1. Low molecular weight heparin treatment of acute moderate and severe pancreatitis: A randomized, controlled,open-label study
- Author
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Yusuf Kayar, Hakan Senturk, Mukaddes Tozlu, Ali Tüzün Ince, Birol Baysal, Tozlu, M, Kayar, Y, Ince, AT, Baysal, B, Senturk, H, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Tozlu, Mukaddes, and ŞENTÜRK, HAKAN
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.drug_class ,Low molecular weight heparin ,Severity of Illness Index ,Gastroenterology ,law.invention ,Necrosis ,Young Adult ,03 medical and health sciences ,Subcutaneous injection ,0302 clinical medicine ,Randomized controlled trial ,A randomized, controlled,open-label study.-, TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.30, ss.81-87, 2019 [Tozlu M., Kayar Y., İNCE A. T. , Baysal B., Şentürk H., -Low molecular weight heparin treatment of acute moderate and severe pancreatitis] ,law ,Internal medicine ,Severity of illness ,medicine ,Humans ,Young adult ,Pancreas ,Aged ,Aged, 80 and over ,Gastroenterology & Hepatology ,business.industry ,Anticoagulants ,Heparin ,Heparin, Low-Molecular-Weight ,Middle Aged ,Prognosis ,medicine.disease ,Treatment Outcome ,Pancreatitis ,030220 oncology & carcinogenesis ,Acute Disease ,Acute pancreatitis ,Female ,Original Article ,030211 gastroenterology & hepatology ,business ,medicine.drug - Abstract
Background/Aims: Acute pancreatitis (AP) runs a moderately severe and severe course in 20%-30% of cases. The purpose of the present study was to determine the effect of low molecular weight heparin (LMWH) for the prevention of pancreatic necrosis (PN) in moderately severe and severe AP (MSAP). Materials and Methods: A total of 100 patients with MSAP were randomized to receive either standard care (SC) or SC plus LMWH. LMWH was administered at 1 mg/kg via subcutaneous injection twice a day between days 1 and 7. The revised Atlanta criteria were used in the diagnosis of MSAP. Patients with a Harmless AP Score of ≥1 and a Balthazar computed tomography (CT) score of D and E were included in the study. Results: The mean age±SD of the patients (46 male and 54 female) was 52±19 years (range, 17-100). There were 50 patients in each group. On admission, clinical and laboratory parameters and Balthazar CT scores were similar between the groups. Initially, PN was present in one patient in the LMWH group and two in the SC group. Over the course, PN developed in 3 (6.1%) patients in the LMWH group and 11 (22.9%) in the SC group (p
- Published
- 2019