Search

5-Fluorouracil (5-FU) is a common chemotherapy drug for patients with advanced colorectal cancer; however, many patients develop resistance to 5-FU and suffer from treatment failure. Discoidin domain receptor 1 (DDR1) is upregulated in multiple cancers and positively associated with chemoresistance. We explored the effect of DDR1a on the cytotoxicity induced by 5-FU in LoVo cells and the underlying mechanism. Therefore, DDR1a overexpression (DDR1a

To establish a prognostic nomogram based on response to bortezomib and BTK expression for treatment-experienced multiple myeloma patients.The Oncomine database was utilized to determine BTK expression, sex, age, albumin, Mayo index, response to bortezomib treatment, follow-up time and survival status in multiple myeloma(MM) patients. Cut-off point for BTK expression was calculated using R software. Univariate and multivariate analyses by Cox proportional hazards regression were then performed. Significant prognostic factors were combined to build a nomogram. The discrimination ability and predictive accuracy of the nomogram were evaluated using the index of concordance (C-index) and calibration curves.Multivariate analysis showed that response to bortezomib, BTK expression and sex were independent risk factors for prognosis. The C-index value of the nomogram made according to the independent risk factors was 0.729 (95%CI, 0.642-0.8164). The calibration curves showed good consistency between predicted and actual survivals for 1-year and 2-year overall survival.The proposed nomogram is accurate in predicting the prognosis of patients with MM.基于硼替佐米治疗反应及BTK表达水平建立非初治多发性骨髓瘤临床预测模型.基于硼替佐米治疗反应及骨髓瘤细胞BTK表达水平建立非初治多发性骨髓瘤（MM）临床预测模型的列线图（nomogram）。.运用Oncomine数据库搜索BTK基因表达水平、性别、年龄、白蛋白水平、Mayo评分、硼替佐米治疗反应、随访时间及生存状态等信息，计算影响MM临床预后的BTK表达水平截断值（cut-off值），对上述因素进行Cox多因素回归分析，并根据独立预后因素制作列线图，用一致性指数（C-index）和校正曲线确定列线图的预测精度和判别能力。.多因素分析结果显示，影响患者预后的因素有硼替佐米治疗反应、BTK表达水平及性别，根据上述指标制作的列线图一致性指数为0.729（95%CI，0.642-0.8164），患者1年及2年的生存率的校正曲线与实际观测结果吻合较好。.基于BTK表达水平及硼替佐米治疗反应的列线图能准确地预测MM患者的预后。.

Supplemental Digital Content is available in the text

Helicobacter pylori (Hp),a proven pathogen of digestive disease,is closely associated with gastrointestinal diseases including peptic ulcer,chronic active gastritis,stomach cancer,and stomach-associated lymphoid tissue lymphoma. Thus,precise and timely diagnosis of Hp is of great significance. In addition to

To detect the changes of expression of PTEN protein and AKT protein in patients with Ulcerative Colitis (UC) in the pathway from inflammation to carcinoma.A total of 110 paraffin colorectal sections were examined, which included 65 cases with UC, 25 cases with colorectal cancer and 25 cases with normal tissues. The expression of PTEN protein and AKT protein was detected with immunohistochemistry.(1) The patients with UC had lower expression of PTEN protein and higher expression of AKT than those with normal tissues (P0.01). (2) The patients with UC had higher expression of PTEN protein and lower expression of AKT protein than those with colorectal cancer (P0.01). (3) With the progress of UC, the expression of PTEN protein decreased while the expression of AKT protein increased (P0.01). (4) The expression of PTEN protein was negatively correlated with the expression with AKT protein in patients with UC and colorectal cancer (r = -0. 542 and -0. 674, respectively P0.01).The change of expressions of PTEN protein and AKT protein might play an important role in the development of UC and colorectal cancer. Decreased PTEN protein and increased AKT protein might be a marker for the early detection of the occurrence of colorectal cancer in patients with UC.