Search

Social interaction complexity makes humans unique. But in times of social deprivation this strength risks to expose important vulnerabilities. Human social neuroscience studies have placed a premium on the default network (DN). In contrast, hippocampus (HC) subfields have been intensely studied in rodents and monkeys. To bridge these two literatures, we here quantified how DN subregions systematically co-vary with specific HC subfields in the context of subjective social isolation (i.e., loneliness). By co-decomposition using structural brain scans of ∼40,000 UK Biobank participants, loneliness was specially linked to midline subregions in the uncovered DN patterns. These association cortex signatures coincided with concomitant HC patterns implicating especially CA1 and molecular layer. These patterns also showed a strong affiliation with the fornix white-matter tract and the nucleus accumbens. In addition, separable signatures of structural HC-DN co-variation had distinct associations with the genetic predisposition for loneliness at the population level.

Despite the well-known tradeoff between speed and accuracy, skilled people often demonstrate the ability to maintain high accuracy during fast movements. We focused on two strategies to improve accuracy, thereby increasing the reproducibility of individual parameters (certain parameters are maintained in low variability) and coordinating covariation among parameters (different parameters compensate each other's variability). The objective of this study was to determine whether coordinated covariation among release parameters is used for high accuracy by skilled baseball pitchers. A model was employed to simulate pitch location after eliminating the coordinated covariation by randomly reshuffling the release parameters, and the variability of simulated and measured pitch locations were compared. The results showed that there was no significant coordinated covariation for any of the release parameters for either the vertical or horizontal pitch location supports strategy of increasing the reproducibility of individual parameter. In addition, for the vertical pitch location, because there was coordinated covariation between the release angle and speed in slow pitching, it was suggested that, the higher speed the task requires, the more important the reproducibility of individual parameter becomes.

Objective There is limited knowledge about how fatigue develops and worsens and what influences fluctuations in daily fatigue. Stress was found to influence fatigue, and being in a relationship seems to either increase or decrease stress depending on the couple interaction. In this study, co-variation of fatigue, self-reported stress, and biological stress markers in couples’ everyday lives was investigated. Specifically, we examined a) whether momentary couple interactions moderated dyadic outcomes and b) whether and how stress and relationship measures influenced individual momentary fatigue. Methods Forty heterosexual couples (age: 28 ± 5 years) reported subjective fatigue and stress levels 4 times a day for 5 consecutive days (1600 measures). Furthermore, participants reported whether they had interacted with their partner since the last data entry and, if so, they rated the valence of this interaction. Salivary cortisol (a measure of HPA axis activity) and alpha amylase (a measure of ANS activity) were analyzed as biological stress markers from saliva samples obtained at the same time points. Moment-to-moment data were analyzed using dyadic multilevel models to account for the nested design. Results Stress (women and men: p ≤ 0.001) and fatigue (women: p = .003, men: p = .020) showed patterns of co-variation within couples, especially if partners had interacted with each other since the previous data entry. Cortisol was also found to co-vary between partners (women: unstandardized coefficient (UC) = 0.12, p ≤ .001, men: UC = 0.18, p ≤ .001), whereas the regulation of alpha-amylase levels depending on the partner’s levels was only present in women (UC = 0.11, p = .002). Valence of couple interaction was negatively associated with fatigue (women: UC = −0.13, p ≤ .001, men: UC = −0.06, p = .011). There was no momentary association of fatigue with an individual’s own or the partner’s subjective or biological stress markers. Conclusions Fatigue and stress levels during the day seem to co-vary within couples. These associations were particularly strong when the partners had interacted with each other since the last measurement. These data underline the importance of social factors in fatigue and stress in everyday life.

Following up on the encouraging results of residue‐residue contact prediction in the CASP11 experiment, we present the analysis of predictions submitted for CASP12. The submissions include predictions of 34 groups for 38 domains classified as free modeling targets which are not accessible to homology‐based modeling due to a lack of structural templates. CASP11 saw a rise of coevolution‐based methods outperforming other approaches. The improvement of these methods coupled to machine learning and sequence database growth are most likely the main driver for a significant improvement in average precision from 27% in CASP11 to 47% in CASP12. In more than half of the targets, especially those with many homologous sequences accessible, precisions above 90% were achieved with the best predictors reaching a precision of 100% in some cases. We furthermore tested the impact of using these contacts as restraints in ab initio modeling of 14 single‐domain free modeling targets using Rosetta. Adding contacts to the Rosetta calculations resulted in improvements of up to 26% in GDT_TS within the top five structures.

a b s t r a c t The present study examines possible relationships between changes in electroencephalogram (EEG) power and in working memory (WM) due to brain maturation. Scores on the phonological loop, visuospatial sketchpad and executive components of WM, measured by the Working Memory Test Battery for Children (WMTB-C), were correlated with the power spectral density (PSD) values on the spontaneous EEG from 1 to 46 Hz. In order to control for non-specific processes of visuomotor abilities, the reaction time (RT) variable was measured with an Oddball task. One hundred and sixty seven subjects (82 males and 85 females) between 6 and 26 years old participated in the study. Three minutes of spontaneous EEG were recorded. The WMTB-C and the Oddball task were also administered. The scores on each WM component increased and the RT in the Oddball decreased with age, while PSD values in the different frequencies decreased with age. Significant negative correlations between each of the components and the PSD were obtained. The maximal negative correlations were obtained in the theta (4–7 Hz) range. A bivariate linear model including theta PSD and RT explained most of the WM variance due to age. The results suggest that spontaneous EEG maturation is closely related to WM maturation, particularly in the theta range.

We are daily exposed to many different environmental contaminants. Mixtures of these contaminants could act together to induce more pronounced effects than the sum of the individual contaminants. To evaluate the effects of such mixtures, it is of importance to assess the co-variance amongst the contaminants. Thirty-seven environmental contaminants representing different classes were measured in blood samples from 1016 individuals aged 70 years. Hierarchical cluster analysis and principal component analysis were used to assess the co-variation among the contaminants. Within each identified cluster, possible marker contaminants were sought for. We validated our findings using data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 study. Two large clusters could be identified, one representing low/medium chlorinated polychlorinated biphenyls (PCBs) (≤6 chlorine atoms), as well as two pesticides and one representing medium/high chlorinated PCBs (≥6 chlorine atoms). PCBs 118 and 153 could be used as markers for the low/medium chlorinated cluster and PCBs 170 and 209 could be used as markers for the medium/high chlorinated cluster. This pattern was similar to data from the NHANES study. Apart from the PCBs, little co-variation was seen among the contaminants. Thus, a large number of chemicals have to be measured to adequately identify mixtures of environmental contaminants.

Visual strain and discomfort may contribute to the generation of work-related musculoskeletal disorders among e.g. computer workers. A positive correlation on a group level between eye-lens accommodation and trapezius muscle activity has been reported. In this study we investigated the possibility of a direct, fast, connection between lens accommodation and trapezius muscles activity. The subjects focused alternately on Near and Far targets, with a mean switch time of 5 s, through four different lenses. The cross-correlation, R(tau) was computed, between the time signals of accommodation and electromyography (EMG) from 23 subjects. In the overall mean R(tau) of 736 curves, a small but significant correlation peak (0.019) with a delay (of the EMG signal) of about 0.3 s, revealed a small common component in the two signals. Among the lenses, the positive lens (3.5 D), showed the highest correlation peak (0.040). The correlation may be caused by a direct "hard-wired" connection between the ciliary and trapezius muscles. But it could also be caused indirectly by the subject's need for a more stable head in a more demanding visual task. The latter is supported by the result that the correlation was the highest in the positive lens condition. The present correlation is however weak and it has probably a low practical importance.

Rumination is a maladaptive form of emotion regulation and seems to be the cognitive mechanism linking stress to depressive symptoms. However, it remains to be investigated whether individuals' variation in rumination in relation to the occurrence of stressful events (e.g., phasic co-variation between stressful events and rumination) prospectively predict the experience of depressive symptoms in lengthy follow-up moments. In this eighteen months prospective design, a large unselected sample of undergraduates was tested before, during, and after a period with prominent naturally occurring stressful events. The multilevel results show that the co-variation of stressful events and ruminative thinking predicts the experience of depressive symptoms at 3 and 15 months follow up moments, also when statistically controlling for baseline depressive symptoms. Moreover, the data demonstrate that the phasic elevations of rumination in relation to the occurrence of stressful events are more predictive of depressive symptoms compared with the stable aspects of rumination measured at one occasion. At the clinical level, the current findings seem to suggest a process-oriented intervention to target the phasic ruminative cognitions where individuals need to learn to control rumination exactly at moments of stress. (C) 2016 Elsevier Ltd. All rights reserved.

The effect of the brain on the morphology of the face has long been recognized in both evolutionary biology and clinical medicine. In this work, we describe factors that are active between the development of the brain and face and how these might impact craniofacial variation. First, there is the physical influence of the brain, which contributes to overall growth and morphology of the face through direct structural interactions. Second, there is the molecular influence of the brain, which signals to facial tissues to establish signaling centers that regulate patterned growth. Importantly, subtle alterations to these physical or molecular interactions may contribute to both normal and abnormal variation. These interactions are therefore critical to our understanding of how a diversity of facial morphologies can be generated both within species and across evolutionary time.

Using masking techniques combined with electrophysiological recordings is a promising way to study neural correlates of visual awareness, as shown in recent studies. Here I comment on the following puzzling aspects typical for this endeavour that have made obstacles for a potentially even more impressive progress. First, the continuing practice of confounds between objective stimulus variables and subjective dependent measures. Second, complexity of timing the emergence of subjective conscious percept which is partly due to complex interactivity between target and mask. Third, the ambiguity of the concept of neural correlates of awareness.

Recent investigations on the passive immunization have proved that neutralizing antibodies directed to the membrane-proximal region of HIV-1 gp41 are potent anti-viral components, so this region is thought to be an attractive target for AIDS vaccine. Three key neutralizing epitopes, ELDKWA (aa662-667), NWFDIT (aa671-676) and ERDRDR (aa739-744) have been mapped in this region. In this study, their genetic variability and co-variation was evaluated. There exists marked shift in the predominant sequence patterns on these three neutralizing epitopes over time. Compared with subtype B, non-B clades exhibit significant genetic variability and co-variation on these three epitopes. Among HIV-1 strains isolated in recent 5 years, about one third displays epitope variants simultaneously on three epitopes. The newly isolated strains with co-variations on several neutralizing epitopes ought to be of strict surveillance in clinical treatment, and those frequent epitope variants should also be considered in vaccine design.

The contribution of the tRNA “core” to aminoacylation is beginning to be recognized. One example is the core region of Escherichia coli tRNA Cys , which has been shown by biochemical studies to be important for aminoacylation. This core has several layers of unusual base-pairs, which are revealed by the recent crystal structure of the tRNA complexed with the elongation factor EF-Tu and an analog of GTP. One of these layers consists of a 9:[13:22] base-triple, rather than the 46:[13:22] or 45:[13:22] base-triple that is commonly observed in tRNA structure. Because 13:22 is an important element in aminoacylation of E. coli tRNA Cys , a better understanding of its structure in the tRNA core will shed light on its role in aminoacylation. In this study, we used the phage T7 transcript of the tRNA as a substrate. We probed the structure of 13:22 by dimethyl sulfate and tested its partner in a base-triple by generating mutations that could be assayed for aminoacylation. The results of this study in general are in a better agreement with a 46:[13:22] base-triple that we previously proposed. Although these results are not interpreted as direct proof for the 46:[13:22] base-triple, they shed new light on features of the tRNA core that are important for aminoacylation.

This paper demonstrates a method for determination of co-variation between some inorganic elements in the bulk and surface areas of human tooth enamel. The technique is based on a computerised induction analysis of data obtained by secondary ion mass spectrometry (SIMS). When comparing the present data with an earlier study from our laboratory, it became evident that with only a moderate increase in the amount of data for the induction analysis, the results increased very considerably in reliability and precision. The patterns of co-variation between different elements differed between the bulk- and surface enamel. Only Mg expressed a similar pattern. In the bulk enamel the elements Na and P expressed a high degree of co-variation. Similarly, Mg and C expressed a high degree of co-variation. Mg was an element often found to co-vary with bulk enamel elements. In the enamel surface, F and Cl co-varied. In addition, Cl was an element often found to co-vary with other enamel surface elements.

Computerized ecological momentary assessment (EMA) is widely accepted as a “gold standard” method for capturing momentary symptoms repeatedly experienced in daily life. Although many studies have addressed the within-individual temporal variations in momentary symptoms compared with simultaneously measured external criteria, their concurrent associations, specifically with continuous physiological measures, have not been rigorously examined. Therefore, in the present study, we first examined the variations in momentary symptoms by validating the associations among self-reported symptoms measured simultaneously (depressive mood, anxious mood, and fatigue) and then investigated covariant properties between the symptoms (especially, depressive mood) and local statistics of locomotor activity as the external objective criteria obtained continuously. Healthy subjects (N = 85) from three different populations (adolescents, undergraduates, and office workers) wore a watch-type computer device equipped with EMA software for recording the momentary symptoms experienced by the subjects. Locomotor activity data were also continuously obtained by using an actigraph built into the device. Multilevel modeling analysis confirmed convergent associations by showing positive correlations among momentary symptoms. The increased intermittency of locomotor activity, characterized by a combination of reduced activity with occasional bursts, appeared concurrently with the worsening of depressive mood. Further, this association remained statistically unchanged across groups regardless of group differences in age, lifestyle, and occupation. These results indicate that the temporal variations in the momentary symptoms are not random but reflect the underlying changes in psychophysiological variables in daily life. In addition, our findings on the concurrent changes in depressive mood and locomotor activity may contribute to the continuous estimation of changes in depressive mood and early detection of depressive disorders.

We evaluated the effects of socioeconomic status on the prevalence of current smoking, number of cigarettes smoked per day and pack-years, and the extent to which prevalence and consumption co-vary across communities, health regions, and provinces in Canada between 2001 and 2010. Current smoking, cigarettes per day, and pack-years were considered as outcomes within individuals using a multilevel analytical framework. Markers of SES were education, income, and occupation. Residual covariance estimated at the different levels of geography was used to determine if areas high in current smoking were also high on levels of consumption. A strong inverse gradient was found between education and current smoking and level of consumption with large variation found in levels of consumption between individual smokers. The co-variation between current smoking and level of consumption was positive and statistically significant at the level of communities and health regions. Our findings suggest that novel policy efforts may be needed to encourage smoking prevention/cessation among certain population groups and in places with high levels of smoking prevalence and tobacco use intensity.

The association between alanine aminotransferase (ALAT) and body mass, sex and age was examined in 6036 consecutively tested blood donors. ALAT, age and body mass were higher in male donors than in female donros. The non-normal ALAT distribution curve normalized after 1n transformation, which made statistical analysis of the data more feasible. Multiple regression analysis demonstrated that ALAT was influenced by sex and relative weight, in that order, and very poorly by age. It is concluded that obesity is a major cause of raised ALAT in this predominantly healthy donor population.

Background and Purpose. The aim of the present study was to analyse the co-variation of different tests commonly used in stroke rehabilitation, and specifi cally used in a recent randomized, controlled study of two different physiotherapy models in stroke rehabilitation. Method. Correlations of the performed tests and recordings from previous work were studied. The test results from three-month, one-year and four-year follow-up were analysed in an SPSS Version 11 statistical package with Pearson and Spearman corr elations. Results. There was an expected high correlation between the motor function tests, both based on partial and total scores. The correlations between Nottingham Health Profi le Part 1 and Motor Assessment Scale (MAS), Sodring Motor Eevaluation Scale (SMES), the Berg Balance Scale (BBS) and Barthel Activities of Daily Living (ADL) index were low for all items except physical condition. The correlations between registered living conditions, assistive devices, recurrent stroke, motor function (MAS, SMES), ADL (Barthel ADL index) and balance (BBS) were high. The same variables showed weak or poor cor- relation to the Nottingham Health Profi le (NHP). Conclusions. The co-variations of motor function tests and functional tests were high, but the co-variations of motor, functional and self-reported life-quality tests were poor. The patients rated themselves on a higher functio- nal level in the self-reported tests than was observed objectively in the performance-based tests. A possible reason for this is that the patients may have been unaware they modifi ed their performance to adjust for physical decline, and consequently overestimate their phy- sical condition. This result underlines the importance of both performance-based and self- reported tests as complementary tools in a rehabilitation process. Copyright © 2006 John Wiley & Sons, Ltd.

Near work is associated with increased activity in the neck and shoulder muscles, but the underlying mechanism is still unknown. This study was designed to determine whether a dynamic change in focus, alternating between a nearby and a more distant visual target, produces a direct parallel change in trapezius muscle activity. Fourteen healthy controls and 12 patients with a history of visual and neck/shoulder symptoms performed a Near-Far visual task under three different viewing conditions; one neutral condition with no trial lenses, one condition with negative trial lenses to create increased accommodation, and one condition with positive trial lenses to create decreased accommodation. Eye lens accommodation and trapezius muscle activity were continuously recorded. The trapezius muscle activity was significantly higher during Near than during Far focusing periods for both groups within the neutral viewing condition, and there was a significant co-variation in time between accommodation and trapezius muscle activity within the neutral and positive viewing conditions for the control group. In conclusion, these results reveal a connection between Near focusing and increased muscle activity during dynamic changes in focus between a nearby and a far target. A direct link, from the accommodation/vergence system to the trapezius muscles cannot be ruled out, but the connection may also be explained by an increased need for eye-neck (head) stabilization when focusing on a nearby target as compared to a more distant target.

Whereas the use of discrete pitch intervals is characteristic of most musical traditions, the size of the intervals and the way in which they are used is culturally specific. Here we examine the hypothesis that these differences arise because of a link between the tonal characteristics of a culture's music and its speech. We tested this idea by comparing pitch intervals in the traditional music of three tone language cultures (Chinese, Thai and Vietnamese) and three non-tone language cultures (American, French and German) with pitch intervals between voiced speech segments. Changes in pitch direction occur more frequently and pitch intervals are larger in the music of tone compared to non-tone language cultures. More frequent changes in pitch direction and larger pitch intervals are also apparent in the speech of tone compared to non-tone language cultures. These observations suggest that the different tonal preferences apparent in music across cultures are closely related to the differences in the tonal characteristics of voiced speech.