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58 results on '"O-Desmethyltramadol"'

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1. Physiologically Based Pharmacokinetic Modeling to Assess the Impact of CYP2D6‐Mediated Drug‐Drug Interactions on Tramadol and O‐Desmethyltramadol Exposures via Allosteric and Competitive Inhibition

2. Automated high‐throughput analysis of tramadol and O‐desmethyltramadol in dried blood spots

3. Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1-3 and Human Plasma Membrane Monoamine Transporter

4. Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR

5. Intrinsic clearance rate of O-desmethyltramadol (M1) by glucuronide conjugation and phase I metabolism by feline, canine and common brush-tailed possum microsomes

6. HPLC-UV assay of tramadol and O-desmethyltramadol in human plasma containing other drugs potentially co-administered to participants in a paediatric population pharmacokinetic study

7. Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling

8. Evaluation of tramadol human pharmacokinetics and safety after co-administration of magnesium ions in randomized, single- and multiple-dose studies

9. On the sulfation of O -desmethyltramadol by human cytosolic sulfotransferases

10. Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6

11. Quantitation of the enantiomers of tramadol and its three main metabolites in human whole blood using LC–MS/MS

12. Non-Medical Use of Novel Synthetic Opioids: A New Challenge to Public Health

13. First report on the pharmacokinetics of tramadol and O-desmethyltramadol in exhaled breath compared to plasma and oral fluid after a single oral dose

14. Pharmacokinetics of Tramadol and O-Desmethyltramadol Enantiomers Following Administration of Extended-Release Tablets to Elderly and Young Subjects

15. Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

16. OCT1 pharmacogenetics in pain management: is a clinical application within reach?

17. µ-Opioid receptor activation by tramadol and O-desmethyltramadol (M1)

18. Simultaneous Determination of Tramadol and O-Desmethyltramadol in Human Plasma Using HPLC–DAD

19. Postmortem Redistribution of Tramadol and O-Desmethyltramadol

20. Simultaneous determination of tramadol, O-desmethyltramadol and N-desmethyltramadol in human urine by gas chromatography–mass spectrometry

21. SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants

22. Enantioselective analysis of unbound tramadol, O-desmethyltramadol and N-desmethyltramadol in plasma by ultrafiltration and LC–MS/MS: Application to clinical pharmacokinetics

23. Determination of tramadol and O-desmethyltramadol in human plasma by high-performance liquid chromatography with mass spectrometry detection

24. Improved liquid chromatographic method for the simultaneous determination of tramadol and its three main metabolites in human plasma, urine and saliva

25. Concentrations of Tramadol and O-desmethyltramadol Enantiomers in Different CYP2D6 Genotypes

26. Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers

27. Enantiomeric Determination of Tramadol and O-Desmethyltramadol by Liquid Chromatography-Mass Spectrometry and Application to Postoperative Patients Receiving Tramadol

28. Improved HPLC method for the simultaneous determination of tramadol and O-desmethyltramadol in human plasma

29. Clinical Pharmacology of Tramadol

30. Method development and validation of a high-performance liquid chromatographic method for tramadol in human plasma using liquid–liquid extraction

31. Effects of type 1 and type 2 diabetes on the pharmacokinetics of tramadol enantiomers in patients with neuropathic pain phenotyped as cytochrome P450 2D6 extensive metabolizers

32. Enantiomeric determination of tramadol and its main metabolite O-desmethyltramadol in human plasma by liquid chromatography–tandem mass spectrometry

33. Automated determination of tramadol enantiomers in human plasma using solid-phase extraction in combination with chiral liquid chromatography

34. Tramadol: A new centrally acting analgesic

35. A suicidal poisoning due to tramadol. A metabolic approach to death investigation

36. Rifampicin markedly decreases the exposure to oral and intravenous tramadol

37. Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton

38. Achiral and chiral high-performance liquid chromatographic determination of tramadol and its major metabolites in urine after oral administration of racemic tramadol

39. Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk

40. Enantiomeric determination of tramadol and O-desmethyltramadol in human plasma by fast liquid chromatographic technique coupled with mass spectrometric detection

42. Enatiomeric determination of tramadol and O-desmethyltramadol in human urine by gas chromatography-mass spectrometry

43. An accurate, rapid and sensitive determination of tramadol and its active metabolite O-desmethyltramadol in human plasma by LC-MS/MS

44. Modelling the Pharmacokinetics of tramadol: On the difference between CYP2D6 extensive and poor metabolizers

46. Development and validation of a rapid HPLC method for simultaneous determination of tramadol, and its two main metabolites in human plasma

47. Metabolism of the analgesic drug ULTRAM (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites

48. Validation of a high-performance liquid chromatography method for tramadol and o-desmethyltramadol in human plasma using solid-phase extraction

49. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor

50. Tramadol: a review of its use in perioperative pain

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