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Transcatheter aortic valve implantation and implantation of other transcatheter heart valves, generally requires insertion of a temporary venous pacemaker. Implantation of a temporary venous pacemaker adds complexity, time and risk to the procedure. Guidewire modification to allow pacing is increasingly popular, however it requires technical expertise and provides unipolar pacing resulting in high thresholds and potential capture loss. The Wattson temporary pacing guidewire is a novel device which offers guidewire support for valve delivery and concomitant bipolar pacing. It may offer a safe and effective solution to guidewire pacing for transcatheter aortic valve implantation and other transcatheter heart valve implantations. Herein, we review the literature surrounding left ventricular guidewire pacing along with the features and clinical data of the Wattson wire.Replacing a heart valve, such as in transcatheter aortic valve implantation, requires the use of a pacemaker. This is often inserted through the veins into the opposite side of the heart to the valve being replaced. However, this method adds risk, time and complexity. New technologies have been developed to simplify this process, by using one wire in only one side of the heart to stimulate the heart muscle and support the valve replacement. The Wattson wire is a new device which acts this way and promises to make the transcatheter aortic valve implantation procedure safer and more efficient.

Background Young men who have sex with men (YMSM) are disproportionately impacted by the HIV epidemic in the USA, and a large number of new infections among YMSM occur in the context of main or primary partnerships. At the same time, healthy romantic relationships promote health and wellbeing by improving social support and encouraging healthy behaviors. Thus, we created 2GETHER: a relationship education and HIV prevention program for young male couples. 2GETHER is delivered face-to-face in a university setting and is composed of two group sessions and two individualized skills coaching sessions. We observed strong support of the feasibility, acceptability, and preliminary efficacy of 2GETHER in a pilot trial. Methods We are conducting an attention-matched randomized controlled trial (RCT) to test the efficacy of 2GETHER relative to a control condition based on a well-validated positive affect enhancement program. Enrollment occurred between August 2017 and March 2021 in Chicago and surrounding areas, and we enrolled and randomized 128 dyads (N = 256 individuals). Follow-up is ongoing and we will examine primary and secondary behavioral outcomes at 12 months post-intervention, with interim follow-up at 3, 6, and 9 months post-intervention. The primary biomedical outcome is sexually transmitted infection incidence at a 12-month follow-up. Discussion 2GETHER is innovative in that it places an equal emphasis on relationship skill building and HIV prevention. Thus, the program has the potential to impact numerous health-related outcomes. Despite challenges related to the recruitment of couples and the COVID-19 pandemic, we were able to enroll a robust sample of young male couples with sufficient power to detect effects on study outcomes. Trial registration ClinicalTrials.gov NCT03186534.

Introduction\ud Patient safety within dental education is paramount. Wrong‐site surgery (WSS) tooth extraction is not uncommon and is a significant never event (NE) in dentistry. This study aimed to explore dental schools’ undergraduate experience of NEs, safety interventions implemented and the impact on student experience.\ud \ud Methods\ud All 16 UK dental schools were surveyed via email.\ud \ud Results\ud The response rate was 100%. A modified World Health Organization (WHO) checklist was used within institutions (94%) including pre‐operative briefings and recording teeth on whiteboards (81%, respectively). Students were directly supervised performing extractions (63%) utilising a 1:4 staff: student ratio. WSS by students was reported in 69% of schools, with student experience being impacted by an increased patient safety focus.\ud \ud Discussion\ud This study demonstrated an increased utilisation of an adapted WHO checklist. Modification of practices to ensure patient safety was demonstrated at all schools, irrespective of student WSS occurrences. Institutions experiencing student NEs commonly implemented WHO checklists and recording teeth for extraction on whiteboards. Other strategies included direct staff supervision and pre‐operative briefings.\ud \ud Conclusion\ud UK dental schools have increased the emphasis on patient safety by the implementation of national healthcare models, for example WHO checklists and pre‐operative briefings. These strategies both aim to improve communication and teamwork. Increased levels of staff supervision foster greater quality of teaching; however, this has resulted in reduced student clinical experience. A proposed minimum standard for undergraduate surgery is suggested to ensure safe and competent dental practitioners of the future.

Aortic insufficiency resulting from radiofrequency (RF) ablation of the left ventricular outflow tract (LVOT) is a rarely reported complication. We describe a 56-year-old man with a significant burden of premature ventricular contractions (PVCs) who underwent unsuccessful LVOT RF ablation and suffered iatrogenic aortic valve injury producing severe aortic insufficiency. He required aortic valve replacement in the setting of a redo sternotomy and ischemic cardiomyopathy. Intraoperative transesophageal echocardiography demonstrated diastolic prolapse of a coronary leaflet and a defect in the right coronary leaflet base. Physical inspection of the valve confirmed the echocardiography findings and revealed extensive damage to the noncoronary and right coronary leaflets. These findings suggest that the trauma of extensive RF ablation was the culprit responsible for the iatrogenic aortic valve damage and not a mechanical, catheter-induced injury.

The relationship between interpersonal distress and psychological health was investigated using a sample of 185 college undergraduates. Subjects completed the Inventory of Interpersonal Problems (a measure of interpersonal distress), the Personal Orientation Inventory (a measure of self-actualization), and the Miller Social Intimacy Scale (a measure of interpersonal closeness). The mean of scores on the Inventory of Interpersonal Problems was compared with the mean of the clinical sample reported in 1988 by Horowitz, et al. The measures of psychological health were correlated with the Inventory of Interpersonal Problems total and with the octant scales of the Inventory of Interpersonal Problems-Circumplex version. The measures were also projected onto the circumplex to summarize their interpersonal connotations.

Baron, Jean-Claude*Black, Sandra E.Butler, Andrew J.Carey, JamesChollet, FrancoisCohen, Leonardo G.*Corbetta, MaurizioCramer, Steven C.*Dobkin, Bruce H.*Frackowiak, RichardHeiss, W.D.Johansen-Berg, Heidi*Krakauer, John W.Lazar, Ronald M.Lennihan, Laura L.Loubinoux, Isabelle*Marshall, Randolph S.*Matthews, PaulMohr, J.P.Nelles, GereonPascual-Leone, AlvaroPomeroy, ValerieRijntjes, MichelRossini, Paolo MariaRothwell, John C.Seitz, Rudiger J.Small, Steven L.Sunderland, AlanWard, N.S.*Weiller, CorneliusWise, Richard J.S.IntroductionThe First International Workshop on Neuroimagingand Stroke Recovery was convened in February, 2004 inNew York City. The purpose of the workshop was to de-scribe the state of the field with regard to technical andanalytical methods, to discuss the use of complementaryimaging modalities, and to assess the current potential toapply functional neuroimaging to the development of ratio-nal treatment strategies for enhanced stroke recovery.Presented herein is a summary statement of topics dis-cussed at the workshop. These included (i) the clinical rel-evance of functional imaging changes after stroke for themotor and language systems; (ii) the technical challengesfaced in moving towards establishing functional neuro-imaging as a clinically useful tool; (iii) the contributions ofneurophysiological probes such as transcranial magnet-ic stimulation (TMS) to improve understanding of themechanisms underlying brain reorganization after stroke;and (iv) the potential role of neuroimaging in the assess-ment and development of rational pharmacological andbehavioral therapies.Clinical RelevanceFunctional recovery commonly occurs in survivingstroke patients in the weeks and months following theinjury. There is evidence from animal models that cere-bral reorganization underlies at least some of this recov-ery and it is hoped that an understanding of the neuro-physiological processes underlying this reorganization inthe human brain will lead to a rational approach to thetreatment of impairment. In animal models, focal braindamage triggers a number of changes at the molecular, cel-lular, and systems level, some of which alter the potentialfor cerebral reorganization and consequent functionalrecovery. Although the same techniques are not availableto study the working human brain, functional brain imag-ing has provided insights into how the human brainresponds to focal injury.

We evaluate a 1.5 mW HeNe laser (544 nm) for use on an EPICS{reg_sign} Elite with a 76 {mu}m Sortsense flow cell. The two applications chosen were immunofluorescence and DNA analysis. We measured the fluorescence threshhold of phycoerytherin calibration beads to be approximately 336 MESF. Cell analysis with a HeNe laser and Argon laser correlated well for the CD4{sup PE}, CD56{sup PE}, CD19{sup PE} conjugates, with correlation coefficients of 0.98, 0.99, 0.94, respectively. The % positive and mean channel fluorescence were comparable to the results obtained with a 15 mW Argon laser. In addition, a three-color configuration PE yielded excellent results. Cell analysis of CD4{sup PE}, CD3{sup ECD} and CD19{sup Cy-Chrome} with the HeNe laser and Argon laser correlated well with correlation coefficients of 0.96, 0.95, and 0.92, respectively. The histograms showed good separation between the negative cells, the dimly staining cells and the brightly staining cells. Propidium Iodide was chosen for DNA analysis. Full CV values for whole blood DNA fluorescence using the green laser were good at 2.6%. These data indicate the low power 544 nm laser is sufficient to do immunophenotyping and DNA analysis. Results may be explained by higher quantum efficiency and lower background fluorescence. Themore » wavelength of the 544 nm laser is much closer to the excitation peaks of PI, PE, and the tandem dyes ECD and Cy-Chrome. Also, the Raman scattering of water for the 544 nm laser has a longer wavelength maximum than the emission peaks of PI, PE, and ECD. The major advantages of this laser for the research laboratory are small size, no cooling fan, low power requirements and low cost. 16 refs., 5 figs., 3 tabs.« less