1. Takayasu's arteritis and secondary membranous nephropathy: an exceptional association
- Author
-
Gonzalo Labarca, Gonzalo P. Méndez, Daniel Enos, and Mariel Hernandez
- Subjects
Male ,medicine.medical_specialty ,Takayasu's arteritis ,030232 urology & nephrology ,Renal function ,Case Report ,Gastroenterology ,Glomerulonephritis, Membranous ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Membranous nephropathy ,Internal medicine ,medicine ,Humans ,Arteritis ,Cyclophosphamide ,Creatinine ,business.industry ,Receptors, Phospholipase A2 ,General Medicine ,Middle Aged ,medicine.disease ,Takayasu Arteritis ,chemistry ,Albuminuria ,Prednisone ,medicine.symptom ,Neoplasm Recurrence, Local ,Vasculitis ,business ,Nephrotic syndrome ,030217 neurology & neurosurgery - Abstract
The association between Takayasu’s arteritis and membranous nephropathy is uncommon. We present the case of a 46-year-old man with Takayasu’s arteritis treated over 10 years by a multidisciplinary medical team. He had an atrophic left kidney due to arterial stenosis, with a basal creatinine of 1.59 mg/dL (140.55 µmol/l). Three years ago, he presented with full nephrotic syndrome, uncontrolled blood pressure, creatinine increases to 4.5 mg/dL (basal: 1.59 mg/dL), severe hypoalbuminaemia (1.4 g/dL) and albuminuria of 24.6 g per day. He underwent percutaneous biopsy of the right kidney that showed membranous nephropathy with negative PLA2R1 and positive IgG 1, 3 and 4 subclasses. After therapy with oral prednisone and cyclophosphamide, the patient’s kidney function improved, without recurrence of disease after 3 years of follow-up. Here, we present this extremely uncommon association of Takayasu’s arteritis and membranous nephropathy.
- Published
- 2023