1. [Diltiazem and modulation of platelet aggregation]
- Author
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G, Colica, D, Salnitro, F, Scopelliti, D, Sergi, R, Pellegrino, A, Zoccali, and P, Lanucara
- Subjects
Adenosine Diphosphate ,Adult ,Male ,Diltiazem ,Dose-Response Relationship, Drug ,Platelet Aggregation ,Drug Evaluation ,Humans ,Female ,Middle Aged ,Platelet Aggregation Inhibitors - Abstract
The calcium antagonists including Diltiazem have been proved to inhibit platelet aggregation caused by ADP. In order to demonstrate the anti-aggregant properties of Diltiazem, a study was conducted on the aggregation curves in blood samples from 20 healthy subjects before and after a week's treatment with 240 mg oral Diltiazem per diem. The experiment confirmed the anti-aggregant properties of Diltiazem which is therefore useful in the treatment of cardiovascular disease given its capacity to dilate the coronary arteries and inhibit platelet aggregation.
- Published
- 1990