5 results on '"Qiu‑Shi Zhang"'
Search Results
2. [Influence of registration based on different reference markers on the displacement of the geometry consisted of all clips in the cavity for external-beam partial breast irradiation at moderate deep inspiration breath holding]
- Author
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Jian-bin, Li, Qiu-shi, Zhang, Zhi-fang, Ma, Jie, Lu, Min, Xu, Ting-yong, Fan, and Qian, Shao
- Subjects
Breath Holding ,Radiography ,Imaging, Three-Dimensional ,Fiducial Markers ,Radiotherapy Planning, Computer-Assisted ,Humans ,Breast Neoplasms ,Female ,Surgical Instruments - Abstract
To investigate the influence of registration based on different reference markers on the displacement of the geometry consisted of all clips in the cavity for external-beam partial breast irradiation at moderate deep inspiration breath holding assisted by active breathing control device.Twenty-seven early stage breast cancer patients feasible for external beam partial breast irradiation (EB-PBI) were selected. The patients undertaken three-dimensional computed tomography (3DCT) simulation scan at moderate deep inspiration breath holding (mDIBH) assisted by active breathing control device, and two sets of mDIBH CT images were got and transferred to the Pinnacle 3 planning system. All of the silver clips were delineated and a geometry consisted of all clips were generated. On the account of automatic registration of mDIBH CT images, manual registration was carried out based separately on the topside clip in the cavity, the labeled skin at anterior surface of the cavity at central level and the metal mark on the body surface near the cavity, then the displacements of center of the geometry in left-right (LR), anterior-posterior (AP) and superior-inferior (SI) directions based separately on the three registrations were measured.The displacements of center of the geometry in LR, AP and SI directions based on registration of the clips, the labeled skin and the metal mark were (0.61 ± 0.62)mm vs. (1.11 ± 1.21)mm vs. (1.31 ± 1.55)mm, (0.63 ± 0.59)mm vs. (0.92 ± 0.93)mm vs. (1.19 ± 1.24)mm and (0.91 ± 0.96)mm vs. (2.13 ± 2.12)mm vs. (1.93 ± 1.55)mm, respectively. Compared the displacements of center of the geometry in the same direction between the three registrations, significant differences were found only in SI direction between clip registration and skin registration, clip registration and mark registration (t = 5.045, 7.210 and P = 0.025, 0.007) . Compared the displacements of center of the geometry between three dimensional directions for each reference registration, there was no significant difference (all P0.05).When EB-PBI is carried out in state of mDIBH, measurement of the intrafraction displacement based on registration of the clip in the cavity is a reasonable selection. Otherwise, excessive margin enlargement of PTV in SI direction will be generated if the regional skin or metal mark is selected as registration reference. more...
- Published
- 2014
Catalog
3. [Comparison of overlap ratios of the target volume in different respiratory states with active breathing control for external-beam partial breast irradiation]
- Author
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Qiu-Shi, Zhang, Jian-Bin, Li, Min, Xu, Ting-Yong, Fan, Jie, Lu, Ying-Jie, Zhang, Jun, Xing, and Shi-Yu, Tian
- Subjects
Immobilization ,Respiration ,Humans ,Breast Neoplasms ,Female ,Dose Fractionation, Radiation ,Postoperative Period ,Radiotherapy, Conformal ,Mastectomy, Segmental ,Tomography, X-Ray Computed - Abstract
To explore the overlap ratio of the target volume in different respiratory statuses of active breath control (ABC) and their differences during external-beam partial breast irradiation (EB-PBI), and from the perspective of target volume overlap to determine the influence of the ABC-assisted breathing condition on intra-fractional target movement of EB-PBI.The patients, who received breast-conserving surgery with silver clips marked at the margins of the cavity and were suitable for EB-PBI, were immobilized on the breast bracket to undertake CT simulation assisted by ABC device, six sets of CT simulation images including two sets of image in state of moderate deep inspiration breathing control (mDIBH), two sets of images in state of free breath (FB) and two sets of images in state of deep expiration breathing control (DEBH) were obtained. The six sets of images were transferred to Pinnacle(3) treatment planning system (TPS), then automatic fusion and registration between two sets of mDIBH images, two sets of FB images, two sets of DEBH images and mDIBH image and DEBH image were achieved separately. Thereafter, the overlap ratios of GTV with GTV, CTV with CTV, PTV with PTV were calculated by the Pinnacle(3) TPS. The differences between the overlap ratios of the three kinds of targets in the same registered image and the difference between the overlap ratios of the same kind of target in the different registered images were statistically analyzed using statistical package of SPSS 11.5.Based on mDIBH/mDIBH registration, the overlap ratios of GTV/GTV, CTV/CTV and PTV/PTV were (83.54 ± 11.41)%, (93.00 ± 6.49)%, and (95.26 ± 4.90)%, respectively, and the differences of the overlap ratios between GTV/GTV and CTV/CTV, GTV/GTV and PTV/PTV were all statistically significant (P0.05), but statistically not significant between CTV/CTV and PTV/PTV (P0.05). Based on FB/FB registration, the overlap ratios of GTV/GTV, CTV/CTV and PTV/PTV were (72.55 ± 29.10)%, (89.36 ± 9.53)% and (92.47 ± 7.25)%, respectively, and the differences of the overlap ratios between GTV/GTV and CTV/CTV, CTV/CTV and PTV/PTV were all not statistically significant (P0.05), but statistically significant between GTV/GTV and PTV/PTV (P0.05). Based on DEBH/DEBH registration, the overlap ratios of GTV/GTV, CTV/CTV and PTV/PTV were (79.48 ± 22.31)%, (92.83 ± 6.77)% and (95.05 ± 4.81)%, respectively, and the differences of the overlap ratios between GTV/GTV and CTV/CTV (P = 0.000), CTV/CTV and PTV/PTV (P = 0.037), GTV/GTV and PTV/PTV (P = 0.000) were statistically all significant (P = 0.000). The differences of the overlap ratios of GTV/GTV, CTV/CTV, and PTV/PTV (P = 0.000) between mDIBH/mDIBH and DEBH/DEBH, mDIBH/mDIBH and FB/FB, FB/FB and DEBH/DEBH were all statistically significant (P = 0.000), and not statistically significant between mDIBH/mDIBH and mDIBH/DEBH, FB/FB and mDIBH/DEBH.During the delivering of EB-PBI assisted by ABC, the intra-fractional overlap ratios of the target volume between the same breathing state is increasing in the order of GTV/GTV → CTV/CTV → PTV/PTV. The difference of the overlap ratios of the target volumes between mDIBH and mDIBH, FB and FB, DEBH and DEBH is not significant, and the overlap ratios of PTV/PTV in the three breathing statuses of mDIBH, FB and DEBH reaches a higher level. Therefore, from the perspective of target volume overlap, if the setup error is corrected online before delivering, the necessity of breathing control during delivering of EB-PBI is worthy discussing. more...
- Published
- 2011
4. A case of 48,XXYY syndrome detected prenatally by QF-PCR
- Author
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Dong-Zhi Li and Qiu-Shi Zhang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Prenatal diagnosis ,Biology ,Fluorescence ,Pregnancy ,Gene Duplication ,Prenatal Diagnosis ,medicine ,Humans ,Sex Chromosome Aberrations ,Gynecology ,Fetus ,Polysomy ,Chromosomes, Human, X ,Chromosomes, Human, Y ,medicine.diagnostic_test ,Reverse Transcriptase Polymerase Chain Reaction ,Meiosis II ,Chromosome ,Obstetrics and Gynecology ,Karyotype ,Syndrome ,medicine.disease ,XXYY syndrome ,Pediatrics, Perinatology and Child Health ,Amniocentesis ,Female ,Abortion, Eugenic - Abstract
We report on the prenatal diagnosis and genetic analysis of a 48,XXYY fetus. A 28-year-old woman was referred for amniocentesis at 18 weeks' gestation because of advanced paternal age. Quantitative-fluorescence polymerase chain reaction (QF-PCR) with small tandem repeat (STR) markers rapidly detected the sex chromosome polysomy from amniotic fluid cells. This abnormality appeared to arise from successive non-disjunction during paternal meiosis I and meiosis II. Cytogenetic analysis revealed a karyotype of 48,XXYY. This case adds to the evidence that an age-related increase in sex chromosomal aneuploidies occurs in sperm. This case also shows that QF-PCR assays can provide rapid prenatal diagnosis of numerical sex chromosome aneuploidy. more...
- Published
- 2009
5. [MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease]
- Author
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Feng, Ding, Qiu-Shi, Zhang, and Fu-Qi, Xing
- Subjects
Tissue Inhibitor of Metalloproteinase-2 ,Hydatidiform Mole, Invasive ,Pregnancy ,Uterine Neoplasms ,Humans ,Matrix Metalloproteinase 2 ,Female ,Choriocarcinoma ,Hydatidiform Mole ,Gestational Trophoblastic Disease ,Immunohistochemistry ,In Situ Hybridization ,Trophoblasts - Abstract
To explore the role of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of MMP-2 (TIMP-2) in the pathogenesis, development and prognosis of gestational trophoblastic disease (GTD).In situ hybridization and immunohistochemistry were utilized for MMP-2/TIMP-2 mRNA and protein detection in normal chorion of women with early gestation, hydatidiform mole, invasive mole, or choricarcinoma.The results revealed that specific staining for mRNA and protein of MMP-2 and the expression of TIMP-2 was reduced in normal chorion of early gestation. In GTD ranging from hydatidiform mole, invasive mole to choricarcinoma, MMP-2 expression tended to increase while TIMP-2 expression underwent an invert change. The positivity rate of MMP-2 and TIMP-2 in gestational trophoblastic tumor group was higher than that of the normal chorion of early gestation group and hydatiform mole group (P0.05 and P0.001, respectively).A disrupted balance between the activation and inhibition of MMP-2 plays a critical role in the pathogenesis, progression and metastasis of GTD. more...
- Published
- 2007
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