1. Clinical Value of Pepsinogen in the Screening, Prevention, and Diagnosis of Gastric Cancer
- Author
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Dong-Yu Liang, Yun-Feng Wang, Xiao-Lei Han, Chang-Lin Yi, Hui-Jian Yang, Jin-Dan Ma, La-Mei Wu, Yanhong He, and Jin-Fang Shi
- Subjects
Gastritis, Atrophic ,medicine.medical_specialty ,Receiver operating characteristic ,biology ,Atrophic gastritis ,business.industry ,Biochemistry (medical) ,Clinical Biochemistry ,Area under the curve ,Cancer ,medicine.disease ,Gastroenterology ,Confidence interval ,Pepsin ,Stomach Neoplasms ,Pepsinogen A ,Internal medicine ,medicine ,biology.protein ,Humans ,Mass Screening ,Histopathology ,Stage (cooking) ,business ,Early Detection of Cancer - Abstract
Objectives To compare the levels of serum pepsinogen (PG) in patients with gastric cancer (GC), patients with atrophic gastritis (AG), and healthy donors. Also, we explored the clinical value of PG detection for the diagnosis and treatment of GC. Methods The PG level in peripheral blood from patients and heathy donors was determined using an Abbott automatic chemiluminescence instrument. The study included 117 patients with GC confirmed by gastroscopy and histopathology, of whom 13 patients had cancer at stage I, 47 at stage II, 41 at stage III, and 16 at stage IV. The AG group included 122 patients, and the control group had 120 healthy donors. The relationship between serum PG levels and the occurrence and development of GC, as well as the evaluation of the clinical value of diagnostic tests based on serum PG detection, were investigated by receiver operating characteristic (ROC) curve analyses. Results Pepsinogen I (PGI) levels gradually decreased from the control group, the AG group, and the GC group. PGI exhibited high diagnostic value for GC (area under the curve [AUC], 0.834; cutoff, 51.2 ng/mL, sensitivity, 81.7%; specificity, 68.4%), PGII (AUC, 0.587; cutoff value, 13.05 ng/mL; sensitivity, 65.8%; specificity, 53.8%), and PGR (AUC, 0.752; cutoff, 5.65; sensitivity, 54.2%; specificity, 87.2%). The occurrence of GC was negatively correlated with serum levels of PGI (B = −0.054; OR = 0.947; 95% confidence interval [CI], 0.925–0.970; P Conclusions The combined detection of PGI, PGII, and PGR has important clinical value for the screening, prevention, and diagnosis of GC and could allow for earlier detection, diagnosis, and treatment of GC.
- Published
- 2021