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3 results on '"Francisco de Avila"'

1. Developmental pathways inferred from modularity, morphological integration and fuctuating asymmetry patterns in the human face

Author

Virginia Ramallo, Andres Ruiz-Linares, Williams Arias, Francisco Rothhammer, Rolando González-José, Javier Rosique, Carolina Paschetta, Paola Everardo, Victor Acuña-Alonzo, Soledad de Azevedo, Jorge Gómez-Valdés, Samuel Canizales-Quinteros, Mirsha Quinto-Sánchez, Francesc Muñoz-Muñoz, Francisco de Avila, G. Poletti, Pablo E. Navarro, Claudia Jaramillo, Caio Cesar Silva de Cerqueira, Celia Cintas, Kaustubh Adhikari, Macarena Fuentes-Guajardo, Gabriel Bedoya, Maria Cátira Bortolini, Carla Gallo, Tábita Hünemeier, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Dept of Genetics, Evolution and Environment [London] (UCL-GEE), University College of London [London] (UCL), State Key Laboratory of Genetics Engineering & MOE Key Laboratory of Contemporary Anthropology, Fudan University [Shanghai]-School of Life Sciences, Molecular Genetics Laboratory, Escuela Nacional de Antropologia y Historia, Departamento de Genética, Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS)-Instituto de Biociencias, Laboratorio de Genética Molecular, Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Unit of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Facultad de Medicina & Instituto de Alta Investigacion, Universidad de Tarapaca-Universidade de Chile, and Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)

Subjects
Male, 0301 basic medicine, Developmental noise, [SDV]Life Sciences [q-bio], Biological anthropology, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, lcsh:Medicine, Genome-wide association study, Evolutionary biology, Fluctuating asymmetry, HUMAN FACE, purl.org/becyt/ford/1 [https], 0302 clinical medicine, FLUCTUATING ASYMMETRY, lcsh:Science, Maxillofacial Development, purl.org/pe-repo/ocde/ford#1.06.15 [https], ComputingMilieux_MISCELLANEOUS, Multidisciplinary, Middle Aged, Phenotype, Female, CIENCIAS NATURALES Y EXACTAS, GEOMETRIC MORPHOMETRIC, Adult, Rostro humano, Adolescent, Otras Ciencias Biológicas, Biology, GENOMAS, Article, Ciencias Biológicas, Young Adult, 03 medical and health sciences, Humans, Set (psychology), purl.org/becyt/ford/1.6 [https], Modularity (networks), Modularidad, lcsh:R, Quantitative genetics, Antropología biológica, Genetic architecture, LATIN AMERICANS, Latin America, 030104 developmental biology, Face, Evolutionary developmental biology, lcsh:Q, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Facial asymmetries are usually measured and interpreted as proxies to developmental noise. However, analyses focused on its developmental and genetic architecture are scarce. To advance on this topic, studies based on a comprehensive and simultaneous analysis of modularity, morphological integration and facial asymmetries including both phenotypic and genomic information are needed. Here we explore several modularity hypotheses on a sample of Latin American mestizos, in order to test if modularity and integration patterns differ across several genomic ancestry backgrounds. To do so, 4104 individuals were analyzed using 3D photogrammetry reconstructions and a set of 34 facial landmarks placed on each individual. We found a pattern of modularity and integration that is conserved across sub-samples differing in their genomic ancestry background. Specifically, a signal of modularity based on functional demands and organization of the face is regularly observed across the whole sample. Our results shed more light on previous evidence obtained from Genome Wide Association Studies performed on the same samples, indicating the action of different genomic regions contributing to the expression of the nose and mouth facial phenotypes. Our results also indicate that large samples including phenotypic and genomic metadata enable a better understanding of the developmental and genetic architecture of craniofacial phenotypes. Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Muñoz-Muñoz, Francesc. Universidad Nacional Autónoma de México; México Fil: Gomez-Valdes, Jorge. Universitat Autònoma de Barcelona; España Fil: Cintas, Celia. Instituto Nacional de Antropologia E Historia, Mexico; México Fil: Navarro, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Cerqueira, Caio Cesar Silva De. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Paschetta, Carolina Andrea. Equipe de Perícias Criminalísticas de Ourinhos; Fil: de Azevedo, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Acuña-Alonzo, Victor. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Adhikari, Kaustubh. Colegio Universitario de Londres; Reino Unido Fil: Fuentes-Guajardo, MacArena. Instituto Nacional de Antropologia E Historia, Mexico; México Fil: Hünemeier, Tábita. Colegio Universitario de Londres; Reino Unido Fil: Everardo, Paola. Universidad de Tarapaca de Arica; Chile Fil: De Avila, Francisco. Colegio Universitario de Londres; Reino Unido Fil: Jaramillo, Claudia. Universidade de Sao Paulo; Brasil Fil: Arias, Williams. Instituto Nacional de Antropologia E Historia, Mexico; México Fil: Gallo, Carla. Universidad Nacional Autónoma de México; México Fil: Poletti, Giovani. Instituto Nacional de Antropologia E Historia, Mexico; México Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia Fil: Bortolini, Maria Catira. Universidad de Antioquia; Colombia Fil: Canizales-Quinteros, Samuel. Universidad Peruana Cayetano Heredia; Perú Fil: Rothhammer, Francisco. Universidad Peruana Cayetano Heredia; Perú Fil: Rosique, Javier. Universidad de Antioquia; Colombia Fil: Ruiz-Linares, Andres. Universidade Federal do Rio Grande do Sul; Brasil Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina

Published
2018
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2. Socioeconomic Status Is Not Related with Facial Fluctuating Asymmetry: Evidence from Latin-American Populations

Author

Samuel Canizales-Quinteros, Virginia Ramallo, Victor Acuña-Alonzo, Tábita Hünemeier, Mirsha Quinto-Sánchez, Lucía Daniela Castillo, Francisco de Avila, Javier Rosique, Rolando González-José, Andres Ruiz-Linares, Celia Cintas, Williams Arias, Lavinia Schuler-Faccini, Caio Cesar Silva de Cerqueira, Paola Everardo, Gabriel Bedoya, Macarena Fuentes, Francisco Rothhammer, Kaustubh Adhikari, Claudia Jaramillo, G. Poletti, Maria Cátira Bortolini, Carla Gallo, Jorge Gómez-Valdés, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), and Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, 0301 basic medicine, Male, Heredity, Fisonomía, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, lcsh:Medicine, Social Sciences, medicine.disease_cause, 01 natural sciences, Fluctuating asymmetry, Geographical locations, América Latina - Aspectos socioecónomicos, purl.org/becyt/ford/1 [https], Mathematical and Statistical Techniques, Sociology, América Latina, Medicine and Health Sciences, Ethnicities, Public and Occupational Health, lcsh:Science, ComputingMilieux_MISCELLANEOUS, Heterocigosidad, Multidisciplinary, Heterozygosity, Assimetria flutuante facial, 1. No poverty, Facial Asymmetry/epidemiology/genetics, Middle Aged, Population groupings, Socioeconomic Aspects of Health, Latin Americans, Phenotypes, Classe social, vocabularies.unesco.org/thesaurus/concept6181 [http], Physical Sciences, Female, Analysis of variance, Condición social, Psychology, CIENCIAS NATURALES Y EXACTAS, Statistics (Mathematics), Facial symmetry, Research Article, Adult, Herencia, Heterozygote, Adolescent, Genetic genealogy, Otras Ciencias Biológicas, Hispanic Americans/genetics, facial asymmetries, Social class, Research and Analysis Methods, 010603 evolutionary biology, socioeconomic status, Ciencias Biológicas, 03 medical and health sciences, Young Adult, purl.org/pe-repo/ocde/ford#5.04.00 [https], medicine, Genetics, Humans, Adults, Social Stratification, Statistical Methods, Pobreza, purl.org/becyt/ford/1.6 [https], América Latina - Población, Socioeconomic status, Latin America - Population, Analysis of Variance, Chile (Country), purl.org/pe-repo/ocde/ford#3.03.12 [https], lcsh:R, Physiognomy, Biology and Life Sciences, Genética de populações, facial fluctuating asymmetry, South America, Social stratification, Social status, Health Care, 030104 developmental biology, Social Class, Facial Asymmetry, Age Groups, People and Places, lcsh:Q, Latin-American populations, Asimetría Facial, Mathematics, Demography
Abstract

The expression of facial asymmetries has been recurrently related with poverty and/or disadvantaged socioeconomic status. Departing from the developmental instability theory, previous approaches attempted to test the statistical relationship between the stress experienced by individuals grown in poor conditions and an increase in facial and corporal asymmetry.Here we aim to further evaluate such hypothesis on a large sample of admixed Latin Americans individuals by exploring if low socioeconomic status individuals tend to exhibit greater facial fluctuating asymmetry values. To do so, we implement Procrustes analysis of variance and Hierarchical Linear Modelling (HLM) to estimate potential associationsbetween facial fluctuating asymmetry values and socioeconomic status. We report significant relationships between facial fluctuating asymmetry values and age, sex, and genetic ancestry, while socioeconomic status failed to exhibit any strong statistical relationship with facial asymmetry. These results are persistent after the effect of heterozygosity (a proxy for genetic ancestry) is controlled in the model. Our results indicate that, at least on the studied sample, there is no relationship between socioeconomic stress (as intended as low socioeconomicstatus) and facial asymmetries. Fil: Quinto Sanchez, Mirsha Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina. Universidad Nacional Autónoma de México; México Fil: Cintas, Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Silva de Cerqueira, Caio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina. Universidad Nacional Autónoma de México; México. Superintendência da Polícia Técnico-Científica do Estado de São Paulo; Brasil Fil: Ramallo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Acuña Alonzo, Victor. University College London; Estados Unidos. Instituto Nacional de Antropología E Historia; México Fil: Adhikari, Kaustubh. University College London; Estados Unidos Fil: Castillo, Lucía Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Gomez Valdés, Jorge. Escuela Nacional de Antropología e Historia; México Fil: Everardo, Paola. Instituto Nacional de Antropología E Historia; México Fil: De Avila, Francisco. Instituto Nacional de Antropología E Historia; México Fil: Hünemeier, Tábita. Universidade de Sao Paulo; Brasil Fil: Jaramillo, Claudia. Universidad de Antioquia; Colombia Fil: Arias, Williams. Universidad de Antioquia; Colombia Fil: Fuentes, Macarena. University College London; Estados Unidos. Universidad de Tarapacá; Chile Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Poletti, Giovani. Universidad Peruana Cayetano Heredia; Perú Fil: Schuler Faccini, Lavinia. Universidade Federal do Rio Grande do Sul; Brasil Fil: Bortolini, Maria Catira. Universidade Federal do Rio Grande do Sul; Brasil Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia Fil: Rosique, Javier. Universidad de Antioquia; Colombia Fil: Ruiz Linares, Andrés. University College London; Estados Unidos. Fudan University; China. Aix Marseille Univ; Francia Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina

Published
2017
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3. Socioeconomic Status Is Not Related with Facial Fluctuating Asymmetry: Evidence from Latin-American Populations

Author

Mirsha Quinto-Sánchez, Celia Cintas, Caio Cesar Silva de Cerqueira, Virginia Ramallo, Victor Acuña-Alonzo, Kaustubh Adhikari, Lucía Castillo, Jorge Gomez-Valdés, Paola Everardo, Francisco De Avila, Tábita Hünemeier, Claudia Jaramillo, Williams Arias, Macarena Fuentes, Carla Gallo, Giovani Poletti, Lavinia Schuler-Faccini, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Javier Rosique, Andrés Ruiz-Linares, and Rolando González-José

Subjects
Adult, Male, Heterozygote, Multidisciplinary, Adolescent, lcsh:R, lcsh:Medicine, Correction, Hispanic or Latino, Middle Aged, Young Adult, Facial Asymmetry, Social Class, Humans, lcsh:Q, Female, lcsh:Science
Abstract

The expression of facial asymmetries has been recurrently related with poverty and/or disadvantaged socioeconomic status. Departing from the developmental instability theory, previous approaches attempted to test the statistical relationship between the stress experienced by individuals grown in poor conditions and an increase in facial and corporal asymmetry. Here we aim to further evaluate such hypothesis on a large sample of admixed Latin Americans individuals by exploring if low socioeconomic status individuals tend to exhibit greater facial fluctuating asymmetry values. To do so, we implement Procrustes analysis of variance and Hierarchical Linear Modelling (HLM) to estimate potential associations between facial fluctuating asymmetry values and socioeconomic status. We report significant relationships between facial fluctuating asymmetry values and age, sex, and genetic ancestry, while socioeconomic status failed to exhibit any strong statistical relationship with facial asymmetry. These results are persistent after the effect of heterozygosity (a proxy for genetic ancestry) is controlled in the model. Our results indicate that, at least on the studied sample, there is no relationship between socioeconomic stress (as intended as low socioeconomic status) and facial asymmetries.

Published
2017
Full Text
View/download PDF

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