1. Mortality Benefit From the Passive Leg Raise Maneuver in Guiding Resuscitation of Septic Shock Patients: A Systematic Review and Meta-Analysis of Randomized Trials
- Author
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Suyee Win, Amir Abdipour, Moosa Azadian, Carolyn Krystal Kim, and H. Bryant Nguyen
- Subjects
Adult ,Resuscitation ,medicine.medical_specialty ,Critical Care and Intensive Care Medicine ,law.invention ,Sepsis ,Leg raise ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Intravascular volume status ,Humans ,Prospective Studies ,Intensive care medicine ,Randomized Controlled Trials as Topic ,Leg ,Septic shock ,business.industry ,Critically ill ,030208 emergency & critical care medicine ,medicine.disease ,Shock, Septic ,030228 respiratory system ,Meta-analysis ,business - Abstract
Background: Fluid therapy plays a major role in the management of critically ill patients. Yet assessment of intravascular volume in these patients is challenging. Different invasive and non-invasive methods have been used with variable results. The passive leg raise (PLR) maneuver has been recommended by international guidelines as a means to determine appropriate fluid resuscitation. We performed this systematic review and meta-analysis to determine if using this method of volume assessment has an impact on mortality outcome in patients with septic shock. Methods: This study is a systematic review and meta-analysis. We searched available data in the MEDLINE, CINAHL, EMBASE, and CENTRAL databases from inception until October 2020 for prospective, randomized, controlled trials that compared PLR-guided fluid resuscitation to standard care in adult patients with septic shock. Our primary outcome was mortality at the longest duration of follow-up. Results: We screened 1,425 article titles and abstracts. Of the 23 full-text articles reviewed, 5 studies with 462 patients met our eligibility criteria. Odds ratios (ORs) and associated 95% confidence intervals (CIs) for mortality at the longest reported time interval were calculated for each study. Using random effects modeling, the pooled OR (95% CI) for mortality with a PLR-guided resuscitation strategy was 0.82 (0.52 -1.30). The included studies were not blinded and they ranged from having low to high risk of bias using the Cochrane Risk of Bias Tool. Conclusion: Our analysis showed there was no statistically significant difference in mortality among septic shock patients treated with PLR-guided resuscitation vs. those with standard care.
- Published
- 2021
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