8 results on '"Ramez I. Haddadin"'
Search Results
2. Experimental use of an extracellular matrix graft in pterygium surgery
- Author
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Suri Dwarakanathan, Ramez I. Haddadin, and Erik W Anderson
- Subjects
Adult ,Male ,medicine.medical_specialty ,Conjunctiva ,Case Report ,Ophthalmologic Surgical Procedures ,Pterygium ,Transplantation, Autologous ,Extracellular matrix ,medicine ,Humans ,Fibrin glue ,business.industry ,Mitomycin C ,Eyelids ,General Medicine ,medicine.disease ,eye diseases ,Surgery ,Extracellular Matrix ,Transplantation ,medicine.anatomical_structure ,sense organs ,Complication ,business ,Ophthalmologic Surgical Procedure ,Follow-Up Studies - Abstract
A 40-year-old man presented with a primary pterygium of the right eye and underwent pterygium excision using mitomycin C and placement of an extracellular matrix (ECM) adjuvant. As an adjuvant in pterygium surgery, ECM serves as a scaffold while promoting the growth of normal conjunctiva. Perioperatively, the ECM graft was found to be easily manipulated on the surgical field. It attached to the scleral bed with fibrin glue without complication. Postoperatively, there was no inflammation or local tissue reaction to the porcine ECM graft. At the most recent follow-up examination, 6 months postoperatively, there were no signs of recurrence of the pterygium past the limbus. This is the first report describing the use of ECM as an adjuvant to pterygium excision. more...
- Published
- 2017
Catalog
3. Corneal Trauma Following Keratoplasty
- Author
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Ramez I. Haddadin, James Chodosh, and Gargi K. Vora
- Subjects
Corneal Trauma ,Wound Healing ,medicine.medical_specialty ,business.industry ,MEDLINE ,Corneal Diseases ,Ophthalmology ,Eye Injuries ,Corneal Injury ,Surgical Wound Dehiscence ,Humans ,Medicine ,Laser Therapy ,business ,Wound healing ,Keratoplasty, Penetrating ,Corneal Injuries - Published
- 2013
- Full Text
- View/download PDF
4. Management of Corneal Lacerations and Perforations
- Author
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James Chodosh, Gargi K. Vora, and Ramez I. Haddadin
- Subjects
medicine.medical_specialty ,Contact Lenses ,Corneal Perforation ,business.industry ,MEDLINE ,Lacerations ,Surgery ,Corneal Transplantation ,Ophthalmology ,Lens Implantation, Intraocular ,Corneal Injury ,medicine ,Humans ,Tissue Adhesives ,Amnion ,business ,Corneal Injuries - Published
- 2013
- Full Text
- View/download PDF
5. Diagnosis and management of herpes zoster ophthalmicus
- Author
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Erik W Anderson, Robert J. Fantus, and Ramez I. Haddadin
- Subjects
medicine.medical_specialty ,Herpesvirus 3, Human ,Herpes Zoster Vaccine ,business.industry ,MEDLINE ,General Medicine ,Dermatology ,Antiviral Agents ,03 medical and health sciences ,0302 clinical medicine ,Herpes Zoster Ophthalmicus ,030221 ophthalmology & optometry ,medicine ,Humans ,030212 general & internal medicine ,business - Published
- 2016
6. Matricellular proteins in the trabecular meshwork
- Author
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Douglas J. Rhee, Min Hyung Kang, Ramez I. Haddadin, and Dong Jin Oh
- Subjects
Male ,Intraocular pressure ,Pathology ,medicine.medical_specialty ,genetic structures ,Tenascin ,Glaucoma ,Extracellular matrix ,Cellular and Molecular Neuroscience ,Trabecular Meshwork ,medicine ,Humans ,Osteopontin ,Eye Proteins ,Aged ,Galectin ,Extracellular Matrix Proteins ,Thrombospondin ,integumentary system ,biology ,medicine.disease ,eye diseases ,Sensory Systems ,Extracellular Matrix ,Cell biology ,Ophthalmology ,medicine.anatomical_structure ,biology.protein ,sense organs ,Trabecular meshwork - Abstract
The trabecular meshwork is one of the primary tissues of interest in the normal regulation and dysregulation of intraocular pressure (IOP) that is a causative risk factor for primary open-angle glaucoma. Matricellular proteins generally function to allow cells to modulate their attachments with and alter the characteristics of their surrounding extracellular matrix (ECM). In non-ocular tissues, matricellular proteins generally increase fibrosis. Since ECM turnover is very important to the outflow facility, matricellular proteins may have a significant role in the regulation of IOP. The formalized study of matricellular proteins in trabecular meshwork is in its infancy. SPARC, thrombospondins-1 and -2, and tenascins-C and -X, and osteopontin have been localized to varying areas within the trabecular meshwork. Preliminary evidence indicates that SPARC and thrombospondin-1 play a role in the regulation of IOP and possibly the pathophysiology of glaucoma. These data show promise that matricellular proteins are involved in IOP dysregulation and are potential therapeutic targets. Further study is needed to clarify these roles. more...
- Published
- 2009
- Full Text
- View/download PDF
7. Corneal transplantation and glaucoma
- Author
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Ramez I. Haddadin and James Chodosh
- Subjects
Intraocular pressure ,medicine.medical_specialty ,genetic structures ,Keratoprosthesis ,medicine.medical_treatment ,Ocular hypertension ,Glaucoma ,Aphakia ,Corneal Diseases ,Risk Factors ,Ophthalmology ,medicine ,Humans ,Corneal transplantation ,business.industry ,Incidence ,General Medicine ,Perioperative ,medicine.disease ,eye diseases ,Surgery ,Descemet Stripping Endothelial Keratoplasty ,Ocular Hypertension ,sense organs ,business ,Keratoplasty, Penetrating - Abstract
Glaucoma is the leading cause of irreversible vision loss post-keratoplasty and an important cause of graft failure. With newer techniques, such as lamellar, endothelial, and laser-assisted keratoplasty as well as keratoprosthesis gaining popularity, clinicians will need to consider the incidence, risks, evaluation, and management of glaucoma for each type of keratoplasty when determining which type of transplant may be most appropriate. A comprehensive literature search of glaucoma in the setting of corneal transplantation was performed and serves as the basis for this review. Preexisting glaucoma and aphakia are notable risk factors. Patients that are candidates for deep anterior lamellar keratoplasty may benefit from reduced rates of post-keratoplasty glaucoma. Although glaucoma also complicates eyes with Descemet stripping endothelial keratoplasty, the severity is less and the intraocular pressure is more easily controlled when compared to penetrating keratoplasty. Endothelial keratoplasty creates unique perioperative issues mostly related to management of anterior chamber air bubbles. more...
- Published
- 2014
8. The Effects of Tenascin C Knockdown on Trabecular Meshwork Outflow Resistance
- Author
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Yong Feng Yang, Dong Jin Oh, Min Hyung Kang, Kate E. Keller, Douglas J. Rhee, Janice A. Vranka, Mary J. Kelley, Ramez I. Haddadin, Ted S. Acott, and Ying Ying Sun
- Subjects
Adult ,Intraocular pressure ,Pathology ,medicine.medical_specialty ,genetic structures ,Swine ,Tenascin ,Extracellular matrix ,Mice ,Organ Culture Techniques ,Anterior Eye Segment ,Trabecular Meshwork ,medicine ,Cadaver ,Outflow resistance ,Animals ,Homeostasis ,Humans ,Osteonectin ,Gene Silencing ,RNA, Messenger ,Uvea ,Intraocular Pressure ,chemistry.chemical_classification ,Mice, Knockout ,Gene knockdown ,biology ,Tenascin C ,Ciliary Body ,Lentivirus ,Articles ,musculoskeletal system ,eye diseases ,Extracellular Matrix ,medicine.anatomical_structure ,chemistry ,biology.protein ,Trabecular meshwork ,sense organs ,Glycoprotein ,Sclera - Abstract
Tenascin C (TNC) is a matricellular glycoprotein whose expression in adult tissue is indicative of tissue remodeling. The purpose of the current study was to determine the localization of TNC in trabecular meshwork (TM) tissue and to analyze the effects of TNC on intraocular pressure (IOP).Human TM frontal sections were immunostained with anti-TNC and imaged by confocal microscopy. TNC mRNA and protein levels were quantitated in anterior segments perfused at physiological and elevated pressure. Short, hairpin RNA (shRNA) silencing lentivirus targeting full-length TNC (shTNC) was applied to anterior segment perfusion organ cultures. The IOPs and central corneal thickness (CCT) of wild-type, TNC(-/-), and tenascin X (TNX(-/-)) knockout mice were measured.TNC was distributed in the juxtacanalicular (JCT) region of adult human TM, predominantly in the basement membrane underlying the inner wall of Schlemm's canal. Application of shTNC lentivirus to human and porcine anterior segments in perfusion culture did not significantly affect outflow rate. Although TNC was upregulated in response to pressure, there was no difference in outflow rate when shTNC-silenced anterior segments were subjected to elevated pressure. Furthermore, IOPs and CCTs were not significantly different between TNC(-/-) or TNX(-/-) and wild-type mice.TNC does not appear to contribute directly to outflow resistance. However, TNC immunolocalization in the JCT of adult human eyes suggests that certain areas of the TM are being continuously remodeled with or without an IOP increase. more...
- Published
- 2013
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