1. LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis
- Author
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Yanhua Zhang, Meng Zheng, Lingyan Zhang, Ping Yuan, Jianbo Zhou, Yongfang Wang, and Haihong Wang
- Subjects
Carcinogenesis ,Uterine Cervical Neoplasms ,Oncogenes ,General Medicine ,Biochemistry ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,Cell Movement ,Cell Line, Tumor ,Genetics ,Humans ,Female ,RNA, Long Noncoding ,Amino Acid Oxidoreductases ,Thiolester Hydrolases ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Cell Proliferation - Abstract
Increasing reports demonstrate that long noncoding RNAs participate in the regulation of numerous malignancies, cervical cancer included. Although lncRNA LOXL1 antisense RNA 1 has been commonly accepted to be an oncogene in many cancers. Here, the role of LOXL1-AS1 in CC still need to be explored. In this study, LOXL1-AS1 was found elevated in CC tissues and cells. LOXL1-AS1 depletion restrained CC cell proliferation, migration, invasion, and angiogenesis in vivo. Furthermore, we found that LOXL1-AS1 upregulated Lysophospholipase 1 expression via sequestering miR-526b-5p. Rescue assays revealed that overexpression of LYPLA1 reversed the LOXL1-AS1 silencing-induced inhibitory effects on the malignant phenotypes of CC cells. To conclude, this study showed that LOXL1-AS1 facilitates cellular process in CC via functioning as a miR-526b-5p sponge.
- Published
- 2022