated IP-10 production in UC patients.Serum IP-10 levels were measured using enzyme-linked immunosorbent assay in 29 patients with active and 21 with inactive UC and in 20 controls. The production of IP-10 by granulocytes and monocytes adsorbed to G-1 beads was examined. In 21 active UC patients treated with granulocyte and monocyte/macrophage adsorptive apheresis (GMA), serum IP-10 levels were measured before and after treatment. IP-10-positive cells in UC mucosa were also examined immunohistochemically using tissues obtained by surgical resection and colonoscopic biopsies.Serum IP-10 levels in active UC patients were significantly higher than those in inactive patients, although even in the latter the levels were increased compared with those in controls. IP-10 production by granulocytes and monocytes in active UC patients was significantly higher than that in controls. Furthermore, the number of IP-10-positive cells was elevated in the colonic mucosa of patients with active UC, and one of the main subpopulations of IP-10-positive cells was granulocytes. Serum IP-10 levels decreased following GMA treatment in responders, but not in nonresponders. Interestingly, serum IP-10 levels before GMA were higher in responders than in nonresponders. In parallel with the serum levels, IP-10-positive cells also decreased following GMA treatment.Serum IP-10 levels reflected UC disease activity, and the source of IP-10 was granulocytes and monocytes. Furthermore, serum IP-10 levels may be a marker for the responsiveness of patients to GMA treatment.
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- 2007
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20. Predictive value of bone marrow accumulation of Tc-99m tetrofosmin for subsequent development of distant metastases in breast cancer
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Shigetoshi Wakasugi, Hideaki Tsukuma, Terumi Hashizume, Takeshi Ohnishi, Atsushi Noguchi, and Hideo Inaji
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Adult ,Oncology ,medicine.medical_specialty ,Breast Neoplasms ,Risk Assessment ,Sensitivity and Specificity ,Organophosphorus Compounds ,Breast cancer ,Bone Marrow ,Risk Factors ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Stage (cooking) ,Radionuclide Imaging ,Lymph node ,Survival analysis ,Aged ,Aged, 80 and over ,Univariate analysis ,business.industry ,Femoral Neoplasms ,Hazard ratio ,Reproducibility of Results ,Organotechnetium Compounds ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,medicine.anatomical_structure ,Lymphatic system ,Lymphatic Metastasis ,Female ,Bone marrow ,Radiopharmaceuticals ,business - Abstract
We evaluated the predictive value of bone marrow accumulation of technetium (Tc)-99m tetrofosmin in patients with breast cancer for distant metastases in comparison with conventional prognostic factors such as clinical stage, tumor size, axillary lymph node (Node) status, and estrogen receptor (ER) status.Bone marrow scans with Tc-99m tetrofosmin were performed on 64 patients with breast cancer who had no clinical evidence of distant metastases. Accumulation in the femoral marrow was classified into four patterns, no detectable, lower, higher, and intensively higher. Higher or intensively higher pattern was interpreted as abnormal. Thirty-six patients with abnormal accumulation (marrow-positive group) and 28 patients without abnormal accumulation (marrow-negative group) were enrolled in the follow-up study. The mean length of observation after scans was approximately 3 years. The predictive value of femoral marrow status and conventional prognostic factors for distant metastases was evaluated by statistical analysis.Univariate analysis showed a significantly higher incidence of subsequent bone metastases (36%4%; P0.005), and distant metastases (69%18%; P0.001) in the marrow-positive group when compared with the marrow-negative group. Conventional prognostic factors except tumor size were also significantly associated with the development of distant metastases; 77% in clinical stage 339% in clinical stages 1, 2, P0.05; 64% in Node-positive29% in Node-negative, P0.01; and 70% in ER negative27% in ER positive, P0.005. These conventional factors were not significantly associated with bone metastases. The Cox proportional hazard ratio for bone metastases was markedly higher in femoral marrow status (hazard ratio=11.07). The distant metastases-free survival was significantly reduced in ER negative (P0.0005), Node-positive (P=0.0215), and clinical stage 3 patients (P=0.0163). On the other hand, a more marked difference was observed in the femoral marrow status (P0.0001). The hazard ratio for distant metastases was 2.44 in clinical stage, 2.74 in tumor size, 2.74 in Node, and 3.68 in ER, which were each independent prognostic factors associated with distant metastases. However, femoral marrow status was markedly associated with distant metastases (hazard ratio=5.27).Bone marrow accumulation of Tc-99m tetrofosmin can be a promising prognostic factor independent of conventional prognostic factors for predicting development of not only bone metastases but also distant metastases in breast cancer.
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- 2007
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21. M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo
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Richard M. Silver, Atsushi Noguchi, Yuichiro Shirai, Ilia Atanelishvili, Tanjina Akter, Galina S. Bogatkevich, and Taylor Buckner
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0301 basic medicine ,Male ,Cell Survival ,Pulmonary Fibrosis ,Molecular Sequence Data ,Caspase 3 ,Smad2 Protein ,Biology ,Bleomycin ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Fibrosis ,Physiology (medical) ,Pulmonary fibrosis ,medicine ,Animals ,Humans ,Amino Acid Sequence ,Peptide sequence ,Lung ,Cells, Cultured ,Skin ,Scleroderma, Systemic ,Biochemistry (medical) ,Anti-Inflammatory Agents, Non-Steroidal ,Public Health, Environmental and Occupational Health ,General Medicine ,Transforming growth factor beta ,Fibroblasts ,Proto-Oncogene Proteins c-met ,medicine.disease ,Molecular biology ,Peptide Fragments ,Mice, Inbred C57BL ,Disease Models, Animal ,030104 developmental biology ,chemistry ,Hepatocyte Growth Factor Receptor ,biology.protein ,Hepatocyte growth factor ,Collagen ,medicine.drug - Abstract
Hepatocyte growth factor receptor, also known as cellular mesenchymal-epithelial transition factor (c-MET, MET), is an important antifibrotic molecule that protects various tissues, including lung, from injury and fibrosis. The intracellular cytoplasmic tail of MET contains a caspase-3 recognition motif "DEVD-T" that on cleavage by caspase-3 generates a 10-amino acid peptide, TRPASFWETS, designated as "M10". M10 contains at its N-terminus the uncharged amino acid proline (P) directly after a cationic amino acid arginine (R) which favors the transport of the peptide through membranes. M10, when added to cell culture medium, remains in the cytoplasm and nuclei of cells for up to 24 hours. M10 effectively decreases collagen in both scleroderma and TGFβ-stimulated normal lung and skin fibroblasts. M10 interacts with the Mad Homology 2 domain of Smad2 and inhibits TGFβ-induced Smad2 phosphorylation, suggesting that the antifibrotic effects of M10 are mediated in part by counteracting Smad-dependent fibrogenic pathways. In the bleomycin murine model of pulmonary fibrosis, M10 noticeably reduced lung inflammation and fibrosis. Ashcroft fibrosis scores and lung collagen content were significantly lower in bleomycin-treated mice receiving M10 as compared with bleomycin-treated mice receiving scrambled peptide. We conclude that M10 peptide interacts with Smad2 and demonstrates strong antifibrotic effects in vitro and in vivo in an animal model of lung fibrosis and should be considered as a potential therapeutic agent for systemic sclerosis and other fibrosing diseases.
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- 2015
22. Reproducibility Between Brain Uptake Ratio Using Anatomic Standardization and Patlak-Plot Methods
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Hiroko Tsuchihashi, Tomoki Yamada, Masahisa Onoguchi, Seigo Kinuya, Atsushi Noguchi, Tadashi Nakajima, and Takayuki Shibutani
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Adult ,Male ,Coefficient of variation ,Perfusion scanning ,Statistical parametric mapping ,Patlak plot ,Image Processing, Computer-Assisted ,Humans ,Radiology, Nuclear Medicine and imaging ,Mathematics ,Aged ,Retrospective Studies ,Brain uptake ,Aged, 80 and over ,Observer Variation ,Tomography, Emission-Computed, Single-Photon ,Reproducibility ,Normal side ,Radiological and Ultrasound Technology ,business.industry ,Brain ,Reproducibility of Results ,Biological Transport ,General Medicine ,Middle Aged ,Reference Standards ,Cerebral blood flow ,Cerebrovascular Circulation ,Female ,Nuclear medicine ,business - Abstract
The Patlak-plot and conventional methods of determining brain uptake ratio (BUR) have some problems with reproducibility. We formulated a method of determining BUR using anatomic standardization (BUR-AS) in a statistical parametric mapping algorithm to improve reproducibility. The objective of this study was to demonstrate the inter- and intraoperator reproducibility of mean cerebral blood flow as determined using BUR-AS in comparison to the conventional-BUR (BUR-C) and Patlak-plot methods. Methods: The images of 30 patients who underwent brain perfusion SPECT were retrospectively used in this study. The images were reconstructed using ordered-subset expectation maximization and processed using an automatic quantitative analysis for cerebral blood flow of ECD tool. The mean SPECT count was calculated from axial basal ganglia slices of the normal side (slices 31–40) drawn using a 3-dimensional stereotactic region-of-interest template after anatomic standardization. The mean cerebral blood flow was calculated from the mean SPECT count. Reproducibility was evaluated using coefficient of variation and Bland–Altman plotting. Results: For both inter- and intraoperator reproducibility, the BUR-AS method had the lowest coefficient of variation and smallest error range about the Bland–Altman plot. Mean CBF obtained using the BUR-AS method had the highest reproducibility. Conclusion: Compared with the Patlak-plot and BUR-C methods, the BUR-AS method provides greater inter- and intraoperator reproducibility of cerebral blood flow measurement.
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- 2015
23. [Significances and issues for capsule endoscopy in patients with Crohn's disease -toward the appropriate use]
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Kenji, Watanabe, Shuhei, Hosomi, Atsushi, Noguchi, Tomomi, Yukawa, Noriko, Kamata, Hirokazu, Yamagami, Kazunari, Tominaga, Toshio, Watanabe, Yasuhiro, Fujiwara, Hiroko, Nebiki, and Tetsuo, Arakawa
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Crohn Disease ,Humans ,Capsule Endoscopy - Published
- 2015
24. Clinical impact of ultrathin colonoscopy for Crohn's disease patients with strictures
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Kenichi, Morimoto, Kenji, Watanabe, Atsushi, Noguchi, Takako, Miyazaki, Yasuaki, Nagami, Satoshi, Sugimori, Noriko, Kamata, Mitsue, Sogawa, Tetsuya, Tanigawa, Hirokazu, Yamagami, Masatsugu, Shiba, Kazunari, Tominaga, Toshio, Watanabe, Yasuhiro, Fujiwara, and Tetsuo, Arakawa
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Adult ,Male ,Treatment Outcome ,Crohn Disease ,Colon ,Humans ,Female ,Colonoscopy ,Constriction, Pathologic ,Intestinal Mucosa ,Middle Aged - Abstract
Mucosal healing is now the ideal treatment goal for patients with Crohn's disease (CD) and endoscopy is suitable for both visualizing the intestinal mucosa and optimizing treatment according to the objective endoscopic findings; however, passing through strictures with a conventional colonoscope is sometimes difficult. An ultrathin colonoscope (outer diameter 9.2 mm) has been developed for superior insertion performance.CD patients with strictures that could not be passed with a conventional colonoscope were eligible for entry into the study. We investigated the rate of passage of the ultrathin colonoscope beyond strictures. We also investigated the clinical impact of optimizing the treatment strategy according to the endoscopic findings beyond the stricture.Of 49 patients, the ultrathin colonoscope could pass the stricture in 59.2% (29/49). The main reason for failure compared with the "pass" group was anal stricture (P = 0.005). When including finger bougie for severe anal stricture, passage of the stricture was achieved in 83.7% (41/49) of cases and the oral mucosa beyond the stricture was visualized. In these cases, 56.1% (23/41) had treatment efficacy confirmed and 43.9% (18/41) required a change of treatment. Importantly, half (9/18) of them were in clinical remission. There were no complications of the study.The ultrathin colonoscope could provide optimized treatment based on objective findings of the activity of the oral-side mucosa in CD patients complicated with stricture. Selection of the appropriate endoscope to visualize the responsible lesion is essential to optimize the treatment strategy in each case of CD.
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- 2015
25. Usefulness of a solid-state gamma camera for sentinel node identification in patients with breast cancer
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Hideo Inaji, Hiroki Koyama, Atsushi Noguchi, Kazuyoshi Motomura, Yoshifumi Komoike, Terumi Hashizume, Toshihide Saida, and Yoshihisa Hasegawa
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Adult ,Solid-state ,Breast Neoplasms ,law.invention ,Breast cancer ,law ,Preoperative Care ,medicine ,Humans ,Gamma Cameras ,In patient ,Aged ,Gamma camera ,Sentinel Lymph Node Biopsy ,business.industry ,General Medicine ,Middle Aged ,Sentinel node ,medicine.disease ,Anger Camera ,Axilla ,medicine.anatomical_structure ,Oncology ,Lymphatic Metastasis ,Female ,Surgery ,Nuclear medicine ,business ,Gamma probe - Abstract
Background A solid-state gamma camera was recently developed. This tool may enable intra-operative imaging of sentinel nodes in breast cancer. The aim of the present study was to evaluate the usefulness of a solid-state gamma camera for the pre- and intra-operative identification of sentinel nodes in patients with breast cancer. Methods Breast cancer patients with clinically negative nodes underwent sentinel node biopsy using dye and radioisotopes. Lymphoscintigraphy using both the conventional Anger camera and the solid-state gamma camera was performed the day before surgery. Sentinel nodes were intra-operatively identified using the gamma probe and imaged with a solid-state gamma camera, and then excised. When several sentinel nodes were present, these steps were repeated. Results Twenty-nine patients (30 basins) were enrolled in the study. The mean patient age was 54 years and the mean tumor size was 16 mm. A total of 41 sentinel nodes were identified using the Anger camera or the solid-state gamma camera pre-operatively. Thirty-eight sentinel nodes (92.7%) were identified using both the Anger camera and the solid-state gamma camera, 1 sentinel node (2.4%) was identified using the Anger camera alone, and 2 sentinel nodes (4.9%) were identified using the solid-state gamma camera alone. A total of 63 sentinel nodes were identified using the gamma probe or the solid-state gamma camera intra-operatively, and were excised. Fifty-seven sentinel nodes (90.5%) were identified using both the gamma probe and the solid-state gamma camera, 3 sentinel nodes (4.8%) were identified using the gamma probe alone, and 3 sentinel nodes (4.8%) were identified using the solid-state gamma camera alone. Conclusions The solid-state gamma camera is useful for pre- and intra-operative identification of sentinel nodes in breast cancer. The significance of the solid-state gamma camera could be that it compensates for the gamma probe when the gamma probe cannot identify some sentinel nodes because of the shine through effect, and avoids leaving the residual sentinel nodes behind the axilla intra-operatively. J. Surg. Oncol. 2005;89:12–17. © 2004 Wiley-Liss, Inc.
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- 2004
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26. Videofluoroscopy-guided balloon dilatation for treatment of severe pharyngeal dysphagia
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Gojiro Nakagami, Jyunko Matsuo, Hiromi Sanada, Atsushi Noguchi, Koichi Yabunaka, and Hideki Konishi
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Male ,medicine.medical_specialty ,Stroke patient ,Food consumption ,Video-Assisted Surgery ,Balloon dilatation ,Catheterization ,Pharyngeal dysphagia ,Long period ,Interventional Radiology ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,Aged ,Aged, 80 and over ,business.industry ,Balloon catheter ,Surgery ,Treatment Outcome ,Fluoroscopy ,Esophageal dilatation ,Pharynx ,Female ,Cardiology and Cardiovascular Medicine ,business ,Deglutition Disorders ,Angioplasty, Balloon - Abstract
Balloon dilatation is a widely accepted technique in the management of esophageal and other types of gastrointestinal strictures, but it is rarely used for the treatment of pharyngeal dysphagia. Therefore, the aim of our prospective study was to evaluate the use of videofluoroscopy-guided balloon dilatation (VGBD) for the treatment of severe pharyngeal dysphagia. The study included 32 stroke patients who had been diagnosed with oral and/or pharyngeal dysphagia. All patients underwent dilatation of the esophageal inlet using a balloon catheter under videofluoroscopic guidance during one or more sessions. Following esophageal dilatation, manual feeding was provided twice weekly. VGBD was effective in 10 out of 32 patients; however, the remaining 22 patients were unable to attempt oral food consumption because aspiration was not completely resolved on videofluoroscopy. According to this case series, VGBD may provide treatment for patients with severe pharyngeal dysphagia, who have not consumed food orally for a long period of time.
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- 2014
27. Efficacy of concomitant elemental diet therapy in scheduled infliximab therapy in patients with Crohn's disease to prevent loss of response
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Tetsuo Arakawa, Kazunari Tominaga, Shuhei Hosomi, Noriko Kamata, Atsushi Noguchi, Nobuhide Oshitani, Kenji Watanabe, Tomomi Yukawa, Hirokazu Yamagami, K. Watanabe, Matsatsugu Shiba, Yasuhiro Fujiwara, Toshio Watanabe, and Tetsuya Tanigawa
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Elemental diet ,Physiology ,Anti-Inflammatory Agents ,Gastroenterology ,Crohn Disease ,Gastrointestinal Agents ,Recurrence ,Risk Factors ,Internal medicine ,medicine ,Combined Modality Therapy ,Humans ,Infusions, Parenteral ,Medical nutrition therapy ,Retrospective Studies ,Crohn's disease ,business.industry ,Remission Induction ,Antibodies, Monoclonal ,Retrospective cohort study ,Drug Tolerance ,Hepatology ,Middle Aged ,medicine.disease ,Infliximab ,Surgery ,Treatment Outcome ,Concomitant ,Female ,business ,medicine.drug - Abstract
Loss of response (LOR) to infliximab (IFX) has become an important clinical issue for patients with Crohn's disease (CD). Elemental diet (ED) therapy has been established as a nutrition therapy for CD in Japan. ED therapy can reduce antigen exposure and is both efficacious and safe.To evaluate the efficacy of concomitant ED therapy in maintaining regular IFX infusion in patients with CD.We retrospectively studied 125 patients with luminal CD treated with scheduled IFX maintenance therapy with a regular dosage. Patients were classified into two groups: the ED group with intake ≥ 900 kcal/day and the non-ED group with intake900 kcal/day. When clinical LOR was detected on the basis of disease activity, laboratory parameters, or endoscopic findings, the physician discontinued the infusion schedule of IFX. We investigated the efficacy of ED therapy for sustaining the scheduled IFX maintenance therapy.With the exception of ED intake, no significant differences were found in patient characteristics between the ED group and the non-ED group. The ED group was significantly superior to the non-ED group (p = 0.049) in sustaining scheduled IFX maintenance therapy. It is well known that ED therapy is more effective for small bowel lesions than colonic lesions in CD. When comparing ileitis and ileocolitis patients with CD, the ED group was significantly superior to the non-ED group (p = 0.015).Concomitant ED therapy is effective in maintaining scheduled IFX maintenance therapy in patients with luminal CD in order to prevent LOR.
- Published
- 2014
28. A Case of Black Dot Ringworm with a Review of Japanese Cases
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Masato Kashima, Atsuhiko Hasegawa, Rui Kano, Yuka Nakamura, Shinichi Kawai, Shinichi Watanabe, Y. Kubota, Atsushi Noguchi, Shiho Ooka, and Masako Mizoguchi
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Adult ,Antifungal Agents ,Erythema ,Trichophyton violaceum ,Physiology ,Dermatology ,Naphthalenes ,Biology ,Black dot ringworm ,Diagnosis, Differential ,Tinea ,Trichophyton ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Terbinafine ,Tinea Capitis ,Alopecia ,General Medicine ,Molecular analysis ,Steroid therapy ,Immunology ,Prednisolone ,Female ,Age distribution ,medicine.symptom ,medicine.drug - Abstract
Black dot ringworm (BDR), caused by Trichophyton violaceum var. glabrum (T. glabrum), was observed in a 28-year-old Japanese female who had been treated with prednisolone (22.5 mg/day) for systemic lupus erythematosus. It was successfully treated with oral terbinafine (125 mg/day) for 12 weeks. The causative fungus was identified by molecular analysis as well as morphological and biochemical examination. The chitin synthase 1 (CHS1) gene cleavage pattern of the clinical isolate with restricted enzyme HinfI was identical to that of T. violaceum. We reviewed previous reports of BDR to determine the historical trend of this infection in Japan. Since 1974, 93 Japanese cases have been reported. The age distribution was bi-modal: the higher peak consisted of children (aged 0–15 years), and the lower peak was composed of the elderly (aged 60–75 years). In the elderly group, females were predominant (M: F=1: 22, p
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- 2000
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29. Accurate quantitative assessment of synovitis in rheumatoid arthritis using pixel-by-pixel, time-intensity curve shape analysis
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Hiroyuki Sugimori, Taro Sakashita, Michihito Kono, Kenneth Sutherland, Tatsuya Atsumi, Yuto Kobayashi, Tamotsu Kamishima, Minghui Tang, and Atsushi Noguchi
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Adult ,Male ,Wrist Joint ,medicine.medical_specialty ,Contrast Media ,Wrist ,030218 nuclear medicine & medical imaging ,Arthritis, Rheumatoid ,Fingers ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Synovitis ,Image Interpretation, Computer-Assisted ,Image Processing, Computer-Assisted ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Aged ,Rank correlation ,030203 arthritis & rheumatology ,Reproducibility ,Contouring ,Full Paper ,Pixel ,business.industry ,Reproducibility of Results ,General Medicine ,Middle Aged ,Hand ,medicine.disease ,Magnetic Resonance Imaging ,Thresholding ,Surgery ,medicine.anatomical_structure ,Female ,business ,Nuclear medicine ,Shape analysis (digital geometry) - Abstract
Objective: To improve on the reproducibility and sensitivity of the assessment of patients with rheumatoid arthritis (RA), two semi-automated measurement methods of the area of enhancing pannus (AEP), based on thresholding (AEP_THRES) and pixel-by-pixel time-intensity curve analysis (AEP_TIC), were evaluated as an alternative for the gold-standard manual contouring method (AEP_MANUAL). Methods: 8 patients (7 females and 1 male) with RA of the wrist or finger joints participated in the study. A three-dimensional contrast-enhanced dynamic sequence was used at 3 T. After identifying the most relevant time-intensity curve (TIC) shape in terms of synovitis by comparing with the synovitis score using the RA-MRI scoring system, three different approaches for measuring the AEP were performed. Spearman's test of rank correlation was used to compare AEPs via two semi-automated methods (AEP_THRES and AEP_TIC) against manual segmentation (AEP_MANUAL) in the entire hand region as well as the wrist and the finger regions. Results: The TIC shape of "washout after fast initial enhancement" had excellent correlation with synovitis score (r = 0.809). The correlation coefficient between AEP_TIC and AEP_MANUAL was evaluated to be better than that of AEP_THRES and AEP_MANUAL in the wrist region (AEP_THRES: r = 0.716, AEP_TIC: r = 0.815), whereas these were of comparable accuracy for the entire hand and the finger regions. Conclusion: This study suggests that TIC analysis may be an alternative to manual contouring for pannus quantification and provides important clinical information of the extent of the disease in patients with RA. Advances in knowledge: TIC shape analysis can be applied for new quantitative assessment for RA synovitis in the wrist.
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- 2016
30. Similarities and differences between US and Japan as to pharmacogenomic biomarker information in drug labels
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Yasuko Asahina, Yumiko Sato, Yoshiaki Uyama, Yuki Ando, Yasuto Otsubo, and Atsushi Noguchi
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Gerontology ,Drug ,medicine.medical_specialty ,Prescription Drugs ,Package insert ,media_common.quotation_subject ,Alternative medicine ,MEDLINE ,Pharmaceutical Science ,Marketing authorization ,Japan ,medicine ,Humans ,Pharmacology (medical) ,Biotransformation ,media_common ,Drug Labeling ,Pharmacology ,business.industry ,United States Food and Drug Administration ,Japanese population ,United States ,Biomarker (cell) ,Biotechnology ,Pharmacogenetics ,Pharmacogenomics ,business ,Biomarkers - Abstract
Pharmacogenomics (PGx) has been utilized as a tool to improve a drug's benefit/risk ratio and the efficiency of drug developments. In order to examine what factors are involved to determine the level of contexts (contents and descriptions) of drug-PGx biomarker information, we graded sections of Japanese package inserts and US drug labels into six levels according to the importance of cautions in regards to clinical practice and compared similarities and differences of the contexts between the two countries. Out of 54 contexts identified, 33 (61%) were graded differently between Japan and the US. The different contexts were mainly related to metabolizing enzymes used in terms of safety, therapeutic areas other than oncology, outcome before 1993, Japan-based companies having marketing authorization and no PGx data on the Japanese population. We describe the potential reasons that could lead to the differences between the two countries such as genetic differences and quantitative evidence in the Japanese population, and also discuss future perspectives to improve PGx utilization in clinical practices in Japan.
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- 2011
31. SPIO-enhanced magnetic resonance imaging for the detection of metastases in sentinel nodes localized by computed tomography lymphography in patients with breast cancer
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Atsushi Noguchi, Hiroki Koyama, Hiroshi Sumino, Makoto Ishitobi, Hideo Inaji, Yoshifumi Komoike, Takashi Horinouchi, Katsuyuki Nakanishi, Kazuyoshi Motomura, and Youji Kumatani
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Adult ,medicine.medical_specialty ,Contrast Media ,Breast Neoplasms ,Sensitivity and Specificity ,Breast cancer ,Surgical oncology ,Medical imaging ,medicine ,Humans ,In patient ,Magnetite Nanoparticles ,Lymph node ,Lymphatic Diseases ,Aged ,Neoplasm Staging ,medicine.diagnostic_test ,business.industry ,Sentinel Lymph Node Biopsy ,Lymphography ,Magnetic resonance imaging ,Dextrans ,Sentinel node ,Middle Aged ,medicine.disease ,Image Enhancement ,Prognosis ,Magnetic Resonance Imaging ,Lymphedema ,medicine.anatomical_structure ,Oncology ,Neoplasm Micrometastasis ,Lymphatic Metastasis ,Surgery ,Female ,Radiology ,business ,Tomography, X-Ray Computed - Abstract
Superparamagnetic nanoparticle-enhanced magnetic resonance (MR) imaging has been reported to be a promising improvement for diagnostic imaging of lymph node metastases from various tumors. Moreover, sentinel nodes have been reported to be well identified using computed tomography (CT) lymphography (CT-LG) in patients with breast cancer. The aim of this study was to evaluate MR imaging with superparamagnetic iron oxide (SPIO) enhancement for the detection of metastases in sentinel nodes localized by CT-LG in patients with breast cancer.This study included 102 patients with breast cancer and clinically negative nodes. Sentinel nodes were identified by CT-LG, and SPIO-enhanced MR imaging of the axilla was performed to detect metastases in the sentinel nodes. A node was considered nonmetastatic if it showed a homogenous low signal intensity and metastatic if the entire node or a focal area did not show low signal intensity on MR imaging. Sentinel node biopsy was performed, and imaging results were correlated with histopathologic findings.The mean number of sentinel nodes identified by CT-LG was 1.1 (range, 1-3). The sensitivity, specificity, and accuracy of MR imaging for the diagnosis of sentinel node metastases were 84.0%, 90.9%, and 89.2%, respectively. In 4 of 10 patients with micrometastases, metastases were not detected, but all 15 patients with macrometastases were successfully identified.SPIO-enhanced MR imaging is a useful method of detecting metastases in sentinel nodes localized by CT-LG in patients with breast cancer and may avoid sentinel node biopsy when the sentinel node is diagnosed as disease-free.
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- 2010
32. Transforming growth factor beta2 level is elevated in neurons of Alzheimer's disease brains
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Mikiro Nawa, Sadakazu Aiso, Koichi Okamoto, Masaaki Matsuoka, and Atsushi Noguchi
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Male ,Programmed cell death ,Amyloid ,Biology ,Hippocampus ,Transforming Growth Factor beta2 ,Downregulation and upregulation ,Alzheimer Disease ,Antibody Specificity ,mental disorders ,Chlorocebus aethiops ,Extracellular ,Animals ,Humans ,Aged ,Aged, 80 and over ,Cerebral Cortex ,Neurons ,COS cells ,Cell Death ,General Neuroscience ,General Medicine ,Middle Aged ,Immunohistochemistry ,In vitro ,Cell biology ,Up-Regulation ,nervous system ,embryonic structures ,COS Cells ,Female ,Neuroscience ,Transforming growth factor - Abstract
Our earlier studies in vitro indicated that expression of TGFbeta2 was induced by toxic amyloid betas (Abetas) in both glial and neuronal cells and increased levels of TGFbeta2 triggered a neuronal cell death pathway related to Alzheimer's disease (AD) by binding to the extracellular domain of amyloid beta precursor protein (APP). In this study we have demonstrated by immunohistochemical analysis that the levels of TGFbeta2 are elevated in cells mainly consisting of neurons of both the hippocampi and cerebral cortices of human AD brains. This result indicates that upregulation of the TGFbeta2 level is a common pathological feature of AD brains and suggests that it may be closely linked to the development of neuronal death related to AD.
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- 2010
33. Coronary and Mesenteric Involvement in Polyarteritis Nodosa
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Shinsuke Yasuda, Tetsuya Horita, Tatsuya Atsumi, Kanako Watanabe, and Atsushi Noguchi
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Pathology ,medicine.medical_specialty ,Aspirin ,Polyarteritis nodosa ,business.industry ,Prednisolone ,Immunology ,medicine.disease ,Coronary Vessels ,Mesenteric Arteries ,Polyarteritis Nodosa ,Treatment Outcome ,Rheumatology ,Celiac Artery ,medicine ,Humans ,Immunology and Allergy ,Drug Therapy, Combination ,Female ,Warfarin ,Tomography, X-Ray Computed ,business ,Cyclophosphamide ,Aged - Published
- 2015
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34. Usefulness of medium-energy collimator for sentinel node lymphoscintigraphy imaging in breast cancer patients
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Hiroyuki, Tsushima, Teruhiko, Takayama, Takashi, Yamanaga, Hiroto, Kizu, Yoshihiro, Shimonishi, Kazuhisa, Kosakai, Atsushi, Noguchi, and Masahisa, Onoguchi
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Phantoms, Imaging ,Lymphatic Metastasis ,Humans ,Reproducibility of Results ,Breast Neoplasms ,Lymph Nodes ,Artifacts ,Image Enhancement ,Sensitivity and Specificity ,Tomography, Emission-Computed - Abstract
This study was performed to investigate the usefulness of a general-purpose medium-energy (ME) collimator for the accurate localization of the sentinel lymph node (SLN) in breast cancer patients.We compared phantom images and lymphoscintigraphy images obtained under different conditions for a patient with breast cancer. Comparisons were performed between 2 cameras, between a low-energy high-resolution (LEHR) collimator and a general-purpose ME collimator, and between energy windows centered at 141 keV and at 146 keV. Profile curves and image contrast were evaluated along with the visual interpretation of images. The most suitable imaging time was selected from the relationship between contrast and the data acquisition time.The images obtained with the general-purpose ME collimator and the energy window centered at 141 keV were of poorer quality than those obtained with the LEHR collimator and the same energy window. However, the quality of the images obtained with the general-purpose ME collimator improved when the energy window was centered at 146 keV. The method involving the general-purpose ME collimator and the energy window centered at 146 keV showed excellent image quality similar to that obtained with the LEHR collimator. The enhancement of contrast was confirmed at more than 3 cm away from the center of the injection site. Stable contrast was obtained with a data acquisition time of 5 min, with the general-purpose ME collimator, and with the energy window centered at 146 keV.The method involving the general-purpose ME collimator and the energy window centered at 146 keV has the merit of the lymph node not being concealed by a lead shield. This new method is expected to improve the rate of detection of SLN and has the potential for shortening the acquisition time.
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- 2006
35. Comparison of Delayed Imaging with Tc-99m PMT and Tc-99m DEIDA for Visualization of Hepatoma
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H. Kasugai, Yoshihisa Hasegawa, J. Kojima, Atsushi Noguchi, Terumi Hashizume, Nakano S, Keijirou Ibuka, and Shigeyuki Ishigami
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Male ,Pathology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Kidney ,Scintigraphy ,Isotopes of technetium ,Technetium Tc 99m Diethyl-iminodiacetic Acid ,Technetium-99 ,Organometallic Compounds ,medicine ,Humans ,Delayed imaging ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Aged ,Tc-99m-PMT ,medicine.diagnostic_test ,business.industry ,Imino Acids ,Liver Neoplasms ,Tryptophan ,Technetium ,Organotechnetium Compounds ,General Medicine ,medicine.disease ,Radiography ,Liver ,Hepatocellular carcinoma ,Female ,Nuclear medicine ,business - Abstract
Delayed imaging was performed after the intravenous administration of Tc-99m DEIDA and Tc-99m PMT in 18 patients with hepatocellular carcinoma. Using Tc-99m DEIDA imaging, sharp uptake by liver tumors was observed in four patients (22%), but the uptake was similar to that of the surrounding normal liver in eight patients (44%). Using Tc-99m PMT imaging, the uptake by the tumor was notable in ten patients (56%) and normal in two (11%). Tc-99m PMT and Tc-99m DEIDA were both concentrated in hepatocellular carcinomas, but the former showed intense uptakes more frequently, and thus is suggested to be useful in the diagnosis of hepatocellular carcinoma.
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- 1989
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36. Sentinel nodes identified by computed tomography-lymphography accurately stage the axilla in patients with breast cancer
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Atsushi Noguchi, Katsuyuki Nakanishi, Hiroshi Sumino, Takashi Horinouchi, and Kazuyoshi Motomura
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Adult ,medicine.medical_specialty ,Staging ,Breast Neoplasms ,Sensitivity and Specificity ,Metastasis ,Breast cancer ,Japan ,Risk Factors ,Node (computer science) ,Biopsy ,Prevalence ,medicine ,Humans ,Mammography ,Radiology, Nuclear Medicine and imaging ,Stage (cooking) ,Computed tomography ,Aged ,Neoplasm Staging ,medicine.diagnostic_test ,Sentinel Lymph Node Biopsy ,business.industry ,Lymphography ,Reproducibility of Results ,Middle Aged ,Sentinel node ,medicine.disease ,Axilla ,medicine.anatomical_structure ,Radiology Nuclear Medicine and imaging ,Lymphatic Metastasis ,Female ,Radiology ,Tomography, X-Ray Computed ,business ,Research Article - Abstract
Background Sentinel node biopsy often results in the identification and removal of multiple nodes as sentinel nodes, although most of these nodes could be non-sentinel nodes. This study investigated whether computed tomography-lymphography (CT-LG) can distinguish sentinel nodes from non-sentinel nodes and whether sentinel nodes identified by CT-LG can accurately stage the axilla in patients with breast cancer. Methods This study included 184 patients with breast cancer and clinically negative nodes. Contrast agent was injected interstitially. The location of sentinel nodes was marked on the skin surface using a CT laser light navigator system. Lymph nodes located just under the marks were first removed as sentinel nodes. Then, all dyed nodes or all hot nodes were removed. Results The mean number of sentinel nodes identified by CT-LG was significantly lower than that of dyed and/or hot nodes removed (1.1 vs 1.8, p
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37. Correlation between the area of high-signal intensity on SPIO-enhanced MR imaging and the pathologic size of sentinel node metastases in breast cancer patients with positive sentinel nodes
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Tetsuta Izumi, Souichirou Tateishi, Hiroshi Sumino, Katsuyuki Nakanishi, Atsushi Noguchi, Kazuyoshi Motomura, and Takashi Horinouchi
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Adult ,Image-Guided Biopsy ,medicine.medical_specialty ,Contrast Media ,Breast Neoplasms ,Risk Assessment ,Sensitivity and Specificity ,Nodal enhancement pattern ,Correlation ,Breast cancer ,Text mining ,Magnetic resonance imaging ,Japan ,medicine ,Carcinoma ,Prevalence ,Humans ,Radiology, Nuclear Medicine and imaging ,Magnetite Nanoparticles ,Computed tomography ,Aged ,Lymph node metastasis ,medicine.diagnostic_test ,business.industry ,Sentinel Lymph Node Biopsy ,Reproducibility of Results ,Dextrans ,Sentinel node ,Middle Aged ,medicine.disease ,Mr imaging ,Intensity (physics) ,Tumor Burden ,Radiology Nuclear Medicine and imaging ,Lymphatic Metastasis ,Female ,Superparamagnetic iron oxide ,Radiology ,business ,Tomography, X-Ray Computed ,Research Article - Abstract
Background We previously demonstrated that superparamagnetic iron oxide (SPIO)-enhanced MR imaging is promising for the detection of metastases in sentinel nodes localized by CT-lymphography in patients with breast cancer. The purpose of this study was to determine the predictive criteria of the size of nodal metastases with SPIO-enhanced MR imaging in breast cancer, with histopathologic findings as reference standard. Methods This study included 150 patients with breast cancer. The patterns of SPIO uptake for positive sentinel nodes were classified into three; uniform high-signal intensity, partial high-signal intensity involving ≥50% of the node, and partial high-signal intensity involving 2 mm sentinel node metastases correlated with the area of high-signal intensity, however, a pathologic ≤2 mm sentinel node metastases did not. Conclusions High-signal intensity patterns that are uniform or involve ≥50% of the node are features of nodes with macro-metastases. The area of high-signal intensity correlated with the pathological size of metastases for nodes with metastases >2 mm in this series.
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