1. Exploring targets and signaling pathways of paeonol involved in relieving inflammation based on modern technology
- Author
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Jian-Hong Qi, Fang-Xu Dong, and Xiao-Long Wang
- Subjects
Target ,Technology ,Anti-Inflammatory Agents ,Inflammation ,Paeonol ,Computational biology ,Catalysis ,Inorganic Chemistry ,chemistry.chemical_compound ,Network pharmacology ,Drug Discovery ,Medicine ,Humans ,Physical and Theoretical Chemistry ,Molecular Biology ,business.industry ,Mechanism (biology) ,Organic Chemistry ,Acetophenones ,Biological activity ,General Medicine ,Moutan cortex ,Molecular Docking Simulation ,chemistry ,Molecular docking ,Original Article ,medicine.symptom ,Signal transduction ,business ,DrugBank ,Information Systems ,Drugs, Chinese Herbal ,Signal Transduction - Abstract
Graphic abstract Paeonol, derived from natural plants (Moutan Cortex), has a wide range of biological effects, including anti-inflammatory and antitumor effects as well as favorable effects against cardiovascular and neurodegenerative diseases. The anti-inflammatory action is the main pharmacological activity of paeonol and has the greatest clinical relevance. However, the anti-inflammatory mechanism of paeonol has not been reported in sufficient detail. We systematically analyzed the anti-inflammatory mechanism of paeonol using network pharmacological databases and platforms, including TCMSP, Swiss TargetPrediction, OMIM, DrugBank, TTD, Jevnn, STRING11.0, and Metascape. Furthermore, we used high-throughput molecular docking method to prove the results of the above analyses, providing a reference for exploring the mechanism of paeonol and developing targeted drugs.
- Published
- 2021