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Your search keyword '"MESH: Congresses as Topic"' showing total 17 results
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17 results on '"MESH: Congresses as Topic"'

1. Current vector research challenges in the greater Mekong subregion for dengue, Malaria, and Other Vector-Borne Diseases: A report from a multisectoral workshop March 2019

Author

Stephen S. Whitehead, Jessica E. Manning, Sazaly AbuBakar, Jesus G. Valenzuela, Jeffrey Hii, Kobporn Boonnak, Bruce A. Wilcox, Daniel M. Parker, Rekol Huy, Rebecca C. Christofferson, Vu Sinh Nam, Thomas E. Wellems, Hans J. Overgaard, Tho Sochantha, Leang Rithea, Gregor J. Devine, Sébastien Boyer, Louisiana State University (LSU), University of California [Irvine] (UCI), University of California, Norwegian University of Life Sciences (NMBU), PMI VectorLink Project [Cambodia], PMI VectorLink Project, U.S. President's Malaria Initiative [Atlanta, GA,]-U.S. President's Malaria Initiative [Atlanta, GA,], QIMR Berghofer Medical Research Institute, Mahidol University [Bangkok], National Institute of Hygiene and Epidemiology [Hanoi, Vietnam] (NIHE), Réseau International des Instituts Pasteur (RIIP), Tropical Infectious Diseases Research & Education Centre [Kuala Lumpur] (TIDREC), University of Malaya [Kuala Lumpur, Malaisie], Institut Pasteur du Cambodge, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), National Center for Parasitology, Entomology and Malaria Control [Phnom Penh, Cambodia] (CNM), National Institute of Allergy and Infectious Diseases [Phnom Penh, Cambodia] (NIAID), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), and Dinglasan, Rhoel Ramos

Subjects
0301 basic medicine, History, [SDV]Life Sciences [q-bio], RC955-962, MESH: Dengue, Disease Vectors, Pathology and Laboratory Medicine, Mosquitoes, Medical and Health Sciences, Dengue, 0302 clinical medicine, Arctic medicine. Tropical medicine, Dengue transmission, Medicine and Health Sciences, Public and Occupational Health, MESH: Animals, Malaria epidemiology, ComputingMilieux_MISCELLANEOUS, Vaccines, Eukaryota, Biological Sciences, Vaccination and Immunization, 3. Good health, Insects, Infectious Diseases, MESH: Health Priorities, MESH: Mekong Valley, Public aspects of medicine, RA1-1270, Pathogens, Mekong Valley, Infectious Disease Control, Arthropoda, 030231 tropical medicine, Immunology, MESH: Malaria, MESH: Insect Vectors, 03 medical and health sciences, Malaria transmission, Tropical Medicine, Vaccine Development, medicine, Parasitic Diseases, Animals, Humans, Symposium, MESH: Humans, Extramural, Health Priorities, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, Congresses as Topic, medicine.disease, Tropical Diseases, Invertebrates, Malaria, Insect Vectors, Vector-Borne Diseases, MESH: Vaccines, Species Interactions, 030104 developmental biology, Good Health and Well Being, Vector (epidemiology), Current vector, Preventive Medicine, Humanities, MESH: Congresses as Topic
Abstract

Author(s): Christofferson, Rebecca C; Parker, Daniel M; Overgaard, Hans J; Hii, Jeffrey; Devine, Gregor; Wilcox, Bruce A; Nam, Vu Sinh; Abubakar, Sazaly; Boyer, Sebastien; Boonnak, Kobporn; Whitehead, Stephen S; Huy, Rekol; Rithea, Leang; Sochantha, Tho; Wellems, Thomas E; Valenzuela, Jesus G; Manning, Jessica E

Published
2020
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2. Establishment of Asia-Pacific Network for Enterovirus Surveillance

Author

Ya-Yen Chen, Yoke Fun Chan, Veasna Duong, Wan Yu Chung, Shu Ting Luo, Philippe Dussart, Huu Khanh Truong, Mu-Lin Chiu, Nguyen Thi Thanh Thao, Mong How Ooi, David Perera, Min-Shi Lee, National Health Research Institutes [Taiwan] (NHRI), Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), University of Malaya [Kuala Lumpur, Malaisie], Universiti Malaysia Sarawak (UNIMAS), Sarawak General Hospital [Kuching, Sarawak, Malaysia], Institut Pasteur d'Ho Chi Minh Ville, Réseau International des Instituts Pasteur (RIIP), Children's Hospital No.1 [Ho Chi Minh City], and This project is partialy funded by National Flagship Project, Taiwan (MOST 106-3114-Y404-002).

Subjects
Echovirus, viruses, Disease, medicine.disease_cause, 0302 clinical medicine, 030212 general & internal medicine, MESH: Hand, Foot and Mouth Disease, Enterovirus, biology, MESH: Asia, MESH: Enterovirus Infections, 3. Good health, Infectious Diseases, MESH: Enterovirus A, Human, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Sentinel Surveillance, Molecular Medicine, Asia, 030231 tropical medicine, Taiwan, Coxsackievirus, Herpangina, 03 medical and health sciences, MESH: Viral Vaccines, Environmental health, medicine, Enterovirus Infections, Humans, MESH: Taiwan, MESH: Pacific Ocean, Disease burden, Licensure, MESH: Humans, Pacific Ocean, General Veterinary, General Immunology and Microbiology, business.industry, Public Health, Environmental and Occupational Health, Outbreak, Viral Vaccines, Congresses as Topic, biology.organism_classification, medicine.disease, Enterovirus A, Human, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Hand, Foot and Mouth Disease, Vaccine, Sentinel Surveillance, Asia-Pacific region, MESH: Congresses as Topic
Abstract

International audience; Enteroviruses (EV), the major pathogens of hand, foot, and mouth disease (HFMD) and herpangina, affect millions of children each year. Most human enteroviruses cause self-limited infections except polioviruses, enterovirus A71 (EV-A71), enterovirus D68 (EV-D68), and several echoviruses (Echo) and coxsackieviruses (CV). Especially, EV-A71 has repeatedly caused large-scale outbreaks in the Asia-Pacific region since 1997. Some Asian countries have experienced cyclical outbreaks of severe EV-A71 infections and initiated development of EV-A71 vaccines. Five EV-A71 vaccine candidates have been clinically evaluated and three of them were approved for marketing in China. However, none of the China-approved products seek marketing approval in other countries. This situation supports a role for collaboration among Asian countries to facilitate clinical trials and licensure of EV-A71 vaccines. Additionally, enterovirus D68 outbreaks have been reported in the US and Taiwan currently and caused severe complications and deaths. Hence, an Asia-Pacific Network for Enterovirus Surveillance (APNES) has been established to estimate disease burden, understand virus evolution, and facilitate vaccine development through harmonizing laboratory diagnosis and data collection. Founded in 2017, the APNES is comprised of internationally recognized experts in the field of enterovirus in Asian countries working to raise awareness of this potentially fatal and debilitating disease. This article demonstrated the summaries of the first expert meeting, 2017 International Workshop on Enterovirus Surveillance and Vaccine Development, held by APNES in Taipei, Taiwan, March 2017.

Published
2019
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3. The Many Faces of Epigenetics Oxford, December 2017

Author

Paola B. Arimondo, Anouk Barberousse, Gaëlle Pontarotti, Chimie biologique épigénétique - Epigenetic Chemical Biology (EpiCBio), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Sciences, Ethique, Société, Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut d'Histoire et de Philosophie des Sciences et des Techniques (IHPST), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7), The authors thank all co-organisers (Frédéric Thibault-Starzyk (MFO/CNRS), Stéphane Jettot (MFO/Sorbonne University), Ludovic Halby (MFO/CNRS) and Michel Dubois (EpiDapo), and funding agents (CNRS, Sorbonne University and COST action CM 1406 Epigenetic Chemical Biology)., Centre National de la Recherche Scientifique (CNRS), Université Panthéon-Sorbonne (UP1)-Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut Humanités Sciences Sociétés (IHSS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Sciences, Normes, Démocratie (SND)

Subjects
0301 basic medicine, Cancer Research, [SDV]Life Sciences [q-bio], MESH: Societies, Medical, Inheritance Patterns, Meeting Report, Biology, molecular tools, Epigenesis, Genetic, [SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, 03 medical and health sciences, MESH: Disease / genetics, 0302 clinical medicine, Humans, Natural (music), definition, [CHIM]Chemical Sciences, Disease, MESH: Epigenesis, Genetic, explanatory tools, MESH: Environment, Molecular Biology, Societies, Medical, ComputingMilieux_MISCELLANEOUS, [SDV.GEN]Life Sciences [q-bio]/Genetics, MESH: Humans, epigenetics, Environmental ethics, Congresses as Topic, MESH: Gene Expression Regulation, 030104 developmental biology, society, Gene Expression Regulation, 030220 oncology & carcinogenesis, DECIPHER, MESH: Inheritance Patterns, environment, MESH: Congresses as Topic
Abstract

International audience; The conference ‘The Many Faces of Epigenetics: Multidisciplinary Perspectives “over” Genetics’ was held in Oxford (6–8 December 2017) and offered a valuable window into the domain of Epigenetics and its promises. The workshop revealed that, among a wealth of discourses about Epigenetics, it is not so easy to decipher which discourses are to be trusted. Because Epigenetics is a rather old notion that has generated many debates and promises, defining precisely what has changed and where we are currently is a challenge in itself. Interestingly, the conference allowed debates beyond statements such as ‘If you don’t know the cause, you say it’s epigenetic’ (Deichmann 2016), pointing out that the lack of a precise definition of Epigenetics was no hindrance to the discussions. Finally, it highlighted the grounds of (dis)agreement among communities of natural and social scientists; but eventually the discussions showed that epigenetic tools open the path to new topics and challenges that are awaiting us.

Published
2019
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4. CRISPR in Parasitology: Not Exactly Cut and Dried!

Author

Jessica M. Bryant, Sebastian Baumgarten, Lucy Glover, Sebastian Hutchinson, Najma Rachidi, Biologie des Interactions Hôte-Parasite - Biology of Host-Parasite Interactions, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Biologie moléculaire des Trypanosomes - Trypanosome Molecular Biology, Institut Pasteur [Paris] (IP), Biologie cellulaire des Trypanosomes - Trypanosome Cell Biology, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Parasitologie moléculaire et Signalisation / Molecular Parasitology and Signaling, S.B. was supported by a European Molecular Biology Organization long-term postdoctoral fellowship (EMBO LTF 1444-2016). S.H. was supported by a Roux postdoctoral fellowship from the Institut Pasteur. N.R. was supported by grant ANR-13-ISV3-0009 and the LabEx IBEID., ANR-13-ISV3-0009,TranSig,Trans-signalisation: Un nouveau mécanisme permettant à Leishmania d'éviter la réponse immunitaire de la cellule hôte par la sécrétion de protéines de signalisation(2013), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris], Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Rachidi, Najma, Blanc – Accords bilatéraux 2013 - Trans-signalisation: Un nouveau mécanisme permettant à Leishmania d'éviter la réponse immunitaire de la cellule hôte par la sécrétion de protéines de signalisation - - TranSig2013 - ANR-13-ISV3-0009 - Blanc – Accords bilatéraux 2013 - VALID, and Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID

Subjects
0301 basic medicine, Engineering, Plasmodium, Trypanosoma, MESH: CRISPR-Cas Systems, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, 030231 tropical medicine, MESH: Parasitology, Computational biology, 03 medical and health sciences, 0302 clinical medicine, Anopheles, CRISPR, Animals, Humans, Parasites, MESH: Animals, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, MESH: Parasites, Leishmania, MESH: Humans, business.industry, Cas9, Research, CRISPRi, Congresses as Topic, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, 3. Good health, 030104 developmental biology, Infectious Diseases, MESH: Research, Parasitology, CRISPR-Cas Systems, business, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, MESH: Congresses as Topic
Abstract

International audience; CRISPR/Cas9 technology has been developing rapidly in the field of parasitology, allowing for the dissection of molecular processes with unprecedented efficiency. Optimization and implementation of a new technology like CRISPR, especially in nonmodel organisms, requires communication and collaboration throughout the field. Recently, a 'CRISPR in Parasitology' symposium was held at the Institut Pasteur Paris, bringing together scientists studying Leishmania, Plasmodium, Trypanosoma, and Anopheles. Here we share technological advances and challenges in using CRISPR/Cas9 in the parasite and vector systems that were discussed. As CRISPR/Cas9 continues to be applied to diverse parasite systems, the community should now focus on improvement and standardization of the technique as well as expanding the CRISPR toolkit to include Cas9 alternatives/derivatives for more advanced applications like genome-wide functional screens.

Published
2019
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5. Are Bacteria Infectious Pathogens in Hidradenitis Suppurativa? Debate at the Symposium for Hidradenitis Suppurativa Advances Meeting, November 2017

Author

Michelle A. Lowes, Mayur Ramesh, Gregory S. Schultz, Vincent Piguet, Aude Nassif, Haley B. Naik, Afsaneh Alavi, University of California [San Francisco] (UCSF), University of California, Centre Médical de l'Institut Pasteur (CMIP), Institut Pasteur [Paris], Centre d'infectiologie Necker-Pasteur [CHU Necker], Institut Pasteur [Paris]-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), University of Toronto, Rockefeller University [New York], University of California [San Francisco] (UC San Francisco), University of California (UC), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-CHU Necker - Enfants Malades [AP-HP], and Centre Médical de l'Institut Pasteur

Subjects
0301 basic medicine, [SDV]Life Sciences [q-bio], Dermatology, MESH: Hidradenitis Suppurativa, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, MESH: Microbiota, Medicine, Humans, Hidradenitis suppurativa, Molecular Biology, Retrospective Studies, MESH: Humans, biology, Bacteria, business.industry, Microbiota, MESH: Retrospective Studies, Cell Biology, Congresses as Topic, medicine.disease, biology.organism_classification, Hidradenitis Suppurativa, MESH: Bacteria, 030104 developmental biology, Infectious disease (medical specialty), 030220 oncology & carcinogenesis, Immunology, business, MESH: Congresses as Topic, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract

Meeting held at Henry Ford Hospital, Detroit, Michigan, in November 2017; International audience; In November 2017, a formal debate on the role of bacteria in the pathogenesis of hidradenitis suppurativa (HS) was held at the 2nd Symposium on Hidradenitis Suppurativa Advances (SHSA) in Detroit, Michigan. In this report, we present both sides of the argument as debated at the SHSA meeting and then discuss the potential role of bacteria as classic infectious pathogens versus an alternative pathogenic role as activators of dysregulated commensal bacterial-host interactions. Although there was consensus that bacteria play a role in pathogenesis and thus are pathogenic, there was a compelling discussion about whether bacteria in HS incite an infectious disease as we classically understand it or whether bacteria might play a different role in HS pathogenesis.

Published
2018
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6. 1st International Workshop on Clinical trial readiness for sarcoglycanopathies 15–16 November 2016, Evry, France

Author

Justine Marsolier, Pascal Laforet, Elena Pegoraro, John Vissing, Isabelle Richard, Christine Barnerias, Robert-Yves Carlier, Jordi Díaz-Manera, Abdallah Fayssoil, Anne Galy, Elisabetta Gazzerro, Dariusz Górecki, Michela Guglieri, Jean-Yves Hogrel, David Israeli, France Leturcq, Helene Moussu, Helene Prigent, Dorianna Sandona, Benedikt Schoser, Claudio Semplicini, Beril Talim, Giorgio Tasca, Andoni Urtizberea, Bjarne Udd, Université Paris-Saclay, Institut de Myologie, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Pierre et Marie Curie - Paris 6 (UPMC), Universita degli Studi di Padova, University of Copenhagen = Københavns Universitet (KU), Approches génétiques intégrées et nouvelles thérapies pour les maladies rares (INTEGRARE), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Généthon, Service de neurologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Imagerie Médicale [Raymond-Poincaré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], CIBER de Enfermedades Raras (CIBERER), Généthon, Institute of Human Genetics, Newcastle University [Newcastle]-International Centre for Life, Hôpital Cochin [AP-HP], Groupe de Recherche Clinique et Technologique sur le Handicap (GRCTH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Medical Genetics and Pediatric Cardiology, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Association française contre les myopathies (AFM-Téléthon), Neurology Department, Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Généthon-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Hôpital Raymond Poincaré [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École pratique des hautes études (EPHE)-Université d'Évry-Val-d'Essonne (UEVE)-GENETHON 3-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Service d'Imagerie Médicale [CHU Raymond Poincaré], AP-HP Hôpital Raymond Poincaré [Garches]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), CHU Cochin [AP-HP], Università degli Studi di Padova = University of Padua (Unipd), University of Copenhagen = Københavns Universitet (UCPH), and École Pratique des Hautes Études (EPHE)

Subjects
0301 basic medicine, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Clinical presentation, International Cooperation, Treatment outcome, Natural history, Clinical presentation, Pathogenic mechanism, Outcome measures, Biomarkers, Animal models of sarcoglycanopathies,Therapies, Outcome measures, MESH: Magnetic Resonance Imaging, Pathogenic mechanism, 0302 clinical medicine, Environmental protection, Medicine, Genetics (clinical), ComputingMilieux_MISCELLANEOUS, MESH: Treatment Outcome, Clinical Trials as Topic, MESH: Muscle, Skeletal, MESH: Sarcoglycanopathies, Animal models of sarcoglycanopathies, Magnetic Resonance Imaging, 3. Good health, Treatment Outcome, Neurology, France, Sarcoglycanopathies, medicine.medical_specialty, MESH: Clinical Trials as Topic, Natural history, MEDLINE, 03 medical and health sciences, Humans, Medical physics, Muscle, Skeletal, MESH: Humans, business.industry, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Congresses as Topic, Clinical trial, MESH: France, MESH: International Cooperation, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Therapies, Pediatrics, Perinatology and Child Health, Neurology (clinical), business, Biomarkers, 030217 neurology & neurosurgery, MESH: Congresses as Topic
Abstract

• The present ENMC workshop report summarises the current state of clinical readiness for sarcoglycanopathies.

Published
2017
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7. 219th ENMC International Workshop Titinopathies International database of titin mutations and phenotypes, Heemskerk, The Netherlands, 29 April–1 May 2016

Author

Peter Hackman, Bjarne Udd, Carsten G. Bönnemann, Ana Ferreiro, Carsten Bonnemann, Alan Beggs, Mathias Gautel, Mark Davis, Teresinha Evangelista, Marco Savarese, Jelena Nikodinovic Glumac, Jocelyn Laporte, John Edward Smith, Isabelle Richard, Henk Granzier, Raphäel Schneider, Heinz Jungbluth, Sarah Foye, Alison Rockett Frase, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Tampere [Finland], National Institute of Neurological Disorders and Stroke [Bethesda] (NINDS), National Institutes of Health [Bethesda] (NIH), Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Titinopathy Database Consortium: Bjarne Udd , Peter Hackman , Ana Ferreiro , Carsten Bonnemann , Alan Beggs , Mathias Gautel , Mark Davis , Teresinha Evangelista , Marco Savarese , Jelena Nikodinovic Glumac , Jocelyn Laporte , John Edward Smith , Isabelle Richard , Henk Granzier , Raphäel Schneider , Heinz Jungbluth , Sarah Foye , Alison Rockett Frase, Richard, Isabelle, Haartman Institute [Helsinki], Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki, Neurology Department, Physiopathologie et thérapie du muscle strié, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-Institut National de la Santé et de la Recherche Médicale (INSERM), Boston Children's Hospital, University of East London & Glasgow Caledonian University, Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Approches génétiques intégrées et nouvelles thérapies pour les maladies rares (INTEGRARE), École pratique des hautes études (EPHE)-Université d'Évry-Val-d'Essonne (UEVE)-GENETHON 3-Institut National de la Santé et de la Recherche Médicale (INSERM), Washington State University (WSU), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Department of Paediatric Neurology, Guy's and St Thomas' Hospital [London]-Evelina Children's Hospital, Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Évry-Val-d'Essonne (UEVE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Généthon, Guy's and St Thomas' Hospital [London]-Evelina London Children's Hospital, Medicum, Department of Medical and Clinical Genetics, and Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I

Subjects
0301 basic medicine, MESH: Connectin, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, International Cooperation, Bioinformatics, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, 0302 clinical medicine, Connectin, C-TERMINAL TITIN, Genetics (clinical), ComputingMilieux_MISCELLANEOUS, Netherlands, biology, MUSCLE INVOLVEMENT, Dilated cardiomyopathy, Phenotype, Early respiratory failure, Neurology, Titin, COMMON-CAUSE, TTN, MESH: Mutation, education, MEDLINE, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, 03 medical and health sciences, Muscular Diseases, Tibial Muscular Dystrophy, International database, DISTAL MYOPATHY, medicine, HEREDITARY MYOPATHY, Humans, TRUNCATING MUTATIONS, TIBIAL MUSCULAR-DYSTROPHY, EARLY RESPIRATORY-FAILURE, MESH: Humans, business.industry, MESH: Muscular Diseases, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Congresses as Topic, medicine.disease, DILATED CARDIOMYOPATHY, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, MESH: International Cooperation, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Mutation, Pediatrics, Perinatology and Child Health, MESH: Netherlands, biology.protein, Neurology (clinical), 3111 Biomedicine, business, 030217 neurology & neurosurgery, MESH: Congresses as Topic
Abstract

International audience; No abstract available

Published
2017
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8. Sixth International AFM BioMed Conference on AFM in life sciences and medicine, December 13 to 17, 2014, San Diego, California

Author

Engler, Adam, Parot, Pierre, Pellequer, Jean-Luc, University of California [San Francisco] (UCSF), University of California, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de biologie structurale (IBS - UMR 5075 ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), University of California [San Francisco] (UC San Francisco), University of California (UC), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
MESH: Microscopy, Atomic Force, Microscopy, MESH: Humans, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Biophysics, Atomic Force, Congresses as Topic, Microscopy, Atomic Force, Biological Science Disciplines, California, MESH: California, MESH: Biological Science Disciplines, Chemical Sciences, Humans, ComputingMilieux_MISCELLANEOUS, MESH: Congresses as Topic
Abstract

International audience

Published
2016
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9. Genomic imprinting in Singapore

Author

Benjamin Loppin, Rebecca J. Oakey, Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
MESH: Singapore, MESH: Plants, Review Article, Biology, Biochemistry, Germline, Genomic Imprinting, 03 medical and health sciences, MESH: Invertebrates, 0302 clinical medicine, X Chromosome Inactivation, Genetics, Animals, Humans, MESH: Animals, Imprinting (psychology), Molecular Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Singapore, 0303 health sciences, MESH: Humans, MESH: X Chromosome Inactivation, Dosage compensation, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Congresses as Topic, Plants, MESH: Gene Expression Regulation, Invertebrates, MESH: Genomic Imprinting, Chromatin, Organization workshop, Gene Expression Regulation, Evolutionary biology, B-Lymphocyte-Induced Maturation Protein 1, Genomic imprinting, Reprogramming, MESH: Congresses as Topic, 030217 neurology & neurosurgery
Abstract

The EMBO Workshop on Genomic Imprinting took place between 21 and 24 September 2008, in Singapore, and was organized by F. Berger, M. Bartolomei and R. Feil. This painting, entitled ‘Back of Telok Ayer Street 2007’ and painted by C. Ek Kay, was the image included in the meeting poster. ![][1] See Glossary for abbreviations used in this article The organizers of the European Molecular Biology Organization Workshop on Genomic Imprinting chose a truly trans‐kingdom selection of speakers; there was a strong representation of those working in plants and mammals, with a sprinkling of those studying flies and worms. This organismal diversity was layered further with talks on topics ranging from germ cells, genomic imprinting and dosage compensation to genome‐wide screens, evolution and human disease. These areas dovetailed well, converging ideas from various species and unifying seemingly divergent fields. Here, we highlight a few of the topics from an excellent programme of riveting news and novel findings. One of the main themes threading through this workshop was that of commitment, reprogramming and pluripotency. A. Surani (Cambridge, UK) discussed the initiation of epigenetic reprogramming in the germline. The main focus was on BLIMP1, which is an important regulator of germ cells that has roles in diverse processes, including the initiation of the PGC‐specification programme and exit from the pluripotent state. In this plenary address, Surani drew from several studies that illustrate the induction of cells to exit the pluripotent state and initiate the PGC‐specific programme, including the role of STELLA —a mammalian maternal‐effect gene that probably has a role in chromosomal organization. The BLIMP1 protein sets up chromatin signatures and influences the epigenetic reprogramming associated with X‐chromosome reactivation (Chuva de Sousa et al , 2008) and imprinting, emphasizing the links among pluripotency, reprogramming and commitment that were reiterated in several other talks. W. … [1]: /embed/graphic-1.gif

Published
2009
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10. Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement

Author

Peter Avery, Claudio Franceschi, Calogero Caruso, Dimitri P. Mikhailidis, Genovefa Kolovou, Niki Katsiki, George Panotopoulos, Helen Bilianou, Ewa Sikora, Irene P. Tzanetakou, Nir Barzilai, Miriam Capri, Athanase Benetos, Avery, Peter, Barzilai, Nir, Benetos, Athanase, Bilianou, Helen, Capri, Miriam, Caruso, Calogero, Franceschi, Claudio, Katsiki, Niki, Mikhailidis, Dimitri P, Panotopoulos, George, Sikora, Ewa, Tzanetakou, Irene P, Kolovou, Genovefa, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CIG - Interdepartmental Center 'L.Galvani', Department of Pathobiology and Medical and Forensic Biotechnologies, Università degli studi di Palermo - University of Palermo, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Nencki Institute of Experimental Biology, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Avery, P, Barzilai, N, Benetos, A, Bilianou, H, Capri, M, Caruso, C, Franceschi, C, Katsiki, N, Mikhailidis, DP, Panotopoulos, G, Sikora, E, Tzanetakou, IP, and Kolovou, G

Subjects
Genetic Markers, Gerontology, Aging, Statement (logic), media_common.quotation_subject, Longevity, MESH: Genetic Markers, Biology, MESH: Phenotype, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Genetic Marker, Animals, Humans, MESH: Aging, MESH: Animals, ComputingMilieux_MISCELLANEOUS, media_common, Pharmacology, MESH: Humans, Animal, Congresses as Topic, Phenotype, Ageing, Longevity, Age-related diseases, MESH: Longevity, Ageing, Biological Marker, MESH: Biomarkers, Cardiology and Cardiovascular Medicine, MESH: Congresses as Topic, Biomarkers, Human
Abstract

In May 2012, a group of scientists and clinicians met in Athens (Greece) to consider the relevance of ageing, longevity, exceptional longevity and related genetic and non genetic markers. During this meeting, we firstly reviewed recent epidemiological and clinical studies on ageing, longevity and exceptional longevity, briefly analysed the ageing theories and discussed successful and unsuccessful ageing also taking into account the evolutionary perspective. Secondly, we considered the three phenotypes based on the definition of ageing, longevity and exceptional longevity and the associated biomarkers. Third, we discussed proposed treatments suitable to counteract or slow down ageing. Finally, this panel produced a consensus statement to highlight the importance of ageing, longevity and exceptional longevity, since this is a rapidly increasing phenotype worldwide. We acknowledge that not all experts in this field may completely agree with this statement.

Published
2014
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11. Dyspnoea: a multidimensional and multidisciplinary approach

Author

Lionel Naccache, Valerie Bougault, Lee Romer, Hans-Joachim Kabitz, Päivi Piirilä, Mark Parshall, Sorbonne Université (SU), Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Université Laval [Québec] (ULaval), Neurophysiologie Respiratoire Expérimentale et Clinique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), INSERM U999, Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université de Toulon (UTLN)-Université Côte d'Azur (UCA), Bougault, Valérie, Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, MESH: Exercise Tolerance, Heart disease, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Health Status, Pulmonary disease, MESH: Pulmonary Disease, Chronic Obstructive, Disease, Angina, Pulmonary Disease, Chronic Obstructive, Quality of life, Multidisciplinary approach, medicine, Pulmonary Medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Exercise, MESH: Pulmonary Medicine, MESH: Health Status, MESH: Treatment Outcome, MESH: Respiration, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, COPD, Exercise Tolerance, MESH: Humans, business.industry, Respiration, Interstitial lung disease, Congresses as Topic, medicine.disease, 3. Good health, respiratory tract diseases, MESH: France, Dyspnea, Treatment Outcome, MESH: Dyspnea, MESH: Exercise, Physical therapy, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], France, business, MESH: Congresses as Topic
Abstract

Item does not contain fulltext Dyspnoea is a debilitating symptom that affects quality of life, exercise tolerance and mortality in various disease conditions/states. In patients with chronic obstructive pulmonary disease (COPD), it has been shown to be a better predictor of mortality than forced expiratory volume in 1 s. In patients with heart disease it is a better predictor of mortality than angina. Dyspnoea is also associated with decreased functional status and worse psychological health in older individuals living at home. It also contributes to the low adherence to exercise training programmes in sedentary adults and in COPD patients. The mechanisms of dyspnoea are still unclear. Recent studies have emphasised the multidimensional nature of dyspnoea in the sensory-perceptual (intensity and quality), affective distress and impact domains. The perception of dyspnoea involves a complex chain of events that depend on varying cortical integration of several afferent/efferent signals and coloured by affective processing. This review, which stems from the European Respiratory Society research symposium held in Paris, France in November 2012, aims to provide state-of-the-art advances on the multidimensional and multidisciplinary aspects of dyspnoea, by addressing three different themes: 1) the neurophysiology of dyspnoea, 2) exercise and dyspnoea, and 3) the clinical impact and management of dyspnoea.

Published
2014
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12. Microbes for Health 2 Symposium: meeting report

Author

Thierry Pedron, Tomas de Wouters, Gianfranco Grompone, Dragana Dobrijevic, Cristel Archambaud, Interactions Bactéries-Cellules (UIBC), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), Danone Research, Pathogénie Microbienne Moléculaire, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
MESH: Health, Gastrointestinal Diseases, [SDV]Life Sciences [q-bio], Microbial Consortia, Physiology, Biology, Microbiology, 03 medical and health sciences, Humans, Molecular Biology, ComputingMilieux_MISCELLANEOUS, MESH: Gastrointestinal Diseases, 030304 developmental biology, 0303 health sciences, MESH: Humans, Bacteria, 030306 microbiology, General Medicine, Congresses as Topic, MESH: Metagenome, Gastrointestinal Tract, MESH: Bacteria, Health, Metagenome, Engineering ethics, MESH: Gastrointestinal Tract, MESH: Congresses as Topic, MESH: Microbial Consortia
Abstract

International audience

Published
2012
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13. [Editorial]

Author

Kerlan, Véronique, Christin-Maitre, Sophie, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Service d'Endocrinologie (CHRU - Endocrino), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Saint-Antoine [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
MESH: Humans, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], 030209 endocrinology & metabolism, General Medicine, Congresses as Topic, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, 030220 oncology & carcinogenesis, Humans, MESH: Endocrinology, ComputingMilieux_MISCELLANEOUS, MESH: Congresses as Topic
Abstract

International audience

Published
2011
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14. [Mortality and morbidity conference: A tool for quality and safety of care continuous improvement]

Author

P, François, E, Sellier, P, Pouzol, G, Bal, J, Labarère, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Biologie Computationnelle et Mathématique (TIMC-IMAG-BCM), and VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
Male, Patient Identification Systems, Safety Management, MESH: Anemia, Adolescent, Blood Safety, MESH: Medical Errors, MESH: Patient Identification Systems, MESH: Blood Group Incompatibility, Hemolysis, Hospitals, University, MESH: Quality Improvement, Postoperative Complications, MESH: Postoperative Complications, Humans, MESH: Bone Marrow Transplantation, Bone Marrow Transplantation, MESH: Adolescent, MESH: Precursor Cell Lymphoblastic Leukemia-Lymphoma, MESH: Hospitals, University, Risk Management, MESH: Humans, Medical Errors, MESH: Risk Management, Anemia, Congresses as Topic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, MESH: Blood Safety, Quality Improvement, MESH: Hemolysis, MESH: Male, MESH: Safety Management, Blood Group Incompatibility, MESH: Erythrocyte Transfusion, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Erythrocyte Transfusion, MESH: Congresses as Topic
Abstract

International audience; OBJECTIVE: The mortality and morbidity conference (MMC) is one of the keystones in the evaluation of quality of care. The objective of this work was to describe a MMC by presenting a case report. CASE REPORT: A 16-year old man suffering from chronic anaemia had to be transfused with two units of red blood cells in an outpatient unit. Although the transfusion went well for the first unit, the patient presented haemolysis during the transfusion of the second unit because the nurse administered the wrong unit. The incident was analysed during a mortality and morbidity conference with the attendance of the hemovigilance local correspondent. Immediate causes of the event were the failure to respect the transfusion procedure: in advance compatibility testing, failure to check the patient and blood component identification just before the transfusion. Factors contributing to the event were the deviation of transfusion practices, poor working conditions of nurses, linked to inadequate staff in relation to the activity. The discussion of the incident led to develop an action plan. DISCUSSION: This case shows the interest for staff members to discuss an adverse event. However, a well-defined methodology for conducting mortality and morbidity conferences is lacking and leads to a wide heterogeneity between teams. Major differences refer to criteria for case selection and quality of participants. This heterogeneity is likely to have an impact of the efficacy of mortality and morbidity conferences regarding the quality and safety of care.

Published
2011
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15. The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia

Author

Stéphane Bretagne, Maurizio Sanguinetti, Paul Verweij, Janos Sinko, MALGORZATA MIKULSKA, Nikolay Klimko, Thierry Calandra, Frederic Lamoth, Malcolm Richardson, Daniel Poulain, Maiken Cavling Arendrup, Division of Infectious Diseases, San Martino University Hospital, nfectious Diseases Service, Université de Lausanne (UNIL)-Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Istituto di Microbiologia - Institute of Microbiology [Rome], Università cattolica del Sacro Cuore [Piacenza e Cremona] (Unicatt), Physiopathologie des Candidoses, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, University of Genoa (UNIGE)-San Martino University Hospital, the Third European Conference on Infections in Leukemia Group, Université de Lausanne = University of Lausanne (UNIL)-Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Università degli studi di Genova = University of Genoa (UniGe)-San Martino University Hospital, BMC, Ed., Third European Conference on Infections in Leukemia Group, Akova, M., Arendrup, M., Barnes, R., Bille, J., Bretagne, S., Calandra, T., Castagnola, E., Cordonnier, C., Cornely, OA., Cruciani, M., Cuenca-Estrella, M., Dannaoui, E., De La Camara, R., Dellow, E., Donnelly, P., Drgona, L., Einsele, H., Engelhard, D., Flückiger, U., Gachot, B., Gonzales-Moreno, J., Groll, A., Hanel, I., Herbrecht, R., Heussel, CP., Jones, B., Kibbler, C., Klimko, N., Klingspor, L., Kouba, M., Lamoth, F., Lanternier, F., Lehrnbecher, T., Loeffler, J., Lortholary, O., Maertens, J., Marchetti, O., Maschan, A., Mikulska, M., Pagano, L., Petrikos, G., Poulain, D., Racil, Z., Reusser, P., Ribaud, P., Richardson, M., Rizzi-Puechal, V., Ruhnke, M., Sanguinetti, M., Sinko, J., Skiada, A., Styczynski, J., Thiebaut, A., Verweij, P., Viscoli, C., Wahl, J., Ward, K., and White, P.

Subjects
[SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Critical Care and Intensive Care Medicine, Gastroenterology, Serology, law.invention, Mannans, 0302 clinical medicine, MESH: Practice Guidelines as Topic, law, Medicine, MESH: Animals, 030212 general & internal medicine, Candida, Randomized Controlled Trials as Topic, Mannan, 0303 health sciences, Leukemia, mannan, Intensive care unit, 3. Good health, Europe, Practice Guidelines as Topic, medicine.medical_specialty, Antigens, Fungal, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, Animals, Antibodies, Fungal/biosynthesis, Antigens, Fungal/immunology, Candida/immunology, Candidiasis, Invasive/diagnosis, Candidiasis, Invasive/immunology, Congresses as Topic, Humans, Leukemia/complications, Leukemia/immunology, Mannans/immunology, Practice Guidelines as Topic/standards, Randomized Controlled Trials as Topic/standards, 03 medical and health sciences, MESH: Mannans, MESH: Candida, Internal medicine, MESH: Leukemia, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Candidiasis, Invasive, Antibodies, Fungal, MESH: Antigens, Fungal, MESH: Humans, 030306 microbiology, business.industry, Research, MESH: Antibodies, Fungal, Cancer, Odds ratio, medicine.disease, Confidence interval, MESH: Candidiasis, Invasive, MESH: Randomized Controlled Trials as Topic, Immunology, Diagnostic odds ratio, MESH: Europe, business, MESH: Congresses as Topic
Abstract

International audience; INTRODUCTION: Timely diagnosis of invasive candidiasis (IC) remains difficult as the clinical presentation is not specific and blood cultures lack sensitivity and need a long incubation time. Thus, non-culture-based methods for diagnosing IC have been developed. Mannan antigen (Mn) and anti-mannan antibodies (A-Mn) are present in patients with IC. On behalf of the Third European Conference on Infections in Leukemia, the performance of these tests was analysed and reviewed. METHODS: The literature was searched for studies using the commercially available sandwich enzyme-linked immunosorbent assays (Platelia™, Bio-Rad Laboratories, Marnes-la-Coquette, France) for detecting Mn and A-Mn in serum. The target condition of this review was IC defined according to 2008 European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria. Sensitivity, specificity and diagnostic odds ratios (DOR) were calculated for Mn, A-Mn and combined Mn/A-Mn testing. RESULTS: Overall, 14 studies that comprised 453 patients and 767 controls were reviewed. The patient populations included in the studies were mainly haematological and cancer cases in seven studies and mainly intensive care unit and surgery cases in the other seven studies. All studies but one were retrospective in design. Mn sensitivity was 58% (95% confidence interval [CI], 53-62); specificity, 93% (95% CI, 91-94) and DOR, 18 (95% CI 12-28). A-Mn sensitivity was 59% (95% CI, 54-65); specificity, 83% (95% CI, 79-97) and DOR, 12 (95% CI 7-21). Combined Mn/A-Mn sensitivity was 83% (95% CI, 79-87); specificity, 86% (95% CI, 82-90) and DOR, 58 (95% CI 27-122). Significant heterogeneity of the studies was detected. The sensitivity of both Mn and A-Mn varied for different Candida species, and it was the highest for C. albicans, followed by C. glabrata and C. tropicalis. In 73% of 45 patients with candidemia, at least one of the serological tests was positive before the culture results, with mean time advantage being 6 days for Mn and 7 days for A-Mn. In 21 patients with hepatosplenic IC, 18 (86%) had Mn or A-Mn positive test results at a median of 16 days before radiological detection of liver or spleen lesions. CONCLUSIONS: Mn and A-Mn are useful for diagnosis of IC. The performance of combined Mn/A-Mn testing is superior to either Mn or A-Mn testing.

Published
2010
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16. Imaging recommendations in paediatric uroradiology. Minutes of the ESPR uroradiology task force session on childhood obstructive uropathy, high-grade fetal hydronephrosis, childhood haematuria, and urolithiasis in childhood. ESPR Annual Congress, Edinburgh, UK, June 2008

Author

Johan G. Blickman, Michael Riccabona, Kassa Darge, Ulrich Willi, Jean-Nicholas Dacher, Fred E. Avni, Maria Luisa Lobo, Breton, Céline, Department of Radiology, University Hospital Graz, Department of Medical Imaging, University Clinics of Brussels, Radboud University Medical Center [Nijmegen], Service d'imagerie médicale [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Children’s Hospital of Philadelphia (CHOP ), Hospital de Santa Maria, Department of Radiology [Stanford], Stanford Medicine, Stanford University-Stanford University, Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-CHU Rouen

Subjects
Diagnostic Imaging, Urologic Diseases, Pediatrics, medicine.medical_specialty, Urology, Fetal hydronephrosis, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Practice Guidelines as Topic, 030225 pediatrics, MESH: Child, Medical imaging, medicine, Humans, Radiology, Nuclear Medicine and imaging, Child, Obstructive uropathy, Hydronephrosis, ComputingMilieux_MISCELLANEOUS, Neuroradiology, [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, Task force, business.industry, MESH: Diagnostic Imaging, Congresses as Topic, medicine.disease, MESH: Urology, MESH: Urologic Diseases, 3. Good health, Europe, Imaging algorithm, Practice Guidelines as Topic, Pediatrics, Perinatology and Child Health, MESH: Pediatrics, Urologic disease, [SDV.IB]Life Sciences [q-bio]/Bioengineering, MESH: Europe, MESH: Radiology, Radiology, business, MESH: Congresses as Topic
Abstract

The imaging and procedural recommendations as elaborated by the ESPR Paediatric Uroradiology Taskforce and the ESUR Paediatric Uroradiology Working Group were presented and discussed at the first uroradiology panel held during the ESPR Annual Congress in Barcelona in 2007. These recommendations were published in this journal [1] and have gained wide acceptance throughout Europe and beyond. A few imaging algorithms have been newly proposed by group members, partially completing the existing recommendations, and further important recommendations have been added. The imaging algorithm for prenatally diagnosed hydronephrosis (HN) has been supplemented by a statement on imaging neonates with fetally diagnosed high-grade HN and suspected posterior urethral valves (PUV). Recommendations referring to imaging children with suspected obstructive uropathy, the imaging algorithm for childhood haematuria, and the imaging algorithm for children with suspected urolithiasis have been formulated. The aim was again to reduce invasive and unnecessary investigations wherever possible without running the risk of missing potentially damaging conditions and increasing patient morbidity. As with the existing algorithms, the new proposals are consensus-based recommendations since little Pediatr Radiol (2009) 39:891–898 DOI 10.1007/s00247-009-1233-6

Published
2009
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17. 32nd annual meeting of European Environmental Mutagen Society. DNA damage and repair fundamental aspects and contribution to human disorders

Author

Tudek, Barbara, Ciesla, Zygmunt, Janion, Celina, Boiteux, Serge, Bebenek, Katarzyna, Shinagawa, Hideo, Bartsch, Helmut, Laval, Jacques, van Zeeland, Albert A, Mullenders, Leon F H, Szyfter, Krzysztof, Collins, Andrew, Kruszewski, Marcin, Institute of Biochemistry and Biophysics, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Radiobiologie moléculaire et cellulaire (RMC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences [Durham] (NIEHS-NIH), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Research Institute for Microbial Diseases [Osaka, Japan] (RIMD), Osaka University [Osaka], Division of Toxicology and Cancer Risk Factors, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Department of Radiation Genetics and Chemical Mutagenesis, Leiden University Medical Center (LUMC), Institute of Human Genetics, Department of Nutrition [Oslo], Institute of Basic Medical Sciences [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, and Universiteit Leiden-Universiteit Leiden

Subjects
MESH: Oxidation-Reduction, DNA Replication, DNA Repair, MESH: Mitochondria, MESH: DNA Replication, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Genomic Instability, DNA Glycosylases, Neoplasms, Humans, MESH: Neoplasms, Genetic Predisposition to Disease, MESH: DNA Glycosylases, ComputingMilieux_MISCELLANEOUS, MESH: Mutagenesis, MESH: DNA Damage, MESH: DNA Repair, Recombination, Genetic, MESH: Werner Syndrome, MESH: Humans, MESH: Genomic Instability, MESH: Genetic Predisposition to Disease, Congresses as Topic, Mitochondria, MESH: Poland, Mutagenesis, MESH: Recombination, Genetic, Poland, Werner Syndrome, Oxidation-Reduction, MESH: Congresses as Topic, DNA Damage
Abstract

International audience

Published
2003
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