Author: "Hansen, Laura A." / Topic: humans - Searchworks@Jio Institute Digital Library Search Results

10 results on '"Hansen, Laura A."'

1. Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the ENIGMA working groups on CNVs

Author: Sønderby, Ida E, Ching, Christopher RK, Thomopoulos, Sophia I, van der Meer, Dennis, Sun, Daqiang, Villalon‐Reina, Julio E, Agartz, Ingrid, Amunts, Katrin, Arango, Celso, Armstrong, Nicola J, Ayesa‐Arriola, Rosa, Bakker, Geor, Bassett, Anne S, Boomsma, Dorret I, Bülow, Robin, Butcher, Nancy J, Calhoun, Vince D, Caspers, Svenja, Chow, Eva WC, Cichon, Sven, Ciufolini, Simone, Craig, Michael C, Crespo‐Facorro, Benedicto, Cunningham, Adam C, Dale, Anders M, Dazzan, Paola, de Zubicaray, Greig I, Djurovic, Srdjan, Doherty, Joanne L, Donohoe, Gary, Draganski, Bogdan, Durdle, Courtney A, Ehrlich, Stefan, Emanuel, Beverly S, Espeseth, Thomas, Fisher, Simon E, Ge, Tian, Glahn, David C, Grabe, Hans J, Gur, Raquel E, Gutman, Boris A, Haavik, Jan, Håberg, Asta K, Hansen, Laura A, Hashimoto, Ryota, Hibar, Derrek P, Holmes, Avram J, Hottenga, Jouke‐Jan, Pol, Hilleke E Hulshoff, Jalbrzikowski, Maria, Knowles, Emma EM, Kushan, Leila, Linden, David EJ, Liu, Jingyu, Lundervold, Astri J, Martin‐Brevet, Sandra, Martínez, Kenia, Mather, Karen A, Mathias, Samuel R, McDonald‐McGinn, Donna M, McRae, Allan F, Medland, Sarah E, Moberget, Torgeir, Modenato, Claudia, Sánchez, Jennifer Monereo, Moreau, Clara A, Mühleisen, Thomas W, Paus, Tomas, Pausova, Zdenka, Prieto, Carlos, Ragothaman, Anjanibhargavi, Reinbold, Céline S, Marques, Tiago Reis, Repetto, Gabriela M, Reymond, Alexandre, Roalf, David R, Rodriguez‐Herreros, Borja, Rucker, James J, Sachdev, Perminder S, Schmitt, James E, Schofield, Peter R, Silva, Ana I, Stefansson, Hreinn, Stein, Dan J, Tamnes, Christian K, Tordesillas‐Gutiérrez, Diana, Ulfarsson, Magnus O, Vajdi, Ariana, van 't Ent, Dennis, van den Bree, Marianne BM, Vassos, Evangelos, Vázquez‐Bourgon, Javier, Vila‐Rodriguez, Fidel, Walters, G Bragi, Wen, Wei, Westlye, Lars T, Wittfeld, Katharina, Zackai, Elaine H, Stefánsson, Kári, and Jacquemont, Sebastien
Subjects: Biological Psychology, Biomedical and Clinical Sciences, Psychology, Mental Health, Clinical Research, Pediatric, Genetics, Basic Behavioral and Social Science, Human Genome, Prevention, Brain Disorders, Behavioral and Social Science, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Mental health, Neurological, Brain, DNA Copy Number Variations, Humans, Magnetic Resonance Imaging, Mental Disorders, Multicenter Studies as Topic, Neurodevelopmental Disorders, Neuroimaging, brain structural imaging, copy number variant, diffusion tensor imaging, evolution, genetics-first approach, neurodevelopmental disorders, psychiatric disorders, ENIGMA-CNV Working Group, ENIGMA 22q11.2 Deletion Syndrome Working Group, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract: The Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA-CNV WG has collated CNV and magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one of the largest studies to date on the effects of CNVs on brain structures in the general population. The 22q-ENIGMA WG includes 12 international research centers that assessed over 533 individuals with a confirmed 22q11.2 deletion syndrome, 40 with 22q11.2 duplications, and 333 typically developing controls, creating the largest-ever 22q11.2 CNV neuroimaging data set. In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. So far, ENIGMA has identified effects of the 22q11.2, 16p11.2 distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and cortical brain structures. Each CNV is associated with differences in cognitive, neurodevelopmental and neuropsychiatric traits, with characteristic patterns of brain structural abnormalities. Evidence of gene-dosage effects on distinct brain regions also emerged, providing further insight into genotype-phenotype relationships. Taken together, these results offer a more comprehensive picture of molecular mechanisms involved in typical and atypical brain development. This "genotype-first" approach also contributes to our understanding of the etiopathogenesis of brain disorders. Finally, we outline future directions to better understand effects of CNVs on brain structure and behavior.
Published: 2022

2. Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics

Author: Forsyth, Jennifer K, Mennigen, Eva, Lin, Amy, Sun, Daqiang, Vajdi, Ariana, Kushan-Wells, Leila, Ching, Christopher RK, Villalon-Reina, Julio E, Thompson, Paul M, Jonas, Rachel K, Pacheco-Hansen, Laura, Bakker, Geor, van Amelsvoort, Therese, Antshel, Kevin M, Fremont, Wanda, Kates, Wendy R, Campbell, Linda E, McCabe, Kathryn L, Craig, Michael C, Daly, Eileen, Gudbrandsen, Maria, Murphy, Clodagh M, Murphy, Declan G, Murphy, Kieran C, Fiksinski, Ania, Koops, Sanne, Vorstman, Jacob, Crowley, T Blaine, Emanuel, Beverly S, Gur, Raquel E, McDonald-McGinn, Donna M, Roalf, David R, Ruparel, Kosha, Schmitt, J Eric, Zackai, Elaine H, Durdle, Courtney A, Goodrich-Hunsaker, Naomi J, Simon, Tony J, Bassett, Anne S, Butcher, Nancy J, Chow, Eva WC, Vila-Rodriguez, Fidel, Cunningham, Adam, Doherty, Joanne L, Linden, David E, Moss, Hayley, Owen, Michael J, van den Bree, Marianne, Crossley, Nicolas A, Repetto, Gabriela M, and Bearden, Carrie E
Subjects: Biomedical and Clinical Sciences, Neurosciences, Clinical Research, Genetics, Pediatric, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, 22q11 Deletion Syndrome, Brain Cortical Thickness, Case-Control Studies, Cerebral Cortex, DNA Copy Number Variations, Gene Expression Profiling, Gene Expression Regulation, Developmental, Haploinsufficiency, Humans, Magnetic Resonance Imaging, MicroRNAs, Mitochondrial Proteins, RNA-Binding Proteins, Receptors, Purinergic P2, copy number variant, cortical thickness, DGCR8, gene expression, surface area, 22q11.2 ENIGMA Consortium, Psychology, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract: 22q11.2 deletion syndrome (22q11DS) results from a hemizygous deletion that typically spans 46 protein-coding genes and is associated with widespread alterations in brain morphology. The specific genetic mechanisms underlying these alterations remain unclear. In the 22q11.2 ENIGMA Working Group, we characterized cortical alterations in individuals with 22q11DS (n = 232) versus healthy individuals (n = 290) and conducted spatial convergence analyses using gene expression data from the Allen Human Brain Atlas to prioritize individual genes that may contribute to altered surface area (SA) and cortical thickness (CT) in 22q11DS. Total SA was reduced in 22q11DS (Z-score deviance = -1.04), with prominent reductions in midline posterior and lateral association regions. Mean CT was thicker in 22q11DS (Z-score deviance = +0.64), with focal thinning in a subset of regions. Regional expression of DGCR8 was robustly associated with regional severity of SA deviance in 22q11DS; AIFM3 was also associated with SA deviance. Conversely, P2RX6 was associated with CT deviance. Exploratory analysis of gene targets of microRNAs previously identified as down-regulated due to DGCR8 deficiency suggested that DGCR8 haploinsufficiency may contribute to altered corticogenesis in 22q11DS by disrupting cell cycle modulation. These findings demonstrate the utility of combining neuroanatomic and transcriptomic datasets to derive molecular insights into complex, multigene copy number variants.
Published: 2021

3. Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study

Author: Villalón-Reina, Julio E, Martínez, Kenia, Qu, Xiaoping, Ching, Christopher RK, Nir, Talia M, Kothapalli, Deydeep, Corbin, Conor, Sun, Daqiang, Lin, Amy, Forsyth, Jennifer K, Kushan, Leila, Vajdi, Ariana, Jalbrzikowski, Maria, Hansen, Laura, Jonas, Rachel K, van Amelsvoort, Therese, Bakker, Geor, Kates, Wendy R, Antshel, Kevin M, Fremont, Wanda, Campbell, Linda E, McCabe, Kathryn L, Daly, Eileen, Gudbrandsen, Maria, Murphy, Clodagh M, Murphy, Declan, Craig, Michael, Emanuel, Beverly, McDonald-McGinn, Donna M, Vorstman, Jacob AS, Fiksinski, Ania M, Koops, Sanne, Ruparel, Kosha, Roalf, David, Gur, Raquel E, Eric Schmitt, J, Simon, Tony J, Goodrich-Hunsaker, Naomi J, Durdle, Courtney A, Doherty, Joanne L, Cunningham, Adam C, van den Bree, Marianne, Linden, David EJ, Owen, Michael, Moss, Hayley, Kelly, Sinead, Donohoe, Gary, Murphy, Kieran C, Arango, Celso, Jahanshad, Neda, Thompson, Paul M, and Bearden, Carrie E
Subjects: Paediatrics, Biomedical and Clinical Sciences, Neurosciences, Pediatric, Biomedical Imaging, Mental Health, Clinical Research, Brain Disorders, Mental health, Adolescent, Adult, Anisotropy, Child, DiGeorge Syndrome, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, White Matter, Young Adult, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract: 22q11.2 deletion syndrome (22q11DS)-a neurodevelopmental condition caused by a hemizygous deletion on chromosome 22-is associated with an elevated risk of psychosis and other developmental brain disorders. Prior single-site diffusion magnetic resonance imaging (dMRI) studies have reported altered white matter (WM) microstructure in 22q11DS, but small samples and variable methods have led to contradictory results. Here we present the largest study ever conducted of dMRI-derived measures of WM microstructure in 22q11DS (334 22q11.2 deletion carriers and 260 healthy age- and sex-matched controls; age range 6-52 years). Using harmonization protocols developed by the ENIGMA-DTI working group, we identified widespread reductions in mean, axial and radial diffusivities in 22q11DS, most pronounced in regions with major cortico-cortical and cortico-thalamic fibers: the corona radiata, corpus callosum, superior longitudinal fasciculus, posterior thalamic radiations, and sagittal stratum (Cohen's d's ranging from -0.9 to -1.3). Only the posterior limb of the internal capsule (IC), comprised primarily of corticofugal fibers, showed higher axial diffusivity in 22q11DS. 22q11DS patients showed higher mean fractional anisotropy (FA) in callosal and projection fibers (IC and corona radiata) relative to controls, but lower FA than controls in regions with predominantly association fibers. Psychotic illness in 22q11DS was associated with more substantial diffusivity reductions in multiple regions. Overall, these findings indicate large effects of the 22q11.2 deletion on WM microstructure, especially in major cortico-cortical connections. Taken together with findings from animal models, this pattern of abnormalities may reflect disrupted neurogenesis of projection neurons in outer cortical layers.
Published: 2020

4. Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size

Author: Sun, Daqiang, Ching, Christopher RK, Lin, Amy, Forsyth, Jennifer K, Kushan, Leila, Vajdi, Ariana, Jalbrzikowski, Maria, Hansen, Laura, Villalon-Reina, Julio E, Qu, Xiaoping, Jonas, Rachel K, van Amelsvoort, Therese, Bakker, Geor, Kates, Wendy R, Antshel, Kevin M, Fremont, Wanda, Campbell, Linda E, McCabe, Kathryn L, Daly, Eileen, Gudbrandsen, Maria, Murphy, Clodagh M, Murphy, Declan, Craig, Michael, Vorstman, Jacob, Fiksinski, Ania, Koops, Sanne, Ruparel, Kosha, Roalf, David R, Gur, Raquel E, Schmitt, J Eric, Simon, Tony J, Goodrich-Hunsaker, Naomi J, Durdle, Courtney A, Bassett, Anne S, Chow, Eva WC, Butcher, Nancy J, Vila-Rodriguez, Fidel, Doherty, Joanne, Cunningham, Adam, van den Bree, Marianne BM, Linden, David EJ, Moss, Hayley, Owen, Michael J, Murphy, Kieran C, McDonald-McGinn, Donna M, Emanuel, Beverly, van Erp, Theo GM, Turner, Jessica A, Thompson, Paul M, and Bearden, Carrie E
Subjects: Biological Psychology, Biomedical and Clinical Sciences, Psychology, Pediatric, Serious Mental Illness, Clinical Research, Mental Health, Schizophrenia, Brain Disorders, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, Adult, Cerebral Cortex, Chromosome Deletion, DiGeorge Syndrome, Female, Gray Matter, Humans, Magnetic Resonance Imaging, Male, Psychotic Disorders, Young Adult, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract: The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date. The imaging data were collected from 10 centers worldwide, including 474 subjects with 22q11DS (age = 18.2 ± 8.6; 46.9% female) and 315 typically developing, matched controls (age = 18.0 ± 9.2; 45.9% female). Compared to controls, 22q11DS individuals showed thicker cortical gray matter overall (left/right hemispheres: Cohen's d = 0.61/0.65), but focal thickness reduction in temporal and cingulate cortex. Cortical surface area (SA), however, showed pervasive reductions in 22q11DS (left/right hemispheres: d = -1.01/-1.02). 22q11DS cases vs. controls were classified with 93.8% accuracy based on these neuroanatomic patterns. Comparison of 22q11DS-psychosis to idiopathic schizophrenia (ENIGMA-Schizophrenia Working Group) revealed significant convergence of affected brain regions, particularly in fronto-temporal cortex. Finally, cortical SA was significantly greater in 22q11DS cases with smaller 1.5 Mb deletions, relative to those with typical 3 Mb deletions. We found a robust neuroanatomic signature of 22q11DS, and the first evidence that deletion size impacts brain structure. Psychotic illness in this highly penetrant deletion was associated with similar neuroanatomic abnormalities to idiopathic schizophrenia. These consistent cross-site findings highlight the homogeneity of this single genetic etiology, and support the suitability of 22q11DS as a biological model of schizophrenia.
Published: 2020

5. Reciprocal Copy Number Variations at 22q11.2 Produce Distinct and Convergent Neurobehavioral Impairments Relevant for Schizophrenia and Autism Spectrum Disorder

Author: Lin, Amy, Vajdi, Ariana, Kushan-Wells, Leila, Helleman, Gerhard, Hansen, Laura Pacheco, Jonas, Rachel K, Jalbrzikowski, Maria, Kingsbury, Lyle, Raznahan, Armin, and Bearden, Carrie E
Subjects: Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Brain Disorders, Neurosciences, Mental Health, Prevention, Clinical Research, Pediatric, Autism, Behavioral and Social Science, Schizophrenia, Intellectual and Developmental Disabilities (IDD), 2.3 Psychological, social and economic factors, 2.1 Biological and endogenous factors, Aetiology, Mental health, Autism Spectrum Disorder, DNA Copy Number Variations, DiGeorge Syndrome, Humans, Psychotic Disorders, Autism spectrum disorder, CNV, Cognition, Social behavior, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biological sciences, Biomedical and clinical sciences
Abstract: Background22q11.2 deletions and duplications are copy number variations (CNVs) that predispose to developmental neuropsychiatric disorders. Both CNVs are associated with autism spectrum disorder (ASD), while the deletion confers disproportionate risk for schizophrenia. Neurobehavioral profiles associated with these reciprocal CNVs in conjunction with brain imaging measures have not been reported.MethodsWe profiled the impact of 22q11.2 CNVs on neurobehavioral measures relevant to ASD and psychosis in 106 22q11.2 deletion carriers, 38 22q11.2 duplication carriers, and 82 demographically matched healthy control subjects. To determine whether brain-behavior relationships were altered in CNV carriers, we further tested for interactions between group and regional brain structure on neurobehavioral domains.ResultsCognitive deficits were observed in both CNV groups, with the lowest IQs in deletion carriers. ASD and dimensionally measured ASD traits were elevated in both CNV groups; however, duplication carriers exhibited increased stereotypies compared to deletion carriers. Moreover, discriminant analysis using ASD subdomains distinguished between CNV cases with 76% accuracy. Both psychotic disorder diagnosis and dimensionally measured positive and negative symptoms were elevated in deletion carriers. Finally, healthy control subjects showed an inverse relationship between processing speed and cortical thickness in heteromodal association areas, which was absent in both CNV groups.Conclusions22q11.2 CNVs differentially modulate intellectual functioning and psychosis-related symptomatology but converge on broad ASD-related symptomatology. However, subtle differences in ASD profiles distinguish CNV groups. Processing speed impairments, coupled with the lack of normative relationship between processing speed and cortical thickness in CNV carriers, implicate aberrant development of the cortical mantle in the pathology underlying impaired processing speed ability.
Published: 2020

6. Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness

Author: Ching, Christopher RK, Gutman, Boris A, Sun, Daqiang, Villalon Reina, Julio, Ragothaman, Anjanibhargavi, Isaev, Dmitry, Zavaliangos-Petropulu, Artemis, Lin, Amy, Jonas, Rachel K, Kushan, Leila, Pacheco-Hansen, Laura, Vajdi, Ariana, Forsyth, Jennifer K, Jalbrzikowski, Maria, Bakker, Geor, van Amelsvoort, Therese, Antshel, Kevin M, Fremont, Wanda, Kates, Wendy R, Campbell, Linda E, McCabe, Kathryn L, Craig, Michael C, Daly, Eileen, Gudbrandsen, Maria, Murphy, Clodagh M, Murphy, Declan G, Murphy, Kieran C, Fiksinski, Ania, Koops, Sanne, Vorstman, Jacob, Crowley, T Blaine, Emanuel, Beverly S, Gur, Raquel E, McDonald-McGinn, Donna M, Roalf, David R, Ruparel, Kosha, Schmitt, J Eric, Zackai, Elaine H, Durdle, Courtney A, Goodrich-Hunsaker, Naomi J, Simon, Tony J, Bassett, Anne S, Butcher, Nancy J, Chow, Eva WC, Vila-Rodriguez, Fidel, Cunningham, Adam, Doherty, Joanne, Linden, David E, Moss, Hayley, Owen, Michael J, van den Bree, Marianne, Crossley, Nicolas A, Repetto, Gabriela M, Thompson, Paul M, and Bearden, Carrie E
Subjects: Clinical Research, Serious Mental Illness, Brain Disorders, Mental Health, Schizophrenia, Clinical Trials and Supportive Activities, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Mental health, Adolescent, Adult, Atrophy, Brain, Brain Mapping, Case-Control Studies, Child, DiGeorge Syndrome, Female, Humans, Hypertrophy, Magnetic Resonance Imaging, Male, Mental Disorders, Middle Aged, Psychotic Disorders, Young Adult, 22q11.2 Deletion Syndrome, Copy Number Variant, Neuroanatomy, Neurodevelopment, Psychosis, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract: Objective22q11.2 deletion syndrome (22q11DS) is among the strongest known genetic risk factors for schizophrenia. Previous studies have reported variable alterations in subcortical brain structures in 22q11DS. To better characterize subcortical alterations in 22q11DS, including modulating effects of clinical and genetic heterogeneity, the authors studied a large multicenter neuroimaging cohort from the ENIGMA 22q11.2 Deletion Syndrome Working Group.MethodsSubcortical structures were measured using harmonized protocols for gross volume and subcortical shape morphometry in 533 individuals with 22q11DS and 330 matched healthy control subjects (age range, 6-56 years; 49% female).ResultsCompared with the control group, the 22q11DS group showed lower intracranial volume (ICV) and thalamus, putamen, hippocampus, and amygdala volumes and greater lateral ventricle, caudate, and accumbens volumes (Cohen's d values, -0.90 to 0.93). Shape analysis revealed complex differences in the 22q11DS group across all structures. The larger A-D deletion was associated with more extensive shape alterations compared with the smaller A-B deletion. Participants with 22q11DS with psychosis showed lower ICV and hippocampus, amygdala, and thalamus volumes (Cohen's d values, -0.91 to 0.53) compared with participants with 22q11DS without psychosis. Shape analysis revealed lower thickness and surface area across subregions of these structures. Compared with subcortical findings from other neuropsychiatric disorders studied by the ENIGMA consortium, significant convergence was observed between participants with 22q11DS with psychosis and participants with schizophrenia, bipolar disorder, major depressive disorder, and obsessive-compulsive disorder.ConclusionsIn the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to subcortical brain structures, which were affected by deletion size and psychotic illness. Findings indicate significant overlap between 22q11DS-associated psychosis, idiopathic schizophrenia, and other severe neuropsychiatric illnesses.
Published: 2020

7. Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry

Author: Lin, Amy, Ching, Christopher RK, Vajdi, Ariana, Sun, Daqiang, Jonas, Rachel K, Jalbrzikowski, Maria, Kushan-Wells, Leila, Hansen, Laura Pacheco, Krikorian, Emma, Gutman, Boris, Dokoru, Deepika, Helleman, Gerhard, Thompson, Paul M, and Bearden, Carrie E
Subjects: Behavioral and Social Science, Brain Disorders, Pediatric, Neurosciences, Mental Health, Biotechnology, Schizophrenia, Genetics, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Mental health, Neurological, 22q11 Deletion Syndrome, Brain, Brain Mapping, DNA Copy Number Variations, Female, Gene Dosage, Gene Rearrangement, Humans, Male, Middle Aged, Organ Size, autism spectrum disorder, chromosome 22, copy number variant, neurodevelopment, psychosis, structural neuroimaging, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract: Reciprocal chromosomal rearrangements at the 22q11.2 locus are associated with elevated risk of neurodevelopmental disorders. The 22q11.2 deletion confers the highest known genetic risk for schizophrenia, but a duplication in the same region is strongly associated with autism and is less common in schizophrenia cases than in the general population. Here we conducted the first study of 22q11.2 gene dosage effects on brain structure in a sample of 143 human subjects: 66 with 22q11.2 deletions (22q-del; 32 males), 21 with 22q11.2 duplications (22q-dup; 14 males), and 56 age- and sex-matched controls (31 males). 22q11.2 gene dosage varied positively with intracranial volume, gray and white matter volume, and cortical surface area (deletion < control < duplication). In contrast, gene dosage varied negatively with mean cortical thickness (deletion > control > duplication). Widespread differences were observed for cortical surface area with more localized effects on cortical thickness. These diametric patterns extended into subcortical regions: 22q-dup carriers had a significantly larger right hippocampus, on average, but lower right caudate and corpus callosum volume, relative to 22q-del carriers. Novel subcortical shape analysis revealed greater radial distance (thickness) of the right amygdala and left thalamus, and localized increases and decreases in subregions of the caudate, putamen, and hippocampus in 22q-dup relative to 22q-del carriers. This study provides the first evidence that 22q11.2 is a genomic region associated with gene-dose-dependent brain phenotypes. Pervasive effects on cortical surface area imply that this copy number variant affects brain structure early in the course of development.SIGNIFICANCE STATEMENT Probing naturally occurring reciprocal copy number variation in the genome may help us understand mechanisms underlying deviations from typical brain and cognitive development. The 22q11.2 genomic region is particularly susceptible to chromosomal rearrangements and contains many genes crucial for neuronal development and migration. Not surprisingly, reciprocal genomic imbalances at this locus confer some of the highest known genetic risks for developmental neuropsychiatric disorders. Here we provide the first evidence that brain morphology differs meaningfully as a function of reciprocal genomic variation at the 22q11.2 locus. Cortical thickness and surface area were affected in opposite directions with more widespread effects of gene dosage on cortical surface area.
Published: 2017

8. Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity.

Author: Ibrahim, Amira FA, Montojo, Caroline A, Haut, Kristen M, Karlsgodt, Katherine H, Hansen, Laura, Congdon, Eliza, Rosser, Tena, Bilder, Robert M, Silva, Alcino J, and Bearden, Carrie E
Subjects: Brain, Humans, Neurofibromatosis 1, Memory Disorders, Magnetic Resonance Imaging, Brain Mapping, Memory, Short-Term, Adolescent, Adult, Middle Aged, Female, Male, Young Adult, Spatial Memory, NF1, Psychophysiological interaction, Spatial ability, Working memory, fMRI, Clinical Research, Rare Diseases, Basic Behavioral and Social Science, Behavioral and Social Science, Pediatric, Neurofibromatosis, Neurosciences, Mental Health, Brain Disorders, Underpinning research, 1.2 Psychological and socioeconomic processes, Mental health, Neurological
Abstract: BackgroundNeurofibromatosis Type 1 (NF1) is a genetic disorder that disrupts central nervous system development and neuronal function. Cognitively, NF1 is characterized by difficulties with executive control and visuospatial abilities. Little is known about the neural substrates underlying these deficits. The current study utilized Blood-Oxygen-Level-Dependent (BOLD) functional MRI (fMRI) to explore the neural correlates of spatial working memory (WM) deficits in patients with NF1.MethodsBOLD images were acquired from 23 adults with NF1 (age M = 32.69; 61% male) and 25 matched healthy controls (age M = 33.08; 64% male) during an in-scanner visuo-spatial WM task. Whole brain functional and psycho-physiological interaction analyses were utilized to investigate neural activity and functional connectivity, respectively, during visuo-spatial WM performance. Participants also completed behavioral measures of spatial reasoning and verbal WM.ResultsRelative to healthy controls, participants with NF1 showed reduced recruitment of key components of WM circuitry, the left dorsolateral prefrontal cortex and right parietal cortex. In addition, healthy controls exhibited greater simultaneous deactivation between the posterior cingulate cortex (PCC) and temporal regions than NF1 patients. In contrast, NF1 patients showed greater PCC and bilateral parietal connectivity with visual cortices as well as between the PCC and the cerebellum. In NF1 participants, increased functional coupling of the PCC with frontal and parietal regions was associated with better spatial reasoning and WM performance, respectively; these relationships were not observed in controls.ConclusionsDysfunctional engagement of WM circuitry, and aberrant functional connectivity of 'task-negative' regions in NF1 patients may underlie spatial WM difficulties characteristic of the disorder.
Published: 2017

9. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Author: Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Li, Elizabeth, Omar, Omar M, Simoes, Joana FF, Abbott, Tom EF, Alser, Osaid, Arnaud, Alexis P, Bankhead-Kendall, Brittany K, Breen, Kerry A, Cunha, Miguel F, Davidson, Giana H, Di Saverio, Salomone, Gallo, Gaetano, Griffiths, Ewen A, Gujjuri, Rohan R, Hutchinson, Peter J, Kaafarani, Haytham MA, Lederhuber, Hans, Löffler, Markus W, Mashbari, Hassan N, Minaya-Bravo, Ana, Morton, Dion G, Moszkowicz, David, Pata, Francesco, Tsoulfas, George, Venn, Mary L, Cox, Daniel, Roslani, April C, Alakaloko, Felix, de Vries, Jean-Paul PM, Aaraj, Mahmoud A, Abbott, Sarah J, Abdalla, Mutwakil OM, Abdelaal, Ahmed S, Ademuyiwa, Adesoji O, Aherne, Thomas M, Ali, Osman M, Alkadeeki, Ghadah Z, Almeida, Ana C, Alrahawy, Mahmoud M, Ambler, Graeme K, Alameer, Ehab, Andreani, Stefano M, De Andrés-Asenjo, Beatriz, Antonanzas, Leyre Lopez, Aoun, Salah G, Ashoush, Fouad M, Augestad, Knut Magne, Avellana, Rocio B, Ayeni, Funbi A, Ayorinde, John OO, Babu, Bheemanakone H, Baig, Mirza MAS, Bajomo, Oreoluwa M, Baker, Olivia J, Baker, Markus P, Baldwin, Alexander J, Ban, Vin Shen, Baron, Ryan D, Barranquero, Alberto G, Barry, Conor P, DI Bartolomeo, Alessandro, Bass, Gary A, Bath, Michael F, Batjer, H Hunt, Beamish, Andrew J, Belgaumkar, Ajay P, Bence, Matthew N, Benson, Ruth A, Bernal-Sprekelsen, Juan Carlos, Bhama, Anuradha R, Bhavaraju, Avi V, Biffl, Walter L, Blundell, Chris M, Boddy, Alexander P, Borgstein, Alexander BJ, Bosanquet, David C, Bosch, Karen D, Bouhuwaish, Ahmad EM, Bozkurt, Mehmet A, Brathwaite, Collin EM, Brown, Benjamin C, Brown, Oliver D, Brown, Allison K, Buarque, Igor Lima, Bueno-Cañones, Alejandro D, Bulugma, Mustafa R, Burke, Joshua R, Byrne, Matthew HV, Cagigal-Ortega, Elima P, Callcut, Rachael A, DI Candido, Francesca, Canova, Michaela E, Carlos, William J, Caruana, Edward J, Cato, Liam D, Catton, Andrew B, Ceretti, Andrea Pisani, Chase, Thomas JG, Chiara, Francesco Di, Chowdhury, Abeed H, Chung, Eric A, Cicerchia, Pierfranco M, Clough, Ethan CS, Coleman, Natasha L, Collins, Chris G, Collins, Michelle L, Colonna, Emily T, Comini, Lara V, Coughlin, Patrick A, Cruzado, Laura Fernández-Gomez, Davidson, Brian R, Davies, Richard J, Davies, Emma J, Davis, Niall F, Dawson, Brett E, Dean, Benjamin JF, Delgado, Maria Garcia-Conde, Diaz, Jose J, Dickson, Kathryn E, Diez-Alonso, Manuel M, Dixon, Jan R, Doe, Matthew J, Drake, Thomas D, Drake, Frederick T, Duffy, John P, Dunne, Declan FJ, Dunne, Naomi JM, Durán-Muñoz-Cruzado, Virginia M, Durst, Alexander ZE, Eardley, Nicola J, Edwards, John G, Elfallal, Ahmed H, Elfiky, Mahmoud MA, Elliott, Jessie A, Emile, Sameh H, Emslie, Katy M, Endorf, Frederick W, Engel, Jamie L, Enjuto, Diego T, Etchill, Eric W, Evans, Jonathan P, Fahey, Brian A, Faria, Carlos S, Feo, Carlo V, Ferguson, Henry JM, Fernandez, Beatriz Dieguez, Fernandez, Andres Garcia, Fernández, Antonio J, Fernández-Pacheco, Borja Camacho, Fitzgerald, J Edward, Fonsi, Giovanni B, Font, Roser Farré, Fowler, Amy L, Fretwell, Kenneth R, Fructuoso, Lorena Sanchon, Fusai, Giuseppe K, Garcia, Miguel Hernandez, Garcia-Ureña, Miguel Angel, Gill, Charn K, Gisbertz, Suzanne S, Del Giudice, Roberto, Giuffrida, Maria Carmela, Di Giuseppe, Matteo, Gómez, María Fanjul, Guariglia, Claudio A, Hainsworth, Alison J, Hall, Bria J, Hall, James RW, Hammond, John S, Haqqani, Maha H, Harrison, Ewen M, Hazelton, Joshua P, van Heinsbergen, Maarten, Hill, Arnold DK, Hing, Caroline B, Hirji, Sameer A, Ho, Michael WS, Holbrook, Charlotte M, Holme, Thomas J, Hopkins, James C, Hopkinson, David N, Hossain, Fahad S, Hudson, Victoria E, Hughes, Jane L, Hwang, E. Shelley, Ibrahim, Mohamed AH, Isolani, Simone M, Jenkinson, Michael D, Jenny, Hillary E, Jeyaretna, Deva S, Jones, Robert P, Jones, Andrew P, Jonker, Pascal KC, Jönsson, Maria L, Joyce, Doireann P, Kalkwarf, Kyle J, Kamarajah, Sivesh K, El Kassas, Mohamed, Kavanagh, Dara O, Keatley, James M, Khalefa, Mohamed A, Khan, Jim S, Kirmani, Bilal H, Kisiel, Aaron P, Kouris, Spyros Marinos, Kowal, Mikolaj R, Labib, Peter L, Larkin, John O, Lauscher, Johannes C, Leclercq, Wouter KG, Ledesma, Frances SJ, Leite-Moreira, André M, Leung, Elaine YL, Lewis, Sophia E, Lima, Maria João, Lin, Daniel J, Liu, Helen H, Lowery, Aoife J, Lozano, Saida Martel, Luney, Catriona R, Maia, Mariana Magalhães, Mariani, Nicolò M, Marino, Marco V, Marra, Angelo A, Marsh, Christopher L, Martin, Robert CG, McCluney, Simon J, McIntyre, Robert C, Mckay, Siobhan C, McKevitt, Kevin L, Meagher, Ashley D, Mehdi, Mohammad Q, Mehigan, Brian J, Gonzalez-De Miguel, Melania, De Miguel-Ardevines, Maria-Carmen, Mills, Sarah J, Mohan, Helen M, Moir, John AG, Monson, John RT, Monteiro, Joana M, Montella, Maria T, Montesinos, Cristina Soto, Morgom, Marwa M, Moura, Francisco S, Muguerza, Jose M, Murphy, Suzanne H, De Nardi, Paola, Naumann, David N, Neary, Paul C, Neely, David TA, Ng-Kamstra, Joshua S, Ngu, Albert WT, Nguyen, Truong A, Nita, George E, Nunes, Quentin M, Nygaard, Rachel M, O'Meara, Lindsay B, O'Neill, John R, Okafor, Barbara U, Olson, Steven A, Oo, Aung Y, Ormazabal, Pablo Collera, Osorio, Alexander L, Pachl, Max J, Parry, James T, Patel, Panna K, Pérez-Sánchez, Luis E, Pevidal, Ana Nogues, Pezzuto, Anna P, Philp, Matthew M, Pinkney, Thomas D, Pollok, Joerg M, Povey, Meical G, Poza, Alfredo Alonso, Rajgor, Amarkumar D, Rao, Jagan N, Raptis, Dimitri A, Rice, Henry E, Ridgway, Paul F, Rivas, Ana Munoz, Rodriguez-Sanjuan, Juan C, Rogers, Luke J, Da Roit, Anna, Rollett, Rebecca A, Romera, Jose L, Rooney, Siobhan M, Roxo, Vanessa I, Le Roy, Bertrand, Rubio, Eduardo E, Ruiz, Carolina Castro, Ruiz, Manuel Losada, Ryan, Éanna J, Saad, Abdel Rahman, Saeed, Samerah A, Salama, Hiba A, Salamah, Abdulrauf A, Sampietro, Gianluca M, Sarma, Diwakar R, Schaffer, Kathryn B, Schnitzbauer, Andreas A, Scurrah, Rachel J, Serevina, Olivia L, Serralheiro, Pedro A, Sewards, Joseph M, Shackcloth, Michael J, Shaw, Abigail V, Sheel, Andrea RG, Sica, Giuseppe S, De Simone, Veronica, Singh, Aminder A, Singh, Rabindra P, Skelly, Brendan L, Smith, Henry G, Sohail, Amir H, Spalding, Duncan R, Springford, Laurie R, Ssentongo, Anna E, Steinkamp, Pieter J, Stevens, Kent A, Stewart, Grant D, Stylianides, Nicholas A, Sullivan, Tom BB, Taher, Ahmed SA, Tamimy, Muhammad S, Tang, Alethea M, Tebala, Giovanni D, Tejero-Pintor, Francisco J, Thaha, Mohamed A, Thomas, Amy J, De Toma, Giorgio, La Torre, Filippo, Torres, Antonio J, Townshend, David N, Trout, Isobel M, Tucker, Sarah C, Ubhi, Harmony K, Vega, Viviana A, Velmahos, George C, Velopulos, Catherine G, Viswanath, Yirupaiahgari KS, Vivas, Alfredo A, Wade, Ryckie G, Wadley, Martin S, Wall, Joshua JS, Walters, Andrew M, Warren, Oliver J, Weerasinghe, Chamindri K, Wilkin, Richard JW, Williams, Katherine J, Winter, Stuart C, Wormald, Justin CR, Wright, Franklin L, Xyda, Souzana E, Young, Alastair L, Youssef, Mina MG, Yousuf, Farhat B, El Youzouri, Hanan, Zappa, Marco A, Abate, Emmanuele, Abdalaziz, Hossam, Abdelkarim, Mostafa, Abdou, Hossam, Aboelkassem-Ibrahim, Ahmad, Abuown, Ala, Acebes-Garcia, Fernando, Acharya, Metesh, Adamina, Michel, Addae-Boateng, Emmanuel, Aftab, Raiyyan, Agarwal, Arnav, Aguilar, José, Ahmed, Yousra, Aitken, Emma, Al-Azzawi, Marwa, Al-Embideen, Somya, Al-Masri, Mahmoud, Al-Najjar, Hani, Al-Sukaini, Ahmad, Alam, Ruhina, Alderson, Derek, Aliyeva, Zumrud, Aljanadi, Firas, Almasri, Murad, Alonso-Ortuño, Paula, Altintoprak, Fatih, Amira, Gamal, Amjad, Rabbia, Anania, Gabriele, Andabaka, Tatjana, Angelou, Dimitrios, Annamalai, Seethalakshmi, Annessi, Valerio, Anthoney, James, Anwar, Sibtain, Anwer, Mariyah, Aragon-Chamizo, Juan, Ardito, Antonella, Arigoni, Michele, Armao, Teodora, Arminio, Armando, Armstrong, Lara, Arnaud, Alexis, Asaad, Peter, Ashcroft, James, Ashmore, Christopher, Asqalan, Ahmad, Asti, Emanuele, Aubry, Emmanuelle, Aytac, Erman, Ayuso-Herrera, Esther, Baeza, Melody, Bailon-Cuadrado, Martin, Bakmaz, Bernarda, Baldi, Caterina, Baldini, Edoardo, Baldo, Stefano, Ballabio, Michele, Baloyiannis, Ioannis, Baltazar, Gerard, Bàmbina, Fabrizio, Bandiera, Alessandro, Barlow, Emma, Barmasse, Roberto, Barmpagianni, Christina, Baronio, Gianluca, Barra, Fabio, Bartsch, Anne-Marie, Basgaran, Amedra, Basha, Amr, Bashkirova, Varvara, Bastazza, Marco, Baumber, Rachel, Belcher, Elizabeth, Belvedere, Angela, Benítez-Linero, Inmaculada, Bergeat, Damien, Bernasconi, Matteo, Bhalla, Ashish, Bhutiani, Neal, Bianco, Federica, Bisagni, Pietro, Blake, Iain, Blanco-Colino, Ruth, Blazquez-Martin, Alma, Boal, Matthew, Bonavina, Luigi, Bonavina, Giulia, Bond-Smith, Giles, Booth, Karen, Borges, Filipe, Borghi, Felice, Bouchagier, Konstantinos, Bourke, Grainne, Boyle, Emily, Brachini, Gioia, Brain, Jessie, Brar, Amanpreet, Breckles, Lisa, Bretagnol, Frédéric, Brixton, Genevieve, Bruzzaniti, Placido, Bueser, Teofila, Burnside, Nathan, Caballero, Albert, Calcerrada-Alises, Enrique, Callahan, Miriam, Camarero, Enrique, Campagnaro, Tommaso, Campanelli, Michela, Candiani, Massimo, Cantalejo-Diaz, Miguel, Cao, Han, Capelli, Patrizio, Capizzi, Vita, Carcano, Giulio, Carissimi, Francesca, Carlini, Massimo, Carlucci, Michele, Carmichael, Heather, Carrasco, Milagros, Carrillo, Mariana, Carvello, Michele, Casati, Massimiliano, Castoro, Carlo, Catalan, Vanesa, Cavaleiro, Salomé, Cellerino, Paola, Centinaio, Giovanna, Cernei, Cristina, Cerro, Cristina, Cervellera, Maurizio, Chakrabortee, Sohini, Chamberlain, Stephanie, Chan, Jeffrey, Chang, Grace, Chaudhry, Dauod, Chebaro, Alexandre, Chen, David, Chetty, Govind, Chia, Zoe, Chiappini, Ambra, Chiarugi, Massimo, Chidambaram, Swathikan, Chiozza, Matteo, Cholewa, Hanna, Chong, Clara, Choolani-Bhojwani, Ekta, Christoforidis, Dimitri, Chui, Karen, Chung, Choyin, Cirillo, Bruno, Citterio, Davide, Clermidi, Pauline, Coccolini, Federico, Colletti, Gaia, Compagnoni, Bruno, Concepción-Martín, Vanesa, Confalonieri, Marco, Connolly, Hannah, Conso, Christel, Conti, Luigi, Cooper, Zara, Cordera, Fernando, Corral, Javier, Costa, Marta, Costanzi, Andrea, Cotsoglou, Christian, Cozza, Valerio, Cuming, Tamzin, Curtis, Miles, Cuschieri, Joseph, D'Agruma, Michele, D'Andrea, Giancarlo, Daliya, Prita, Dare, Oliver, Darko, Ebenezer, Day, Andrew, Dehal, Ahmed, Dehart, Dustin, Delgado-Oliver, Eduardo, Denning, Max, Desai, Anant, Desender, Liesbeth, Dester, Sara, Díaz-García, Alberto, Diaz-Peña, Patricia, Dousset, Bertrand, Doussot, Alexandre, Duchateau, Nicolas, Duff, Sarah, Dunning, Joel, Duque-Mallen, Victoria, Dziakova, Jana, Egan, Bridget, Egan, Richard, El-Ali, Abess, Elfeki, Hossam, Elhadi, Muhammed, Eljareh, Mohammed, Elkady, Ramy, Elkhafeefi, Fatimah, Elmore, Ugo, Elmoslemany, Tarek, Emmerson, Oliver, Enemosah, Ibrahim, English, Camilla, English, William, Escartin, Jorge, Estaire-Gomez, Mercedes, Evans, Luke, Evans, Jessica, Exley, Rebecca, Fabbri, Nicoló, Falco, Giuseppe, Familiari, Pietro, Fancellu, Alessandro, Farik, Shebani, Farrell, Tony, Fehervari, Matyas, Fell, Adam, Fernandez-Camuñas, Angel, Fernández-Marín, Reyes, Fernández-Martínez, María, Ferrara, Francesco, Ferrari, Guglielmo, Ferrero, Simone, Findlay, Laura, Fiore, Marco, Fiori, Enrico, Flatman, Michael, Flindall, Ian, Flor, Blas, Fontana, Tommaso, Ford, Samuel, Ford, David, Forlani, Stefano, Francone, Elisa, Frattaruolo, Colomba, Frio, Federico, Gagliano, Annalisa, Gagliardi, Filippo, Gahunia, Sukhpreet, Gaino, Francesca, Gala, Tanzeela, Galfrascoli, Elisa, Galimberti, Luca, Gallagher, Phoebe, Galleano, Raffaele, Galván-Pérez, Armando, Gammeri, Emanuele, Ganau, Mario, Garcés-García, Raúl, Garulli, Gianluca, Gascon-Ferrer, Isabel, Gattolin, Andrea, Gaujoux, Sebastien, Gentilli, Sergio, Georgiades, Fanourios, Ghanbari, Amir, Ghosh, Dhruv, Giacometti, Marco, Giblin, Anna-Victoria, Gilbert, Catherine, Giménez, Clara, Giorgakis, Emmanouil, Gipponi, Manuel, Glen, Paul, Goatly, Giles, Gobatti, Davide, Godbole, Chintamani, Gohil, Kajal, Gómez, Marcos, Gomez-Rosado, Juan-Carlos, Gonullu, Emre, Gonzalez-Gonzalez, Enrique, Gordini, Luca, Gracia, Isabel, Gracia-Roche, Carlos, Granieri, Stefano, Green, Susanna, Grivon, Manuela, Grove, Thomas, Guaglio, Marcello, Guaitoli, Eleonora, Guglielmi, Alfredo, Guha, Soumya, Gustavino, Claudio, Habeeb, Amir, Hagger, Robert, Hakmi, Hazim, Halkias, Constantine, Hall, Claire, Hampton, Matthew, Handa, Siddhartha, Hansen, Laura, Haq, Iram, Harky, Amer, Harries, Rhiannon, Harrison, Joseph, Hasan, Raashad, Hawari, Mohammad, Hawkin, Paul, Hebblethwaite, Bethany, Henriques, Susana, Heritage, Emily, Hernandez-Juara, Pilar, Herrero-Lopez, Maria, Hervieux, Erik, Heyd, Bruno, Higgs, Simon, Hitchman, Louise, Ho, Beatrice, Hogan, Aisling, Hölzle, Frank, Hossain, Tanvir, Hurt, Libor, Hutchinson, Peter, Iacob, Giulio, Iannone, Immacolata, Ibrahim, Sherif, Iovino, Domenico, Isik, Arda, Jafarova, Sevda, Jamil, Tahir, Jayaraju, Ullas, Jenner, Edward, Jimenez-Higuera, Elisa, Jimeno, Jaime, Jones, Mark, Judkins, Nicholas, Kalavrezos, Nicholas, Kalidindi, Venugopala, Kalkat, Maninder, Kamal, Mona, Kamphues, Carsten, Kang, Chong, Kara, Yasin, Karam, Edward, Karim, Ahmed, Kashora, Florence, Kearney, David, Khajuria, Apoorva, Khan, Umul, Khan, Azam, Khatri, Chetan, Kinnaman, Gabriel, Kinross, James, Kler, Aaron, Klimopoulos, Serafeim, Kocataş, Ali, Kolias, Angelos, Königsrainer, Alfred, Konsten, Joop, Kontovounisios, Christos, Kourdouli, Amar, Krishnan, Emily, Kristinsson, Sverrir, Kruijff, Schelto, Kudsk-Iversen, Søren, Kufeji, Dorothy, Kugler, Nadav, Kulkarni, Rugved, Kurihara, Hayato, Laface, Letizia, Lakkis, Zaher, Lami, Mariam, Landaluce-Olavarria, Aitor, Lapolla, Pierfrancesco, Lawani, Ismail, Lawday, Samuel, Lázaro, André, Lecolle, Katia, Leventoglu, Sezai, Li, Zoe, Liew, Ignatius, Lisi, Giorgio, Lizzi, Vincenzo, Lo, Terence, Lomiento, Daniele, Longhi, Marco, Lostis, Emilie, Lostoridis, Eftychios, Loubani, Mahmoud, Lowy-Benoliel, Alejandro, Lucianetti, Alessandro, Luke, Louis, Lunevicius, Raimundas, Luraghi, Marco, Lye, George, Mabrouk, Islam, Macchi, Alberto, MacDonald, Luisa, Machairas, Nikolaos, Madonini, Marco, Magowan, Drew, Maisonneuve, Emeline, Majkowska, Agata, Majkowski, Lawrence, Mak, Jason, Malabarba, Stefano, Malerba, Michele, Mannan, Syed, Manson, Joanna, Mansuri, Ahmer, Mantoglu, Baris, Manu, Nichola, Maqsood, Afnan, Marano, Alessandra, Marchbank, Adrian, Marcos-Santos, Pablo, Marrano, Enrico, Martin, Janet, Martin, Emmeline, Martin, Guy, Martin-Albo, Lorena, Martín-Román, Lorena, Martinelli, Fabio, Martínez-dePaz, Fernando, Martinez-German, Antonio, Martinez-Pinedo, Carlos, Martins, Ricardo, Marwan, Hisham, Marzi, Federica, Mathieu, Pierre, Matute-Najarro, Maria-Soledad, Maw, Andrew, Mazingi, Dennis, Mazzaferro, Vincenzo, McCanny, Andrew, McKenzie, Katherine, McLarty, Nicola, McPherson, Iain, Medina, Esther, Mediratta, Saniya, Medone, Marzia, Mehra, Gautam, Mele, Simone, Melero-Cortés, Lidia, Mendoza-Moreno, Fernando, Meneghini, Simona, Mercante, Giuseppe, Merdrignac, Aude, Merola, Stephen, Metallidis, Symeon, Michel, Martin, Migliore, Marco, Mihanovic, Jakov, Miller, Douglas, Mingoli, Andrea, Minto, Gary, Mirabella, Antonello, Misra, Nikhil, Mitrasinovic, Stefan, Miu, Victor, Moawad, Nader, Mochet, Sylvie, Modabber, Ali, Mohammad, Adam, Mohan, Midhun, Moliner-Sánchez, Carmen, Mongelli, Francesco, Monteleone, Michela, Montuori, Mauro, Moore, Rachel, Mora-Guzmán, Ismael, Morales, Xavier, Morales, Dieter, Morelli, Luca, Morelli, Lucia, Morgan, Richard, Morris, Chris, Mortini, Pietro, Mosca, Angelo, Motter, Dema, Moug, Susan, Mukherjee, Samrat, Najdy, Manhal, Nakas, Apostolos, Namazov, Ilgar, Naredla, Pradyumna, Nasef, Emmhamed, Nassa, Heeam, Nath, Rahul, Navarro-Sánchez, Antonio, Nazarian, Scarlet, Negri, Giampiero, Nehra, Deepika, Neil-Dwyer, Jason, Neri, Jacopo, Newton, Katy, Nikaj, Herald, Niquen, Milagros, Nobile, Sara, Nogueiro, Jorge, Ntirenganya, Faustin, Nugent, Michael, Núñez, Jordi, Ocaña, Juan, Okechukwu, Valentine, Oliva-Mompean, Fernando, Oliveira, Ana, Ollat, Didier, Onos, Lavinia, Osagie-Clouard, Liza, Osman, Khabab, Ottolina, Jessica, Ourieff, Jared, Outani, Oumaima, Oyewole, Bankole, Ozben, Volkan, Pacheco-Sanchez, David, Padilla-Valverde, David, Pai, Madhava, Paiella, Salvatore, Paisley, Samuel, Palini, Gianmarco, Palmeri, Matteo, Panahi, Pedram, Parente, Alessandro, Parlanti, Daniele, Parmar, Chetan, Pascual, Angela, Patel, Mahul, Pathak, Abhijit, Patil, Sangram, Pattyn, Piet, Peckham-Cooper, Adam, Pedrazzani, Corrado, Pellino, Gianluca, Peluso, Chiara, Pereira, André, Pereira-Neves, António, Perez-Diaz, MD, Pérez-González, Marta, Pérez-Saborido, Baltasar, Perivoliotis, Konstantinos, Perkins, Clare, Peros, Georgios, Perotto, Ornella, Perra, Teresa, Petrone, Patrizio, Phenix, George, Picazo, Sara, Picon-Rodriguez, Rafael, Piloni, Martina, Pingarrón-Martín, Lorena, Pinotti, Enrico, Pisanu, Adolfo, Pizzini, Paolo, Pockney, Peter, Podda, Mauro, Podolsky, Dina, Poggioli, Gilberto, Pompili, Cecilia, Pontari, Michael, Porcu, Alberto, Potter, Ryan, Price, Claire, Pruvot, François-René, Pujol-Muncunill, Roger, Puppo, Andrea, Quante, Markus, Quintana-Villamandos, Begoña, Qureshi, Ali, Radenkovic, Dejan, Rakvin, Ivan, Ramallo-Solís, Irene, Ramcharan, Sean, Ramos, Diego, Ramos-Bonilla, Antonio, Ramzi, Joussi, Rathinam, Sridhar, Rausa, Emanuele, Ravaioli, Matteo, Ravindran, Sharanya, Raymond, Thomas, Razik, Aisha, Redfern, Jennifer, Reguera-Rosal, Julio, Rela, Mariam, Rey-Biel, Juan, Rey-Valcarcel, Cristina, Ribolla, Marta, Richards, Tomos, Richmond, Michael, Righini, Erminio, Rio-Gomez, Javier, Riyat, Harjoat, Rizvi, Sana, Roberts, Keith, Roberts, Matthew, Robertson, Stuart, Robertson, Ronald, Robin-Valle, Alvaro, Rochon, Melissa, Rojo, Mikel, Rolli, Luigi, Romano, Silvio, Ross, Elizabeth, Ross, Howard, Rossborough, Catherine, Rottoli, Matteo, Ruiz-Grande, Fernando, Ruiz-Martin, Irene, Ruiz-Soriano, María, Ruzzenente, Andrea, Ryska, Ondrej, Saez, Carlos, Sagnotta, Andrea, Sahnan, Kapil, Sahni, Arun, Salim, Ali, Sallam, Ibrahim, Salvia, Roberto, Samadov, Elgun, Sammarco, Giuseppe, Sampaio-Alves, Mafalda, Sánchez-Arteaga, Alejandro, Sanchez-Fuentes, Maria-Nieves, Sanchez-Pelaez, Daniel, Sanchez-Perez, Coral, Sanchez-Rubio, Maria, Sancho-Muriel, Jorge, Sanders, Julie, Santero-Ramirez, Maria-Pilar, Santora, Thomas, Santoro, Antonio, Santos, Irene, Santos-Sousa, Hugo, Sapienza, Paolo, Sartarelli, Lodovico, Sarveswaran, Janahan, Sasia, Diego, Saudemont, Alain, Saudi-Moro, Sef, Saxena, Shobhit, Saxena, Dolly, Sayasneh, Ahmad, Scalabre, Aurelien, Schache, Andrew, Schiavina, Riccardo, Schineis, Christian, Schreckenbach, Teresa, Scorza, Antonella, Scott, Lucy, Seegert, Sara, Seguin-Givelet, Agathe, Senent-Boza, Ana, Seymour, Keith, Shabana, Amanda, Shah, Karishma, Shah, Jigar, Shah, Preena, Shah, Sujay, Shakir, Taner, Shalaby, Mostafa, Shankar, Sushma, Shaw, Richard, Shehata, Sameh, Shenfine, Amy, Sheridan, Kelda, Sherief, Ahmed, Sherief, Mohamed, Sherif, Mohamed, Shinkwin, Michael, Shu, Sebastian, Siaw-Acheampong, Kwabena, Sileri, Pierpaolo, Singh, Abhinav, Singh, Shailendra, Sinha, Sanjay, Sinha, Deepti, Siragusa, Leandro, Sivaprakasam, Rajesh, Sivayoganathan, Sriharan, Smillie, Robert, Smith, Claire, Smith, Andrew, Smith, Christopher, Sochorova, Dana, Soggiu, Fiammetta, Sohrabi, Catrin, Solari, Francesca, Solli, Piergiorgio, Soreide, Kjetil, Spinelli, Antonino, Spoletini, Domenico, Spriano, Giuseppe, Sravanam, Sanskrithi, Ssentongo, Paddy, Stanger, Sophie, Stavroulias, Dionisios, Steel, Ben, Stella, Marco, Stewart, Robbie, Stringer, Sally, Sulen, Nina, Sundar, Sudha, Sundhu, Matthew, Suri, Avni, Syed, Arooj, Szatmary, Peter, Tabiri, Stephen, Tadross, Daniel, Taglietti, Lucio, Tansey, Rosamond, Tartaglia, Dario, Tawheed, Ahmed, Tayeh, Salim, Teles, Tobias, Testa, Valentina, Tewari, Nilanjana, Thoenissen, Philipp, Thomas, Kane, Thomin, Anne, Thrush, Jessica, Tierney, Sean, Tiwari, Abhinav, Toh, Simon, Toledo, Enrique, Tonini, Valeria, Torkington, Jared, Torquati, Alfonso, Torzilli, Guido, Totty, Joshua, Tourountzi, Paraskevi, Tousidonis, Manuel, Townend, Philip, Townsend, Catherine, Trompeter, Alex, Trotta, Francesco, Truant, Stéphanie, Trujillo-Díaz, Jeancarlos, Tsoulfas, Georgios, Turco, Celia, Turrado-Rodriguez, Victor, Turri, Giulia, Tustin, Harry, Tyler, Jayne, Tzedakis, Stylianos, Tzovaras, George, Uittenbogaart, Martine, Ullah, Ramzan, Urban, Shane, Urbani, Alessia, Usai, Antonella, Vaccarella, Gianpaolo, Valdes-Hernandez, Javier, Valsecchi, Luca, Vashisht, Rajiv, Vázquez-Fernández, Andrea, Venn, Mary, Vera-Mansilla, Cristina, Vergari, Roberto, Vescio, Giuseppina, Vidya, Raghavan, Vieira, Paula, Vijay, Vardhini, Vimalachandran, Dale, Violante, Tommaso, Volpe, 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Aloka S D, Al Maadany, Faraj S, De Marchi, Joshua A, Ramos-De la Medina, Antonio, Mithany, Reda H M, Sanchez del Pueblo, Cristina, van Ramshorst, Gabriëlle, De Salas, Maria Marqueta, De Souza, Anthony C, Dolores Del Toro, M, Archer, James E, Odeh, Abdulrahman, Erridge, Simon, Salem, Hosni Khairy, Jones, Gareth P, Gardner, Anne, Tripathi, Shiva S, Gregg, Anne, Jeganathan, Reuben, Siddique, Muhammad Harris, Lombardi, Celestino P, Martin, Benjamin, Leo, Cosimo Alex, Dass, Debashis, Di Franco, Gregorio, Jiao, Long R, Mari, Giulio Maria, Capitan-Morales, Luis-Cristobal, Connelly, Tara M, Alanbuki, Ammar, De Virgilio, Armando, Schilling, Clare, San Miguel Mendez, Carlos, Kulkarni, Gauri, Nizami, Kulsoom, Walsh, Stewart, Dean, Harry, Ruiz-Marin, Miguel, Houston, Rory, Trompetto, Mario, Chrastek, David, Kouritas, Vasileios, Cannoletta, Maria, Rosato, Francesco, Kaushal, Manish V, Costa, Paulo Matos, Elkadi, Hannah H, Johnstone, Jack R, Irvine, Esmee, Alvarez, Maria R, Corbellini, Carlo, Venkatesan, Gowtham S, Mateo-Sierra, Olga, Martínez-Pérez, Carolina, Serrano González, Javier, Hernández Bartolomé, Miguel Ángel, Díaz Pérez, David, Gutiérrez Samaniego, María, Galindo Jara, Pablo, Sharma, Neil, Smart, Neil J, Keller, Deborah S, COVIDsurg Collaborative, [missing], Nepogodiev, Dmitri, Glasbey, James C, Li, Elizabeth, Omar, Omar M, Simoes, Joana FF, Abbott, Tom EF, Alser, Osaid, Arnaud, Alexis P, Bankhead-Kendall, Brittany K, Breen, Kerry A, Cunha, Miguel F, Davidson, Giana H, Di Saverio, Salomone, Gallo, Gaetano, Griffiths, Ewen A, Gujjuri, Rohan R, Hutchinson, Peter J, Kaafarani, Haytham MA, Lederhuber, Han, Löffler, Markus W, Mashbari, Hassan N, Minaya-Bravo, Ana, Morton, Dion G, Moszkowicz, David, Pata, Francesco, Tsoulfas, George, Venn, Mary L, Bhangu, Aneel, Cox, Daniel, Roslani, April C, Alakaloko, Felix, de Vries, Jean-Paul PM, Aaraj, Mahmoud A, Abbott, Sarah J, Abdalla, Mutwakil OM, Abdelaal, Ahmed S, Ademuyiwa, Adesoji O, Aherne, Thomas M, Ali, Osman M, Alkadeeki, Ghadah Z, Almeida, Ana C, Alrahawy, Mahmoud M, Ambler, Graeme K, Alameer, Ehab, Andreani, Stefano M, De Andrés-Asenjo, Beatriz, Antonanzas, Leyre Lopez, Aoun, Salah G, Ashoush, Fouad M, Augestad, Knut Magne, Avellana, Rocio B, Ayeni, Funbi A, Ayorinde, John OO, Babu, Bheemanakone H, Baig, Mirza MAS, Bajomo, Oreoluwa M, Baker, Olivia J, Baker, Markus P, Baldwin, Alexander J, Ban, Vin Shen, Baron, Ryan D, Barranquero, Alberto G, Barry, Conor P, DI Bartolomeo, Alessandro, Bass, Gary A, Bath, Michael F, Batjer, H Hunt, Beamish, Andrew J, Belgaumkar, Ajay P, Bence, Matthew N, Benson, Ruth A, Bernal-Sprekelsen, Juan Carlo, Bhama, Anuradha R, Bhavaraju, Avi V, Biffl, Walter L, Blundell, Chris M, Boddy, Alexander P, Borgstein, Alexander BJ, Bosanquet, David C, Bosch, Karen D, Bouhuwaish, Ahmad EM, Bozkurt, Mehmet A, Brathwaite, Collin EM, Brown, Benjamin C, Brown, Oliver D, Brown, Allison K, Buarque, Igor Lima, Bueno-Cañones, Alejandro D, Bulugma, Mustafa R, Burke, Joshua R, Byrne, Matthew HV, Cagigal-Ortega, Elima P, Callcut, Rachael A, DI Candido, Francesca, Canova, Michaela E, Carlos, William J, Caruana, Edward J, Cato, Liam D, Catton, Andrew B, Ceretti, Andrea Pisani, Chase, Thomas JG, Chiara, Francesco Di, Chowdhury, Abeed H, Chung, Eric A, Cicerchia, Pierfranco M, Clough, Ethan CS, Coleman, Natasha L, Collins, Chris G, Collins, Michelle L, Colonna, Emily T, Comini, Lara V, Connolly, Tara M, Coughlin, Patrick A, Cruzado, Laura Fernández-Gomez, Davidson, Brian R, Davies, Richard J, Davies, Emma J, Davis, Niall F, Dawson, Brett E, Dean, Benjamin JF, Delgado, Maria Garcia-Conde, Diaz, Jose J, Dickson, Kathryn E, Diez-Alonso, Manuel M, Dixon, Jan R, Doe, Matthew J, Drake, Thomas D, Drake, Frederick T, Duffy, John P, Dunne, Declan FJ, Dunne, Naomi JM, Durán-Muñoz-Cruzado, Virginia M, Durst, Alexander ZE, Eardley, Nicola J, Edwards, John G, Elfallal, Ahmed H, Elfiky, Mahmoud MA, Elliott, Jessie A, Emile, Sameh H, Emslie, Katy M, Endorf, Frederick W, Engel, Jamie L, Enjuto, Diego T, Etchill, Eric W, Evans, Jonathan P, Fahey, Brian A, Faria, Carlos S, Feo, Carlo V, Ferguson, Henry JM, Fernandez, Beatriz Dieguez, Fernandez, Andres Garcia, Fernández, Antonio J, Fernández-Pacheco, Borja Camacho, Fitzgerald, J Edward, Fonsi, Giovanni B, Font, Roser Farré, Fowler, Amy L, Franco, Gregorio Di, Fretwell, Kenneth R, Fructuoso, Lorena Sanchon, Fusai, Giuseppe K, Garcia, Miguel Hernandez, Garcia-Ureña, Miguel Angel, Gill, Charn K, Gisbertz, Suzanne S, Del Giudice, Roberto, Giuffrida, Maria Carmela, Di Giuseppe, Matteo, Gómez, María Fanjul, González, Javier Serrano, Guariglia, Claudio A, Hainsworth, Alison J, Hall, Bria J, Hall, James RW, Hammond, John S, Haqqani, Maha H, Harrison, Ewen M, Hazelton, Joshua P, van Heinsbergen, Maarten, Hill, Arnold DK, Hing, Caroline B, Hirji, Sameer A, Ho, Michael WS, Holbrook, Charlotte M, Holme, Thomas J, Hopkins, James C, Hopkinson, David N, Hossain, Fahad S, Hudson, Victoria E, Hughes, Jane L, Hwang, E. Shelley, Ibrahim, Mohamed AH, Isolani, Simone M, Jara, Pablo Galindo, Jenkinson, Michael D, Jenny, Hillary E, Jeyaretna, Deva S, Jones, Robert P, Jones, Andrew P, Jonker, Pascal KC, Jönsson, Maria L, Joyce, Doireann P, Kalkwarf, Kyle J, Kamarajah, Sivesh K, El Kassas, Mohamed, Kavanagh, Dara O, Keatley, James M, Khalefa, Mohamed A, Khan, Jim S, Kirmani, Bilal H, Kisiel, Aaron P, Kouris, Spyros Marino, Kowal, Mikolaj R, Labib, Peter L, Larkin, John O, Lauscher, Johannes C, Leclercq, Wouter KG, Ledesma, Frances SJ, Leite-Moreira, André M, Leung, Elaine YL, Lewis, Sophia E, Lima, Maria João, Lin, Daniel J, Liu, Helen H, Lowery, Aoife J, Lozano, Saida Martel, Luney, Catriona R, Maia, Mariana Magalhãe, Mariani, Nicolò M, Marino, Marco V, Marra, Angelo A, Marsh, Christopher L, Martin, Robert CG, Mccluney, Simon J, Mcintyre, Robert C, Mckay, Siobhan C, Mckevitt, Kevin L, Meagher, Ashley D, Mehdi, Mohammad Q, Mehigan, Brian J, Gonzalez-De Miguel, Melania, De Miguel-Ardevines, Maria-Carmen, Miguel-Mendez, Carlos San, Mills, Sarah J, Mohan, Helen M, Moir, John AG, Monson, John RT, Monteiro, Joana M, Montella, Maria T, Montesinos, Cristina Soto, Morgom, Marwa M, Moura, Francisco S, Muguerza, Jose M, Murphy, Suzanne H, De Nardi, Paola, Naumann, David N, Neary, Paul C, Neely, David TA, Ng-Kamstra, Joshua S, Ngu, Albert WT, Nguyen, Truong A, Nita, George E, Nunes, Quentin M, Nygaard, Rachel M, O'Meara, Lindsay B, O'Neill, John R, Okafor, Barbara U, Olson, Steven A, Oo, Aung Y, Ormazabal, Pablo Collera, Osorio, Alexander L, Pachl, Max J, Parry, James T, Patel, Panna K, Pérez, David Díaz, Pérez, Carolina Martínez, Pérez-Sánchez, Luis E, Pevidal, Ana Nogue, Pezzuto, Anna P, Philp, Matthew M, Pinkney, Thomas D, Pollok, Joerg M, Povey, Meical G, Poza, Alfredo Alonso, Rajgor, Amarkumar D, Rao, Jagan N, Raptis, Dimitri A, Rice, Henry E, Ridgway, Paul F, Rivas, Ana Munoz, Rodriguez-Sanjuan, Juan C, Rogers, Luke J, Da Roit, Anna, Rollett, Rebecca A, Romera, Jose L, Rooney, Siobhan M, Roxo, Vanessa I, Le Roy, Bertrand, Rubio, Eduardo E, Ruiz, Carolina Castro, Ruiz, Manuel Losada, Ryan, Éanna J, Saad, Abdel Rahman, Saeed, Samerah A, Salama, Hiba A, Salamah, Abdulrauf A, Samaniego, María Gutiérrez, Sampietro, Gianluca M, Sarma, Diwakar R, Schaffer, Kathryn B, Schnitzbauer, Andreas A, Scurrah, Rachel J, Serevina, Olivia L, Serralheiro, Pedro A, Sewards, Joseph M, Shackcloth, Michael J, Shaw, Abigail V, Sheel, Andrea RG, Sica, Giuseppe S, De Simone, Veronica, Singh, Aminder A, Singh, Rabindra P, Skelly, Brendan L, Smith, Henry G, Sohail, Amir H, Spalding, Duncan R, Springford, Laurie R, Ssentongo, Anna E, Steinkamp, Pieter J, Stevens, Kent A, Stewart, Grant D, Stylianides, Nicholas A, Sullivan, Tom BB, Taher, Ahmed SA, Tamimy, Muhammad S, Tang, Alethea M, Tebala, Giovanni D, Tejero-Pintor, Francisco J, Thaha, Mohamed A, Thomas, Amy J, De Toma, Giorgio, La Torre, Filippo, Torres, Antonio J, Townshend, David N, Trout, Isobel M, Tucker, Sarah C, Ubhi, Harmony K, Vega, Viviana A, Velmahos, George C, Velopulos, Catherine G, Viswanath, Yirupaiahgari KS, Vivas, Alfredo A, Wade, Ryckie G, Wadley, Martin S, Wall, Joshua JS, Walters, Andrew M, Warren, Oliver J, Weerasinghe, Chamindri K, Wilkin, Richard JW, Williams, Katherine J, Winter, Stuart C, Wormald, Justin CR, Wright, Franklin L, Xyda, Souzana E, Young, Alastair L, Youssef, Mina MG, Yousuf, Farhat B, El Youzouri, Hanan, Zappa, Marco A, Abate, Emmanuele, Abdalaziz, Hossam, Abdelkarim, Mostafa, Abdou, Hossam, Aboelkassem-Ibrahim, Ahmad, Abuown, Ala, Acebes-Garcia, Fernando, Acharya, Metesh, Adamina, Michel, Addae-Boateng, Emmanuel, Aftab, Raiyyan, Agarwal, Arnav, Aguilar, José, Ahmed, Yousra, Aitken, Emma, Al-Azzawi, Marwa, Al-Embideen, Somya, Al-Masri, Mahmoud, Al-Najjar, Hani, Al-Sukaini, Ahmad, Alam, Ruhina, Alderson, Derek, Aliyeva, Zumrud, Aljanadi, Fira, Almasri, Murad, Alonso-Ortuño, Paula, Altintoprak, Fatih, Amira, Gamal, Amjad, Rabbia, Anania, Gabriele, Andabaka, Tatjana, Angelou, Dimitrio, 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Fernando, Martinez-German, Antonio, Martinez-Pinedo, Carlo, Martins, Ricardo, Marwan, Hisham, Marzi, Federica, Mateos-Sierra, Olga, Mathieu, Pierre, Matute-Najarro, Maria-Soledad, Maw, Andrew, Mazingi, Denni, Mazzaferro, Vincenzo, Mccanny, Andrew, Mckenzie, Katherine, Mclarty, Nicola, Mcpherson, Iain, Medina, Esther, Mediratta, Saniya, Medone, Marzia, Mehra, Gautam, Mele, Simone, Melero-Cortés, Lidia, Mendoza-Moreno, Fernando, Meneghini, Simona, Mercante, Giuseppe, Merdrignac, Aude, Merola, Stephen, Metallidis, Symeon, Michel, Martin, Migliore, Marco, Mihanovic, Jakov, Miller, Dougla, Mingoli, Andrea, Minto, Gary, Mirabella, Antonello, Misra, Nikhil, Mitrasinovic, Stefan, Miu, Victor, Moawad, Nader, Mochet, Sylvie, Modabber, Ali, Mohammad, Adam, Mohan, Midhun, Moliner-Sánchez, Carmen, Mongelli, Francesco, Monteleone, Michela, Montuori, Mauro, Moore, Rachel, Mora-Guzmán, Ismael, Morales, Xavier, Morales, Dieter, Morelli, Luca, Morelli, Lucia, Morgan, Richard, Morris, Chri, Mortini, Pietro, Mosca, Angelo, Motter, Dema, Moug, Susan, Mukherjee, Samrat, Najdy, Manhal, Nakas, Apostolo, Namazov, Ilgar, Naredla, Pradyumna, Nasef, Emmhamed, Nassa, Heeam, Nath, Rahul, Navarro-Sánchez, Antonio, Nazarian, Scarlet, Negri, Giampiero, Nehra, Deepika, Neil-Dwyer, Jason, Neri, Jacopo, Newton, Katy, Nikaj, Herald, Niquen, Milagro, Nobile, Sara, Nogueiro, Jorge, Ntirenganya, Faustin, Nugent, Michael, Núñez, Jordi, Ocaña, Juan, Okechukwu, Valentine, Oliva-Mompean, Fernando, Oliveira, Ana, Ollat, Didier, Onos, Lavinia, Osagie-Clouard, Liza, Osman, Khabab, Ottolina, Jessica, Ourieff, Jared, Outani, Oumaima, Oyewole, Bankole, Ozben, Volkan, Pacheco-Sanchez, David, Padilla-Valverde, David, Pai, Madhava, Paiella, Salvatore, Paisley, Samuel, Palini, Gianmarco, Palmeri, Matteo, Panahi, Pedram, Parente, Alessandro, Parlanti, Daniele, Parmar, Chetan, Pascual, Angela, Patel, Mahul, Pathak, Abhijit, Patil, Sangram, Pattyn, Piet, Peckham-Cooper, Adam, Pedrazzani, Corrado, Pellino, Gianluca, 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Tomo, Richmond, Michael, Righini, Erminio, Rio-Gomez, Javier, Riyat, Harjoat, Rizvi, Sana, Roberts, Keith, Roberts, Matthew, Robertson, Stuart, Robertson, Ronald, Robin-Valle, Alvaro, Rochon, Melissa, Rojo, Mikel, Rolli, Luigi, Romano, Silvio, Ross, Elizabeth, Ross, Howard, Rossborough, Catherine, Rottoli, Matteo, Ruiz, Miguel, Ruiz-Grande, Fernando, Ruiz-Martin, Irene, Ruiz-Soriano, María, Ruzzenente, Andrea, Ryska, Ondrej, Saez, Carlo, Sagnotta, Andrea, Sahnan, Kapil, Sahni, Arun, Salim, Ali, Sallam, Ibrahim, Salvia, Roberto, Samadov, Elgun, Sammarco, Giuseppe, Sampaio-Alves, Mafalda, Sánchez-Arteaga, Alejandro, Sanchez-Fuentes, Maria-Nieve, Sanchez-Pelaez, Daniel, Sanchez-Perez, Coral, Sanchez-Rubio, Maria, Sancho-Muriel, Jorge, Sanders, Julie, Santero-Ramirez, Maria-Pilar, Santora, Thoma, Santoro, Antonio, Santos, Irene, Santos-Sousa, Hugo, Sapienza, Paolo, Sartarelli, Lodovico, Sarveswaran, Janahan, Sasia, Diego, Saudemont, Alain, Saudi-Moro, Sef, Saxena, Shobhit, Saxena, Dolly, 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Mendoza-Moreno F., Meneghini S., Mercante G., Merdrignac A., Merola S., Metallidis S., Michel M., Migliore M., Mihanovic J., Miller D., Mingoli A., Minto G., Mirabella A., Misra N., Mitrasinovic S., Miu V., Moawad N., Mochet S., Modabber A., Mohammad A., Mohan M., Moliner-Sanchez C., Mongelli F., Monteleone M., Montuori M., Moore R., Mora-Guzman I., Morales X., Morales D., Morelli L., Morgan R., Morris C., Mortini P., Mosca A., Motter D., Moug S., Mukherjee S., Najdy M., Nakas A., Namazov I., Naredla P., Nasef E., Nassa H., Nath R., Navarro-Sanchez A., Nazarian S., Negri G., Nehra D., Neil-Dwyer J., Neri J., Newton K., Nikaj H., Niquen M., Nobile S., Nogueiro J., Ntirenganya F., Nugent M., Nunez J., Ocana J., Okechukwu V., Oliva-Mompean F., Oliveira A., Ollat D., Onos L., Osagie-Clouard L., Osman K., Ottolina J., Ourieff J., Outani O., Oyewole B., Ozben V., Pacheco-Sanchez D., Padilla-Valverde D., Pai M., Paiella S., Paisley S., Palini G., Palmeri M., Panahi P., Parente A., Parlanti D., Parmar C., Pascual A., Patel M., Pathak A., Patil S., Pattyn P., Peckham-Cooper A., Pedrazzani C., Pellino G., Peluso C., Pereira A., Pereira-Neves A., Perez-Diaz M.D., Perez-Gonzalez M., Perez-Saborido B., Perivoliotis K., Perkins C., Peros G., Perotto O., Perra T., Petrone P., Phenix G., Picazo S., Picon-Rodriguez R., Piloni M., Pingarron-Martin L., Pinotti E., Pisanu A., Pizzini P., Pockney P., Podda M., Podolsky D., Poggioli G., Pompili C., Pontari M., Porcu A., Potter R., Price C., Pruvot F.-R., Pujol-Muncunill R., Puppo A., Quante M., Quintana-Villamandos B., Qureshi A., Radenkovic D., Rakvin I., Ramallo-Solis I., Ramcharan S., Ramos D., Ramos-Bonilla A., Ramzi J., Rathinam S., Rausa E., Ravaioli M., Ravindran S., Raymond T., Razik A., Redfern J., Reguera-Rosal J., Rela M., Rey-Biel J., Rey-Valcarcel C., Ribolla M., Richards T., Richmond M., Righini E., Rio-Gomez J., Riyat H., Rizvi S., Roberts K., Roberts M., Robertson S., Robertson R., Robin-Valle A., Rochon M., Rojo M., Rolli L., Romano S., Ross E., Ross H., Rossborough C., Rottoli M., Ruiz-Grande F., Ruiz-Martin I., Ruiz-Soriano M., Ruzzenente A., Ryska O., Saez C., Sagnotta A., Sahnan K., Sahni A., Salim A., Sallam I., Salvia R., Samadov E., Sammarco G., Sampaio-Alves M., Sanchez-Arteaga A., Sanchez-Fuentes M.-N., Sanchez-Pelaez D., Sanchez-Perez C., Sanchez-Rubio M., Sancho-Muriel J., Sanders J., Santero-Ramirez M.-P., Santora T., Santoro A., Santos I., Santos-Sousa H., Sapienza P., Sartarelli L., Sarveswaran J., Sasia D., Saudemont A., Saudi-Moro S., Saxena S., Saxena D., Sayasneh A., Scalabre A., Schache A., Schiavina R., Schineis C., Schreckenbach T., Scorza A., Scott L., Seegert S., Seguin-Givelet A., Senent-Boza A., Seymour K., Shabana A., Shah K., Shah J., Shah P., Shah S., Shakir T., Shalaby M., Shankar S., Shaw R., Shehata S., Shenfine A., Sheridan K., Sherief A., Sherief M., Sherif M., Shinkwin M., Shu S., Siaw-Acheampong K., Sileri P., Singh A., Singh S., Sinha S., Sinha D., Siragusa L., Sivaprakasam R., Sivayoganathan S., Smillie R., Smith C., Smith A., Sochorova D., Soggiu F., Sohrabi C., Solari F., Solli P., Soreide K., Spinelli A., Spoletini D., Spriano G., Sravanam S., Ssentongo P., Stanger S., Stavroulias D., Steel B., Stella M., Stewart R., Stringer S., Sulen N., Sundar S., Sundhu M., Suri A., Syed A., Szatmary P., Tabiri S., Tadross D., Taglietti L., Tansey R., Tartaglia D., Tawheed A., Tayeh S., Teles T., Testa V., Tewari N., Thoenissen P., Thomas K., Thomin A., Thrush J., Tierney S., Tiwari A., Toh S., Toledo E., Tonini V., Torkington J., Torquati A., Torzilli G., Totty J., Tourountzi P., Tousidonis M., Townend P., Townsend C., Trompeter A., Trotta F., Truant S., Trujillo-Diaz J., Turco C., Turrado-Rodriguez V., Turri G., Tustin H., Tyler J., Tzedakis S., Tzovaras G., Uittenbogaart M., Ullah R., Urban S., Urbani A., Usai A., Vaccarella G., Valdes-Hernandez J., Valsecchi L., Vashisht R., Vazquez-Fernandez A., Venn M., Vera-Mansilla C., Vergari R., Vescio G., Vidya R., Vieira P., Vijay V., Vimalachandran D., Violante T., Volpe A., Vovola F., Vulliamy P., Wall R., Wallwork K., Ward A., Warwick D., Waseem S., Weaver H., Wells F., Wen J., West R., Whitehall E., Wild L., Wilkins A., Williams G., Williams M., Winnand P., Wong K., Worku D., Wright N., Yalamanchili S., Yershov D., Yildiz A., Young R., Yurttas C., Zadegan F., Zafar N., Zakaria R., Zambon M., Zanini N., Zarate A., Zerbib P., Zizzo M., Zmora O., Zonta S., van Berge Henegouwen M.I., van der Plas W.Y., Ali I.A.M., Bakri N.A.C., Bauset J.C.C., Abou Chaar M.K., Marino Cosentino L.M., Gomez Diaz C.J., Garcia Galocha J.L., de Gheldere C.A., Ataide Gomes G.M., Beltran de Heredia J., Blazer III D.G., Nugent III W.C., Ali karar A.A., Borja De Lacy F., Blas Laina J.L., Shane Lester M.J., Liyanage A.S.D., Al Maadany F.S., De Marchi J.A., Ramos-De la Medina A., Mithany R.H.M., Sanchez del Pueblo C., van Ramshorst G.H., De Salas M.M., De Souza A.C., Dolores Del Toro M., Archer J.E., Odeh A., Erridge S., Salem H.K., Jones G.P., Gardner A., Tripathi S.S., Gregg A., Jeganathan R., Siddique M.H., Lombardi C.P., Martin B., Leo C.A., Dass D., Di Franco G., Jiao L.R., Mari G.M., Capitan-Morales L.-C., Connelly T.M., Alanbuki A., De Virgilio A., Schilling C., San Miguel Mendez C., Kulkarni G., Nizami K., Walsh S., Dean H., Ruiz-Marin M., Houston R., Trompetto M., Chrastek D., Kouritas V., Cannoletta M., Rosato F., Kaushal M.V., Costa P.M., Elkadi H.H., Johnstone J.R., Irvine E., Alvarez M.R., Corbellini C., Venkatesan G.S., Mateo-Sierra O., Martinez-Perez C., Serrano Gonzalez J., Hernandez Bartolome M.A., Diaz Perez D., Gutierrez Samaniego M., Galindo Jara P., Sharma N., Smart N.J., Keller D.S., AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, Graduate School, Almaadany, F. S., Samadov, E., Namazov, I., Jafarova, S., Ramshorst, G. H. V., Pattyn, P., Desender, L., Gheldere, C. A. D., Duchateau, N., Mihanovic, J., Sulen, N., Andabaka, T., Rakvin, I., Bakmaz, B., Smith, H. G., Jonsson, M. L., Kassas, M. E., Tawheed, A., Shehata, S., Ashoush, F. M., Abdelaal, A. S., Elfiky, M. M. A., Emile, S. H., Elfallal, A. H., Elfeki, H., Shalaby, M., Alrahawy, M. M., Sallam, I., Amira, G., Sherief, A., Sherief, M., Lakkis, Z., Doussot, A., Turco, C., Heyd, B., Mathieu, P., Chebaro, A., Lecolle, K., Zerbib, P., Truant, S., Saudemont, A., Pruvot, F. -R., Arnaud, A. P., Bergeat, D., Merdrignac, A., Scalabre, A., Roy, B. L., Perotto, O., Tzedakis, S., Gaujoux, S., Dousset, B., Moszkowicz, D., Bretagnol, F., Hervieux, E., Maisonneuve, E., Clermidi, P., Aubry, E., Thomin, A., Seguin-Givelet, A., Zadegan, F., Conso, C., Ollat, D., Kamphues, C., Lauscher, J. C., Schineis, C., Schnitzbauer, A. A., Thoenissen, P., Youzouri, H. E., Schreckenbach, T., Nguyen, T. A., Modabber, A., Holzle, F., Winnand, P., Konigsrainer, A., Quante, M., Yurttas, C., Loffler, M. W., Klimopoulos, S., Tzovaras, G., Baloyiannis, I., Perivoliotis, K., Lostoridis, E., Tourountzi, P., Marchi, J. A. D., Farrell, T., Davis, N. F., Kearney, D., Larkin, J. O., Mohan, H. M., Mehigan, B. J., Fahey, B. A., Barry, C. P., Elliott, J. A., Bass, G. A., Connelly, T. M., Kavanagh, D. O., Elkady, R., Neary, P. C., Ridgway, P. F., Joyce, D. P., Tierney, S., Boyle, E., Egan, B., Lowery, A. J., Collins, C. G., Hogan, A., Mckevitt, K. L., Ryan, E. J., Fowler, A. L., Aherne, T. M., Nizami, K., Walsh, S., Zmora, O., Kugler, N., Falco, G., Ruiz, C. C., Mele, S., Annessi, V., Ferrari, G., Montella, M. T., Mariani, N. M., Ceretti, A. P., Lomiento, D., Taglietti, L., Giudice, R. D., Compagnoni, B., Dester, S., Granieri, S., Cotsoglou, C., Campagnaro, T., Turri, G., Guglielmi, A., Ruzzenente, A., Pedrazzani, C., Salvia, R., Paiella, S., Nobile, S., Marino, M. 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C., Palini, G., Garulli, G., Ballabio, M., Bisagni, P., Pizzini, P., Gagliano, A., Armao, T., Longhi, M., Madonini, M., Luraghi, M., Galimberti, L., Romano, S., Bastazza, M., Trotta, F., Gipponi, M., Malabarba, S., Centinaio, G., Mochet, S., Usai, A., Grivon, M., Barmasse, R., Sagnotta, A. S., Marino, L. M. P., Galleano, R., Malerba, M., Baldo, S., Ligure, P., Casati, M., Abate, E., Laface, L., Brianza, C., Lizzi, V., Vovola, F., Arminio, A., Vergari, R., Rausa, E., Bianco, F., Lucianetti, A., Guaitoli, E., Pinotti, E., Carissimi, F., Montuori, M., Baronio, G., Campanelli, M., Sica, G. S., Siragusa, L. S., Lapolla, P., Mingoli, A., Toma, G. D., Fiori, E., Torre, F. L., Sapienza, P., Brachini, G., Cirillo, B., Iannone, I., Zambon, M., Chiappini, A., Meneghini, S., Fonsi, G. B., Cicerchia, P. M., Bruzzaniti, P., Santoro, A., Bartolomeo, A. 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S., Ganau, M., Chidambaram, S., Sravanam, S., Sinha, S., Smillie, R., Shah, K., Shankar, S., Dunstan, M., Beak, P., Gerogiannis, I., Jones, G. P., Gardner, A., Tripathi, S. S., Boddy, A. P., Hossain, T., Ashmore, C., Annamalai, S., Irvine, E., Kourdouli, A., Kirmani, B. H., Shackcloth, M. J., Harky, A., Stylianides, N. A., Abdalla, M. O., Newton, K., Bajomo, O. M., Rizvi, S., Darko, E., Saad, A. R., Li, Z., Motter, D., Hurt, L., Egan, R., Harries, R., Youssef, M. M. G., Evans, L., Chrastek, D., Kouritas, V., Shah, J., Anthoney, J., Amjad, R., Harrison, J., Mabrouk, I., Hebblethwaite, B., Emmerson, O., Bosch, K. D., Kalidindi, V., Bashkirova, V., Edwards, J. G., Rao, J. N., Hopkinson, D. N., Chetty, G., Forlani, S., Guha, S., Sherif, M., Giblin, A. -V., Lye, G., Whitehall, E., Blundell, C. M., Ward, A., Tadross, D., Wells, F., Majkowski, L., Townshend, D. N., Mills, S. J., Seymour, K., Shenfine, A., Mclarty, N., Kashora, F., Lewis, S. E., Ubhi, H. K., Exley, R., Singh, A., Basgaran, A., Bartsch, A. -M., Okechukwu, V., Basha, A., Barmpagianni, C., Gallagher, P., Khan, U., Maqsood, A., Shah, P., Saxena, S., Sahnan, K., Siddique, M. H., Leo, C. A., Zafar, N., Rollett, R. A., Collins, M. L., Tamimy, M. S., Riyat, H., Neil-Dwyer, J., Wen, J., Burnside, N., Weaver, H., Hawari, M., Addae-Boateng, E., Duffy, J. P., Dean, B. J. F., Luney, C. R., Sarveswaran, J., Patil, S., Ravindran, S., Scott, L., Michel, M., Toh, S., Ahmed, Y., Vijay, V., Shakir, T., Hasan, R., Tansey, R., Alanbuki, A., Patel, M., Shabana, A., Paisley, S., Khan, J. S., Griffiths, E. A., Kisiel, A. P., Kamal, M., Cato, L. D., Parente, A., Kulkarni, R., Saeed, S. A., Mak, J., Liew, I., Al-Sukaini, A., Saxena, D., Mediratta, S., Ali, I. A. M., Smith, A., Fell, A., English, C., Kristinsson, S., Goatly, G., Halkias, C., Evans, J., Glen, P., Al-Azzawi, M., Aitken, E., Mukherjee, S., Singh, S., English, W., Vulliamy, P., Karam, E., Chui, K., Mansuri, A., Sivayoganathan, S., Aaraj, M. A., El-Ali, A., Chowdhury, A. H., Worku, D., Hampton, M., Manson, J., Findlay, L., Majkowska, A., Brixton, G., Potter, R., De Souza, A. C., Rochon, M., Cannoletta, M., Bhalla, A., Daliya, P., Chia, Z., Pollok, J. M., Raptis, D. A., Davidson, B. R., Fusai, G. K., Xyda, S. E., Soggiu, F., Machairas, N., Bosanquet, D. C., Tang, A. M., Beamish, A. J., Nassa, H., Price, C., Williams, G., Magowan, D., Solari, F., Davies, E. J., Ryska, O., Hawkin, P., Raymond, T., Baron, R. D., Szatmary, P., Gahunia, S., Thomas, A. J., Dunne, D. F. J., Nita, G. E., Sochorova, D., Sivaprakasam, R., Venn, M. L., Ledesma, F. S. J., Thaha, M. A., Sullivan, T. B. B., Parry, J. T., Baumber, R., Archer, J. E., Odeh, A., Stewart, R., Ullah, R., Armstrong, L., Jones, M., Aljanadi, F., Moawad, N., Gregg, A., Jeganathan, R., Ferguson, H. J. M., Ramcharan, S., Yershov, D., Hopkins, J. C., Doe, M. J., Ambler, G. K., Lostis, E., Lawday, S., Babu, B. H., Liyanage, A. S. D., Weerasinghe, C. K., Blake, I., Sanders, J., Bueser, T., Curtis, M., Oo, A. Y., Abbott, T. E. F., Anwar, S., Sohrabi, C., Williams, K. J., Chung, E. A., Hagger, R., Karim, A., Hainsworth, A. J., Flatman, M., Hing, C. B., Trompeter, A., Lo, T., Wade, R. G., Bourke, G., Burke, J. R., Young, A. L., Wall, J. J. S., Johnstone, J. R., Peckham-Cooper, A., Elkadi, H. H., Kowal, M. R., Pompili, C., Ho, M. W. S., Kinross, J., Ibrahim, M. A. H., Abuown, A., Denning, M., Erridge, S., Yalamanchili, S., Martin, G., Hall, C., Hall, J. R. W., Baldwin, A. J., Gammeri, E., West, R., Wormald, J. C. R., Catton, A. B., Kudsk-Iversen, S., Kouris, S. M., Nugent, M., Lin, D. J., Kang, C., Scurrah, R. J., Rajgor, A. D., Steel, B., Day, A., Belgaumkar, A. P., Oyewole, B., Gilbert, C., Dass, D., Ford, D., Duff, S., Khan, A., Asaad, P., Brown, B. C., Jenkinson, M. D., Zakaria, R., Elmoslemany, T., Parmar, C., Mccluney, S. J., Shah, S., Kalavrezos, N., Sinha, D., Schilling, C., Tewari, N., Dunne, N. J. M., Carlos, W. J., Gill, C. K., Godbole, C., Dickson, K. E., Khajuria, A., Connolly, H., Naredla, P., Sarma, D. R., Robertson, S., Morris, C., Richards, T., Torkington, J., Williams, M., Shinkwin, M., Jayaraju, U., Singh, R. P., Aftab, R., Warwick, D., Khalefa, M. A., Hossain, F. S., Osman, K., Andreani, S. M., Bath, M. F., Sahni, A., Judkins, N., Springford, L. R., Wadley, M. S., Tyler, J., Wild, L., Wall, R., Jenner, E., Chamberlain, S., Thrush, J., Brain, J., Townsend, C., Stringer, S., Breckles, L., Flindall, I., Phenix, G., Thomas, K., Young, R., Macdonald, L., Green, S., Miu, V., Sheridan, K., Onos, L., Monson, J. R. T., Drake, F. T., Haqqani, M. H., Cooper, Z., Salim, A., Hirji, S. A., Brown, A. K., Chung, C., Hansen, L., Okafor, B. U., Roxo, V. I., Rice, H. E., Hwang, E. S., Blazer, D. G., Hall, B. J., Olson, S. A., Nehra, D., Cuschieri, J., Davidson, G. H., Walters, A. M., Nygaard, R. M., Colonna, E. T., Endorf, F. W., Meagher, A. D., Kinnaman, G., Mckenzie, K., Fretwell, K. R., Chan, J., Nugent, W. C., Chen, D., Stevens, K. A., Etchill, E. W., Jenny, H. E., Dehal, A., Kaafarani, H. M., Breen, K. A., Bankhead-Kendall, B. K., Alser, O., Mashbari, H. N., Velmahos, G. C., Chang, G., Dehart, D., Ourieff, J., Merola, S., Volpe, A., Podolsky, D., Coleman, N. L., Callahan, M., Brathwaite, C. E. M., Liu, H. H., Petrone, P., Baltazar, G., Hakmi, H., Sohail, A. H., Hazelton, J. P., Ssentongo, A. E., Ssentongo, P., Jamil, T., Al-Embideen, S., Seegert, S., Torquati, A., Bhama, A. R., Biffl, W. L., Schaffer, K. B., Marsh, C. L., Philp, M. M., Ross, H., Santora, T., Pathak, A., Sewards, J. M., Pontari, M., Engel, J. L., Giorgakis, E., Bhavaraju, A. V., Kalkwarf, K. J., Roberts, M., Robertson, R., Callcut, R. A., Canova, M. E., Suri, A., Velopulos, C. G., Carmichael, H., Mcintyre, R. C., Wright, F. L., Urban, S., Martin, R. C. G., Bhutiani, N., Diaz, J. J., Abdou, H., O'Meara, L. B., Richmond, M., Almasri, M., Marwan, H., Mehdi, M. Q., Kulkarni, G., Ban, V. S., Aoun, S. G., Batjer, H. H., Bhangu, A., Guided Treatment in Optimal Selected Cancer Patients (GUTS), Robotics and image-guided minimally-invasive surgery (ROBOTICS), and Universidad de Cantabria
Subjects: Male, Emergency Medical Services, Respiratory Tract Diseases, Coronavirus Infections/complications, sars cov2, Settore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIO, 030204 cardiovascular system & hematology, SARS-CoV-2, acute respiratory syndrome, pulmonary complication, 0302 clinical medicine, Postoperative Complications, Retrospective Studie, CONSENSUS DEFINITIONS, Epidemiology, Medicine and Health Sciences, Medicine, Surgery, Postoperative complications, Mortality, COVID-19, 030212 general & internal medicine, Hospital Mortality, Viral, Respiratory Tract Disease, 11 Medical and Health Sciences, Mortality rate, Covid19, Operative/adverse effects, General Medicine, Middle Aged, Elective Surgical Procedures/adverse effects, Operative, Elective Surgical Procedures, Surgical Procedures, Operative, Female, COVID-19. Global surgery. Perioperative SARS-CoV-2 infection. International cohort study, Coronavirus Infections, Human, Cohort study, Surgical Procedures, Operative/adverse effects, Adult, medicine.medical_specialty, Respiratory Tract Diseases/etiology, Pneumonia, Viral, NO, COVIDSurg Collaborative, 03 medical and health sciences, Viral/complications, Betacoronavirus, Young Adult, General & Internal Medicine, Humans, Mortality, Elective surgery, Pandemics, LS7_4, Aged, Retrospective Studies, Surgical Procedures, Betacoronaviru, Elective Surgical Procedure, Pandemic, Coronavirus Infection, Emergency Medical Service, business.industry, No key words available, Postoperative complication, COVID-19, Retrospective cohort study, Odds ratio, Perioperative, Pneumonia, Surgery, Pneumonia, Viral/complications, Postoperative Complication, business
Abstract: The lancet 396(10243), 27-38 (2020). doi:10.1016/S0140-6736(20)31182-X, Published by Elsevier, London [u.a.]
Published: 2020
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10. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs

Author: Sønderby, Ida E, Ching, Christopher R K, Ayesa-Arriola, Rosa, Thompson, Paul M, Bearden, Carrie E, Andreassen, Ole A, Group, ENIGMA-CNV Working, 2 Deletion Syndrome Working Group, ENIGMA 22q11., Bernard, Manon, Blackburn, Nicholas B, Bøen, Rune, de Geus, Eco, de Zwarte, Sonja M C, Bakker, Geor, Forti, Marta Di, Frei, Oleksandr, Fukunaga, Masaki, Hehir-Kwa, Jayne Y, Hillegers, Manon H J, Hoffmann, Per, Homuth, Georg, Jahanshad, Neda, Koops, Sanne, Kumar, Kuldeep, Bassett, Anne S, Kikuchi, Masataka, Le Hellard, Stephanie, Leu, Costin, Murray, Robin M, Naerland, Terje, Nyberg, Lars, Ophoff, Roel A, Pike, G Bruce, Sando, Sigrid B, Shin, Jean, Boomsma, Dorret I, Shumskaya, Elena, Sisodiya, Sanjay M, Steen, Vidar M, Teumer, Alexander, Uhlmann, Anne, Wright, Margaret J, Antshel, Kevin M, Campbell, Linda E, Crossley, Nicolas A, Crowley, T Blaine, Bülow, Robin, Daly, Eileen, Fiksinski, Ania M, Forsyth, Jennifer K, Fremont, Wanda, Goodrich-Hunsaker, Naomi J, Gudbrandsen, Maria, Jonas, Rachel K, Kates, Wendy R, Lin, Amy, McCabe, Kathryn L, Butcher, Nancy J, Moss, Hayley, Murphy, Declan G, Murphy, Kieran C, Owen, Michael J, Ruparel, Kosha, Simon, Tony J, van Amelsvoort, Therese, Vorstman, Jacob A S, Calhoun, Vince D, Caspers, Svenja, Chow, Eva W C, Cichon, Sven, Thomopoulos, Sophia I, Ciufolini, Simone, Craig, Michael C, Crespo-Facorro, Benedicto, Cunningham, Adam C, Dale, Anders M, Dazzan, Paola, de Zubicaray, Greig I, Djurovic, Srdjan, Doherty, Joanne L, Donohoe, Gary, van der Meer, Dennis, Draganski, Bogdan, Durdle, Courtney A, Ehrlich, Stefan, Emanuel, Beverly S, Espeseth, Thomas, Fisher, Simon E, Ge, Tian, Glahn, David C, Grabe, Hans J, Gur, Raquel E, Sun, Daqiang, Gutman, Boris A, Haavik, Jan, Håberg, Asta K, Hansen, Laura A, Hashimoto, Ryota, Hibar, Derrek P, Holmes, Avram J, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E, Jalbrzikowski, Maria, Villalon-Reina, Julio E, Knowles, Emma E M, Kushan, Leila, Linden, David E J, Liu, Jingyu, Lundervold, Astri J, Martin-Brevet, Sandra, Martínez, Kenia, Mather, Karen A, Mathias, Samuel R, McDonald-McGinn, Donna M, Agartz, Ingrid, McRae, Allan F, Medland, Sarah E, Moberget, Torgeir, Modenato, Claudia, Monereo Sánchez, Jennifer, Moreau, Clara A, Mühleisen, Thomas W, Paus, Tomas, Pausova, Zdenka, Prieto, Carlos, Amunts, Katrin, Ragothaman, Anjanibhargavi, Reinbold, Céline S, Reis Marques, Tiago, Repetto, Gabriela M, Reymond, Alexandre, Roalf, David R, Rodriguez-Herreros, Borja, Rucker, James J, Sachdev, Perminder S, Schmitt, James E, Arango, Celso, Schofield, Peter R, Silva, Ana I, Stefansson, Hreinn, Stein, Dan J, Tamnes, Christian K, Tordesillas-Gutiérrez, Diana, Ulfarsson, Magnus O, Vajdi, Ariana, van 't Ent, Dennis, van den Bree, Marianne B M, Armstrong, Nicola J, Vassos, Evangelos, Vázquez-Bourgon, Javier, Vila-Rodriguez, Fidel, Walters, G Bragi, Wen, Wei, Westlye, Lars T, Wittfeld, Katharina, Zackai, Elaine H, Stefánsson, Kári, Jacquemont, Sebastien, the ENIGMA-CNV Working Group, the ENIGMA 22q11.2 Deletion Syndrome Working Group, Stochastics, Biological Psychology, APH - Mental Health, APH - Methodology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, ENIGMA-CNV Working Group, ENIGMA 22q11.2 Deletion Syndrome Working Group, and Universidad de Cantabria
Subjects: Review Article, genetics [Mental Disorders], 0302 clinical medicine, genetics-first approach, pathology [Brain], Multicenter Studies as Topic, Copy-number variation, Review Articles, education.field_of_study, brain structural imaging, Radiological and Ultrasound Technology, genetics [Neurodevelopmental Disorders], Mental Disorders, neurodevelopmental disorders, 05 social sciences, growth & development [Brain], Brain, pathology [Mental Disorders], Cognition, Human brain, diffusion tensor imaging, Magnetic Resonance Imaging, diagnostic imaging [Neurodevelopmental Disorders], medicine.anatomical_structure, psychiatric disorders, Neurology, Anatomy, medicine.medical_specialty, Brain development, DNA Copy Number Variations, Population, Neuroimaging, Biology, 050105 experimental psychology, 03 medical and health sciences, evolution, medicine, pathology [Neurodevelopmental Disorders], Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Deletion syndrome, copy number variant, ddc:610, genetics‐first approach, education, Psychiatry, diagnostic imaging [Brain], Neurology (clinical), Working group, 030217 neurology & neurosurgery, diagnostic imaging [Mental Disorders]
Abstract: The Enhancing NeuroImaging Genetics through Meta‐Analysis copy number variant (ENIGMA‐CNV) and 22q11.2 Deletion Syndrome Working Groups (22q‐ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA‐CNV WG has collated CNV and magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one of the largest studies to date on the effects of CNVs on brain structures in the general population. The 22q‐ENIGMA WG includes 12 international research centers that assessed over 533 individuals with a confirmed 22q11.2 deletion syndrome, 40 with 22q11.2 duplications, and 333 typically developing controls, creating the largest‐ever 22q11.2 CNV neuroimaging data set. In this review, we outline the ENIGMA infrastructure and procedures for multi‐site analysis of CNVs and MRI data. So far, ENIGMA has identified effects of the 22q11.2, 16p11.2 distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and cortical brain structures. Each CNV is associated with differences in cognitive, neurodevelopmental and neuropsychiatric traits, with characteristic patterns of brain structural abnormalities. Evidence of gene‐dosage effects on distinct brain regions also emerged, providing further insight into genotype–phenotype relationships. Taken together, these results offer a more comprehensive picture of molecular mechanisms involved in typical and atypical brain development. This “genotype‐first” approach also contributes to our understanding of the etiopathogenesis of brain disorders. Finally, we outline future directions to better understand effects of CNVs on brain structure and behavior., The enhancing neuroimaging genetics through meta‐analysis (ENIGMA) copy number variant (CNV) and 22q11.2 Working Groups focus on gaining insight into how rare genetic variants affect human brain development, cognition, and behavior. The two ENIGMA working groups have collated CNV and brain‐imaging data from numerous individuals, gathered by numerous international research centers, and analyzed this data with standardized processing and analysis pipelines. Future directions for the ENIGMA CNV and 22q11.2 working groups are to analyze CNVs with larger sample sizes and more imaging modalities to better understand how rare genetic variants affect the brain, and their clinical and behavioral consequences.
Published: 2021
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10 results on '"Hansen, Laura A."'

1. Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the ENIGMA working groups on CNVs

2. Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics

3. Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study

4. Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size

5. Reciprocal Copy Number Variations at 22q11.2 Produce Distinct and Convergent Neurobehavioral Impairments Relevant for Schizophrenia and Autism Spectrum Disorder

6. Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness

7. Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry

8. Spatial working memory in neurofibromatosis 1: Altered neural activity and functional connectivity.

9. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

10. Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs

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