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3 results on '"Ji, B.T."'

1. Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)

Author

Manal M. Hassan, Anthony B. Miller, E. A. Holly, Paolo Boffetta, Parviz Ghadirian, William R. Bamlet, Jerry Polesel, Ersilia Lucenteforte, C. La Vecchia, Michelle Cotterchio, Elizabeth T. H. Fontham, Steve Gallinger, Eric J. Duell, J. Su, Donghui Li, Bu Tian Ji, Debra T. Silverman, Paige M. Bracci, Witold Zatonski, R. Talamini, Eva Negri, Yu-Tang Gao, Patrick Maisonneuve, Cristina Bosetti, H. B. Bueno-de-Mesquita, Gloria M. Petersen, Peter A. Baghurst, Lucenteforte, E., La Vecchia, C., Silverman, D., Petersen, G.M., Bracci, P.M., Ji, B.T., Bosetti, C., Li, D., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E., Bamlet, W.R., Holly, E.A., Gao, Y.T., Negri, E., Hassan, M., Cotterchio, M., Su, J., Maisonneuve, P., Boffetta, P., Duell, E.J., International Prevention Research Institute (IPRI), The Tisch Cancer Institute, and Icahn School of Medicine at Mount Sinai [New York] (MSSM)

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Pathology, alcohol drinking, case–control, studies, ethanol, pancreatic cancer, pooled analysis, risk factors, Alcohol, chemistry.chemical_compound, Internal medicine, Pancreatic cancer, Odds Ratio, medicine, Adult Aged Alcohol Drinking/*adverse effects Case-Control Studies Confounding Factors (Epidemiology) Female Humans Logistic Models Male Middle Aged Odds Ratio Pancreatic Neoplasms/*epidemiology/etiology Pancreatitis/complications Risk Factors Smoking/adverse effects, Humans, risk of pancreatic cancer, Aged, business.industry, Smoking, Confounding Factors, Epidemiologic, Original Articles, Hematology, Middle Aged, medicine.disease, Pancreatic Neoplasms, Logistic Models, Pooled analysis, Pancreatitis, chemistry, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, business, Alcohol consumption, heavy alcohol consumptio
Abstract

Lucenteforte, E La Vecchia, C Silverman, D Petersen, G M Bracci, P M Ji, B T Bosetti, C Li, D Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Bamlet, W R Holly, E A Gao, Y T Negri, E Hassan, M Cotterchio, M Su, J Maisonneuve, P Boffetta, P Duell, E J eng CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-CP-05225/CP/NCI NIH HHS/ N01-CP-05227/CP/NCI NIH HHS/ N01-CP-31022/CP/NCI NIH HHS/ N01-CP-51089/CP/NCI NIH HHS/ N01-CP-51090/CP/NCI NIH HHS/ N01-CP-51092/CP/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't England 2011/05/04 06:00 Ann Oncol. 2012 Feb;23(2):374-82. doi: 10.1093/annonc/mdr120. Epub 2011 May 2.; International audience; BACKGROUND: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. METHODS: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11,827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. RESULTS: Compared with abstainers and occasional drinkers (< 1 drink per day), we observed no association for light-to-moderate alcohol consumption (/= 9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. CONCLUSION: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.

Published
2012
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2. Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author

Robert C. Kurtz, Emmy Ludwig, E. A. Holly, Elizabeth T.H. Fontham, Gloria M. Petersen, Steve Gallinger, Herbert Yu, Albert B. Lowenfels, Patrick Maisonneuve, D. Silverman, Harvey A. Risch, Donghui Li, Paolo Boffetta, Paige M. Bracci, H. B. Bueno-de-Mesquita, Ersilia Lucenteforte, Bu Tian Ji, Eric J. Duell, C. La Vecchia, D. Seminara, Parviz Ghadirian, Sara H. Olson, Duell, E.J., Lucenteforte, E., Olson, S.H., Bracci, P.M., Li, D., Risch, H.A., Silverman, D.T., Ji, B.T., Gallinger, S., Holly, E.A., Fontham, E.H., Maisonneuve, P., Bueno-de-Mesquita, H.B., Ghadirian, P., Kurtz, R.C., Ludwig, E., Yu, H., Lowenfels, A.B., Seminara, D., Petersen, G.M., La Vecchia, C., and Boffetta, P.

Subjects
Male, medicine.medical_specialty, Alcohol Drinking, Population, Case-control studies, Pancreatic cancer, Pancreatitis, Pooled analysis, Risk factors, Adenocarcinoma, Gastroenterology, Diabetes Complications, Risk Factors, Internal medicine, Odds Ratio, Medicine, Humans, Risk factor, education, Aged, education.field_of_study, Hereditary pancreatitis, Pancreatiti, business.industry, General surgery, Smoking, Cancer, Hematology, Odds ratio, Original Articles, Middle Aged, medicine.disease, Pancreatic Neoplasms, medicine.anatomical_structure, Oncology, Case-Control Studies, Female, business, Pancreas
Abstract

Background: Pancreatitis is a known risk factor for pancreatic cancer; however, an unknown fraction of the disease is thought to be a consequence of tumor-related duct obstruction. Patients and methods: A pooled analysis of a history of pancreatitis and risk of pancreatic cancer was carried out considering the time interval between diagnoses and potential modification by covariates. Adjusted pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from 10 case-control studies (5048 cases of ductal pancreatic adenocarcinoma and 10 947 controls) taking part in the International Pancreatic Cancer Case-Control Consortium (PanC4). Results: The association between pancreatitis and pancreatic cancer was nearly three-fold at intervals of >2 years between diagnoses (OR: 2.71, 95% CI: 1.96-3.74) and much stronger at intervals of =2 years (OR: 13.56, 95% CI: 8.72-21.90) probably reflecting a combination of reverse causation and antecedent misdiagnosis of pancreas cancer as pancreatitis. The younger (2 years) pancreatitis (OR: 3.91, 95% CI: 2.53-6.04) than the older (=65 years) cases (OR: 1.68, 95% CI: 1.02-2.76; P value for interaction: 0.006). Conclusions: Despite a moderately strong association between pancreatitis (diagnosed before >2 years) and pancreatic cancer, the population attributable fraction was estimated at 1.34% (95% CI: 0.612-2.07%), suggesting that a relatively small proportion of pancreatic cancer might be avoided if pancreatitis could be prevented. © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology.

Published
2012

3. Cigarette smoking and pancreatic cancer : an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author

Yu-Tang Gao, Parviz Ghadirian, E. A. Holly, Michelle Cotterchio, C. La Vecchia, Gloria M. Petersen, Steven Gallinger, Donghui Li, Patrick Maisonneuve, Cristina Bosetti, Elizabeth T. H. Fontham, R. Talamini, H. B. Bueno-de-Mesquita, Sara H. Olson, Paola Bertuccio, Paige M. Bracci, Jerry Polesel, Bu Tian Ji, Ersilia Lucenteforte, Debra T. Silverman, William R. Bamlet, J. Su, Witold Zatonski, Paolo Boffetta, Eva Negri, Peter A. Baghurst, Robert C. Kurtz, Manal M. Hassan, Anthony B. Miller, Herbert Yu, Harvey A. Risch, Eric J. Duell, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Bosetti, C., Lucenteforte, E., Silverman, D.T., Petersen, G., Bracci, P.M., Ji, B.T., Negri, E., Li, D., Risch, H.A., Olson, S.H., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E., Bamlet, W.R., Holly, E.A., Bertuccio, P., Gao, Y.T., Hassan, M., Yu, H., Kurtz, R.C., Cotterchio, M., Su, J., Maisonneuve, P., Duell, E.J., Boffetta, P., and La Vecchia, C.

Subjects
medicine.medical_specialty, Multivariate analysis, analysi, pancreatic cancer, cigarette smoking, cancer, Sensitivity and Specificity, PANC4, Cigarette smoking, Internal medicine, Pancreatic cancer, Odds Ratio, medicine, case–control study, pooled analysis, Humans, and pancreatic, Case-Control Studies Humans Logistic Models Multivariate Analysis Odds Ratio Pancreatic Neoplasms/*etiology Sensitivity and Specificity Smoking/*adverse effects, Cigarette, Cancer, Pancreatic, business.industry, Smoking, Case-control study, Original Articles, Hematology, Odds ratio, medicine.disease, Former Smoker, Confidence interval, Surgery, Pancreatic Neoplasms, Case-Control, Logistic Models, Oncology, International, Case-Control Studies, Meta-analysis, Multivariate Analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Corrigendum, business, Consortium
Abstract

Bosetti, C Lucenteforte, E Silverman, D T Petersen, G Bracci, P M Ji, B T Negri, E Li, D Risch, H A Olson, S H Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Bamlet, W R Holly, E A Bertuccio, P Gao, Y T Hassan, M Yu, H Kurtz, R C Cotterchio, M Su, J Maisonneuve, P Duell, E J Boffetta, P La Vecchia, C eng 5R01-CA098870/CA/NCI NIH HHS/ CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-CP-05225/CP/NCI NIH HHS/ N01-CP-05227/CP/NCI NIH HHS/ N01-CP-31022/CP/NCI NIH HHS/ N01-CP-51089/CP/NCI NIH HHS/ N01-CP-51090/CP/NCI NIH HHS/ N01-CP-51092/CP/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ P50 CA102701/CA/NCI NIH HHS/ R01 CA97075/CA/NCI NIH HHS/ Canadian Institutes of Health Research/Canada Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2011/11/23 06:00 Ann Oncol. 2012 Jul;23(7):1880-8. doi: 10.1093/annonc/mdr541. Epub 2011 Nov 21.; International audience; BACKGROUND: To evaluate the dose-response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables. METHODS: We analyzed data from 12 case-control studies within the International Pancreatic Cancer Case-Control Consortium (PanC4), including 6507 pancreatic cases and 12 890 controls. We estimated summary odds ratios (ORs) by pooling study-specific ORs using random-effects models. RESULTS: Compared with never smokers, the OR was 1.2 (95% confidence interval [CI] 1.0-1.3) for former smokers and 2.2 (95% CI 1.7-2.8) for current cigarette smokers, with a significant increasing trend in risk with increasing number of cigarettes among current smokers (OR=3.4 for >/=35 cigarettes per day, P for trend

Published
2012
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