1. Effects of propofol and sevoflurane on T-cell immune function and Th cell differentiation in children with SMPP undergoing fibreoptic bronchoscopy
- Author
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Hui, Yu, Lin, Chen, Cheng-Jin, Yue, Heng, Xu, Jing, Cheng, Elyse M, Cornett, Alan D, Kaye, Ivan, Urits, Omar, Viswanath, and Henry, Liu
- Subjects
Remifentanil ,Methyl Ethers ,Sevoflurane ,T-Lymphocytes ,Bronchoscopy ,Immunity ,Humans ,Cell Differentiation ,General Medicine ,Child ,Propofol - Abstract
The potentially different effects of commonly used anaesthetic agents propofol and sevoflurane on T-cell immune function and Th cell differentiation were investigated in patients with severe mycoplasmal pneumonia (SMPP) undergoing fibreoptic bronchoscopy.Sixty children (2-12 years of age) with SMPP were randomized into the sevoflurane group and the propofol group. Patients in the sevoflurane group were anaesthetised with inhalational sevoflurane and intravenous remifentanil. Patients in the propofol group were anaesthetised with intravenous propofol and remifentanil. Patients in both groups underwent fibreoptic bronchoscopy and lavage therapy. We compared the clinical outcomes, cellular immunity function, and Th cell differentiation into Th1 and Th2 levels in both groups.There was no significant difference in clinical outcomes and hospital stay between the two groups (7.94 vs 7.36,Propofol might have a less inhibitory effect on T lymphocytes in children with SMPP than sevoflurane. And propofol may have less impact on the differentiation of Th cells into Th
- Published
- 2022
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