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2 results on '"Edward McKone"'

1. COVID-19 vaccine prioritisation for people with cystic fibrosis

Author

Satenik Harutyunyan, Marco Salvatore, Rasa Ruseckaite, Elena Zhekayte, Keith G. Brownlee, Albert Faro, Luiz Vicente Ribeiro Ferreira da Silva Filho, Catherine A. Byrnes, Samar Rizvi, Siobhán B. Carr, Elena Kondratyeva, Andeas Jung, Harriet Corvol, Pierre Régis Burgel, Pedro Mondejar-Lopez, Bruce C. Marshall, Olzhas Abdrakhmanov, Géraldine Daneau, Peter G. Middleton, Susannah Ahern, Nataliya Kashirskaya, Lutz Nährlich, Alexander Elbert, Marco Zampoli, Vincent Gulmans, Elliot McClenaghan, Isabelle de Monestrol, M. Dolores Pastor-Vivero, R. Padoan, Hector Gutierrez, Joel Melo, Carla Colombo, Stephanie Y. Cheng, Christopher H. Goss, Anne L. Stephenson, Elena Amelina, Edward McKone, and Rebecca Cosgriff

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), Cystic Fibrosis, business.industry, Health Priorities, Health Policy, Patient Selection, COVID-19, medicine.disease, Cystic fibrosis, Coronavirus, Pediatrics, Perinatology and Child Health, medicine, Humans, Intensive care medicine, business, Letter to the Editor, Vaccine, COVID
Published
2021

2. Amikacin liposome inhalation suspension for chronic Pseudomonas aeruginosa infection in cystic fibrosis

Author

Diana Bilton, Tacjana Pressler, Isabelle Fajac, John Paul Clancy, Dorota Sands, Predrag Minic, Marco Cipolli, Ivanka Galeva, Amparo Solé, Alexandra L. Quittner, Keith Liu, John P. McGinnis, Gina Eagle, Renu Gupta, Michael W. Konstan, Sabine Renner, Christiane Knoop, Anne Malfroot, Lieven Dupont, Kristine Desager, Frans De Baets, Miroslava Bosheva, Vania Nedkova, Ivan Galabov, Andreas Freitag, Nancy Morrison, Pearce Wilcox, Tanja Pressler, Yves Martinet, Raphael Chiron, Stephan Dominique, Philippe Reix, Anne Prevotat, Isabelle Sermet, Isabelle Durieu, Rainald Fischer, Rudolf Huber, Doris Staab, Uwe Mellies, Wolfgang Sextro, Tobias Welte, Heinrike Wilkens, Urte Sommerwerk, Burkhard Bewig, Ilias Inglezos, Stavros-Eleftherios Doudounakis, Olga Bede, Ferenc Gönczi, Rita Újhelyi, Edward McKone, Paul McNally, Vincenzina Lucidi, Mario La Rosa, Laura Minicucci, Rita Padoan, Giovanna Pisi, Rolando Gagliardini, Carla Colombo, Inez Bronsveld, Ewa Sapiejka, Henryk Mazurek, Grażyna Górnicka, Iwona Stelmach, Halina Batura-Gabryel, Marta Rachel, Jaroslava Orosova, Branko Takac, Anna Feketova, Carmen Martinez, Gloria Garcia Hernandez, Jose Ramon Villa-Asensi, Silvia Gartner, Amparo Sole, Anders Lindblad, Martin Ledson, Joanna Whitehouse, Alan Smyth, Ian Ketchell, Timothy Lee, and Gordon MacGregor

Subjects
0301 basic medicine, Male, Cystic Fibrosis, Gastroenterology, Cystic fibrosis, 0302 clinical medicine, Surveys and Questionnaires, Tobramycin, education.field_of_study, Inhalation, Symptom Flare Up, 3. Good health, Anti-Bacterial Agents, Respiratory Function Tests, Hospitalization, medicine.anatomical_structure, Treatment Outcome, Amikacin, Pseudomonas aeruginosa, Female, medicine.symptom, Symptom Assessment, medicine.drug, Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, Population, Article, 03 medical and health sciences, Internal medicine, Administration, Inhalation, medicine, Humans, Pseudomonas Infections, education, Adverse effect, Lung, Dose-Response Relationship, Drug, business.industry, Sputum, medicine.disease, respiratory tract diseases, 030104 developmental biology, 030228 respiratory system, Pediatrics, Perinatology and Child Health, Liposomes, business
Abstract

Background Shortcomings of inhaled antibiotic treatments for Pseudomonas aeruginosa infection in patients with cystic fibrosis (CF) include poor drug penetration, inactivation by sputum, poor efficiency due to protective biofilm, and short residence in the lung. Methods Eligible patients with forced expiratory volume in 1 s (FEV1) ≥25% of predicted value at screening and CF with chronic P. aeruginosa infection were randomly assigned to receive 3 treatment cycles (28 days on, 28 days off) of amikacin liposome inhalation suspension (ALIS, 590 mg QD) or tobramycin inhalation solution (TIS, 300 mg BID). The primary endpoint was noninferiority of ALIS vs TIS in change from baseline to day 168 in FEV1 (per-protocol population). Secondary endpoints included change in respiratory symptoms by Cystic Fibrosis Questionnaire-Revised (CFQ-R). Results The study was conducted February 2012 to September 2013. ALIS was noninferior to TIS (95% CI, −4.95 to 2.34) for relative change in FEV1 (L) from baseline. The mean increases in CFQ-R score from baseline on the Respiratory Symptoms scale suggested clinically meaningful improvement in both arms at the end of treatment in cycle 1 and in the ALIS arm at the end of treatment in cycles 2 and 3; however, the changes were not statistically significant between the 2 treatment arms. Treatment-emergent adverse events (TEAEs) were reported in most patients (ALIS, 84.5%; TIS, 78.8%). Serious TEAEs occurred in 17.6% and 19.9% of patients, respectively; most were hospitalisations for infective pulmonary exacerbation of CF. Conclusions Cyclical dosing of once-daily ALIS was noninferior to cyclical twice-daily TIS in improving lung function. ClinicalTrials.gov Identifier: NCT01315678

Published
2019

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