35 results on '"Thi Bui"'
Search Results
2. Association of Fruit, Vegetable, and Animal Food Intakes with Breast Cancer Risk Overall and by Molecular Subtype among Vietnamese Women
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Sang M. Nguyen, Huong T.T. Tran, Lan M. Nguyen, Oanh Thi Bui, Dong V. Hoang, Martha J. Shrubsole, Qiuyin Cai, Fei Ye, Wei Zheng, Hung N. Luu, Thuan V. Tran, and Xiao-Ou Shu
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Risk ,Epidemiology ,Breast Neoplasms ,Diet ,Eating ,Asian People ,Oncology ,Risk Factors ,Case-Control Studies ,Fruit ,Surveys and Questionnaires ,Vegetables ,Animals ,Humans ,Female - Abstract
Background: Evidence on associations between dietary intake and risk of breast cancer subtypes is limited and inconsistent. We evaluated associations of fruit, vegetable, meat, and fish consumption with risk of breast cancer overall and by molecular subtype in the Vietnamese Breast Cancer Study (VBCS). Method: VBCS includes 476 incident breast cancer cases and 454 age-matched controls. Dietary habits over the past 5 years were assessed by in-person interviews using a validated food frequency questionnaire. Associations of food groups with breast cancer were evaluated via logistic regression for overall and molecular subtype with adjustment for age, education, income, family history of cancer, menopausal status, body mass index, exercise, total energy intake, and other potential dietary confounders. Odds ratio (OR) was used to approximate relative risk. Results: High fruit intake was inversely associated with breast cancer risk, with adjusted ORs [95% confidence intervals (CI)] of 0.67 (95% CI, 0.47–0.95) and 0.41 (95% CI, 0.27–0.61) for second and third tertiles versus first tertile, respectively (Ptrend < 0.001). This association was stronger for triple-negative than other subtypes (Pheterogeneity < 0.001). High intake of freshwater fish was inversely associated with overall breast cancer (ORT3vsT1 = 0.63; 95% CI, 0.42–0.95; Ptrend = 0.03). An inverse association was observed between HER2-enriched subtype and red and organ meat intake (ORT3vsT1 = 0.40; 95% CI, 0.17–0.93; Ptrend = 0.04; Pheterogeneity = 0.50). Conclusions: High intakes of fruit and freshwater fish were associated with reduced breast cancer risk; association for the former was stronger for triple-negative subtype. Impact: Our findings suggest high intakes of fruit and freshwater fish may reduce breast cancer risk among Vietnamese women.
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- 2022
3. Foodborne zoonotic trematode infections in Yen Bai, Vietnam : a situational analysis on knowledge, attitude, and practice (KAP) and risk behaviors
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Thi Bui, Dung, Thi Thuy Phi, Ngan, Thi Bich Nguyen, Thao, Thi Huyen Le, Trang, Trung Do, Dung, Lenaerts, Marc, Losson, Bertrand, Vandenberg, Olivier, Dorny, Pierre, Van Gerven, Minna, Boere-Boonkamp, Magda, Faculty Common Matters (Faculty of Social Sciences), Helsinki Inequality Initiative (INEQ), University of Helsinki, and Faculty of Social Sciences
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Male ,Health Knowledge, Attitudes, Practice ,Foodborne Zoonotic Trematode Infections ,Intestinal flukes ,Trematode Infections ,3142 Public health care science, environmental and occupational health ,Cross-Sectional Studies ,Risk-Taking ,Vietnam ,Zoonoses ,KAP ,Liver flukes ,Animals ,Humans ,Female - Abstract
Introduction: Foodborne Zoonotic Trematode Infections (FZTi) are neglected tropical diseases of public health concern in Vietnam. The transmission of FZTi is linked to human behavior patterns. The aim was to investigate the knowledge, attitude, and practices regarding FZTi among local people. Methods: A cross-sectional study was conducted using a mixed method, which included a baseline survey and in-depth interviews. 375 participants were interviewed face-to-face in the survey, and 27 participants had the in-depth interviews. Results: The results showed that 36.3% passed the knowledge assessment, 86.7% passed the attitude assessment, and 24% passed the practical assessment. There were differences in average knowledge scores among gender (men higher than women, p=0.006), ethnicities (Kinh higher than Dao and Tay, p, Journal of Preventive Medicine and Hygiene, Vol. 63 No. 2 (2022): 2022632
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- 2022
4. Semi-nested RT-PCR enables sensitive and high-throughput detection of SARS-CoV-2 based on melting analysis
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Ngoc Anh Thi Nguyen, Hoai Thi Bui, Quynh Thi-Huong Pham, Ly Thi Thao Hoang, Hung Xuan Ta, Timo Heikkinen, Duyet Van Le, Trang Dinh Van, Nam Quoc Ngo, Phuong Thi Hong Huynh, Trang Thi Huyen Tran, Hoan Quoc Phan, Luong Van Hoang, H.Rogier van Doorn, Diep Thi Ngoc Nguyen, Tam Thi Nguyen, Nam Sy Vo, Cuong Viet Vo, Sau Khac Trinh, Tai The Pham, Quang Duc Le, Phan Van Le, Son Thai Nguyen, Loan Thi Tran, Toan Dinh Vu, Quynh Anh Vu Nguyen, Nguyet Thi Trieu, Thuy Thi Le, Ung Dinh Nguyen, Jakob Steman, and Tho Huu Ho
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Artificial Intelligence ,Reverse Transcriptase Polymerase Chain Reaction ,SARS-CoV-2 ,Biochemistry (medical) ,Clinical Biochemistry ,COVID-19 ,Humans ,RNA, Viral ,General Medicine ,Biochemistry ,Pandemics ,Sensitivity and Specificity - Abstract
Asymptomatic transmission was found to be the Achilles' heel of the symptom-based screening strategy, necessitating the implementation of mass testing to efficiently contain the transmission of COVID-19 pandemic. However, the global shortage of molecular reagents and the low throughput of available realtime PCR facilities were major limiting factors.A novel semi-nested and heptaplex (7-plex) RT-PCR assay with melting analysis for detection of SARS-CoV-2 RNA has been established for either individual testing or 96-sample pooled testing. The complex melting spectrum collected from the heptaplex RT-PCR amplicons was interpreted with the support of an artificial intelligence algorithm for the detection of SARS-CoV-2 RNA. The analytical and clinical performance of the semi-nested RT-PCR assay was evaluated using RNAs synthesized in-vitro and those isolated from nasopharyngeal samples.The LOD of the assay for individual testing was estimated to be 7.2 copies/reaction. Clinical performance evaluation indicated a sensitivity of 100% (95% CI: 97.83-100) and a specificity of 99.87% (95% CI: 99.55-99.98). More importantly, the assay supports a breakthrough sample pooling method, which makes possible parallel screening of up to 96 samples in one real-time PCR well without loss of sensitivity. As a result, up to 8,820 individual pre-amplified samples could be screened for SARS-CoV-2 within each 96-well plate of realtime PCR using the pooled testing procedure.The novel semi-nested RT-PCR assay provides a solution for highly multiplex (7-plex) detection of SARS-CoV-2 and enables 96-sample pooled detection for increase of testing capacity. .
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- 2022
5. Feasibility of a pharmacist-led physical health monitoring for patients on antipsychotic medications: protocol for a longitudinal study
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Tien Ngoc Thi Bui, Elizabeth Hotham, Fiona Kelly, Vijayaprakash Suppiah, Bui, Tien Ngoc Thi, Hotham, Elizabeth, Kelly, Fiona, and Suppiah, Vijayaprakash
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Metabolic Syndrome ,severe mental illness ,education ,Feasibility Studies ,Humans ,Longitudinal Studies ,General Medicine ,Pharmacists ,metabolic syndrome ,Antipsychotic Agents ,physical health conditions - Abstract
IntroductionPhysical health conditions are the leading causes of death in people living with severe mental illness. In particular, the risk of metabolic syndrome; the constellation of abnormalities in weight, blood pressure, blood glucose and lipid levels, is high in this cohort. It has been recognised that commonly prescribed pharmacological agents for mental illness can further amplify the risk of developing metabolic syndrome; therefore, monitoring guidelines are in place for consumers prescribed antipsychotics. However, there is a disconnect between recommended guidelines and current practice. Our study aims to investigate: (1) the feasibility of a community pharmacist-led physical health monitoring for metabolic parameters in consumers with mental illness currently taking second generation antipsychotics and (2) the potential outcomes of the intervention (eg, rates and outcome of referrals to general practitioners, relationship between the pharmacist’s lifestyle counselling advice and change in metabolic parameters).Methods and analysisWe propose a longitudinal metabolic monitoring study led by community pharmacists with one-to-one consultations between trained pharmacists and participants at set intervals over a 12-month period. Our primary outcome is to determine the feasibility of the pharmacist-led intervention. The secondary outcome is to explore the overall health outcomes of consumers enrolled in the intervention. This is a mixed-methods study including both quantitative and qualitative outcomes. Qualitative data will be analysed via the process of data immersion, coding and identification of themes. Quantitative outcomes will be analysed using IBM Statistics SPSS software. Univariate descriptive, regression analysis and dependent t-tests will be performed. Statistical significance will be at α 0.05.Ethics and disseminationOur study has been approved by the institutional Human Research Ethics Committee (Protocol no: 203433). Findings will be made publicly available in peer-reviewed articles, conference presentations to health professionals, as well as other stakeholders. Protocol V.2.1, August 2021.Trial registration numberACTRN12621001435875.
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- 2022
6. A high-throughput sequencing determination method for upstream genetic structure (UGS) of ISEcp1-bla
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Nobuyoshi, Yagi, Kouta, Hamamoto, Kim Ngan, Thi Bui, Shuhei, Ueda, Saki, Tawata, Danh Tuyen, Le, Mai Huong, Thi Bui, and Itaru, Hirai
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Escherichia coli ,High-Throughput Nucleotide Sequencing ,Humans ,Escherichia coli Infections ,beta-Lactamases ,Anti-Bacterial Agents ,Plasmids - Abstract
Because blaExtracted DNA samples obtained from 168 Escherichia coli isolates possessing blaNucleotide sequences and locations of 168 UGSs obtained from the examined E. coli isolates were determined. Among the 168 determined UGSs, 150 (89.3%) UGS were confirmed on plasmid and classified into eight types. Interestingly, coding sequence of ISEcp1 transposase gene in seven of the eight types were disrupted by IS26 insertion. The remaining 18 (10.7%) UGSs were observed in identical chromosomal region. The obtained nucleotide sequences the locations of UGSs were confirmed by conventional capillary sequencer and Southern blotting, respectively, and any discrepant result was not observed with these confirmation procedures.Our results indicated that the established method was efficient for simultaneously determining at least 100 different UGS, and suggested that the determined UGSs of ISEcp1-bla
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- 2021
7. Nasal-spraying Bacillus spores as an effective symptomatic treatment for children with acute respiratory syncytial virus infection
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Dien Minh Tran, Tu Thanh Tran, Thuy Thi Bich Phung, Huyen Thi Bui, Phuc Thanh Thi Nguyen, Tam Thi Vu, Nga Thi Phuong Ngo, Mai Thi Nguyen, Anh Hoa Nguyen, and Anh Thi Van Nguyen
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Spores, Bacterial ,Multidisciplinary ,Child, Preschool ,Respiratory Syncytial Virus, Human ,Humans ,Bacillus ,Nasal Sprays ,Respiratory Syncytial Virus Infections ,Child ,Respiratory Tract Infections - Abstract
Respiratory syncytial virus (RSV) is a leading cause of Acute Respiratory Tract Infections (ARTIs) in young children. However, there is currently no vaccine or treatment available for children. Here, we demonstrated that nasal-spraying probiotics containing 5 billion of Bacillus spores (LiveSpo Navax) is an effective symptomatic treatment in a 6-day randomized controlled clinical study for RSV-infected children (n = 40–46/group). Navax treatment resulted in 1-day faster recovery-time and 10–50% better efficacy in relieving ARTI symptoms. At day 3, RSV load and level of pro-inflammatory cytokines in nasopharyngeal samples was reduced by 630 folds and 2.7–12.7 folds respectively. This showed 53-fold and 1.8–3.6-fold more effective than those in the control-standard of care-group. In summary, nasal-spraying Bacillus spores can rapidly and effectively relieve symptoms of RSV-induced ARTIs while exhibit strong impacts in reducing viral load and inflammation. Our nasal-spraying probiotics may provide a basis for simple-to-use, low-cost, and effective treatment against viral infection in general.
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- 2021
8. Analysis of the upstream genetic structures of the ISEcp1-bla
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Fikri S, Widyatama, Nobuyoshi, Yagi, Rosantia, Sarassari, Toshiro, Shirakawa, Danh Tuyen, Le, Mai Huong Thi, Bui, Kuntaman, Kuntaman, and Itaru, Hirai
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Asian People ,Vietnam ,Indonesia ,Escherichia coli ,Humans ,Escherichia coli Infections ,beta-Lactamases ,Anti-Bacterial Agents ,Plasmids - Abstract
Extended spectrum β-lactamase (ESBL)-producing Escherichia coli have been found in healthy individuals in Indonesia and Vietnam. The ISEcp1-bla
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- 2021
9. The effect of mental health screening and referral on symptoms of depression among HIV positive outpatients in Vietnam: Findings from a three-month follow up study
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Robert Heard, Hy-Han Thi Bui, Mairwen K. Jones, Truc Thanh Thai, and Lynne M. Harris
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Adult ,Male ,Mental Health Services ,medicine.medical_specialty ,Health (social science) ,Social Psychology ,Referral ,HIV Infections ,Alcohol use disorder ,03 medical and health sciences ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,Outpatients ,Humans ,Medicine ,Outpatient clinic ,030212 general & internal medicine ,Referral and Consultation ,Depression (differential diagnoses) ,030505 public health ,Depression ,business.industry ,Public Health, Environmental and Occupational Health ,medicine.disease ,Mental health ,Substance abuse ,Vietnam ,Family medicine ,Anxiety ,Female ,medicine.symptom ,0305 other medical science ,business ,Follow-Up Studies - Abstract
This study investigated whether screening for symptoms of mental disorders and referral to mental health services was associated with decreased depression symptoms among people living with HIV/AIDS (PLHIV) in Vietnam. Four hundred PLHIV (63.5% male, mean age 34.8 (SD = 6.8) years) at two outpatient clinics in Ho Chi Minh City were interviewed by psychiatrists and also completed the Center for Epidemiologic Studies-Depression scale (CES-D). One hundred and seventy-four (43.5%) were identified with symptoms of a range of mental illnesses, including depression, anxiety, alcohol use disorder, substance use disorder and HIV associated dementia and were referred to mental health services. Of the 174 PLHIV referred, 162 (93%) returned and completed the CES-D three months later and 125 of these 162 (77%) had attended a mental health service and undertaken treatment. A significant improvement was found in the mean CES-D scores of the 125 attenders from baseline (M = 19.0, SD = 7.5) to month three (M = 11.7, SD = 7.9, p < 0.001). PLHIV who had attended a mental health service and undertaken treatment demonstrated a greater reduction of mean scores on the CES-D compared to PLHIV who had either received a referral but not attended a mental health service to undertake treatment, or not been referred initially.
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- 2019
10. The diagnosis of infection in chronic leg ulcers: A narrative review on clinical practice
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Helen Edwards, Kathleen Finlayson, and Ut Thi Bui
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Adult ,Male ,medicine.medical_specialty ,Evidence-based practice ,Erythema ,MEDLINE ,Dermatology ,PsycINFO ,CINAHL ,Cochrane Library ,Infections ,Varicose Ulcer ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Anti-Infective Agents ,medicine ,Humans ,030212 general & internal medicine ,Intensive care medicine ,Aged ,Aged, 80 and over ,Wound Healing ,business.industry ,Leg Ulcer ,Australia ,Original Articles ,Evidence-based medicine ,Middle Aged ,Systematic review ,Chronic Disease ,Female ,Surgery ,medicine.symptom ,business - Abstract
This literature review aimed to provide a narrative review of evidence on validity of clinical and microbial indicators of infection and to gain insights into the diagnosis of infection in chronic leg ulcers (CLUs). A search was conducted in Cinahl, Medline, the Cochrane Library databases, Embase, Web of Science, ScienceDirect, Pubmed, PsycINFO, ProQuest dissertations, and Google Scholar from January 1990 to July 2017. The inclusion criteria were original studies, systematic reviews, and consensus documents focused on "infection" in CLUs, English language, clinical and community settings, and human. The reviewed studies were inconsistent in criteria for infection between investigated wound types and lack of specificity regarding wound types. There were few studies investigating the criteria for diagnosis of infection in leg ulcers. The identification of leg ulcer infection still remains problematic and relies on out-of-date and not uniform evidence. Literature in this area was mostly limited to level III and IV evidence based on The Australian National Health and Medical Research Council Levels of Evidence, or expert opinion. This literature review showed seven clinical signs and symptoms that could be diagnostic for infection in CLUs, including: new, increased, or altered ulcer pain; malodour; increased ulcer area; wound breakdown, delayed or non-healing; and erythema and increased local temperature, whilst the microbial indicators used to diagnose infected leg ulcers were varied and regarded as less important.
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- 2019
11. Using ‘infodemics’ to understand public awareness and perception of SARS-CoV-2: A longitudinal analysis of online information about COVID-19 incidence and mortality during a major outbreak in Vietnam, July—September 2020
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Ha-Linh Quach, Thai Quang Pham, Ngoc-Anh Hoang, Dinh Cong Phung, Viet-Cuong Nguyen, Son Hong Le, Thanh Cong Le, Thu Minh Thi Bui, Dang Hai Le, Anh Duc Dang, Duong Nhu Tran, Nghia Duy Ngu, Florian Vogt, and Cong-Khanh Nguyen
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Infodemic ,Multidisciplinary ,Vietnam ,SARS-CoV-2 ,Incidence ,COVID-19 ,Humans ,Perception ,Longitudinal Studies ,Pandemics ,Social Media - Abstract
Background Trends in the public perception and awareness of COVID-19 over time are poorly understood. We conducted a longitudinal study to analyze characteristics and trends of online information during a major COVID-19 outbreak in Da Nang province, Vietnam in July-August 2020 to understand public awareness and perceptions during an epidemic. Methods We collected online information on COVID-19 incidence and mortality from online platforms in Vietnam between 1 July and 15 September, 2020, and assessed their trends over time against the epidemic curve. We explored the associations between engagement, sentiment polarity, and other characteristics of online information with different outbreak phases using Poisson regression and multinomial logistic regression analysis. We assessed the frequency of keywords over time, and conducted a semantic analysis of keywords using word segmentation. Results We found a close association between collected online information and the evolution of the COVID-19 situation in Vietnam. Online information generated higher engagements during compared to before the outbreak. There was a close relationship between sentiment polarity and posts’ topics: the emotional tendencies about COVID-19 mortality were significantly more negative, and more neutral or positive about COVID-19 incidence. Online newspaper reported significantly more information in negative or positive sentiment than online forums or social media. Most topics of public concern followed closely the progression of the COVID-19 situation during the outbreak: development of the global pandemic and vaccination; the unfolding outbreak in Vietnam; and the subsiding of the outbreak after two months. Conclusion This study shows how online information can reflect a public health threat in real time, and provides important insights about public awareness and perception during different outbreak phases. Our findings can help public health decision makers in Vietnam and other low and middle income countries with high internet penetration rates to design more effective communication strategies during critical phases of an epidemic.
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- 2022
12. Granulocyte-colony stimulating factor GCSF mobilizes hematopoietic stem cells in Kasai patients with biliary atresia in a phase 1 study and improves short term outcome
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Huong Thuy Thi Bui, Binh Thanh Nguyen, Parvathi Mohan, Evan P. Nadler, Giap H. Vu, Megan Vu, Hien Duy Pham, Hoa Pham Anh Nguyen, Anh Tran Quynh, Ai Xuan Holterman, and Thuy Thi Trinh
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Adult ,medicine.medical_specialty ,CD34 ,Portoenterostomy, Hepatic ,Gastroenterology ,law.invention ,chemistry.chemical_compound ,Randomized controlled trial ,Colony-Stimulating Factors ,Biliary atresia ,law ,Biliary Atresia ,Internal medicine ,medicine ,Humans ,Adverse effect ,Retrospective Studies ,Creatinine ,business.industry ,Infant ,General Medicine ,medicine.disease ,Hematopoietic Stem Cells ,Granulocyte colony-stimulating factor ,Haematopoiesis ,Treatment Outcome ,chemistry ,Pediatrics, Perinatology and Child Health ,Surgery ,Stem cell ,business ,Granulocytes - Abstract
Aims In RCT of adults with decompensated cirrhosis, GCSF mobilizes hematopoietic stem cells HSC and improves short-term outcome. An FDA-IND for sequential Kasai-GCSF treatment in biliary atresia BA was approved. This phase 1 study examines GCSF safety in Kasai subjects. Preliminary short-term outcome was evaluated. Methods GCSF (Neupogen) at 5 or 10 μg/kg (n = 3/group) was given in 3 daily doses starting on day 3 of Kasai surgery (NCT03395028). Serum CD34+ HSC cell counts, and 1-month of GCSF-related adverse events were monitored. The 6-months Phase 1 clinical outcome was compared against 10 subsequent post Phase 1 Kasai patients who did not receive GCSF. Results With GCSF, WBC and platelet count transiently increased, LFT and serum creatinine remained stable. Reversible splenic enlargement (by 8.5–20%) occurred in 5/6 subjects. HSC count increased 12-fold and 17.5-fold for the 5 μg/kg and10 ug/kg dose respectively; with respective median total bilirubin levels for GCSF vs no-GCSF groups of 55 vs 91 μM at 1 month, p = 0.05; 15 vs 37 μM at 3 months, p = 0.24); and the 6-months cholangitis frequency of 40% vs 90%, p = 0.077. Conclusions GCSF safely mobilizes HSC in Kasai infants and may improve short-term biliary drainage and cholangitis. Phase 2 efficacy outcome of GCSF adjunct therapy for sequential Kasai and GCSF is pending.
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- 2021
13. Evolving landscape of cancer survivorship research: an analysis of the Journal of Cancer Survivorship, 2007-2020
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Larissa Nekhlyudov, Raymond Javan Chan, Chi-Wai Lui, Olivia Hollingdrake, Ut Thi Bui, Nicolas H. Hart, and Michael Feuerstein
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medicine.medical_specialty ,education ,Breast Neoplasms ,Survivorship ,Health informatics ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Quality of life (healthcare) ,medicine ,Humans ,030212 general & internal medicine ,Exercise ,Impact factor ,Oncology (nursing) ,business.industry ,Public health ,Cancer ,medicine.disease ,humanities ,Cross-Sectional Studies ,Oncology ,030220 oncology & carcinogenesis ,Quality of Life ,Female ,Citation ,business ,Psychosocial ,Demography - Abstract
To provide an analysis of papers published by the Journal of Cancer Survivorship (JCSU) from March 1, 2007 (its inception) until December 31, 2020. Characteristics (locations, study type, cancer type, keywords assigned by original authors) of all included articles were extracted into EndNote X9 and were coded and analyzed using Excel, NVivo v.R1.3 and VOSviewer, v.1.616. Journal Impact Factor and citation counts of each manuscript were downloaded from Clarivate Journal Citation Reports and Scopus®, respectively. Published papers are predominantly from the USA, Australia, and the UK. While breast cancer continues to be the dominant cancer type, a range of different cancer types and populations with mixed-cancer types have been addressed in the journal. Cross-sectional designs were the most used. JCSU’s impact factor experienced a steady growth between 2011 and 2015 and stabilized over recent years (2016–2020), at 3.296 (1 year) and 3.830 (5 years). Keyword co-occurrence analyses indicated prominent themes including quality of life, physical activity, late effects, follow-up care, and psychosocial aspects of cancer survivorship. JCSU has made a significant contribution thus far by disseminating knowledge in cancer survivorship. This paper provides insights of JCSU’s success to date and recommends further diversification and directions for practice areas that are novel or have received less attention by the cancer survivorship community. This journal stands ready to publish new information that informs the cancer survivorship community on the multidimensional nature of cancer and facilitates translation into quality care across many different settings and across the globe.
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- 2021
14. Risk factors of Pancreatic Cancer in Vietnam: A Matched Case–Control Hospital-Based Study
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Huong T. T. Tran, Khanh Truong Vu, To van Ta, Khac-Dung Nguyen, Oanh Thi Bui, Son Hong Trinh, Hiep Le Nguyen, Tu Van Dao, Hoang Cong Nguyen, Thuan V. Tran, Hoan Duc Vu, and Quang Tien Nguyen
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Adult ,Male ,medicine.medical_specialty ,Alcohol Drinking ,Family Cancer History ,pancreatic cancer ,Developing country ,lcsh:RC254-282 ,Diabetes Complications ,Hospital based study ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Pancreatic cancer ,Diabetes mellitus ,Humans ,Medicine ,Original Research Article ,030212 general & internal medicine ,Developing Countries ,Aged ,Aged, 80 and over ,diabetes ,business.industry ,Smoking ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Pancreatic Neoplasms ,Vietnam ,Oncology ,Case-Control Studies ,030220 oncology & carcinogenesis ,Female ,business - Abstract
Background:Data about the risk factors and pancreatic cancer in developing countries remain limited. We investigated for the first time the role of a number of risk factors (family cancer history, smoking, alcohol consumption, diabetes, inflammation disease, HBV infection) associated with pancreatic cancer among Vietnamese patients.Methods:We included all patients hospitalized at 4 Northern Vietnamese hospitals (Vietnam National Cancer Hospital, Bach Mai, Viet Duc, Thai Nguyen) and diagnosed with pancreatic cancer during the period from 2017 to 2019. Risk factors of eligible patients were collected and assessed the associations using a matched control study and logistic regression model analysis.Results:We identified 196 patients with diagnosis of pancreatic cancer of which 114 males and 82 females. The average age of the patient at the time of diagnosis was 58.28 years (standard deviation of 12.94, ranging from 25 to 87). Most of patients were diagnosed at advanced stage (85%). Smoking, diabetes, inflammation disease significantly increased the cancer risks (OR and 95% CI were 2.42 (1.38-4.37), 3.09 (1.54-6.68), 2.21 (1.42-3.45), respectively). HBV infection demonstrated a significant link with pancreatic cancer in univariate model (OR = 2.94 (1.08-9.36)), but not in multivariate model. However, cancer family history and alcohol drinkers did not show any significantly increased risk related to pancreatic cancer.Conclusions:Our finding showed smoking, diabetes, inflammation disease significantly increased the risk of pancreatic cancer in Vietnam.
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- 2021
15. Evaluation of Tumor Budding in Predicting Survival for Gastric Carcinoma Patients in Vietnam
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Thuan V. Tran, Oanh Thi Bui, Ha Thi Ngoc Vu, Chu Van Nguyen, Bang Viet Luong, Tu Van Dao, Quang Tien Nguyen, Dung Khac Nguyen, and Huyen Thi Phung
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Prognostic factor ,Oxaloacetates ,Gastric carcinoma ,Kaplan-Meier Estimate ,tumor budding ,Risk Assessment ,lcsh:RC254-282 ,Disease-Free Survival ,clinical ,Tumor budding ,Gastrectomy ,Stomach Neoplasms ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Capecitabine ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,gastric cancer ,Carcinoma ,Stomach ,Cancer ,Hematology ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Original Research Paper ,Vietnam ,Chemotherapy, Adjuvant ,Female ,pathology ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies - Abstract
Background: Tumor budding (Bd) has been demonstrated to be a promising prognostic factor in many carcinomas and in gastric cancer. It may represent an optimal additional parameter that is helpful for risk stratification in gastric adenocarcinoma. Hence, the present research was designed to predict the survival outcomes of gastric cancer in Vietnam, applying the tumor budding criteria of the International Tumor Budding Consensus Conference (ITBCC) 2016. Methods: The present study was conducted on 109 gastric cancer patients who underwent surgery but did not receive neo-adjuvant chemotherapy from 2012 to 2015. The patients’ clinicopathological features were recorded. Bd was evaluated according to the 2016 ITBCC criteria and classified as Bd1 (0–4 buds), Bd2 (5–9 buds), and Bd3 (≥10 buds) grades, in addition to being categorized into 2 main Bd groups: low (Results: Of all the patients, 22.9% were classified as Bd1, 31.2% as Bd2, and 45.9% as Bd3 grades. Furthermore, 54.1% patients were categorized into the low and 45.9% into the high Bd groups. Patients with Bd1 and Bd2 grades (the low Bd group) exhibited the best prognosis, with 5-year overall survival (OS) rates of 85.7%, 90.8%, and90.3%, respectively. Patients with Bd3 grade (the high Bd group exhibited the worst prognosis, and none of them lived for 5 years (p < 0.001). Similar to OS rates, disease-free survival (DFS) rates markedly reduced from the Bd1 to Bd3 grade: Bd1, 95.0%; Bd2, 84.7%; and Bd3, 0% (p < 0.001). Conclusion: Patients with different gastric cancer Bd grades exhibited significantly different OS and DFS rates. The present study findings suggest that the ITBCC criteria can be used to stratify Bd for the treatment and prognosis of gastric cancer patients in Vietnam.
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- 2020
16. Menstrual and Reproductive Factors in Association With Breast Cancer Risk in Vietnamese Women: A Case-Control Study
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Oanh Thi Bui, Huong Thanh Tran, Sang Minh Nguyen, Tu Van Dao, Quang Vinh Bui, Anh Tuan Pham, Martha J. Shrubsole, Qiuyin Cai, Fei Ye, Wei Zheng, Hung Nguyen Luu, Thuan Van Tran, and Xiao-Ou Shu
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Receptor, ErbB-2 ,Breast Neoplasms ,Triple Negative Breast Neoplasms ,Hematology ,General Medicine ,Middle Aged ,Vietnam ,Asian People ,Oncology ,Risk Factors ,Case-Control Studies ,Humans ,Female ,Child ,Receptors, Progesterone ,Retrospective Studies - Abstract
Objectives Though menstrual and reproductive factors have been associated with the risk of breast cancer in many populations, very few studies have been conducted among Vietnamese women. This study aimed to assess the association between menstrual and reproductive factors and the risk of breast cancer in Vietnamese women. Methods A retrospective case-control study of 490 breast cancer cases and 468 controls was conducted in Northern Vietnam. Unconditional logistic regression models adjusting for confounders were used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) for the associations of menstrual and reproductive factors with the risk of breast cancer; overall and by cancer subtype. Results Among breast cancer patients, the luminal B subtype was the most frequent (48.6%), followed by HER2-overexpressing (24.5%), luminal A (16.7%), and triple-negative breast cancer (TNBC; 10.2%). Among menopausal women, menopausal age at 50 years or older (OR = 1.71, 95% CI: 1.15-2.57 vs. Conclusion Associations of menstrual and reproductive factors with breast cancer among Vietnamese women, particularly for among premenopausal women and for the luminal A subtype, are generally consistent with those reported from other countries. These findings suggest that changes in menstrual and reproductive patterns among young Vietnamese women may contribute to the recent rising incidence of breast cancer in Vietnam.
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- 2022
17. Prevalence and risk factors associated with Clonorchis sinensis infections in rural communities in northern Vietnam
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Ngan T T Phi, Veronique Dermauw, Dung Trung Do, Bertrand Losson, Pierre Dorny, Trang T H Le, Dung Thi Bui, Thao T B Nguyen, Laetitia Lempereur, Hafid Dahma, and Olivier Vandenberg
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0301 basic medicine ,Male ,Rural Population ,Epidemiology ,Physiology ,RC955-962 ,Flatworms ,Clonorchis sinensis Infections ,Marine and Aquatic Sciences ,Social Sciences ,Logistic regression ,Geographical Locations ,Eating ,Habits ,Feces ,0302 clinical medicine ,Medical Conditions ,Food Parasitology ,Risk Factors ,Arctic medicine. Tropical medicine ,Medicine and Health Sciences ,Odds Ratio ,Prevalence ,Medicine ,Psychology ,Sanitation ,Clonorchis sinensis ,Clonorchis ,biology ,Fishes ,Eukaryota ,Middle Aged ,Freshwater Fish ,Infectious Diseases ,Vietnam ,Helminth Infections ,Vertebrates ,Clonorchiasis ,Health education ,Female ,Public aspects of medicine ,RA1-1270 ,Research Article ,Neglected Tropical Diseases ,Adult ,medicine.medical_specialty ,Asia ,Adolescent ,030231 tropical medicine ,Trematodes ,03 medical and health sciences ,Young Adult ,Environmental health ,Helminths ,Parasitic Diseases ,Animals ,Humans ,Mass drug administration ,Ponds ,Behavior ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Organisms ,Tropical disease ,Biology and Life Sciences ,Bodies of Water ,medicine.disease ,biology.organism_classification ,Tropical Diseases ,Invertebrates ,030104 developmental biology ,Fish ,Socioeconomic Factors ,Medical Risk Factors ,People and Places ,Earth Sciences ,business ,Physiological Processes ,Zoology ,Foodborne Trematodiases - Abstract
Background Clonorchiasis, caused by the fish-borne trematode Clonorchis sinensis, is a neglected tropical disease and a public health issue in endemic countries. In Vietnam, an in-depth analysis of risk factors for the condition is missing up to now. This study aimed to determine the prevalence of C. sinensis infection and associated risk factors in rural communities in northern Vietnam. Methodology/Principal findings A cross-sectional survey was conducted in 4 communes in Yen Bai and Thanh Hoa provinces where clonorchiasis is known to be present and raw fish consumption is a common. Using a simple random sampling approach, stool was collected from 841 participants over 6 years old for coprological examination, and a questionnaire measured knowledge, attitudes, and practices with regard to clonorchiasis in 757 participants over 15 years old. Univariable and multivariable logistic regression models were run to identify risk factors for infection with C. sinensis. The overall prevalence of C. sinensis infection was 40.4%, with commune prevalences ranging between 26.5% and 53.3%. In the final model, males were significantly more likely to be infected with C. sinensis (OR 2.00; 95% CI 1.31–3.05). Recent (i.e. last year) consumption of raw fish (OR 8.00, 95% CI 4.78–13.36), low education level (OR 5.57; 95% CI 2.37–13.07), lack of treatment (OR 1.82, 95% CI 1.15–2.89), being between 19 to 39 years old (OR 6.46; 95% CI 1.25–33.37), and the presence of an unhygienic toilet (OR 2.74, 95% CI 1.53–4.92) were significantly associated with C. sinensis infection. Conclusion/Significance This study demonstrated a high prevalence of C. sinensis infection in rural communities in northern Vietnam. Thus, control measures including, mass drug administration for those communes should be applied to reduce the prevalence. Moreover, specific health education activities should be developed for risk groups in C. sinensis endemic areas., Author summary Clonorchiasis, caused by the fish-borne trematode Clonorchis sinensis, is a chronic liver infection and is classified as a neglected tropical disease, particularly in some Asian countries such as Vietnam. Light infections with C. sinensis are asymptomatic, yet heavy chronic infections are associated with clinical complications such as, bile duct obstruction, hepatic fibrosis and the most serious complication being bile duct cancer. We carried out a community-based study on C. sinensis infection in rural communities in northern Vietnam. Our results indicated that the Thac Ba lake area in Yen Bai province is a hot spot of C. sinensis infection, and that Thanh Hoa province remains an area with widespread small liver fluke infection. Eating raw fish was confirmed to be an important risk factor for C. sinensis infection in Vietnam. Presence of infection was furthermore associated with gender, age, education and hygienic practices. Mass drug administration and improved awareness campaigns for the population in these regions are needed. Setting-specific interventions targeting different risk groups should be considered to reduce the disease transmission.
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- 2020
18. Clinical evaluation of rapid fluorescent diagnostic immunochromatographic test for influenza A virus (H1N1)
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Anh Viet Thi Nguyen, Seung-Taek Yu, Cuc Thi Bui, Thuy Tien Thi Trinh, Do Thi Hoang Kim, and Seon-Ju Yeo
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,Point-of-care testing ,030106 microbiology ,Immunochromatographic test ,Fluorescent Antibody Technique ,lcsh:Medicine ,medicine.disease_cause ,Gastroenterology ,Article ,03 medical and health sciences ,0302 clinical medicine ,McNemar's test ,Influenza A Virus, H1N1 Subtype ,Limit of Detection ,Internal medicine ,Influenza, Human ,Influenza A virus ,Medicine ,Humans ,H1n1 infection ,030212 general & internal medicine ,Child ,lcsh:Science ,Multidisciplinary ,business.industry ,lcsh:R ,Confidence interval ,Child, Preschool ,Female ,lcsh:Q ,business ,Clinical evaluation ,Kappa - Abstract
Rapid diagnostic tests (RDTs) have been developed to detect influenza A virus for the swift diagnosis and management of patients. However, despite the simplicity and convenience, the low sensitivity of RDTs remains a limitation for their use in point of care testing (POCT). In this study, we developed a rapid fluorescent immunochromatographic strip test (FICT) and the performance of FICT was confirmed by the real-time reverse transcription-polymerase chain reaction (rRT-PCR) of H1N1, compared with that of RDT. The limit of detection (LOD) of FICT was improved by 16-fold compared to RDT. FICT showed 85.29% sensitivity (29/34) (95% Confidence Interval [95% CI]: 68.94 to 95.05), 100% specificity (26/26) (95% CI: 86.78 to 100.00), and a strong correlation (kappa; 0. 92) compared with rRT-PCR (20 ≤ Ct ≤ 36). In contrast, RDT (Standard Diagnostics [SD] BIOLINE Influenza Ag A/ B/ A(H1N1) Pandemic) showed 55.88% sensitivity (19/34) (95% CI: 37.87 to 72.82), 100% specificity (26/26) (95% CI: 77.07 to 100), and had a fair correlation with rRT-PCR (kappa; 0. 75). FICT had better sensitivity than RDT (P
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- 2018
19. Establishment of Recombinase Polymerase Amplification assay for rapid and sensitive detection of Orientia tsutsugamushi in Southeast Asia
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Chinh Trong Nguyen, Ung Dinh Nguyen, Thuy Thi Le, Hoai Thi Bui, Anh Ngoc Thi Nguyen, Nguyet Thi Trieu, Long Phi Trieu, Sy Tien Bui, Chuyen Nguyen, Luong Van Hoang, Son Anh Ho, Ba Van Nguyen, Jakob Stenman, and Tho Huu Ho
- Subjects
0301 basic medicine ,Orientia tsutsugamushi ,Veterinary (miscellaneous) ,030231 tropical medicine ,Recombinase Polymerase Amplification ,Scrub typhus ,Delayed diagnosis ,Real-Time Polymerase Chain Reaction ,Sensitivity and Specificity ,Southeast asia ,Recombinases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Asia, Southeastern ,biology ,medicine.diagnostic_test ,030108 mycology & parasitology ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease ,Virology ,genomic DNA ,Infectious Diseases ,Scrub Typhus ,Insect Science ,Immunoassay ,Parasitology ,Primer (molecular biology) ,Nucleic Acid Amplification Techniques - Abstract
Scrub typhus, caused by Orientia tsutsugamushi, is a common fever in parts of Southern and Southeast Asia. As delayed diagnosis of scrub typhus leads to inappropriate treatment and high mortality rates, of up to 70%, sensitive and rapid detection of O. tsutsugamushi is required for timely and appropriate treatment. Molecular assays, such as PCR and real-time PCR, have been shown to be more sensitive than conventional immunoassay, however, they are only available in centralized laboratories. In contrast to PCR assays, Recombinase Polymerase Amplification (RPA) is conducted under a constant temperature ranging from 24°C to 45°C. Therefore, this technology is very promising for nucleic acid testing in the field, and in resource-limited areas. An RPA assay for the detection of O. tsutsugamushi based on the target gene encoding for the 47 kDa outer membrane protein has been reported, but the primer and probe sequences of this assay are suboptimal for detection of the majority of recently published sequences of O. tsutsugamushi isolates from Southeast Asia. We have established a real-time RPA assay with primer and probe sequences that are optimized for most Southeast Asia's isolates of O. tsutsugamushi. As a result, the new RPA assay showed better performance than the previous assay in detecting O. tsutsugamushi in clinical samples of scrub typhus cases found in Vietnam. The specificity of RPA assay was also evaluated using genomic DNA from microorganisms commonly encountered in the differential diagnosis of scrub typhus, and blood samples from healthy controls and O. tsutsugamushi negative confirmed cases.
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- 2019
20. Polypharmacy among people living with type 2 diabetes mellitus in rural communes in Vietnam
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Dat Cong Truong, Jens Søndergaard, Dan W. Meyrowitsch, Dieu Huyen Thi Bui, Ib C. Bygbjerg, Nielsen Jannie, Tine Gammeltoft, and Bai Xuan Nguyen
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Male ,Rural Population ,Thai People ,Type 2 diabetes ,Geographical Locations ,Endocrinology ,Medical Conditions ,Medicine and Health Sciences ,Ethnicities ,Multidisciplinary ,Middle Aged ,Type 2 Diabetes ,Distress ,Vietnam ,Medicine ,Female ,Over-the-counter ,Research Article ,Adult ,medicine.medical_specialty ,Asia ,Prescription Drugs ,Endocrine Disorders ,Science ,MEDLINE ,Complementary and Alternative Medicine ,Asian People ,Adverse Reactions ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,medicine ,Humans ,Hypoglycemic Agents ,Medical prescription ,Nutrition ,Aged ,Pharmacology ,Polypharmacy ,business.industry ,Biology and Life Sciences ,Type 2 Diabetes Mellitus ,Traditional Medicine ,medicine.disease ,Diet ,Diet and Type 2 Diabetes ,Diabetes Mellitus, Type 2 ,Metabolic Disorders ,People and Places ,Dietary Supplements ,Population Groupings ,Medicine, Traditional ,business - Abstract
Objectives People with diabetes are at high risk of polypharmacy owing to complex treatment of diabetes and comorbidities. Polypharmacy is associated with increased risk of adverse reactions and decreased compliance. Therefore, the objectives of this study were to assess polypharmacy in people with type 2 diabetes (T2D) and associated diabetes-related factors in rural areas in Vietnam. Method People with T2D (n = 806) who had received treatment for diabetes at a district hospital were invited to participate in a questionnaire-based cross-sectional survey. Polypharmacy was defined as ≥5 types of medicine and assessed as a) prescription medicine and non-prescription/over the counter (OTC) medicine and b) prescription medicine and non-prescription/OTC, herbal and traditional medicine, and dietary supplement. Multiple logistic regression was used to investigate the association between polypharmacy and diabetes specific factors: duration, comorbidities and diabetes-related distress. Results Of the people with T2D, 7.8% had a medicine use corresponding to polypharmacy (prescription medicine and non-prescription/OTC), and 40.8% when herbal and traditional medicine, and dietary supplement were included. Mean number of medicine intake (all types of medicines and supplements) were 3.8±1.5. The odd ratios (ORs) of polypharmacy (medicine and supplements) increased with diabetes duration (5 years OR = 1.74; 95%CI: 1.14–2.64 as compared to ≤1-year duration of diabetes), number of comorbidities (1–2 comorbidities: OR = 2.0; 95%CI: 1.18–3.42; ≥3 comorbidities: OR = 2.63;95%CI: 1.50–4.61 as compared to no comorbidities), and suffering from diabetes-related distress (OR = 1.49; 95%CI: 1.11–2.01) as compared to those without distress. Conclusions In rural northern Vietnam, persons with longer duration of T2D, higher number of comorbidities and diabetes-related stress have higher odds of having a medicine use corresponding to polypharmacy. A high proportion of people with T2D supplement their prescription, non-prescription/OTC medicine with herbal and traditional medicine and dietary supplements.
- Published
- 2021
21. The structure of nursing: a national examination of titles and practice profiles
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Anna Doubrovsky, Margaret Adams, Christine Duffield, Glenn Gardner, and Ut Thi Bui
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Adult ,Male ,Job description ,Nursing ,Young Adult ,InformationSystems_GENERAL ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,030212 general & internal medicine ,Nurse education ,General Nursing ,Health policy ,Aged ,Practice Patterns, Nurses' ,ComputingMilieux_THECOMPUTINGPROFESSION ,030504 nursing ,business.industry ,Health Policy ,Nursing research ,Australia ,Middle Aged ,Cross-Sectional Studies ,Skill mix ,Job Description ,Occupational health nursing ,Workforce ,Workforce planning ,Nursing Staff ,Female ,Clinical Competence ,0305 other medical science ,business - Abstract
© 2017 International Council of Nurses Aim: To identify the practice patterns of the Australian registered nurse workforce according to position title and to map these disparate titles across all jurisdictions of the country. Introduction: Effective nursing workforce planning can contribute to improved patient care and increased effectiveness and efficiency of healthcare systems. Background: The prevailing approach to nursing workforce planning focuses on number of nursing staff needed in relation to the number of patients. The level of expertise and skill mix of registered nurses as a variable in workforce planning is rarely considered. Methods: A national cross-sectional electronic survey of registered nurses in Australia was conducted using the validated Advanced Practice Role Delineation tool developed from the Strong Model of Advanced Practice. The study involved a sample of 5599 registered nurses. Results: Sixty-six nursing position titles nationally were mapped using cluster analysis technique and gave rise to seven clusters of equivalent Australian jurisdictional nursing position titles and practice profiles. Discussion: Effective workforce policy and planning is reliant upon access to reliable evidence. This research is an international first in that it has provided comprehensive knowledge of the clinical level and practice profiles of a national nursing workforce. Implications for nursing policy: Effective, patient-centred workforce planning must consider both the numerical and expertise mix of a nursing workforce. This research provides Australian health service and policy planners with evidence-base knowledge of the nursing workforce. Internationally, this research establishes a platform from which to develop validated tools and established processes to support replication of this research.
- Published
- 2017
22. Validation of predictive factors for infection in adults with chronic leg ulcers: A prospective longitudinal study
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Kathleen Finlayson, Helen Edwards, and Ut Thi Bui
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Male ,medicine.medical_specialty ,Longitudinal study ,Risk Assessment ,Varicose Ulcer ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,Health care ,medicine ,Humans ,030212 general & internal medicine ,Longitudinal Studies ,Prospective Studies ,General Nursing ,Aged ,Proportional Hazards Models ,030504 nursing ,Descriptive statistics ,business.industry ,Risk of infection ,Australia ,General Medicine ,Middle Aged ,medicine.disease ,Gout ,Wound Infection ,Observational study ,Female ,0305 other medical science ,business - Abstract
Aims and objectives : To validate the ability of factors to predict infection in adults with chronic leg ulcers over a 12-week period. Background: Leg ulcers affect ~3% of older adults and are often hard to heal. Infection is a leading contributor for delayed healing, causing delayed wound healing, increased hospitalisation, increased healthcare costs and reduced patient quality of life. The importance of early identification of infection has been highlighted for decades, yet little is known about factors that are associated with increased risk of infection in this specific population. Design : A longitudinal, prospective observational study in a single centre. Methods : Between August 2017 and May 2018, a total of 65 adults with chronic leg ulcers were prospectively observed for a 12-week period. Patients were recruited from an outpatient wound clinic at a tertiary hospital in Australia. Data were collected from recruitment (baseline) and each visit (weekly or fortnightly) up until 12 weeks. Descriptive statistics were calculated for all variables. A Cox proportional hazards regression model was used to identify predictive factors for infection. The TRIPOD guidelines for reporting were followed (See Data S1). Results : The sample consisted of 65 adults with chronic leg ulcers, and 9.2% of these had their ulcer infected at baseline. Two predictive factors, using walking aids and gout, were found to be significantly related to increased likelihood of developing infection within 12 weeks. Conclusion : The present study showed that patients who either used walking aids or were diagnosed with gout were at greater risk of infection compared to those without these factors. Relevance to clinical practice: These findings provide new information for clinicians in early identification of patients at risk of infection, and for patients in enhancing their awareness of their own risk.
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- 2019
23. Direct Hospitalization Cost of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Vietnam
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Long Hoang Nguyen, Carl A. Latkin, Giap Van Vu, Thuy Thi Bui, Giang Thu Vu, Phuong Thu Phan, Bach Xuan Tran, Hanh Thi Chu, Chau Quy Ngo, Roger C.M. Ho, Giang Hai Ha, Ha Ngoc Pham, and Cyrus S.H. Ho
- Subjects
Adult ,Male ,medicine.medical_specialty ,Acute exacerbation of chronic obstructive pulmonary disease ,Adolescent ,Health, Toxicology and Mutagenesis ,Psychological intervention ,lcsh:Medicine ,Article ,Drug Costs ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,Young Adult ,0302 clinical medicine ,Medication cost ,cost ,medicine ,Humans ,COPD ,030212 general & internal medicine ,Hospital Costs ,co-morbidity ,acute exacerbation ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Public health ,lcsh:R ,Public Health, Environmental and Occupational Health ,economics ,Direct cost ,Middle Aged ,medicine.disease ,Obstructive lung disease ,humanities ,respiratory tract diseases ,Cross-Sectional Studies ,030228 respiratory system ,Vietnam ,Emergency medicine ,Hospitalization cost ,Female ,business ,hospitalization - Abstract
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have been found to contribute, predominantly, to increasing costs of COPD&mdash, a major public health issue. This study aimed to fill the gap in literature concerning costs of AECOPD in Vietnam, by examining the direct cost of AECOPD hospitalization and determining potentially associated factors. A cross-sectional study was conducted at the Respiratory Center of Bach Mai Hospital, Hanoi. A total of 57 participants were selected. Information regarding sociodemographic features, clinical characteristics, and hospitalization costs were collected. A multivariate generalized linear regression model was utilized to determine the factors associated with hospitalization costs. The mean total and daily hospitalization cost were 18.3 million VND (SD = 12.9) and 2.5 million VND (SD = 3.2), respectively. Medication cost accounted for 53.9% of hospitalization cost (from 44.0% in the Global Initiative for Chronic Obstructive Lung Disease Classification A (GOLD A) to 55.3% in GOLD C). Patients having GOLD D COPD (Coef. = 5.78, 95% CI = 0.73&ndash, 10.83), higher age (Coef. = 0.37, 95% CI = 0.13&ndash, 0.61), and higher duration of hospitalization (Coef. = 1.91, 95% CI = 1.28&ndash, 2.53) had higher hospitalization costs (p <, 0.05). This study suggested that interventions to screen COPD patients as well as provide timely treatment should be conducted widely in the community in order to avoid any unnecessary hospitalization cost, consequently reducing the economic burden of COPD.
- Published
- 2018
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24. Administration of As-Needed Psychotropic Medications in Aged Care: Decision Matrix Employed by Nursing Staff
- Author
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Josef Kaplan, Hope J. Stahl, Elizabeth Hotham, Tien Ngoc Thi Bui, Megan Corlis, Vijayaprakash Suppiah, Helen Loffler, Bui, Tien Ngoc Thi, Stahl, Hope J, Kaplan, Josef, Hotham, Elizabeth, Loffler, Helen, Corlis, Megan, and Suppiah, Vijayaprakash
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Psychotropic Drugs ,medicine.medical_specialty ,Nursing staff ,business.industry ,Health Policy ,General Medicine ,Decision matrix ,Family medicine ,medicine ,Homes for the Aged ,Humans ,Nursing Staff ,Aged care ,Geriatrics and Gerontology ,business ,Administration (government) ,General Nursing ,Aged - Published
- 2021
25. Retail fresh vegetables as a potential source of Salmonella infection in the Mekong Delta, Vietnam
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Thy Anh Truong, Hideki Hayashidani, Hien Thi Bui, Shunsuke Ikeuchi, Thuan Khanh Nguyen, Takahide Taniguchi, Lien Khai Thi Ly, Yukiko Hara-Kudo, and Diep Ngoc Lam
- Subjects
Wet season ,Serotype ,Salmonella ,Veterinary medicine ,Food Contamination ,Salmonella infection ,Microbial Sensitivity Tests ,Biology ,medicine.disease_cause ,Microbiology ,law.invention ,03 medical and health sciences ,law ,Drug Resistance, Bacterial ,Vegetables ,Dry season ,medicine ,Animals ,Humans ,030304 developmental biology ,0303 health sciences ,030306 microbiology ,General Medicine ,Contamination ,medicine.disease ,Anti-Bacterial Agents ,Transmission (mechanics) ,Vietnam ,Salmonella Food Poisoning ,Mekong delta ,Food Science - Abstract
From July 2017 to Jan 2019, a total of 572 retail fresh vegetables were collected to clarify the contamination of Salmonella in the Mekong Delta, Vietnam. Salmonella was isolated from 74 (12.9%) of 572 samples. The isolation rate of Salmonella from retail fresh vegetables in the rainy season (15.3%) was significantly higher than that in the dry season (7.6%) (P
- Published
- 2021
26. The effect of adverse childhood experiences on depression, psychological distress and suicidal thought in Vietnamese adolescents: Findings from multiple cross-sectional studies
- Author
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Han Hy Thi Bui, Truc Thanh Thai, Doan Phuoc Tran, Minh Binh Bui, Phuong Le Tran Cao, and Loan Xuan Kim
- Subjects
Male ,Adolescent ,Vietnamese ,education ,Psychological intervention ,Poison control ,Adverse Childhood Experiences Study ,Psychological Distress ,Suicide prevention ,Suicidal Ideation ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,Adverse Childhood Experiences ,Risk Factors ,Humans ,Medicine ,General Psychology ,Depression (differential diagnoses) ,Depression ,business.industry ,General Medicine ,Youth Risk Behavior Survey ,Mental health ,language.human_language ,030227 psychiatry ,Psychiatry and Mental health ,Cross-Sectional Studies ,Vietnam ,language ,Female ,business ,030217 neurology & neurosurgery ,Clinical psychology - Abstract
Exposing to adverse childhood experiences (ACEs) has been identified as one of the major contributing factors to poor mental health and suicide in adolescents. However, little is known about this relationship in Vietnamese adolescents. This study aimed to evaluate the effect of ACEs on depression, psychological distress and suicidal thought among Vietnamese adolescents across different areas in Vietnam. Cross-sectional surveys were conducted among 4957 secondary school and high school students aged 13-20 in urban area, rural area, border area and mountainous area. The students were asked to complete a self-report questionnaire which included the Center for Epidemiological studies - Depression, the Kessler-10 and ACE questionnaire from the WHO Adverse Childhood Experiences Study. Suicidal thought was evaluated by a single question from the U.S. Youth Risk Behavior Survey. Among 4720 students included in the analysis, 54.4% were female. The prevalence of depression, psychological distress and suicidal thought was 22.9%, 30.6% and 10.9% respectively. About 86% of participants experienced at least one type of ACEs and nearly 56% reported multiple types of ACEs. Students with four or more types of ACEs had 6.98 (95% CI 5.09 -9.56), 4.72 (95 % CI 3.58-6.23) and 6.43 (95 % CI 4.45-9.30) times higher in odds of having depression, psychological distress and suicidal thought respectively. In conclusion, ACEs are common in Vietnamese adolescents and are strongly associated with depression, psychological distress and suicidal thought. Our finding indicates urgent needs for interventions targeting both ACEs and depression, psychological distress in Vietnamese adolescents.
- Published
- 2020
27. Risk factors for infection in patients with chronic leg ulcers: A survival analysis
- Author
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Helen Edwards, Ut Thi Bui, and Kathleen Finlayson
- Subjects
Chronic wound ,Male ,medicine.medical_specialty ,Kaplan-Meier Estimate ,Walkers ,Varicose Ulcer ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Medicine ,Humans ,030212 general & internal medicine ,Prospective cohort study ,Survival analysis ,Depression (differential diagnoses) ,Aged ,Proportional Hazards Models ,business.industry ,Proportional hazards model ,Depression ,Confounding ,Leg Ulcer ,General Medicine ,Middle Aged ,medicine.anatomical_structure ,Chronic Disease ,Etiology ,Wound Infection ,Female ,medicine.symptom ,Ankle ,business - Abstract
Aim: This study aimed to validate the relationships between possible predictive factors and clinically diagnosed infection in adult patients with chronic leg ulcers. Methods: This study used a sample of 636 adult participants whose ulcers were diagnosed as either venous, arterial or mixed aetiology leg ulcers and had no clinical signs of infection at recruitment. Data were extracted from recruitment to 12 weeks from six longitudinal prospective studies from 2004 to 2015. Survival analysis was used to investigate mean time-to-infection, including the Kaplan-Meier method and the Cox proportional-hazards regression model. Results: The sample included 74.7% venous, 19.6% mixed and 5.7% arterial leg ulcers. There were 101 (15.9%) participants diagnosed with infection at least once within 12 weeks of follow-up. Mean time-to-infection was 10.89 weeks (95% CI = 10.66-11.12). After adjustment for potential confounders, a Cox proportional hazards regression model found that depression, using walking aids, calf ankle ratio
- Published
- 2018
28. Improving a pivotal hospital documentation tool utilised by clinical pharmacists
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Elizabeth Hotham, Tien Ngoc Thi Bui, Sharon Goldsworthy, Bui, Tien Ngoc Thi, Goldsworthy, Sharon, and Hotham, Elizabeth
- Subjects
medicine.medical_specialty ,health promotion ,Pharmaceutical Science ,Pharmacy ,Audit ,Documentation ,Pharmacists ,030226 pharmacology & pharmacy ,Patient care ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,clinical pharmacy ,Surveys and Questionnaires ,medicine ,Humans ,adherence ,030212 general & internal medicine ,business.industry ,Health Policy ,Public health ,public health ,Public Health, Environmental and Occupational Health ,Australia ,Focus Groups ,Focus group ,Quality Improvement ,clinical practice ,Clinical pharmacy ,Clinical Practice ,Health promotion ,business ,Pharmacy Service, Hospital - Abstract
Objective To improve an adherence documentation tool utilised by Australian Clinical Pharmacists in hospitals. Method Surveys and a focus group session were methods employed to study the perceptions of clinical pharmacists and medical officers on the ‘Medication Management Plan (MedMAP)’ as an adherence documentation tool and the perceived limitations, if any, of the form. Key findings The MedMAP had limitations which could potentially affect patient care in hospitals. The modified form was successfully trialled over a period of two weeks with favourable results. Conclusion The study identified the shortcomings of the MedMAP form and further underlined the importance of continual auditing of pivotal adherence documentation tools in hospital.
- Published
- 2018
29. Identifying risk factors associated with infection in patients with chronic leg ulcers
- Author
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Kathleen Finlayson, Helen Edwards, and Ut Thi Bui
- Subjects
Adult ,Male ,medicine.medical_specialty ,Population ,Dermatology ,Infections ,Risk Assessment ,Varicose Ulcer ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Risk Factors ,Internal medicine ,Medicine ,Outpatient clinic ,Infection control ,Humans ,030212 general & internal medicine ,Risk factor ,education ,Depression (differential diagnoses) ,Aged ,Aged, 80 and over ,education.field_of_study ,Infection Control ,Wound Healing ,business.industry ,Risk of infection ,Australia ,Original Articles ,Middle Aged ,Anti-Bacterial Agents ,Logistic Models ,Chronic Disease ,Quality of Life ,Surgery ,Female ,business ,Risk assessment - Abstract
Leg ulcers are hard to heal. Infection causes delayed healing, negatively impacting patients’ quality of life, the healthcare system, and society. Early recognition of patients at high risk of infection is essential to prevent complications and reduce negative impacts. However, at present, factors associated with infection in this population are not yet clearly understood. The study aimed to identify factors that were significantly associated with infection in chronic leg ulcers. A sample of 561 patients with chronic leg ulcers, who were previously recruited at outpatient clinics and community settings within Australia between 2008 and 2015, were selected for the current analysis. The prevalence of infection in the sample at study recruitment was 7.8%. A multivariate logistic regression model was used to identify factors associated with infection. The study identified 7 factors that were significantly independently associated with infection, including depression, chronic pulmonary disease, anti‐coagulant use, calf ankle circumference ratio
- Published
- 2017
30. Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans
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Channa K Jayawickreme, Katrina L. Creech, John T. Moore, Fabrice Viviani, Cathy Simmons, Susan H. Smith, Timothy M. Willson, Thi Bui, David L. Mayhew, Dalei Wu, Edwige Nicodeme, William M. Pryor, Jessica Neil, David J. Rickard, Christine M. Coquery, Deepak K. Rajpal, David C. Morris, James Lee, Fraydoon Rastinejad, Javier Cote-Sierra, and Sylvia Furst
- Subjects
0301 basic medicine ,Agonist ,Aryl hydrocarbon receptor nuclear translocator ,medicine.drug_class ,medicine.medical_treatment ,Administration, Topical ,Human skin ,Dermatology ,Biochemistry ,Proinflammatory cytokine ,Dermatitis, Atopic ,Interleukin 22 ,03 medical and health sciences ,Mice ,Psoriasis ,Stilbenes ,medicine ,Basic Helix-Loop-Helix Transcription Factors ,Animals ,Humans ,Molecular Biology ,Cells, Cultured ,Skin ,Inflammation ,integumentary system ,biology ,business.industry ,Cell Biology ,Resorcinols ,respiratory system ,medicine.disease ,Aryl hydrocarbon receptor ,Disease Models, Animal ,030104 developmental biology ,Cytokine ,Receptors, Aryl Hydrocarbon ,Immunology ,biology.protein ,Cytokines ,business - Abstract
Tapinarof (GSK2894512) is a naturally derived topical treatment with demonstrated efficacy for patients with psoriasis and atopic dermatitis, although the biologic target and mechanism of action had been unknown. We demonstrate that the anti-inflammatory properties of tapinarof are mediated through activation of the aryl hydrocarbon receptor (AhR). We show that tapinarof binds and activates AhR in multiple cell types, including cells of the target tissue—human skin. In addition, tapinarof moderates proinflammatory cytokine expression in stimulated peripheral blood CD4+ T cells and ex vivo human skin, and impacts barrier gene expression in primary human keratinocytes; both of these processes are likely to be downstream of AhR activation based on current evidence. That the anti-inflammatory properties of tapinarof derive from AhR agonism is conclusively demonstrated using the mouse model of imiquimod-induced psoriasiform skin lesions. Topical treatment of AhR-sufficient mice with tapinarof leads to compound-driven reductions in erythema, epidermal thickening, and tissue cytokine levels. In contrast, tapinarof has no impact on imiquimod-induced skin inflammation in AhR-deficient mice. In summary, these studies identify tapinarof as an AhR agonist and confirm that its efficacy is dependent on AhR.
- Published
- 2016
31. Imatinib-resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprogramming
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Anthony A. Mancuso, Julian J. Lum, Alexander E. Perl, Craig B. Thompson, Nabil Sayed, Thi Bui, Xuemei Tong, Fangping Zhao, Joshua J. Gruber, Cezary R. Swider, Martin Carroll, Patricia V. Sanchez, Stephen W. Tuttle, and Junia V. Melo
- Subjects
Male ,Cancer Research ,Ribose ,Fusion Proteins, bcr-abl ,Apoptosis ,Piperazines ,Mice ,hemic and lymphatic diseases ,Glycolysis ,RNA, Small Interfering ,Hypoxia ,Pyruvate dehydrogenase complex ,Up-Regulation ,Gene Expression Regulation, Neoplastic ,Leukemia ,Benzamides ,Imatinib Mesylate ,medicine.drug ,glucose metabolism ,pentose phosphate pathway ,HIF-1α ,Mice, Nude ,Pentose phosphate pathway ,Transketolase ,Biology ,cell survival ,Article ,imatinib (gleevec, STI571) ,resistance ,Cell Line, Tumor ,Leukemia, Myelogenous, Chronic, BCR-ABL Positive ,Genetics ,medicine ,Animals ,Humans ,Molecular Biology ,neoplasms ,Protein Kinase Inhibitors ,Cell Proliferation ,Imatinib ,medicine.disease ,Hypoxia-Inducible Factor 1, alpha Subunit ,Xenograft Model Antitumor Assays ,Citric acid cycle ,Imatinib mesylate ,Glucose ,Pyrimidines ,Drug Resistance, Neoplasm ,Cancer research ,Blast Crisis - Abstract
As chronic myeloid leukemia (CML) progresses from the chronic phase to blast crisis, the levels of BCR-ABL increase. In addition, blast-transformed leukemic cells display enhanced resistance to imatinib in the absence of BCR-ABL-resistance mutations. In this study, we show that when BCR-ABL-transformed cell lines were selected for imatinib resistance in vitro, the cells that grew out displayed a higher BCR-ABL expression comparable to the increase seen in accelerated forms of the disease. This enhanced expression of BCR-ABL was associated with an increased rate of glycolysis but with a decreased rate of proliferation. The higher level of BCR-ABL expression in the selected cells correlated with a nonhypoxic induction of hypoxia-inducible factor-1alpha (HIF-1alpha) that was required for cells to tolerate enhanced BCR-ABL signaling. HIF-1alpha induction resulted in an enhanced rate of glycolysis but with reduced glucose flux through both the tricarboxylic acid cycle and the oxidative arm of the pentose phosphate pathway (PPP). The reduction in oxidative PPP-mediated ribose synthesis was compensated by the HIF-1alpha-dependent activation of the nonoxidative PPP enzyme, transketolase, in imatinib-resistant CML cells. In both primary cultures of cells from patients exhibiting blast transformation and in vivo xenograft tumors, use of oxythiamine, which can inhibit both the pyruvate dehydrogenase complex and transketolase, resulted in enhanced imatinib sensitivity of tumor cells. Together, these results suggest that oxythiamine can enhance imatinib efficacy in patients who present an accelerated form of the disease.
- Published
- 2010
32. ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
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Kathryn E. Wellen, Georgia Hatzivassiliou, Craig B. Thompson, Uma M. Sachdeva, Thi Bui, and Justin R. Cross
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Cytoplasm ,Transcription, Genetic ,Acetate-CoA Ligase ,SAP30 ,Biology ,Citric Acid ,Histone Deacetylases ,Article ,Cell Line ,Histones ,Mice ,Acetyl Coenzyme A ,Cell Line, Tumor ,Histone H2A ,Adipocytes ,Animals ,Humans ,Cell Proliferation ,Cell Nucleus ,Histone deacetylase 5 ,Multidisciplinary ,HDAC11 ,Histone deacetylase 2 ,Acetylation ,Cell Differentiation ,3T3 Cells ,HDAC4 ,Histone Deacetylase Inhibitors ,Glucose ,Gene Expression Regulation ,Biochemistry ,Histone methyltransferase ,ATP Citrate (pro-S)-Lyase ,Intercellular Signaling Peptides and Proteins ,Interleukin-3 ,RNA Interference ,Glycolysis - Abstract
Chromatin Modifier Modulates Gene Expression Modification of chromatin structure is usually thought of as a global, relatively nonspecific way of modulating gene expression. However, Wellen et al. (p. 1076 ; see the Perspective by Rathmell and Newgard ) demonstrate that such regulation helps link growth factor–stimulated increases in metabolism to appropriate changes in gene expression. Adenosine triphosphate (ATP)–citrate lyase (ACL), which converts citrate to acetyl–coenzyme A (CoA) in the mitochondria of mammalian cells during metabolism of glucose, was also found to be present in the nucleus, where it might regulate activity of histone acetyl transferases (HATs) by controlling the availability of acetyl-CoA. Indeed, depletion of ACL from cultured human colon carcinoma cells specifically decreased histone acetylation in the nucleus, but appeared not to affect the overall amount of acetylation of proteins in the cells. Loss of ACL in cultured mouse 3T3-L1 cells diminished the increase in histone acetylation normally associated with hormone-stimulated differentiation of these cells and inhibited the increase in expression of specific genes, such as that encoding the Glut4 glucose transporter. Thus, ACL may help cells link metabolic activity to changes in gene expression.
- Published
- 2009
33. Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin
- Author
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David J. Rickard, Edwige Nicodeme, Jessica Neil, Javier Cote-Sierra, Véronique Birault, Anton M. Jetten, Susan H. Smith, Elizabeth Millerman, Thi Bui, Hans Hofland, Yukimasa Takeda, Fabrice Viviani, Jean-Marie Brusq, Jean-Philippe Therrien, and Carlos E. Peredo
- Subjects
0301 basic medicine ,Physiology ,Biopsy ,Drug Evaluation, Preclinical ,lcsh:Medicine ,Gene Expression ,Imiquimod ,Human skin ,Pharmacology ,Translational Research, Biomedical ,Jurkat Cells ,Mice ,White Blood Cells ,0302 clinical medicine ,Genes, Reporter ,Animal Cells ,RAR-related orphan receptor gamma ,Immune Physiology ,Medicine and Health Sciences ,Medicine ,lcsh:Science ,Luciferases ,Skin ,Mice, Inbred BALB C ,Innate Immune System ,Multidisciplinary ,Cytokine Therapy ,T Cells ,Interleukin-17 ,Animal Models ,Nuclear Receptor Subfamily 1, Group F, Member 3 ,3. Good health ,030220 oncology & carcinogenesis ,Aminoquinolines ,Cytokines ,Female ,Interleukin 17 ,Cellular Types ,Anatomy ,Integumentary System ,Research Article ,medicine.drug ,Immune Cells ,Inflammatory Diseases ,Primary Cell Culture ,Immunology ,Mouse Models ,Surgical and Invasive Medical Procedures ,Administration, Cutaneous ,Research and Analysis Methods ,Permeability ,Autoimmune Diseases ,Small Molecule Libraries ,03 medical and health sciences ,Model Organisms ,Immune system ,Psoriasis ,Genetics ,Animals ,Humans ,Immunologic Factors ,Blood Cells ,business.industry ,lcsh:R ,Biology and Life Sciences ,Cell Biology ,Molecular Development ,medicine.disease ,030104 developmental biology ,Immune System ,Th17 Cells ,lcsh:Q ,Clinical Immunology ,Clinical Medicine ,business ,Ex vivo ,Developmental Biology - Abstract
Background Psoriasis is a chronic inflammatory skin disorder involving marked immunological changes. IL-17-targeting biologics have been successful in reducing the disease burden of psoriasis patients with moderate-to-severe disease. Unfortunately, the stratum corneum prevents penetration of large molecule weight proteins, including monoclonal antibodies. Thus, for the majority of psoriasis patients ineligible for systemic treatments, a small molecule targeting RORγt, the master regulator of IL-17 family cytokines, may represent an alternative topical medicine with biologic-like efficacy. Methods and Findings The preclinical studies described in this manuscript bridge the gap from bench to bedside to provide the scientific foundation for a compound entering clinical trials for patients with mild to moderate psoriasis. In addition to several ex vivo reporter assays, primary T cell cultures, and the imiquimod mouse model, we demonstrate efficacy in a newly developed human ex vivo skin assay, where Th17-skewed cytokine expression is induced from skin-resident immune cells. Importantly, the skin barrier remains intact allowing for the demonstration of topical drug delivery. With the development of this novel assay, we demonstrate potent compound activity in the target tissue: human skin. Finally, target engagement by this small molecule was confirmed in ex vivo lesional psoriatic skin. Conclusions Our work describes a progressive series of assays to demonstrate the potential clinical value of a novel RORγ inverse agonist small molecule with high potency and selectivity, which will enter clinical trials in late 2015 for psoriasis patients.
- Published
- 2016
34. Comparison of two minimally invasive techniques for treating chronic rhinosinusitis in the pediatric population
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Gregory J. Kruper, Nathan A. Deckard, James M. Coticchia, and Thi Bui
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Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Therapeutic irrigation ,Adenoidectomy ,medicine ,Humans ,Sinusitis ,Child ,Therapeutic Irrigation ,Retrospective Studies ,Rhinitis ,medicine.diagnostic_test ,business.industry ,Infant ,Retrospective cohort study ,Endoscopy ,General Medicine ,Functional endoscopic sinus surgery ,Maxillary Sinus ,medicine.disease ,Surgery ,Anti-Bacterial Agents ,Treatment Outcome ,Otorhinolaryngology ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Chronic Disease ,Female ,Nasal Cavity ,business ,Complication - Abstract
Objective To compare two minimally invasive techniques for the treatment of chronic rhinosinusitis in young children. Background Chronic rhinosinusitis (CRS) is a common diagnosis in young children. Maxillary sinus aspiration & irrigation with adenoidectomy (MSI) followed by an extended course of oral antibiotics has been shown to be an alternative to functional endoscopic sinus surgery. However, since MSI is not performed under direct visualization, it has inherent risk. This study analyzes the techniques of MSI and endoscopically guided middle meatus cultures & antral biopsy with adenoidectomy (EGC) in the (1) diagnosis of bacterial infection by culture, (2) time to resolution using double antibiotic therapy, and (3) associated morbidity of the two procedures. Methods The medical records at Wayne State University, Department of Otolaryngology Head & Neck Surgery were reviewed from 2004 to 2010. All children who presented with CRS who underwent MSI or EGC were included in this retrospective case series. Results Patients presented with a history of cough, nasal discharge, and congestion. The mean age was 3.7 years. Symptom duration prior to treatment was 7.4 months in the 64 patients who underwent MSI and 9.1 months in the 46 patients who underwent EGC. MSI identified bacteria in 80% of patients compared to 73% in EGC patients (p = 0.45). The MSI group underwent antibiotic treatment for 8.7 weeks and achieved symptom resolution in 8.7 weeks compared to 6.9 weeks and 4.9 weeks respectively in the EGC group (p = 0.08 and 0.01). However, if patients presented with snoring or cough, time to resolution of symptoms was significantly lower in patients undergoing EGC versus MSI (p = 0.02 and p = 0.01, respectively). One patient who underwent MSI experienced epistaxis requiring nasal packing, and two patients had pseudoproptosis following irrigation that resolved spontaneously shortly thereafter. No complications were reported in the EGC group. Conclusion EGC is an effective treatment for young children with CRS. EGC and MSI are equally effective in obtaining diagnostic cultures. EGC decreases time to symptom resolution, and it lowers the risk of complication when compared to MSI.
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- 2011
35. Cancer's sweet tooth
- Author
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Craig B. Thompson and Thi Bui
- Subjects
medicine.medical_specialty ,Cancer Research ,Oxidative phosphorylation ,Biology ,Carbohydrate metabolism ,Oxidative Phosphorylation ,Adenosine Triphosphate ,Oxygen Consumption ,Internal medicine ,Neoplasms ,medicine ,Animals ,Humans ,Glycolysis ,Cell growth ,Cancer ,Cell Biology ,medicine.disease ,Hypoxia-Inducible Factor 1, alpha Subunit ,Phenotype ,Cell biology ,Mitochondria ,Endocrinology ,Cell Transformation, Neoplastic ,Glucose ,Oncology ,Cancer cell ,Energy Metabolism ,Function (biology) - Abstract
Even in the presence of an adequate oxygen supply, many tumors metabolize the majority of the glucose they take up through glycolysis. It has been a long-held belief that this glycolytic phenotype is due to cancer-specific defects in mitochondrial oxidative phosphorylation. In this issue of Cancer Cell, Fantin et al. now report that most tumor cells have a substantial reserve capacity to produce ATP by oxidative phosphorylation when glycolysis is suppressed. These new data add to mounting evidence that the high rate of glycolysis exhibited by most tumors is required to support cell growth rather than to compensate for defect(s) in mitochondrial function.
- Published
- 2006
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