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Your search keyword '"Mignogna, T"' showing total 3 results
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3 results on '"Mignogna, T"'

1. Reliability of clinical outcome measures in Charcot-Marie-Tooth disease

Author

Solari, A, Laurà, M, Salsano, E, Radice, D, Pareyson, D, CMT TRIAAL, Sg, Marelli, C, Scaioli, V, Ciano, C, Rimoldi, M, Lauria, G, Rizzetto, E, Camozzi, F, Schenone, Angelo, Grandis, Marina, Narciso, E, Nobbio, L, Benedetti, L, Rizzuto, N, Fabrizi, Gm, Cavallaro, T, Bertolasi, L, Casano, A, Santoro, L, Manganelli, F, Pisciotta, C, Nolano, M, Vita, G, Mazzeo, A, Di Leo, R, Girlanda, P, Majorana, G, Aguennouz, M, Ciranni, A, Lanzano, N, Quattrone, A, Valentino, P, Nisticò, R, Pirritano, D, Clodomiro, A, Canino, M, Padua, L, Pazzaglia, C, Mignogna, T, Gemignani, F, Brindani, F, Vitetta, F, Visioli, F, Bogani, P, Hughes, Ra, Schenone, A, Mancardi, GIOVANNI LUIGI, Cavaletti, G, Galimberti, S, Calabrese, D, Ferrari, G, Sereda, Mw, Lauria, G., Solari, A, Laurà, M, Salsano, E, Radice, D, Pareyson, D, The CMT TRIAAL Study, G, Cavaletti, G, Marelli, C, Scaioli, V, Ciano, C, Rimoldi, M, Lauria, G, Rizzetto, E, Camozzi, F, Schenone, A, Grandis, M, Narciso, E, Nobbio, L, Benedetti, L, Rizzuto, N, Fabrizi, G, Cavallaro, T, Bertolasi, L, Casano, A, Santoro, L, Manganelli, F, Pisciotta, C, Nolano, M, Vita, G, Mazzeo, A, Di Leo, R, Girlanda, P, Majorana, G, Aguennouz, M, Ciranni, A, Lanzano, N, Quattrone, A, Valentino, P, Nisticò, R, Pirritano, D, Clodomiro, A, Canino, M, Padua, L, Pazzaglia, C, Mignogna, T, Gemignani, F, Brindani, F, Vitetta, F, Bogani, P, Hughes, R, Visioli, F, Mancardi, G, Galimberti, S, Calabrese, D, Ferrari, G, and Sereda, M

Subjects
Male, instrumentation/methods, Predictive Value of Test, Isometric exercise, Ascorbic Acid, Outcome measures, Randomised clinical trial, Tooth disease, Disability Evaluation, Charcot-Marie-Tooth Disease, Medicine, Genetics (clinical), Reliability (statistics), Reliability, Charcot-Marie-Tooth disease, Observer Variation, Neurologic Examination, Muscle Weakness, innervation/physiopathology, Skeletal, Middle Aged, Treatment Outcome, Neurology, Predictive value of tests, Arm, Muscle, Female, medicine.symptom, Foot (unit), Human, Muscle Weakne, Muscle Contraction, Restraint, Physical, Adult, medicine.medical_specialty, Adolescent, Movement, education, Reproducibility of Result, diagnosis/etiology/therapy, Restraint, Adolescent, Adult, Aged, Arm, innervation/physiopathology, Ascorbic Acid, therapeutic use, Charcot-Marie-Tooth Disease, diagnosis/drug therapy/physiopathology, Disability Evaluation, Female, Humans, Leg, physiopathology, Male, Middle Aged, Movement, physiology, Muscle Contraction, physiology, Muscle Weakness, diagnosis/etiology/therapy, Muscle, innervation/physiopathology, Neurologic Examination, instrumentation/methods, Observer Variation, Placebo Effect, Predictive Value of Tests, Reproducibility of Results, Restraint, Physical, instrumentation/methods, Treatment Outcome, Physical medicine and rehabilitation, Predictive Value of Tests, Humans, Muscle, Skeletal, Aged, Leg, business.industry, Muscle weakness, Reproducibility of Results, Ascorbic acid, Placebo Effect, diagnosis/drug therapy/physiopathology, body regions, therapeutic use, Pediatrics, Perinatology and Child Health, physiology, Physical therapy, Neurology (clinical), physiopathology, business
Abstract

We assessed inter- and intra-rater reliability of outcome measures in Charcot-Marie-Tooth disease (CMT) patients. In 40 CMT patients, we assessed reliability of Overall Neuropathy Limitations Scale (ONLS), 10-m timed walk (T10MW), 9-hole-peg test (9-HPT), maximal voluntary isometric contraction (MVIC) of arm (elbow flexion, hand-grip, and three-point pinch) and leg (knee extension, foot dorsiflexion/plantar flexion). Reliability was substantial for ONLS, excellent for T10MW and 9-HPT. For MVIC, inter and intra-rater reliability was excellent for hand contractions; for leg contractions, intra-rater agreement was moderate to substantial, whereas inter-rater agreement was poor. An ad hoc device was produced to immobilize the foot and MVIC reliability was re-assessed in 26 CMT patients, resulting in excellent inter-rater and intra-rater reliability for foot dorsiflexion, and clear inter-rater improvement for foot plantar flexion. All outcome measures appear adequate for CMT assessment. Use of an immobilization device improves foot MVIC reliability, preventing biased findings in patients with greater strength.

Published
2008

2. Charcot-Marie-Tooth and pain: correlations with neurophysiological, clinical, and disability findings

Author

Padua, L, Cavallaro, T, Pareyson, D, Quattrone, A, Vita, Giuseppe, Schenone, A, Grandis, M., Benedetti, L., Caliandro, P., Pazzaglia, C., Irene, A., Mazza, O., Ferraro, D., Mignogna, T., Tonali, P., Fabrizi, G. M., Rizzuto, N., Laurà, M., Mazzeo, Anna, Majorana, G., Valentino, P., and Nisticò, R.

Subjects
Adult, Male, Quality of life, Charcot-Marie-Tooth, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Activities of daily living, Neurology, Charcot-Marie-Tooth pain, Multidimensional assessment, Pain, Dermatology, Disability Evaluation, Sex Factors, Physical medicine and rehabilitation, Charcot-Marie-Tooth Disease, Surveys and Questionnaires, Activities of Daily Living, medicine, Humans, Peripheral Nerves, Pain Measurement, Neuroradiology, business.industry, General Medicine, Middle Aged, Neurophysiology, nervous system diseases, Settore MED/26 - NEUROLOGIA, Psychiatry and Mental health, Bodily pain, Disease Progression, Physical therapy, Female, Neurology (clinical), Neurosurgery, business, Quality of Life, 2708, Psychiatry and Mental Health
Abstract

Pain is not considered a relevant symptom in Charcot-Marie-Tooth (CMT) patients and no studies have comprehensively assessed it. We performed a multidimensional assessment in 211 consecutive CMT patients to evaluate the clinical features, quality of life (QoL) and disability. For QoL we used the SF-36, which comprises one domain called "Bodily Pain" (BP), which is a generic measure of intensity of pain. Results showed that pain is a relevant symptom related to gender, CMT subtypes, clinical picture, disability, and mildly to neurophysiological impairment. In our study the importance of pain was an occasional finding. Because of the study design we are not able to ascertain if pain is primarily due to the neuropathy or if it is due to the muscoloskeletal deformities arising as a consequence of the neuropathy. Our study underlined that pain should be considered as a relevant symptom in CMT patients and further studies should be performed.

Published
2008

3. Pure motor chronic inflammatory demyelinating polyneuropathy

Author

Sabatelli, Mario, Sabatelli, M, Madia, F, Mignogna, T, Lippi, G, Quaranta, L, and Tonali, P.

Subjects
Adult, Male, Recruitment, Neurophysiological, medicine.medical_specialty, Pathology, Neurology, Neural Conduction, Alpha interferon, Neurological examination, Chronic inflammatory demyelinating polyneuropathy, CIDP, Electromyography, Neurological disorder, Recurrence, Humans, Medicine, Neurons, Afferent, Child, Muscle, Skeletal, Motor Neurons, medicine.diagnostic_test, business.industry, Immunoglobulins, Intravenous, Interferon-alpha, Polyradiculoneuropathy, medicine.disease, Surgery, Settore MED/26 - NEUROLOGIA, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Retreatment, Female, Steroids, Neurology (clinical), business, Polyneuropathy
Abstract

We describe four patients affected by chronic inflammatory demyelinating polyneuropathy (CIDP) in a pure motor form. Selective involvement of motor fibers was suggested by the absence of sensory symptoms, normal sensation at neurological examination and normal findings on electrophysiological testing of sensory fibres and sural nerve biopsy. The onset of the disease occurred at a young age (3-29 years) and the clinical course was relapsing-remitting. Over a follow-up period of 1.5-14 years, periodical clinical and electrophysiological examinations showed that selective involvement of motor fibers remained a constant feature. Electromyography and nerve conduction studies continued to show a purely demyelinating neuropathy without signs of axonal impairment. All patients were steroid-unresponsive, whereas they considerably improved after being treated with immunoglobulins. Two patients were treated with interferon alpha and showed a good response. In conclusion, the occurrence in our four patients of pure motor involvement over a long period of time during which several relapses occurred, suggests that pure motor CIDP may represent the result of a specific immunological process rather than of a random distribution of inflammation throughout peripheral nerves.

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