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3 results on '"P. O. Comby"'

1. [Idiopathic intracranial hypertension: From physiopathological mechanisms to therapeutic decision]

Author

F, Robelin, M, Lenfant, F, Ricolfi, Y, Béjot, and P-O, Comby

Subjects
Pseudotumor Cerebri, Transverse Sinuses, Quality of Life, Humans, Female, Stents, Constriction, Pathologic
Abstract

Clinical features include visual disturbances, headaches, and pulsatile tinnitus that can be associated with reduced quality of life, and a risk of irreversible visual impairment in some cases. Obese women of childbearing age represent the main at-risk population, and the incidence of the disease is increasing because of rising prevalence of obesity worldwide. In addition, an imbalance in sex hormones is reported as a contributing risk factor. The pathophysiology of idiopathic intracranial hypertension involves a disturbance of the evacuation pathway of intracranial fluids caused by the increase in intracranial venous pressure. Brain imaging is useful for diagnosis with several signs including bilateral stenosis of the transverse sinuses that plays a major role in the pathogenesis of the disease by creating a positive feedback loop that increases intracranial venous hypertension and contributes to clinical manifestations. Treatment aims to relieve symptoms and prevent permanent visual impairment. Drug therapies including acetazolamide and topiramate have moderate effectiveness. Among invasive treatments, transverse sinus stenting seems to be the most interesting option to consider in drug-resistant patients. Weight loss remains essential to achieve a sustainable improvement by reducing central venous pressure. Future randomized trials are expected to reach a consensus on this treatment.

Published
2022

2. Advanced multiparametric magnetic resonance imaging of multinodular and vacuolating neuronal tumor

Author

François Cotton, Jean-Philippe Cottier, M. Mejdoubi, Sylvie Grand, M. Rodallec, René Anxionnat, N. Magne, Seyyid Baloglu, Capucine Diard-Detoeuf, Stéphane Kremer, Julien Savatovsky, Natalia Shor, Loïc Duron, D. Chauvet, Sonia Nagi, G. Forestier, Antoine Moulignier, Cyrine Drissi, Thomas Tourdias, Hugues Loiseau, J. Bailleux, Monique Elmaleh, J. Aguilar Garcia, Fabrice Bonneville, Romain Deschamps, C. Vandendries, E. Gerardin, E. Calvier, Augustin Lecler, V. Broquet, Dragos Catalin Jianu, B. Carsin, P. O. Comby, Homa Adle-Biassette, François Ducray, Jaume Farràs, M. Ollivier, Fondation Ophtalmologique Adolphe de Rotschild, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Hôpital Bretonneau, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bretonneau, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), RMN et optique : De la mesure au biomarqueur, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de neuro-oncologie [Hôpital Pierre Wertheimer - HCL], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Université de Lyon, Centre National d'Études Spatiales [Toulouse] (CNES), Service de Radiologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Wageningen University and Research [Wageningen] (WUR), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Fondation Ophtalmologique Adolphe de Rothschild [Paris], Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de radiologie, Fondation Hôpital Saint-Joseph, Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), RMX-medical center, 80, avenue Felix-Faure, 75015 Paris, France, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Departement de Neuroradiologie [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Département de Radiologie [CHU de Rennes], Université de Rennes (UR), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Service de radiologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Service de Neuroradiologie interventionnelle [CHU Limoges], CHU Limoges, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre hospitalier universitaire de Nantes (CHU Nantes), Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Hôpital Sainte Perine [AP-HP], Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), AP-HP Hôpital universitaire Robert-Debré [Paris], Service de neuroradiologie [Grenoble], CHU Grenoble, Victor Babeş University of Medicine and Pharmacy (UMFT), CHU Bordeaux [Bordeaux], Groupe hospitalier Pellegrin, Centre cardiologique du Nord (CCN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), and Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
In vivo magnetic resonance spectroscopy, Adult, Male, diagnosis, diagnostic imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, neoplasms, Lesion, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Medical imaging, medicine, Effective diffusion coefficient, Humans, 030212 general & internal medicine, Multiparametric Magnetic Resonance Imaging, Retrospective Studies, medicine.diagnostic_test, business.industry, Brain Neoplasms, Magnetic resonance imaging, Middle Aged, Magnetic Resonance Imaging, Diffusion Magnetic Resonance Imaging, Neurology, Cerebral blood flow, multinodular and vacuolating neuronal tumor, Female, Neurology (clinical), medicine.symptom, Nuclear medicine, business, 030217 neurology & neurosurgery
Abstract

Background and purpose Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a rare brain lesion with suggestive imaging features. The aim of our study was to report the largest series of MVNTs so far and to evaluate the utility of advanced multiparametric magnetic resonance (MR) techniques. Methods This multicenter retrospective study was approved by our institutional research ethics board. From July 2014 to May 2019, two radiologists read in consensus the MR examinations of patients presenting with a lesion suggestive of an MVNT. They analyzed the lesions' MR characteristics on structural images and advanced multiparametric MR imaging. Results A total of 64 patients (29 women and 35 men, mean age 44.2 ± 15.1 years) from 25 centers were included. Lesions were all hyperintense on fluid-attenuated inversion recovery and T2-weighted imaging without post-contrast enhancement. The median relative apparent diffusion coefficient on diffusion-weighted imaging was 1.13 [interquartile range (IQR), 0.2]. Perfusion-weighted imaging showed no increase in perfusion, with a relative cerebral blood volume of 1.02 (IQR, 0.05) and a relative cerebral blood flow of 1.01 (IQR, 0.08). MR spectroscopy showed no abnormal peaks. Median follow-up was 2 (IQR, 1.2) years, without any changes in size. Conclusions A comprehensive characterization protocol including advanced multiparametric magnetic resonance imaging sequences showed no imaging patterns suggestive of malignancy in MVNTs. It might be useful to better characterize MVNTs.

Published
2020
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3. Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance

Author

Antoine Moulignier, C. Vandendries, E. Gerardin, J. Farras, C. Bogey, Thomas Tourdias, Cyrine Drissi, Julien Savatovsky, F. Ducray, M. Rodallec, N. Magne, François Cotton, Sonia Nagi, M. Mejdoubi, Jean-Philippe Cottier, Romain Deschamps, J.A. Garcia, Dragos Catalin Jianu, V. Broquet, B. Carsin, Seyyid Baloglu, Jean-Claude Sadik, Sylvie Grand, Capucine Diard-Detoeuf, Stéphane Kremer, Monique Elmaleh, Natalia Shor, Fabrice Bonneville, Homa Adle-Biassette, P. O. Comby, J. Bailleux, Loïc Duron, M. Ollivier, E. Calvier, and Augustin Lecler

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Supratentorial region, Posterior fossa, Infratentorial Neoplasms, 030218 nuclear medicine & medical imaging, Lesion, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Unknown Significance, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, business.industry, Cerebrum, Adult Brain, Brain, Nodule (medicine), Middle Aged, Magnetic Resonance Imaging, medicine.anatomical_structure, Posterior fossa lesion, Female, Neurology (clinical), Signal intensity, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Multinodular and vacuolating neuronal tumor of the cerebrum is a rare supratentorial brain tumor described for the first time in 2013. Here, we report 11 cases of infratentorial lesions showing similar striking imaging features consisting of a cluster of low T1-weighted imaging and high T2-FLAIR signal intensity nodules, which we referred to as multinodular and vacuolating posterior fossa lesions of unknown significance. No relationship was found between the location of the lesion and clinical symptoms. A T2-FLAIR hypointense central dot sign was present in images of 9/11 (82%) patients. Cortical involvement was present in 2/11 (18%) of patients. Only 1 nodule of 1 multinodular and vacuolating posterior fossa lesion of unknown significance showed enhancement on postcontrast T1WI. DWI, SWI, MRS, and PWI showed no malignant pattern. Lesions did not change in size or signal during a median follow-up of 3 years, suggesting that multinodular and vacuolating posterior fossa lesions of unknown significance are benign malformative lesions that do not require surgical intervention or removal.

Published
2019
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